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Inactivation Of Androgen-Induced Regulator Ard1 Inhibits Androgen Receptor Acetylation And Prostate Tumorigenesis, Zehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, Wanguo Liu Feb 2012

Inactivation Of Androgen-Induced Regulator Ard1 Inhibits Androgen Receptor Acetylation And Prostate Tumorigenesis, Zehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, Wanguo Liu

Faculty Publications

Androgen signaling through androgen receptor (AR) is critical for prostate tumorigenesis. Given that AR-mediated gene regulation is enhanced by AR coregulators, inactivation of those coregulators is emerging as a promising therapy for prostate cancer (PCa). Here, weshowthat the N-acetyltransferase arrest-defect 1 protein (ARD1) functions as a unique AR regulator in PCa cells. ARD1 is up-regulated in human PCa cell lines and primary tumor biopsies. The expression of ARD1 was augmented by treatment with synthetic androgen (R1881) unless AR is deficient or is inhibited by AR-specific siRNA or androgen inhibitor bicalutamide (Casodex). Depletion of ARD1 by shRNA suppressed PCa cell proliferation, …

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Slow Amyloid Nucleation Via Α-Helix-Rich Oligomeric Intermediates In Short Polyglutamine-Containing Huntingtin Fragments, Murali Jayaraman, Ravindra Kodali, Bankanidhi Sahoo, Ashwani K. Thakur, Anand Mayasundari, Rakesh Mishra, Cynthia B. Peterson, Ronald Wetzel Feb 2012

Slow Amyloid Nucleation Via Α-Helix-Rich Oligomeric Intermediates In Short Polyglutamine-Containing Huntingtin Fragments, Murali Jayaraman, Ravindra Kodali, Bankanidhi Sahoo, Ashwani K. Thakur, Anand Mayasundari, Rakesh Mishra, Cynthia B. Peterson, Ronald Wetzel

Faculty Publications

The 17-amino-acid N-terminal segment (httNT) that leads into the polyglutamine (polyQ) segment in the Huntington's disease protein huntingtin (htt) dramatically increases aggregation rates and changes the aggregation mechanism, compared to a simple polyQ peptide of similar length. With polyQ segments near or above the pathological repeat length threshold of about 37, aggregation of htt N-terminal fragments is so rapid that it is difficult to tease out mechanistic details. We describe here the use of very short polyQ repeat lengths in htt N-terminal fragments to slow this disease-associated aggregation. Although all of these peptides, in addition to httNT itself, form α-helix-rich …

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Epithelial Na + Sodium Channels In Magnocellular Cells Of The Rat Supraoptic And Paraventricular Nuclei, Ryoichi Teruyama, Mayumi Sakuraba, Lori L. Wilson, Narine E.J. Wandrey, William E. Armstrong Feb 2012

Epithelial Na + Sodium Channels In Magnocellular Cells Of The Rat Supraoptic And Paraventricular Nuclei, Ryoichi Teruyama, Mayumi Sakuraba, Lori L. Wilson, Narine E.J. Wandrey, William E. Armstrong

Faculty Publications

The epithelial Na + channels (ENaCs) are present in kidney and contribute to Na + and water homeostasis. All three ENaC subunits (α, β, and γ) were demonstrated in the cardiovascular regulatory centers of the rat brain, including the magnocellular neurons (MNCs) in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN). However, the functional significance of ENaCs in vasopressin (VP) and oxytocin (OT) synthesizing MNCs is completely unknown. In this study, we show with immunocytochemical double-labeling that the α-ENaC is colocalized with either VP or OT in MNCs in the SON and PVN. In addition, parvocellular neurons in the …

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Ethylene's Role In Phosphate Starvation Signaling: More Than Just A Root Growth Regulator, Vinay K. Nagarajan, Aaron P. Smith Feb 2012

Ethylene's Role In Phosphate Starvation Signaling: More Than Just A Root Growth Regulator, Vinay K. Nagarajan, Aaron P. Smith

