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Exploring The Photocatalytic And Photodynamic Effects Of Bodipy-Linked Titanium Dioxide Nanoparticles, Seda Demi̇rel Topel
Exploring The Photocatalytic And Photodynamic Effects Of Bodipy-Linked Titanium Dioxide Nanoparticles, Seda Demi̇rel Topel
Turkish Journal of Chemistry
This study aimed to investigate the photocatalytic and photodynamic actions of a 2,6-diiodinated-BODIPY (2,6-diI2-Bod) photosensitizer (PS) covalently linked to TiO2 nanoparticles (NPs). The TiO2 NPs were synthesized utilizing the hydrothermal technique, yielding an average particle size of 4–5 nm as ascertained by transmission electron microscopy and 6.4 nm as determined by dynamic light scattering measurements. The integration of the nonsoluble Bod PS to TiO2 NPs provided increased dispersibility in physiological media, making it more applicable to photodynamic therapy applications. Bod-TiO2 NPs exhibited moderate efficiency of 56.9% in singlet oxygen generation. Additionally, the photocatalytic behavior of the TiO2 NPs was evaluated …
Removal Of Toxic Cr(Vi) From Aqueous Medium With Effective Magnetic Carbon-Based Nanocomposites, Ferda Ci̇van Çavuşoğlu, Gülsüm Özçeli̇k, Şahi̇ka Sena Bayazi̇t
Removal Of Toxic Cr(Vi) From Aqueous Medium With Effective Magnetic Carbon-Based Nanocomposites, Ferda Ci̇van Çavuşoğlu, Gülsüm Özçeli̇k, Şahi̇ka Sena Bayazi̇t
Turkish Journal of Chemistry
Cr(VI), which has toxic effects, is a heavy metal and it must be removed from the environment due to the various damages it causes. In this study, the removal of Cr(VI) pollutants from aqueous solutions with Fe3O4-based materials using a batch adsorption technique was investigated. Magnetically modified graphene nanoplatelet (GNP)-based nanocomposites were prepared and their structures were characterized by FTIR, XRD, SEM, BET, and TGA techniques. The effects of various physicochemical parameters such as adsorbent dose, contact time, initial Cr(VI) solution concentration, pH, and the presence of coexisting ions (NaCl) on the adsorption process were investigated. Accordingly, the optimum conditions …
Production Of Gelatin Fibrous Mats Using Different Nanofiber Production Methods For Medical Applications And Comparison Of Their Properties, Melike Güngör, Kevser Sağlamkol, Zeynep Yağmur Baydemi̇r, Ali̇ Kiliç
Production Of Gelatin Fibrous Mats Using Different Nanofiber Production Methods For Medical Applications And Comparison Of Their Properties, Melike Güngör, Kevser Sağlamkol, Zeynep Yağmur Baydemi̇r, Ali̇ Kiliç
Turkish Journal of Chemistry
In the literature, there are studies on medical applications using different nanofiber production methods with natural polymers. However, each system has different fiber-forming capabilities. For this reason, in this study, we investigated the production of nanofibers from a biodegradable natural polymer, gelatin, using four separate nanofiber production methods, namely electrospinning (ES), electroblowing (EB), solution blowing (SB), and centrifugal spinning (CS). Our aim was to determine the most suitable fibrous web structure for medical applications and contribute to science in this respect. It was observed that the thinnest fibers (386 nm) and the heaviest mats (15.975 g m–2) were produced by …
Quaternized Chitosan/Pva/Natural Bioactive Agent Electrospun Wound Scaffolds: Production, Characterization, And Investigation Of Release Kinetics, Ezgi Eren Belgin, Cankiz Gi̇zem Deli̇balta
Quaternized Chitosan/Pva/Natural Bioactive Agent Electrospun Wound Scaffolds: Production, Characterization, And Investigation Of Release Kinetics, Ezgi Eren Belgin, Cankiz Gi̇zem Deli̇balta
Turkish Journal of Chemistry
Quaternized chitosan (HTCC) was synthesized and characterized to increase chitosan solubility. Then HTCC was electrospun with poly (vinyl alcohol) (PVA) and prepared natural bioactive agent (Calendula officinalis) extract was loaded onto fibers for wound scaffold applications. Morphological, structural, and mechanical characterization of the produced wound scaffolds was performed and their in vitro bioactive component release behavior was investigated. As a result, it was observed that the degree of quaternization of chitosan was 0.89, and synthesized HTCC was soluble in acidic, basic, alkaline media and could be electrospun with PVA in the presence of a natural bioactive agent. The presence of …
