Digital Commons Network^™

The Invisible Playground For Taboos: A Framework For Recognising And Designing For Inner Play To Engage With Death And Anticipatory Grief, Manuela Melo, Sofie Kinch, Andrew Tibbles, Allan Køster

DRS Biennial Conference Series

Death and Anticipatory Grief remain culturally taboo, limiting opportunities for open dialogue and emotional preparedness. This paper explores how design can facilitate such conversations through play. Inner Play is a form of imaginative and introspective play that aids engagement with taboos in an empathic way, but lacks ways to understand and evaluate how to design for it. Employing a Research-through-Design approach, the papers presents a speculative design project that mediates communication between the bereaved and the deceased with a game kit resulting in a shared grief artefact. Ten participants in five workshops engaged in an iterative prototyping process, which resulted …

City Of Longevity: A Framework To Integrate Emerging Technologies And Participatory Design Into Urban Environments, Camilla Borghi, Beatrice Ferrarini, Valeria Leonardi, Xueying Xiong

DRS Biennial Conference Series

The City of Longevity (CoL) framework integrates emerging technologies, participatory methodologies, and systemic service design to mainstream longevity in urban planning. Anchored in equity and intergenerational engagement, CoL introduces an AI-driven decision-support platform that translates longevity evidence into actionable urban policy through participatory co-design, KPI setting, and systemic service design principles. Following the Longevity as a Service (LaaS) concept, CoL advances a phased, coordinated implementation architecture whose deliverables are tailored to each municipality's cultural heritage and civic identity. This architecture is embedded within a collaborative inter-city network. Methodologically, this work synthesises convergent evidence from exposome science, longevity-ready urbanism, participatory design, …

Reflective Sociomaterialist Learning For Design For Sustainability (Dfs) In The Global South: Evaluations Of Students’ Product Service System (Pss) Design Projects At A Thai Design School, Hyunwook Hwangbo

DRS Biennial Conference Series

This study explores how teaching service design through Product-Service System projects can encourage reflective sociomaterialist learning for Design for Sustainability in the Global South. It analyses 22 Product-Service Systems projects by undergraduate students at a Thai design school to examine how design education, aligned with Thailand’s bio-circular-green (BCG) economy initiative, helps develop students as social agents who drive sustainable innovation. Using ethnographic action research and thematic analysis, six case vignettes illustrate how participatory design methods and systems thinking in Product-Service Systems projects empower students to build sociotechnical systems and offer localized, community-centered solutions. Findings show that integrating Product-Service Systems practices …

Design Materials, Roberta Bernabei, Maria Maclennan

DRS Biennial Conference Series

No abstract provided.

The Transformative Nature Of Food – Adaptation, Connectivity And Identity, Dolly Daou, Claudia De Souza Libanio, Juan Montalván Lume

DRS Biennial Conference Series

This theme track examines the transformative role of food migration in shaping cultural identity, ecological systems, and practices of belonging through a food design lens. Building on The Transformative Nature of Food: Adaptation, Connectivity and Identity (Daou & Sarantou, 2026), it conceptualises food as a dynamic, designed system that evolves across geographies through processes of adaptation, connectivity and identities. As food travels, it connects people to both their original homeland and to the existing and emerging cultural identities, to develop a sense of belonging to local ecosystems. Food migration reinforces cultural continuity, political and social cohesion and belonging while influencing …

What Is Regenerative Design, Anyway? Foundations, Lexicons, And Interdisciplinary Intersections, Angela Kilford, Inge Panneels, Iohanna Nicenboim, Sonya Withers, Rob Phillips, Chris Speed

DRS Biennial Conference Series

This theme track seeks papers that establish foundational understanding of Regenerative Design as an emerging paradigm in design research and practice. Moving beyond sustainability approaches focused on harm reduction and consequences, regenerative design actively fosters ecological and cultural renewal through relational, more-than-human perspectives. Recent work across biodesign, materials research, and ecological design demonstrates growing interest in regenerative approaches, yet the field lacks conceptual coherence and metrics of success. Existing papers span diverse domains—living materials, Indigenous design methodologies, multispecies interaction design, and data practices that challenge extractive digital economies and ecological restoration—often using inconsistent terminology and theoretical frameworks. This fragmentation limits …