Faculty Publications

Phosphate (Pi) is a common limiter of plant growth due to its low availability in most soils. Plants have evolved elaborate mechanisms for sensing Pi deficiency and for initiating adaptive responses to low Pi conditions. Pi signaling pathways are modulated by both local and long-distance, or systemic, sensing mechanisms. Local sensing of low Pi initiates major root developmental changes aimed at enhancing Pi acquisition, whereas systemic sensing governs pathways that modulate expression of numerous genes encoding factors involved in Pi transport and distribution. The gaseous phytohormone ethylene has been shown to play an integral role in regulating local, root developmental …

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Soil Compaction Thresholds For The M1a1 Abrams Tank: Field Study At Camp Minden, La. (Bulletin #891), Michael R. Lindsey, H. Magdi Selim, Tamer A. Elbana, Jerry Daigle, Charles Guillory, Marc Bordelon, Mitchell Mouton Feb 2012

Soil Compaction Thresholds For The M1a1 Abrams Tank: Field Study At Camp Minden, La. (Bulletin #891), Michael R. Lindsey, H. Magdi Selim, Tamer A. Elbana, Jerry Daigle, Charles Guillory, Marc Bordelon, Mitchell Mouton

LSU AgCenter Bulletins

The purpose of this study was to establish critical soil compaction thresholds for M1A1 Abrams battle tank traffic in an effort to minimize soil physical properties that adversely affect vegetation regeneration.

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Addressing The Clumsiness Loophole In A Leggett-Garg Test Of Macrorealism, Mark M. Wilde, Ari Mizel Feb 2012

Addressing The Clumsiness Loophole In A Leggett-Garg Test Of Macrorealism, Mark M. Wilde, Ari Mizel

Faculty Publications

The rise of quantum information theory has lent new relevance to experimental tests for non-classicality, particularly in controversial cases such as adiabatic quantum computing superconducting circuits. The Leggett-Garg inequality is a "Bell inequality in time" designed to indicate whether a single quantum system behaves in a macrorealistic fashion. Unfortunately, a violation of the inequality can only show that the system is either (i) non-macrorealistic or (ii) macrorealistic but subjected to a measurement technique that happens to disturb the system. The "clumsiness" loophole (ii) provides reliable refuge for the stubborn macrorealist, who can invoke it to brand recent experimental and theoretical …

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Syntheses And Properties Of Trimethylaminophenoxy-Substituted Zn(Ii)-Phthalocyanines, Benson G. Ongarora, Xiaoke Hu, Hairong Li, Frank R. Fronczek, M. Graa H. Vicente Feb 2012

Syntheses And Properties Of Trimethylaminophenoxy-Substituted Zn(Ii)-Phthalocyanines, Benson G. Ongarora, Xiaoke Hu, Hairong Li, Frank R. Fronczek, M. Graa H. Vicente

Faculty Publications

The syntheses, photophysical properties and in vitro biological behavior of a series of nine Zn(ii)-phthalocyanines (ZnPcs) bearing one to eight positively-charged trimethylaminophenoxy groups are reported. All ZnPcs are highly soluble in polar organic solvents, and show fluorescence and singlet oxygen quantum yields in the ranges 0.11-0.21 and 0.16-0.47, respectively. The cytotoxicity of the ZnPcs depends on both the number of charges and their site of substitution (α vs. β) on the Pc isoindole units; the most promising for PDT application are the α-substituted di-cationic ZnPcs 6a and 17a. © 2012 The Royal Society of Chemistry.

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Differences In Folate-Protein Interactions Result In Differing Inhibition Of Native Rat Liver And Recombinant Glycine N-Methyltransferase By 5-Methyltetrahydrofolate, Zigmund Luka, Svetlana Pakhomova, Lioudmila V. Loukachevitch, Marcia E. Newcomer, Conrad Wagner Feb 2012

Differences In Folate-Protein Interactions Result In Differing Inhibition Of Native Rat Liver And Recombinant Glycine N-Methyltransferase By 5-Methyltetrahydrofolate, Zigmund Luka, Svetlana Pakhomova, Lioudmila V. Loukachevitch, Marcia E. Newcomer, Conrad Wagner