Svm-Do: Identification Of Tumor-Discriminating Mrna Signatures Via Support Vectormachines Supported By Disease Ontology, Mustafa Erhan Özer, Pemra Özbek Sarica, Kazim Yalçin Arğa
Svm-Do: Identification Of Tumor-Discriminating Mrna Signatures Via Support Vectormachines Supported By Disease Ontology, Mustafa Erhan Özer, Pemra Özbek Sarica, Kazim Yalçin Arğa
Turkish Journal of Biology
Background/aim: The complicated nature of tumor formation makes it difficult to identify discriminatory genes. Recently, transcriptome-based supervised classification methods using support vector machines (SVMs) have become popular in this field. However, the inclusion of less significant variables in the construction of classification models can lead to misclassification. To improve model performance, feature selection methods such as enrichment analysis can be used to extract useful variable sets. The detection of genes that can discriminate between normal and tumor samples in the association of cancer and disease remains an area of limited information. We therefore aimed to discover novel and practical sets …
Compcorona: A Web Application For Comparative Transcriptome Analyses Ofcoronaviruses Reveals Sars-Cov-2-Specific Host Response, Rana Sali̇hoğlu, Fati̇h Saraçoğlu, Mustafa Si̇bai̇, Tali̇p Zengi̇n, Başak Abak Masud, Onur Karasoy, Tuğba Önal Süzek
Compcorona: A Web Application For Comparative Transcriptome Analyses Ofcoronaviruses Reveals Sars-Cov-2-Specific Host Response, Rana Sali̇hoğlu, Fati̇h Saraçoğlu, Mustafa Si̇bai̇, Tali̇p Zengi̇n, Başak Abak Masud, Onur Karasoy, Tuğba Önal Süzek
Turkish Journal of Biology
Background/aim: Understanding the mechanism of host transcriptomic response to infection by the SARS-CoV-2 virus is crucial, especially for patients suffering from long-term effects of COVID-19, such as long COVID or pericarditis inflammation, potentially linked to side effects of the SARS-CoV-2 spike proteins. We conducted comprehensive transcriptome and enrichment analyses on lung and peripheral blood mononuclear cells (PBMCs) infected with SARS-CoV-2, as well as on SARS-CoV and MERS-CoV, to uncover shared pathways and elucidate their common disease progression and viral replication mechanisms. Materials and methods: We developed CompCorona, the first interactive online tool for visualizing gene response variance among the family …
Stemnesscore: An R Package To Estimate The Stemness Of Glioma Cancer Cells At Single-Cell Resolution, Necla Koçhan, Yavuz Oktay, Gökhan Karakülah
Stemnesscore: An R Package To Estimate The Stemness Of Glioma Cancer Cells At Single-Cell Resolution, Necla Koçhan, Yavuz Oktay, Gökhan Karakülah
Turkish Journal of Biology
Background/aim: Glioblastoma is the most heterogeneous and the most difficult-to-treat type of brain tumor and one of the deadliest among all cancers. The high plasticity of glioma cancer stem cells and the resistance they develop against multiple modalities of therapy, along with their high heterogeneity, are the main challenges faced during treatment of glioblastoma. Therefore, a better understanding of the stemness characteristics of glioblastoma cells is needed. With the development of various single-cell technologies and increasing applications of machine learning, indices based on transcriptomic and/or epigenomic data have been developed to quantitatively measure cellular states and stemness. In this study, …
Suma: A Lightweight Machine Learning Model Powered Shared Nearest Neighbour Based Clustering Application Interface Of Scrna-Seq, Hamza Umut Karakurt, Pınar Pir
Suma: A Lightweight Machine Learning Model Powered Shared Nearest Neighbour Based Clustering Application Interface Of Scrna-Seq, Hamza Umut Karakurt, Pınar Pir
Turkish Journal of Biology
Background/aim: Single-cell transcriptomics (scRNA-Seq) explores cellular diversity at the gene expression level. Due to the inherent sparsity and noise in scRNA-Seq data and the uncertainty on the types of sequenced cells, effective clustering and cell type annotation are essential. The graph-based clustering of scRNA-Seq data is a simple yet powerful approach which presents data as a “shared nearest neighbour” graph and clusters the cells using graph clustering algorithms. These algorithms are dependent on several user-defined parameters. Here we present SUMA, a lightweight tool that uses a random forest model to predict the optimum number of neighbours to have the optimum …