Temporalities Of More-Than-Human Design, Larissa Pschetz, Gizem Oktay, Valentina Nisi, Jiwei Zhou, Doris Kosminsky, Keili Koppel, Fiona Bell, Katharina Vones, Marta Ferreira

DRS Biennial Conference Series

This theme track builds on emerging research that foreground time as relational, situated, and plural, while examining how a shift towards more-than-human temporalities could reshape design practices, material engagements, and ethical responsibilities. The track proposes five areas of exploration: a) experimental representations of entangled temporalities; b) material transformations, geological formations, and temporal scales of planetary life; c) accounts on practices of noticing, attuning, and orchestrating more-than-human times; d) designerly ways of negotiating and coordinating rhythms; and e) etico-onto-epistemological reflections on time and design. The contributions engage these areas across contexts such as coastal ecologies, plant systems, and bio-based materials, framing …

Designing Preventive Health Technologies And Practices, Ayşe Özge Ağça, Teresa Almeida, Armağan Karahanoğlu, Anna Vallgårda

DRS Biennial Conference Series

This track explores how design influences preventive health technologies and practices, considering them as spaces for care, negotiation, and future planning. While preventive health is often examined through medical and technological lenses, design offers a unique perspective by focusing on lived experiences, care relationships, and the processes of making sense of things. In this editorial, we outline five contributions that investigate preventive health across diverse contexts, including behavior change, immersive care technologies, critical perspectives on healthcare systems, health communication, and bio-inspired design frameworks. These findings together show that designing for preventive health goes beyond just predicting or reducing future problems …

Bodies In Design: Rethinking Norms, Materials, Technologies, And Methods, Gözde Göncü-Berk, Sarah Kettley, Elif Ozden-Yenigun, Theodore Hughes-Riley

DRS Biennial Conference Series

The Bodies in Design track deals with the ways design engages with the human body with an emphasis on critical and creative investigations into the role of the body in contemporary design. While the body remains implicitly central to design thinking, it can be rendered invisible by a focus on the rational user or the cognitively motivated actor, and unreflexively normalized through forms of conservative and market-driven design agendas. Advancements in wearables and soft systems however, are reshaping design as a practice that engages the body in more considered and complex ways. We therefore sought contributions across material domains that …

Tilapia Fish Collagen: Potential As Halal Biomaterial In Tissue Engineering Applications, Norhidayu Muhamad Zain, Mohammad Naqib Hamdan

Nusantara Halal Journal

Collagen is a natural bioactive polymer widely utilized in tissue engineering applications due to its biocompatibility and biodegradability. Collagen derived from mammalian sources such as porcine and bovine is commonly used as biomaterials. However, due to religious concerns, the halal status of collagen must be taken into consideration. Since most of the mammalian collagen is hampered by its haram origins, marine collagens are widely investigated as alternatives for mammalian collagen in tissue engineering applications. Even though marine collagens are safe and easy to extract, these sources of collagen are hindered by their low denaturing temperature. Tilapia fish (Oreochromis niloticus) has …

Applications Of Geosynthetics In Tunnels Construction: A Sustainable Approach To Carbon Footprint Reduction, Ibraheem Rais, Abdullah H. Alsabhan, Md. Rehan Sadique, Shamshad Alam

Journal of Sustainable Construction Materials and Technologies

The use of geosynthetics has transformed tunnelling practices by enhancing structural integrity, durability, and environmental sustainability. This review adopts a systematic literature review design, covering publications from 2000 to 2025 sourced from Scopus, Web of Science, ScienceDirect, and Google Scholar. The selected studies were screened based on relevance, quality, and focus on tunnelling applications, then thematically analyzed into four domains: geosynthetic types, applications, sustainability, and performance evaluation. This review focuses on the applications of various geosynthetics, including geotextiles, geogrids, geocomposites, geocells, and geomembranes, in tunnelling projects. These materials play crucial roles in reinforcing tunnel walls and slopes, improving load distribution, …

Home Is Not Always Where The Heart Is: Examining The Inadequacy Of Legal Measures In The Deportation Of American Intercountry Adoptees, Katie X. Kaessinger, Esq.