Faculty Publications

Glycine N-methyltransferase (GNMT) is a key regulatory enzyme in methyl group metabolism. In mammalian liver it reduces S-adenosylmethionine levels by using it to methylate glycine, producing N-methylglycine (sarcosine) and S-adenosylhomocysteine. GNMT is inhibited by binding two molecules of 5-methyltetrahydrofolate (mono- or polyglutamate forms) per tetramer of the active enzyme. Inhibition is sensitive to the status of the N-terminal valine of GNMT and to polyglutamation of the folate inhibitor. It is inhibited by pentaglutamate form more efficiently compared to monoglutamate form. The native rat liver GNMT contains an acetylated N-terminal valine and is inhibited much more efficiently compared to the recombinant …

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Genetic Diversity And Colony Breeding Structure In Native And Introduced Ranges Of The Formosan Subterranean Termite, Coptotermes Formosanus, Claudia Husseneder, Dawn M. Simms, Jennifer R. Delatte, Changlu Wang, J. Kenneth Grace, Edward L. Vargo Feb 2012

Genetic Diversity And Colony Breeding Structure In Native And Introduced Ranges Of The Formosan Subterranean Termite, Coptotermes Formosanus, Claudia Husseneder, Dawn M. Simms, Jennifer R. Delatte, Changlu Wang, J. Kenneth Grace, Edward L. Vargo

Faculty Publications

The Formosan subterranean termite, Coptotermes formosanus is recognized as one of the most important invasive pest species. Originating from China, C. formosanus has spread to many tropical and subtropical regions around the globe in the last 400 years, including Japan, Hawaii and the continental USA. Although the current distribution is well documented, information about the patterns of invasion and effects of introduction on the population genetics of this species is largely lacking. We analyzed the genetic structure of populations from two native populations (Guangdong and Hunan provinces, China) and two introduced populations (Maui and Kauai, Hawaii) using microsatellite genotyping. We …

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Predicting Patch Occupancy In Fragmented Landscapes At The Rangewide Scale For An Endangered Species: An Example Of An American Warbler, Bret A. Collier, Julie E. Groce, Michael L. Morrison, John C. Newnam, Andrew J. Campomizzi, Shannon L. Farrell, Heather A. Mathewson, Robert T. Snelgrove, Raymond J. Carroll, Robert N. Wilkins Feb 2012

Predicting Patch Occupancy In Fragmented Landscapes At The Rangewide Scale For An Endangered Species: An Example Of An American Warbler, Bret A. Collier, Julie E. Groce, Michael L. Morrison, John C. Newnam, Andrew J. Campomizzi, Shannon L. Farrell, Heather A. Mathewson, Robert T. Snelgrove, Raymond J. Carroll, Robert N. Wilkins

Faculty Publications

Aim Our objective was to identify the distribution of the endangered golden-cheeked warbler (Setophaga chrysoparia) in fragmented oak-juniper woodlands by applying a geoadditive semiparametric occupancy model to better assist decision-makers in identifying suitable habitat across the species breeding range on which conservation or mitigation activities can be focused and thus prioritize management and conservation planning. Location Texas, USA. Methods We used repeated double-observer detection/non-detection surveys of randomly selected (n=287) patches of potential habitat to evaluate warbler patch-scale presence across the species breeding range. We used a geoadditive semiparametric occupancy model with remotely sensed habitat metrics (patch size and landscape composition) …

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Charge-Based Interaction Conserved Within Histone H3 Lysine 4 (H3k4) Methyltransferase Complexes Is Needed For Protein Stability, Histone Methylation, And Gene Expression, Douglas P. Mersman, Hai Ning Du, Ian M. Fingerman, Paul F. South, Scott D. Briggs Jan 2012

Charge-Based Interaction Conserved Within Histone H3 Lysine 4 (H3k4) Methyltransferase Complexes Is Needed For Protein Stability, Histone Methylation, And Gene Expression, Douglas P. Mersman, Hai Ning Du, Ian M. Fingerman, Paul F. South, Scott D. Briggs