Physicochemical Differences Between Camelid Single-Domain Antibodies And Mammalian Antibodies, Nazli Eda Eski̇er, Doğa Eski̇er, Esi̇n Fi̇ruzan, Si̇bel Kalyoncu
Physicochemical Differences Between Camelid Single-Domain Antibodies And Mammalian Antibodies, Nazli Eda Eski̇er, Doğa Eski̇er, Esi̇n Fi̇ruzan, Si̇bel Kalyoncu
Turkish Journal of Biology
Background/aim: In recent years, single-domain antibodies, also known as nanobodies, have emerged as an alternative to full immunoglobulin Gs (IgGs), due to their various advantages including increased solubility, faster clearance, and cheaper production. Nanobodies are generally derived from the variable domain of the camelid heavy-chain-only immunoglobulin Gs (hcIgGs). Due to the high sequence homology between variable heavy chains of camelids (VHHs) and humans (VHs), hcIgGs are ideal candidates for nanobody development. However, further examination is needed to understand the structural differences between VHs and VHHs. This analysis is essential for nanobody engineering to mitigate potential immunogenicity while preserving stability, functionality, …
Deep Learning In Bioinformatics, Malik Yousef, Jens Allmer
Deep Learning In Bioinformatics, Malik Yousef, Jens Allmer
Turkish Journal of Biology
Deep learning is a powerful machine learning technique that can learn from large amounts of data using multiple layers of artificial neural networks. This paper reviews some applications of deep learning in bioinformatics, a field that deals with analyzing and interpreting biological data. We first introduce the basic concepts of deep learning and then survey the recent advances and challenges of applying deep learning to various bioinformatics problems, such as genome sequencing, gene expression analysis, protein structure prediction, drug discovery, and disease diagnosis. We also discuss future directions and opportunities for deep learning in bioinformatics. We aim to provide an …
Classification Of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines, Necla Koçhan, Baris Emre Dayanc
Classification Of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines, Necla Koçhan, Baris Emre Dayanc
Turkish Journal of Biology
Background/aim: The molecular heterogeneity of colon cancer has made classification of tumors a requirement for effective treatment. One of the approaches for molecular subtyping of colon cancer patients is the Consensus Molecular Subtypes (CMS) developed by the Colorectal Cancer Subtyping Consortium (CRCSC). CMS-specific RNA-Seq dependent classification approaches are recent with relatively low sensitivity and specificity. In this study, we aimed to classify patients into CMS groups using RNA-seq profiles. Materials and methods: We first identified subtype specific and survival associated genes using Fuzzy C-Means (FCM) algorithm and log-rank test. Then we classified patients using Support Vector Machines with Backward Elimination …
Validation Of A Chimeric Proteins-Based Elisa For The Diagnosis Of Brucellosis In Kazakhstan, Aitbay Bulashev, Saule Eskendirova, Bakytkali Ingirbay, Alfiya Syzdykova, Fariza Zhagipar
Validation Of A Chimeric Proteins-Based Elisa For The Diagnosis Of Brucellosis In Kazakhstan, Aitbay Bulashev, Saule Eskendirova, Bakytkali Ingirbay, Alfiya Syzdykova, Fariza Zhagipar
Turkish Journal of Veterinary & Animal Sciences
This study aimed to compare the suitability of three chimeric recombinant outer membrane proteins of Brucella (rOmps 19 + 25, 19 + 31, and 25 + 31) for the diagnosis of bovine and sheep brucellosis using an indirect ELISA (i-ELISA). The diagnostic properties of these proteins in an i-ELISA were studied using blood serum samples from cattle and sheep with known positive and negative results for brucellosis based on the rose Bengal plate test (RBT), complement fixation test (CFT), and a commercial ELISA (c-ELISA) kit, as well as using animal sera from fresh foci of infection with unknown reactivity. rOmps19 …
Effect Of Thermo-Insulated Kid Hutch On Location Preference, Growth Performance, And Blood Haemato-Biochemical Indices Of Winter-Born Goat Kids (Capra Hircus), Ajoy Das, Dilip Kumar Mandal, Asish Debbarma, Muthupalani Karunakaran, Anupam Chatterjee, Debajyoti Sarkar