San Diego International Law Journal

Despite entering the United States legally as children through intercountry adoption, thousands of American adoptees face deportation as adults because their parents failed to finalize their citizenship. Many of these adoptees have no meaningful linguistic, cultural, or familiar ties to their birth countries, and most have lived in the United States practically their entire lives. This Article explores the legal implications regarding the deportation of intercountry adoptees. More specifically, this Article argues that the deportation of intercountry adoptees reflects a grave systemic failure that violates international human rights law, rather than a mere shortcoming of domestic immigration policy.

Consulting various …

How Quickly Do Eastern Floodplains Store Carbon? Quantifying Reference Carbon Flux On The Dead Diamond River, Jacob Schnell

Earth Sciences Undergraduate Senior Theses

Terrestrial Earth systems sequester an estimated 30% of annual anthropogenic CO2 emissions. The largest share is stored in global soils which collectively store more than 3 times the amount of carbon as the atmosphere. Floodplains and river systems, while covering only 5–8% of land area, store 20–30% of the global soil organic carbon (SOC), yet, the rate at which floodplains sequester carbon remains highly uncertain. Here I constrain floodplain carbon sequestration rates for a model northeastern river that has not been impacted by development or significant human activity. I calculate carbon stock using total organic carbon and derive carbon flux …

Holy Cross Magazine, Vol. 60 No. 2, Summer 2026, College Of The Holy Cross

Holy Cross Magazine

For a GoodTime, Call ...
How Holy Cross’ Goodtime Marching Band and Bettertime Pep Band deliver much more than music.
Story by Abby Riviello
Photography by Colin McAlister ’29

Read Like a Professor (on Summer Break)
Holy Cross faculty share the books they’re taking to the beach.
Story by Marybeth Reilly-McGreen ’89
Photography by Michael Ivins

Michelle Mondoux Paused at the Middle — And it Changed Everything
Stick with Associate Professor Michelle Mondoux and you’re going to learn a lot about biology in the classroom, and perhaps more about life beyond it.
Story by Abby Riviello
Photography by Michael Ivins …

Parent Cultural Wealth: How Beliefs, Curriculum Familiarity, And Community Awareness Facilitate Home-Based Cs Conversations, Nicol Howard, Leiny Y. Garcia, Jean Ryoo, Julie Flapan, Michelle Choi, Paula Nazario, Wei Wei

Mathematics, Physics, and Computer Science Faculty Articles and Research

Parents are critical influences on children's computer science (CS) pathways, yet families’ involvement remains understudied. Guided by parental involvement and community cultural wealth frameworks, this work-in-progress examined survey data from 53 parents representing families historically underrepresented in computing within California (71% women; 54% Hispanic/Latin/x/e). Findings revealed that CS school curriculum familiarity and awareness of CS community events significantly predicted parent-child CS conversations, while parent CS confidence and attitudes did not, suggesting that curriculum transparency and community connections can promote equitable involvement. Future work will integrate qualitative interviews to examine how families draw upon their cultural wealth.

Gunk - Genetic Underwater Nucleic-Acid Collector, Kay Hall, Harumy Miura, Isaac Carlos Hernandez-Nguyen, Oscar Emilio Alvarado Flores

Interdisciplinary Design Senior Theses

Environmental DNA sampling is a powerful and minimally invasive tool for biodiversity assessment and species monitoring. However, existing environmental DNA collection systems are costly, difficult to deploy at depth at low cost and with small teams, non-standardized, and inaccessible to non-technical users. This report presents GUNK, the Georeferenced Underwater Nucleic-acid Kollector, a submersible environmental DNA sampler developed in collaboration with ConservationXLabs and the Santa Clara University Robotics Systems Laboratory. GUNK is designed to address three primary goals: reaching sampling depths unachievable by existing low-cost solutions, reducing the financial barrier associated with environmental DNA research, and ensuring the system is easily …

Late Pleistocene-Holocene Environmental Change From May Pond Sediment Cores And Upland 10be Ages, Adrianna Drindak