Faculty Publications

Histone H3 lysine 4 (H3K4) methyltransferases are conserved from yeast to humans, assemble in multisubunit complexes, and are needed to regulate gene expression. The yeast H3K4 methyltransferase complex, Set1 complex or complex of proteins associated with Set1 (COMPASS), consists of Set1 and conserved Set1-associated proteins: Swd1, Swd2, Swd3, Spp1, Bre2, Sdc1, and Shg1. The removal of the WD40 domain-containing subunits Swd1 and Swd3 leads to a loss of Set1 protein and consequently a complete loss ofH3K4methylation. However, until now, how these WD40 domain-containing proteins interact with Set1 and contribute to the stability of Set1 and H3K4 methylation has not been …

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Small-Scale Variation In Fuel Loads Differentially Affects Two Co-Dominant Bunchgrasses In A Species-Rich Pine Savanna, Paul R. Gagnon, Kyle E. Harms, William J. Platt, Heather A. Passmore, Jonathan A. Myers Jan 2012

Small-Scale Variation In Fuel Loads Differentially Affects Two Co-Dominant Bunchgrasses In A Species-Rich Pine Savanna, Paul R. Gagnon, Kyle E. Harms, William J. Platt, Heather A. Passmore, Jonathan A. Myers

Faculty Publications

Ecological disturbances frequently control the occurrence and patterning of dominant plants in high-diversity communities like C 4 grasslands and savannas. In such ecosystems disturbance-related processes can have important implications for species, and for whole communities when those species are dominant, yet mechanistic understanding of such processes remains fragmentary. Multiple bunchgrass species commonly co-dominate disturbance-dependent and species-rich pine savannas, where small-scale fuel heterogeneity may influence bunchgrass survival and growth following fires. We quantified how fire in locally varying fuel loads influenced dynamics of dominant C 4 bunchgrasses in a species-rich pine savanna in southeastern Louisiana, USA. We focused on two congeneric, …

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Ecological Guild Evolution And The Discovery Of The World's Smallest Vertebrate, Eric N. Rittmeyer, Allen Allison, Michael C. Gründler, Derrick K. Thompson, Christopher C. Austin Jan 2012

Ecological Guild Evolution And The Discovery Of The World's Smallest Vertebrate, Eric N. Rittmeyer, Allen Allison, Michael C. Gründler, Derrick K. Thompson, Christopher C. Austin

Faculty Publications

Living vertebrates vary drastically in body size, yet few taxa reach the extremely minute size of some frogs and teleost fish. Here we describe two new species of diminutive terrestrial frogs from the megadiverse hotspot island of New Guinea, one of which represents the smallest known vertebrate species, attaining an average body size of only 7.7 mm. Both new species are members of the recently described genus Paedophryne, the four species of which are all among the ten smallest known frog species, making Paedophryne the most diminutive genus of anurans. This discovery highlights intriguing ecological similarities among the numerous independent …

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Protein Docking Prediction Using Predicted Protein-Protein Interface, Bin Li, Daisuke Kihara Jan 2012

Protein Docking Prediction Using Predicted Protein-Protein Interface, Bin Li, Daisuke Kihara

Faculty Publications

Background: Many important cellular processes are carried out by protein complexes. To provide physical pictures of interacting proteins, many computational protein-protein prediction methods have been developed in the past. However, it is still difficult to identify the correct docking complex structure within top ranks among alternative conformations.Results: We present a novel protein docking algorithm that utilizes imperfect protein-protein binding interface prediction for guiding protein docking. Since the accuracy of protein binding site prediction varies depending on cases, the challenge is to develop a method which does not deteriorate but improves docking results by using a binding site prediction which may …

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Uncoupling Of Inflammation And Insulin Resistance By Nf-Κb In Transgenic Mice Through Elevated Energy Expenditure (Journal Of Biological Chemistry (2010) 285, (4637-4644)), Tianyi Tang, Jin Zhang, Jun Yin, Jaroslaw Staszkiewicz, Barbara Gawronska-Kozak, Dae Young Jung, Hwi Jin Ko, Helena Ong, Jason K. Kim, Randy Mynatt, Roy J. Martin, Michael Keenan, Zhanguo Gao, Jianping Ye Jan 2012