Effect Of Thermo-Insulated Kid Hutch On Location Preference, Growth Performance, And Blood Haemato-Biochemical Indices Of Winter-Born Goat Kids (Capra Hircus), Ajoy Das, Dilip Kumar Mandal, Asish Debbarma, Muthupalani Karunakaran, Anupam Chatterjee, Debajyoti Sarkar
Turkish Journal of Veterinary & Animal Sciences
This study assessed the effect of thermo-insulated kid hutch (TIKH) on location preference, body surface temperature, growth performance, and blood haemato-biochemical indices of winter-born Black Bengal goat kids. Does were maintained in the same shed, born kids (n = 12) were divided into two groups along with mothers to begin experiments from day 1 of birth. The treatment group (TIKH) of kids was given a TIKH to which kids had free access, but not the adults. However, in the control group (CONT) kids were reared without TIKH. The floor surface temperature of TIKH was significantly (p < 0.05) higher at night as compared to goat shed in December (4.28%), January (3.98%), and February (7.72%). The interior roof surface of TIKH had 25.12%, 33.55%, 31.85%, 10.99%, and 4.37% higher (p < 0.01) temperatures at night compared to the roof surface temperature of the goat shed in December, January, February, March, and April, respectively. The presence of kids inside the TIKH at the age of 1–15 days was the greatest in morning (80.5%) and evening (72.2%). Between the ages of 16–-60 days, the preference of kids for the TIKH varied from 69.2% to 54.2% in the morning and from 70.0% to 66.7% in the evening. However, at the age of 61–75 days, kids’ preference for TIKH gradually declined in the morning (11.6%) and evening (19.9%) due to the increased inside temperature. Kids weaning weight was 23.25% higher (p < 0.05) in the TIKH group as compared to that of CONT. The average daily gain (0–30 days) was higher (41.34%; p < 0.05) in kids in the TIKH compared to the CONT shed. The haemato-biochemical profiles of kids were similar in both groups except for blood serum glucose, which was greater (p < 0.05) in kids of the TIKH than that of CONT shed. In conclusion, the provision of TIKH improved the growth and overall performance of winter-born Black Bengal goat kids during pre and postweaning periods.
Water Buffalo Social Networks During Their Activities On Pasture Under The Rain, Eleni Tsiobani, Maria Yiakoulaki, Nikolaos Hasanagas, Ioannis Antoniou
Water Buffalo Social Networks During Their Activities On Pasture Under The Rain, Eleni Tsiobani, Maria Yiakoulaki, Nikolaos Hasanagas, Ioannis Antoniou
Turkish Journal of Veterinary & Animal Sciences
Water buffaloes exhibit various social structures during their activities on pasture, but the impact of abiotic factors (i.e. rainfall) on these structures remains unknown. While existing research has provided evidence concerning the effect of weather conditions on grazing animals’ behavior, they have not examined how animals differentiate their social organization within the herd during their activities on pasture under the rainfall. This study utilized social network analysis to construct, depict, and analyze the proximity networks among buffaloes in each activity they perform on pasture before, during, and after the rainfall. By applying various network indices, we have shown that water …
Noninvasive Pregnancy Detection In Wild Felids Using Enzyme Immunoassay Of Fecal 13, 14–Dihydro–15–Keto–Pgf2Α Metabolite (Pgfm), Nikitha Prakash, Suchitra Bhadravathi Raju, Sahadev Annayappa, Leena Gowda, Veena Malavalli Prabhushankar
Noninvasive Pregnancy Detection In Wild Felids Using Enzyme Immunoassay Of Fecal 13, 14–Dihydro–15–Keto–Pgf2Α Metabolite (Pgfm), Nikitha Prakash, Suchitra Bhadravathi Raju, Sahadev Annayappa, Leena Gowda, Veena Malavalli Prabhushankar
Turkish Journal of Veterinary & Animal Sciences
The study was carried out on Panthera species (4 lions and 5 tigers) housed in Bannerghatta Biological Park, Bengaluru, and Sri Chamarajendra Zoological Gardens, Mysuru. Estrus behavior such as rolling, licking, nudging, chuffing, frequent urination, whitish discharge, vocalisation, lordosis and copulatory behavior such as vocalisation, allowed to be mounted, aggression towards male, mounting, and biting of the nape of female were exhibited both in lions and tigers which helped to identify the time of fecal sample collection. The study’s main aim was to carry out noninvasive and noncontact pregnancy detection in these wild felids. Feces samples collected from the female …