Earth Sciences Undergraduate Senior Theses

The goal of this project is to reconstruct the deglaciation and post-glacial environmental conditions of northern Vermont that occurred during the transition from the Pleistocene to the Holocene, ~15,000 to 11,000 years ago. This transition marks a major climatic shift, from a glacial period to an interglacial period, and regionally involved the retreat of the Laurentide Ice Sheet (LIS). The retreat of the LIS influenced the surficial geology of North America, exposing the Earth’s surface, leaving glacial deposits, and carving out proglacial lakes. The timing of ice retreat in the region provides information about past climate conditions, which may inform …

Soaring To New Heights Through The Lens Of The Scarlet Macaw–A Post-Loper Bright Interpretation Of The Endangered Species Act’S “Significant Portion Of Its Range” For A Climate-Driven “Foreseeable Future”, Kathryn Wood

San Diego Journal of Climate & Energy Law

This Comment will argue for particular interpretations of “significant portion of its range” and “foreseeable future” under the ESA to prioritize species preservation in the face of climate change.

The analysis begins by describing key aspects of the ESA, including its historical background, its conceptual definitions, its prescribed method for determining endangered species and threatened species, its listing process, and critical habitat requirements. This Comment then discusses climate change as a source of threat and endangerment “within the foreseeable future,” and whether acts worsening climate change can constitute an unlawful taking. Next, this Comment considers how the Supreme Court’s decision …

Recent Antibiotic Exposure And Response To Treatment Of Juvenile Idiopathic Arthritis: A Retrospective Cohort Study, Daniel Horton, Charu Verma, Sanika Rege, Stephen Crystal, Tobias Gerhard, Alicia Iizuka, Matthew Iozzio, Dawn Koffman, Lauren Parlett, Julianne Varga, Carlos Rose, Brian Strom

Department of Medicine Faculty Papers

BACKGROUND: Juvenile idiopathic arthritis (JIA) has been tied to microbiome disruption and antibiotic exposure. Gut microbiota may affect how adults with rheumatoid arthritis respond to methotrexate. We tested if exposure to antibiotics was associated with response to methotrexate for JIA.

METHODS: We conducted a retrospective cohort study using national US public and private insurance claims data (2001-2023). We included children ages 1-17 continuously enrolled for ≥ 10 months and diagnosed with JIA who initiated methotrexate monotherapy or, for comparison, tumor necrosis factor inhibitor (TNFi) monotherapy without prior disease-modifying antirheumatic drug (DMARD) exposure. Antibiotic exposure during the 10-month baseline period was …

Structure And Spectroscopy Of Free Base, Copper, And Zinc Tetrapentylporphyrin, Christopher J. Ziegler, Nneka Damola Ajayi, Victor N. Nemkyin, G Richard Geier Iii

University Research

Synthetic porphyrins have been crucial as models for heme units and other biological porphyrins, as well as components of advanced materials and catalysts. Much of the work on synthetic porphyrins has focused on the meso-substituted 5,10,15,20-tetraphenylporphyrin (TPP) or the pyrrole-substituted 2,3,7,8,12,13,17,18-octaethylporphyrin (OEP). In this report, we present a comprehensive spectroscopic, electrochemical, and computational study of free-base, zinc(II), and copper(II) 5,10,15,20-tetrapentylporphyrin (TPeP). TPeP can be prepared via a two-step, one-flask reaction of pyrrole and hexanal mediated by Montmorillonite K10, followed by oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in yields of around 40%. Similar to TPP, the TPeP systems have the highest occupied molecular …

Structure And Spectroscopy Of Free Base, Copper, And Zinc Tetrapentylporphyrin, Christopher J. Ziegler, Nneka Damola Ajayi, Victor N. Nemkyin, G Richard Geier Iii

University Research

Synthetic porphyrins have been crucial as models for heme units and other biological porphyrins, as well as components of advanced materials and catalysts. Much of the work on synthetic porphyrins has focused on the meso-substituted 5,10,15,20-tetraphenylporphyrin (TPP) or the pyrrole-substituted 2,3,7,8,12,13,17,18-octaethylporphyrin (OEP). In this report, we present a comprehensive spectroscopic, electrochemical, and computational study of free-base, zinc(II), and copper(II) 5,10,15,20-tetrapentylporphyrin (TPeP). TPeP can be prepared via a two-step, one-flask reaction of pyrrole and hexanal mediated by Montmorillonite K10, followed by oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in yields of around 40%. Similar to TPP, the TPeP systems have the highest occupied molecular …