Uncoupling Of Inflammation And Insulin Resistance By Nf-Κb In Transgenic Mice Through Elevated Energy Expenditure (Journal Of Biological Chemistry (2010) 285, (4637-4644)), Tianyi Tang, Jin Zhang, Jun Yin, Jaroslaw Staszkiewicz, Barbara Gawronska-Kozak, Dae Young Jung, Hwi Jin Ko, Helena Ong, Jason K. Kim, Randy Mynatt, Roy J. Martin, Michael Keenan, Zhanguo Gao, Jianping Ye

Faculty Publications

No abstract provided.

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Will Coastal Wetlands Continue To Sequester Carbon In Response To An Increase In Global Sea Level?: A Case Study Of The Rapidly Subsiding Mississippi River Deltaic Plain, R. D. Delaune, J. R. White Jan 2012

Will Coastal Wetlands Continue To Sequester Carbon In Response To An Increase In Global Sea Level?: A Case Study Of The Rapidly Subsiding Mississippi River Deltaic Plain, R. D. Delaune, J. R. White

Faculty Publications

The highly visible coastal phenomenon of wetland loss in coastal Louisiana (LA) was examined through the prism of carbon accumulation and loss. Carbon storage or sequestration in rapidly subsiding LA coastal marsh soils was based on vertical marsh accretion and aerial change data. Marshes sequester significant amount of carbon through vertical accretion however, large amounts of carbon previously sequestration in the soil profile is lost through annual deterioration of these coastal marshes. Hurricanes, such as Katrina and Rita, have triggered instantaneous large carbon losses of sequestered soil carbon through the destruction of large areas of marsh. This analysis shows proposed …

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Landscape-Scale Analysis Of Wetland Sediment Deposition From Four Tropical Cyclone Events, A W. Tweel, R. Eugene Turner Jan 2012

Landscape-Scale Analysis Of Wetland Sediment Deposition From Four Tropical Cyclone Events, A W. Tweel, R. Eugene Turner

Faculty Publications

Hurricanes Katrina, Rita, Gustav, and Ike deposited large quantities of sediment on coastal wetlands after making landfall in the northern Gulf of Mexico. We sampled sediments deposited on the wetland surface throughout the entire Louisiana and Texas depositional surfaces of Hurricanes Katrina, Rita, Gustav, and the Louisiana portion of Hurricane Ike. We used spatial interpolation to model the total amount and spatial distribution of inorganic sediment deposition from each storm. The sediment deposition on coastal wetlands was an estimated 68, 48, and 21 million metric tons from Hurricanes Katrina, Rita, and Gustav, respectively. The spatial distribution decreased in a similar …

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Atmospheric Correction And Vicarious Calibration Of Oceansat-1 Ocean Color Monitor (Ocm) Data In Coastal Case 2 Waters, P. Dash, N. Walker, D. Mishra, E. D'Sa, S. Ladner Jan 2012

Atmospheric Correction And Vicarious Calibration Of Oceansat-1 Ocean Color Monitor (Ocm) Data In Coastal Case 2 Waters, P. Dash, N. Walker, D. Mishra, E. D'Sa, S. Ladner

Faculty Publications

No abstract provided.

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Phytoplankton Light Absorption Of Cultures And Natural Samples: Comparisons Using Two Spectrophotometers, P. Naik, E.J. D'Sa Jan 2012

Phytoplankton Light Absorption Of Cultures And Natural Samples: Comparisons Using Two Spectrophotometers, P. Naik, E.J. D'Sa

Faculty Publications

No abstract provided.

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Histological Analysis Reveals Larger Size At Maturity For Southern Flounder With Implications For Biological Reference Points, Stephen Midway Jan 2012

Histological Analysis Reveals Larger Size At Maturity For Southern Flounder With Implications For Biological Reference Points, Stephen Midway

Faculty Publications

No abstract provided.