Investigation Of Three Single-Nucleotide Polymorphisms (1252 G>A, 2534 G>A, And 2569 T>C) Of The Mbl1 Gene In Anatolian Buffaloes, Esma Gamze Aksel, Bi̇lal Akyüz
Investigation Of Three Single-Nucleotide Polymorphisms (1252 G>A, 2534 G>A, And 2569 T>C) Of The Mbl1 Gene In Anatolian Buffaloes, Esma Gamze Aksel, Bi̇lal Akyüz
Turkish Journal of Veterinary & Animal Sciences
It has been reported that since the MBL gene is involved in the first step of infection and inflammation processes, it may be associated with susceptibility to bacterial and viral diseases in living organisms. In this study, it was aimed to determine the genotypic variation of Anatolian buffaloes in terms of three (1252G>A, 2534 G>A, and 2569 T>C) single nucleotide polymorphisms (SNPs) within the MBL-1 gene. For this purpose, 103 Anatolian buffaloes were genotyped for relevant SNPs by PCR-RFLP process. The allele and genotype frequencies of the examined samples were determined, and the population was examined for …
Virological And Pathological Investigation Of Canine Parvovirus-2 (Cpv-2) With The Assessment Of The Genetic Variability Of Field Strains, Zeynep Karapinar, Musa Karaman, İhsan Kisadere, Mustafa Usta, Mehmet Özkan Ti̇murkan
Virological And Pathological Investigation Of Canine Parvovirus-2 (Cpv-2) With The Assessment Of The Genetic Variability Of Field Strains, Zeynep Karapinar, Musa Karaman, İhsan Kisadere, Mustafa Usta, Mehmet Özkan Ti̇murkan
Turkish Journal of Veterinary & Animal Sciences
Canine parvovirus-2 (CPV-2), which is common worldwide, is a highly contagious pathogen in domestic dogs and some wild carnivore species. The agent causes a multisystemic infection in affected animals, especially acute hemorrhagic enteritis and fatal myocarditis in puppies. The study aimed to reveal the presence of virus in dogs with clinical symptoms of CPV-2 infection using virological, pathological, and immunohistochemical methods and make molecular characterization based on partial VP-2 gene of strains circulating in the region. As a result of PCR studies, 9 out of 16 rectal swab samples and 17 out of 38 blood samples were positive. A phylogenetic …
Oral Small Molecule Agents In Management Of Ulcerative Colitis: Fact Or Fancy, Benan Kasapoğlu, Ati̇lla Ertan
Oral Small Molecule Agents In Management Of Ulcerative Colitis: Fact Or Fancy, Benan Kasapoğlu, Ati̇lla Ertan
Turkish Journal of Medical Sciences
Ulcerative colitis is a chronic, immune-mediated disease characterized by recurring episodes of mucosal inflammation in the colon and rectum. The primary pathogenic mechanism of ulcerative colitis is the dysregulation of the mucosal immune response. The disease follows a relapsing-remitting course, and the goal of management is to successfully induce and then maintain remission. Effectively managing this chronic disease requires addressing all aspects of it. Currently, we have various antitumor necrosis factor agents and novel biologics available for treating ulcerative colitis patients with moderate-to-severe disease. However, none of the existing treatments are considered entirely satisfactory or ideal in these cases. After …
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Turkish Journal of Medical Sciences
Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are …
Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler
Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler
Turkish Journal of Medical Sciences
Background/aim: Type 1 diabetes mellitus (T1DM) is caused by the autoimmune-mediated destruction of insulin-producing cells (IPCs) and still has no effective cure. Better understanding of the molecular mechanisms involved in the differentiation of embryonic stem cells (ESCs) into IPCs may help us improve the therapeutic strategies for treating T1DM. 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatases (Pfkfb1-4) are key regulators of glucose metabolism. Although Pfkfb3 has been shown to be required for the growth of early differentiated mouse ESCs (mESCs), more studies are needed to further assess the roles of Pfkfb isoenzymes in embryonic development and differentiation, particularly into specific cell types. In this study, …
[6]-Shogaol And [6]-Gingerol Active Ingredients May Improve Neuropathic Pain By Suppressing Cytokine Levels In An Experimental Model, Fi̇kri̇ Özdemi̇r, Güven Akçay, Sevi̇l Özkinali, Çağla Çeli̇k