Towards Efficient Continual Deep Learning, Md Yousuf Harun

Theses

Modern AI systems can achieve remarkable performance on tasks such as image recognition, object detection, and language understanding, but they often struggle with a basic ability that humans rely on every day: learning continuously. When deep neural networks (DNNs) are updated with new information, they can unexpectedly forget what they previously learned, making them difficult to deploy in changing real-world environments. This dissertation explores how to build AI systems that can learn more like humans: adapting to new data, preserving past knowledge, and using prior experience to learn future tasks more efficiently. Rather than focusing only on preventing forgetting, this …

Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan

Markey Cancer Center Faculty Publications

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, yet its molecular drivers are not fully defined. Emerging evidence highlights the importance of tumor-stroma interactions mediated by secreted glycoproteins. However, the mechanisms by which cancer cells regulate the secretion of these protumorigenic proteins remain largely unknown. Endoplasmic reticulum-resident (ER-resident) N-glycan-processing enzymes regulate proper protein folding, a prerequisite for glycoproteins to exit the ER and undergo secretion. By evaluating their prognostic significance in lung tumors and conducting functional screening in lung cancer cells, we identify α-glucosidase II (α-Glc II) as a key regulator of NSCLC progression. α-Glc …

Notch1 Acts As A Tumor Suppressor That Induces Early Differentiation In Head And Neck Cancer, Chenfei Huang, Shhyam Moorthy, Qiuli Li, Kazi M Ahmed, Kalil Saab, Defeng Deng, Jiping Wang, Xiayu Rao, Jiexin Zhang, Yuanxin Xi, Jing Wang, Zhiyi Liu, Noriaki Tanaka, David A Wheeler, Eve Shinbrot, Rami Saade, Curtis R Pickering, Tong-Xin Xie, Adel K El-Naggar, Abdullah A Osman, Kunal Rai, Patrick A Zweidler-Mckay, John V Heymach, Lauren A Byers, Faye M Johnson, Vlad C Sandulache, Jeffrey N Myers, Pedram Yadollahi, Mitchell J Frederick

Faculty, Staff and Students Publications

Inactivating NOTCH1 mutations in head and neck squamous cell carcinoma (HNSCC) were described over a decade ago, suggesting a tumor suppressor function - unlike its oncogenic role in other tumors. Today, much debate persists regarding a putative oncogenic role in HNSCC as well, with reports that NOTCH1 signaling drives tumor growth and a cancer stem cell (CSC) phenotype. In this work, comprehensive experiments unequivocally demonstrate that NOTCH1 is a tumor suppressor in HNSCC regardless of mutation or activation status and that it reduces CSC frequency. We developed a signature of NOTCH1 activation showing the pathway is associated with very early …

Structured Telehealth Community Health Worker-Clinician Feedback And Diabetes Outcomes: A Randomized Clinical Trial, Elizabeth M Vaughan, Xiaoying Yu, Amber B Amspoker, Aanand D Naik, Ashok Balasubramanyam, Craig A Johnston, Christi M Ballantyne, Salim S Virani, H Shelton Brown, Kristina Mena, Laura R Porterfield

Faculty, Staff and Students Publications

Importance: Community health workers (CHWs) improve chronic disease management in underserved populations, but scalable integration strategies are limited.

Objective: To evaluate whether a multidimensional intervention incorporating telementored CHWs and a structured participant-CHW-clinician feedback loop can improve diabetes outcomes.

Design, setting, and participants: This 12-month randomized clinical trial was conducted at 3 institutionally and geographically diverse community clinics in Texas between September 1, 2023, and April 30, 2025, and included low-income, uninsured White Hispanic adults with type 2 diabetes identified through clinic databases. Data were analyzed between May 1 and July 31, 2025.

Intervention: Individuals were randomized 1:1 to the intervention …

Development And Preliminary Validation Of Orca-Pd, An Online Rapid Cognitive Assessment For Parkinson Disease: Mixed Methods Study, Avigail Lithwick Algon, Sarah Brisman, Chi-Ying R Lin, William Saban

Faculty, Staff and Students Publications

Background: Traditional in-person neuropsychological tests for Parkinson disease (PD) lack accessibility, scalability, and PD specificity. Mobility impairments hinder access to in-person assessments, and long waiting times for expert evaluation limit scalability. Common tools for cognitive screening, such as the Montreal Cognitive Assessment, are generic and not specific to PD.