[6]-Shogaol And [6]-Gingerol Active Ingredients May Improve Neuropathic Pain By Suppressing Cytokine Levels In An Experimental Model, Fi̇kri̇ Özdemi̇r, Güven Akçay, Sevi̇l Özkinali, Çağla Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Neuropathic pain (NP) is a type of chronic pain usually caused by damage to the somatosensory system. Bioactive antioxidant compounds, such as curcumin and ginger, are widely preferred in the treatment of NP. However, the ingredient-based mechanism that underlies their pain-relieving activity remains unknown. The aim of this study was to investigate the therapeutic effects of trans-[6]-Shogaol and [6]-Gingerol active ingredients of the Zingiber officinale Roscoe extract on the spinal cord and cortex in the neuroinflammatory pathway in rats with experimental sciatic nerve injury. Materials and methods: Forty-six volatile phenolic components were identified in ginger samples using gas chromatography-mass …
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Turkish Journal of Medical Sciences
Background/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO4) used separately and together on feto-maternal outcomes. Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy. Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, …
Smpdl3b Contributes To Gastric Adenocarcinoma Cells Progression By Promoting The Infiltration Of M2 Macrophages, Li Su, Jian Hao, Na Zhang, Shan Wu, Xiuhua Wu, Wei Wei
Smpdl3b Contributes To Gastric Adenocarcinoma Cells Progression By Promoting The Infiltration Of M2 Macrophages, Li Su, Jian Hao, Na Zhang, Shan Wu, Xiuhua Wu, Wei Wei
Turkish Journal of Medical Sciences
Background/aim: The common disease gastric adenocarcinoma (GAC) has a high morbidity and mortality, so there is an urgent need for research to explore new diagnostic markers and therapeutic targets. This investigation was carried out to investigate the expression of sphingomyelin phosphodiesterase acid-like 3b (SMPDL3B) in GAC and its effects on tumor progression. Materials and methods: Samples were collected from patients who underwent radical gastrectomy from January 2021 to December 2022. Along with the normal gastric epithelial cell lines GES-1 and SGC-7901, the AGS, MGC-803, and MSN-45 human gastric cancer cell lines were used to confirm SMPDL3B expression. RT-qPCR, Western blot, …
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Turkish Journal of Medical Sciences
Background/aim: Titanium dioxide nanoparticles are widely used in a variety of products, including sunscreens, paints, and ceramics. However, their increasing use has raised concerns about their potential health risks. Titanium dioxide nanoparticles have been shown to have the ability to enter the bloodstream and accumulate in various tissues, reaching the fetus via the placenta. The aim of this study was to investigate the cytotoxic effects of titanium dioxide nanoparticles on a human embryonic lung cell line (HEL 299/An1) and the formation of oxidative DNA damage. Materials and methods: The cytotoxic effects of brookite-based titanium dioxide nanoparticles (<100 nm) were assessed using the 3-(4,5-dimethyldiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay for 24 and 48 h. Cell titanium levels were determined using inductively coupled plasma mass spectrometry. Oxidative DNA damage was assessed by measuring the levels of 8-hydroxy-2- deoxyguanosine (8-OHdG) as a biomarker. Results: Titanium dioxide nanoparticles caused dose-dependent cytotoxicity in HEL 299/An1 cells. The IC50 values were 25.93 μM and 0.054 μM after 24 h and 48 h of exposure, respectively. Cell titanium levels were found to be 25,967 ppb after 24 h and 210,353 ppb after 48 h (p < 0.01). 8-OHdG was detected at 32.96 ng/mL after 24 h of exposure and 17.89 ng/mL after 48 h of exposure. Conclusion: In our study, it was shown that titanium nanoparticles caused dose-dependent cytotoxicity and oxidative DNA damage in human embryonic lung cells. The nanoparticles also accumulated in cells and were taken up in higher amounts after 48 h of exposure. These findings suggest that titanium dioxide nanoparticles may pose a health risk, especially for pregnant women who may not be aware of their pregnancy. Therefore, it is important to take preventive measures to reduce exposure to these nanoparticles.
Effect Of Humanine On The Notch Signaling Pathway In Myocardial Infarction, Eli̇f Onat, Ebru Önalan, Berna Özdem, Merve Kavak Balgeti̇r, Tuncay Kuloğlu
Effect Of Humanine On The Notch Signaling Pathway In Myocardial Infarction, Eli̇f Onat, Ebru Önalan, Berna Özdem, Merve Kavak Balgeti̇r, Tuncay Kuloğlu
Turkish Journal of Medical Sciences
Background/aim: By applying humanin (HN) before myocardial infarction (MI), its protection in myocardial injury and the possible roles of its cellular mechanism in the Notch pathway were investigated. Materials and methods: The study was carried out at Fırat University Experimental Research Center (12/24/2018-12/23/2019). Spraque-Dawley rats were divided into 10 groups: I (control) (n = 6), II (HN 6 h) (n = 6), III (HN 24 h) (n = 6), IV (HN day 7) (n = 6), V (MI 6 h) (n = 7), VI (MI 24 h) (n = 7), VII (MI day 7) (n = 7), VIII (MI+HN 6 …
Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian
Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian
Turkish Journal of Medical Sciences
MDABackground/ aim: Atherosclerosis is significantly influenced by endothelial cell activation and dysfunction. Studies have demonstrated the substantial presence of fibronectin (Fn) within atherosclerotic plaques, promoting endothelial inflammation and activation. However, cellular Fn (cFn) secreted by various cell types, including endothelial cells and smooth muscle cells, and plasma Fn (pFn) produced by hepatocytes. They are distinct forms of Fn that differ in both structure and function. The specific contribution of different types of Fn in promoting endothelial cell activation and dysfunction remain uncertain. Therefore, this study aimed to investigate the respective roles of pFn and endothelial cell-derived Fn (FnEC) in promoting …
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
Turkish Journal of Medical Sciences
Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …
Efficacy Of Rituximab On Disease Activity, Severity, And Disease-Related Damage In Patients With Immunosuppressive-Resistant Systemic Sclerosis, Yasemi̇n Yalçinkaya, Bahar Artim Esen, Shirkhan Amikishiyev, Numune Aliyeva, Ahmet Gül, Mahdume Lale Öçal, Murat İnanç
Efficacy Of Rituximab On Disease Activity, Severity, And Disease-Related Damage In Patients With Immunosuppressive-Resistant Systemic Sclerosis, Yasemi̇n Yalçinkaya, Bahar Artim Esen, Shirkhan Amikishiyev, Numune Aliyeva, Ahmet Gül, Mahdume Lale Öçal, Murat İnanç
Turkish Journal of Medical Sciences
Background/aim: B-cell depletion with rituximab (RTX) is widely used as a rescue therapy in patients with systemic sclerosis (SSc). The aim herein was to analyze the progress of disease-related outcomes after RTX therapy in severe SSc patients. Materials and methods: Included in this study were 27 SSc patients who were followed-up between 2012 and 2020 and received at least 1 cycle of RTX for active disease, despite receiving standard immunosuppressives (ISs). In addition to the European Scleroderma Study Group and European Scleroderma Trials and Research Group activity scores, Medsger's severity, and the recently developed Scleroderma Clinical Trials Consortium Damage Index …
Craniocervical Junction Involvement In Inflammatory Arthritis: A Single-Center Radiologic Study, Fatma Yalçinkaya, Şafak Parlak Sağol, Aynur Azizova, Emre Bi̇lgi̇n, Kader Karli Oğuz, Umut Kalyoncu
Craniocervical Junction Involvement In Inflammatory Arthritis: A Single-Center Radiologic Study, Fatma Yalçinkaya, Şafak Parlak Sağol, Aynur Azizova, Emre Bi̇lgi̇n, Kader Karli Oğuz, Umut Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: Craniocervical junction (CCJ) can be involved in inflammatory arthritis. We aimed to define types of CCJ involvement in rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) and compare them with patients without inflammatory arthritides. Materials and methods: In this retrospective analysis, cervical CT or MRIs of patients with RA, SpA, or PsA, taken for any reason between 2010 and 2020, according to ICD-10 codes, were scanned. Demographic data of the patients were recorded. CCJ involvements (atlantoaxial, vertical, or subaxial subluxation, odontoid process involvement) were reevaluated by an experienced radiologist. The control group consisted of consecutive patients without inflammatory …