Objective: The goal of this study was to address these challenges by leveraging the internet. This study aimed to develop a sensitive tool to detect cognitive impairments in early- to mid-stage PD in an accessible and scalable manner.

Methods: We developed the Online Rapid Cognitive Assessment for Parkinson's Disease (ORCA-PD), a …

Assessment Of The Readiness Of Architectural Design Companies To Adopt Eco-Friendly Nanotechnologies In Sustainable Building Design, Ashwaq Essa Al Khalil

Dissertations and Theses

Nanotechnology is emerging as a promising innovation in sustainable architectural design, although its adoption remains slow. Research highlights the advantages of incorporating nanotechnologies in architecture, including improved material performance, enhanced thermal efficiency, reduced energy consumption, improved durability, and progress toward the Sustainable Development Goals (SDGs). These advantages make nanomaterials a promising solution for sustainable building design, particularly in hot-climate regions where energy consumption and carbon emissions associated with conventional building design practices remain major concerns.

Despite this potential, nanotechnology adoption in architecture faces several challenges, including limited real-world applications, slow diffusion in practice, and persistent organizational, economic, and regulatory barriers. …

The Law And Policy Of Gender Provisions In Multilateral And Regional Trade Governance, Maria Panezi

Brooklyn Journal of International Law

Trade is neither gender-neutral in its design nor in its outcomes. This Article offers a bird's-eye view of the law and policy of gender provisions in multilateral and regional trade governance, examines the conceptual boundaries of incorporating gender into trade policy, and evaluates legal and policy approaches that can make trade more responsive to the asymmetries that disproportionately affect women. Using Canada as a case study, the Article examines one of the most comprehensive national frameworks for mainstreaming gender in trade, including the Gender-Based Analysis Plus (GBA Plus) methodology and the inclusion of dedicated gender and trade chapters in several …

Necessary Biosafety Precautions For Patented Gmos: Ramifications Of Inconsistent Parties Between The Cartagena Protocol And Trips Agreement, Lauren Clements

Brooklyn Journal of International Law

Genetically Modified Organisms (“GMOs”) compose a class of potentially patentable biotechnology that are prominent in international markets. Developed countries like the United States, function as leading producers of these patented GMOs and therefore play a significant role in their development and transnational export. Minimum protections for these forms of biotechnology are outlined in the Agreement on Trade-Related Aspects of Intellectual Property Rights (“TRIPS Agreement”), which permits the patenting of GMOs that ultimately enter the stream of international commerce. Notwithstanding the potential risks GMOs present to the environment, public health, and the economy, the TRIPS Agreement fails to address any form …

Proof-Of-Concept Study For The Detection Of Somatic Structural Variant Driver Alterations Using Hifi Long-Read Sequencing In A Pediatric Leukemia Cohort., Lisa A. Lansdon, Byunggil Yoo, Ayse Keskus, Irina Pushel, Chengpeng Bi, Tanveer Ahmad, Asher Bryant, Adam Walter, Margaret Gibson, Mary Rindler, Weijie Li, Sahibu Sultan M Habeebu, Linda D. Cooley, John Herriges, Elena Repnikova, Lei Zhang, Keith August, Terrie Flatt, Alan S. Gamis, Erin M. Guest, J Allyson Hays, Maxine Hetherington, Karen Lewing, Tomi Pastinen, Mikhail Kolmogorov, Midhat S. Farooqi

Manuscripts, Articles, Book Chapters and Other Papers

Gene fusions are common primary drivers of pediatric leukemias and are the result of underlying structural variants (SVs). Current clinical workflows to detect such alterations rely on a multimodal approach, which often increases analysis time and overall cost of testing. In this study, we used long-read sequencing (lrSeq) as a proof-of-concept to determine whether clinically relevant (cr) SVs could be detected within a small (n = 17) pediatric leukemia cohort. We show that this methodology successfully determined all known crSVs (n = 5/5) detected through routine clinical testing. This approach also identified crSVs that resulted in the classification of a …