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Short Conduction Delays Cause Inhibition Rather Than Excitation To Favor Synchrony In Hybrid Neuronal Networks Of The Entorhinal Cortex., Wang S, Chandrasekaran L, Fernandez Fr, White Ja, Canavier Cc Jan 2012

Short Conduction Delays Cause Inhibition Rather Than Excitation To Favor Synchrony In Hybrid Neuronal Networks Of The Entorhinal Cortex., Wang S, Chandrasekaran L, Fernandez Fr, White Ja, Canavier Cc

Faculty Publications

No abstract provided.

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Membrane Properties And The Balance Between Excitation And Inhibition Control Gamma-Frequency Oscillations Arising From Feedback Inhibition., Economo Mn, White Ja Jan 2012

Membrane Properties And The Balance Between Excitation And Inhibition Control Gamma-Frequency Oscillations Arising From Feedback Inhibition., Economo Mn, White Ja

Faculty Publications

No abstract provided.

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On The Formation, Ventilation, And Erosion Of Mode Waters In The North Atlantic And Southern Oceans, D.S. Trossman, L. Thompson, S. Mecking, M.J. Warner Jan 2012

On The Formation, Ventilation, And Erosion Of Mode Waters In The North Atlantic And Southern Oceans, D.S. Trossman, L. Thompson, S. Mecking, M.J. Warner

Faculty Publications

No abstract provided.

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The Relation Between The Structure Of The First Solvation Shell And The Ir Spectra Of Aqueous Solutions, Revati Kumar, Tom Keyes Jan 2012

The Relation Between The Structure Of The First Solvation Shell And The Ir Spectra Of Aqueous Solutions, Revati Kumar, Tom Keyes

Faculty Publications

The spectroscopic signatures of solvated anions and cations, in the O-H stretch region of water, are studied using the POLIR potential. Shifts in the spectra are shown to correlate very well with the distribution of a particular hydrogen bond angle for the waters in the first solvation shell. The results indicate that the spectral shifts might be predicted from MD simulations in a computationally convenient fashion, avoiding an explicit calculation of the spectra, as first suggested by Sharp et al. (J Chem Phys 114(4):1791-1796, 2001). © 2011 Springer Science+Business Media B.V.

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Retrotransposons As A Major Source Of Epigenetic Variations In The Mammalian Genome, Muhammad B. Ekram, Keunsoo Kang, Hana Kim, Joomyeong Kim Jan 2012

Retrotransposons As A Major Source Of Epigenetic Variations In The Mammalian Genome, Muhammad B. Ekram, Keunsoo Kang, Hana Kim, Joomyeong Kim

Faculty Publications

Transcription of retrotransposons is usually repressed by DNA methylation, but a few elements, such as intracisternal A-particles (IAPs) associated with the Agouti and Axin-fused loci, partially escape this repression mechanism. The levels of this repression are also variable among individuals with an identical genome sequence, generating epigenetically different states of loci or epialleles. In the current study, we tested the existence of additional retrotransposon-derived epialleles in the mouse genome. Using a series of bioinformatics approaches, 143 candidate epialleles were first identified from the mouse genome based on their promoter activity and association with active histone modification marks. Detailed analyses suggest …

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Contextual Chemosensory Urine Signaling In An African Cichlid Fish, Karen P. Maruska, Russell D. Fernald Jan 2012

Contextual Chemosensory Urine Signaling In An African Cichlid Fish, Karen P. Maruska, Russell D. Fernald

Faculty Publications

Chemosensory signaling is crucial for communication in many fish species, but little is known about how signalers modulate chemical output in response to sensory information and social context. Here, we tested the hypothesis that dominant male African cichlid fish (Astatotilapia burtoni) use urine signals during social interactions, and demonstrate that this signaling depends on social context (reproductive; territorial) and on available sensory information (visual cues; full interaction). We injected males with dye to visualize urine pulses and exposed them to full sensory information or visual cues alone of four types: (1) dominant male; (2) gravid (reproductively receptive) females; (3) mouth-brooding …

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Faculty Senate Newsletter, January 2012, Louisiana State University And Agricultural & Mechanical College Jan 2012

Faculty Senate Newsletter, January 2012, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: Few would doubt that experience carries a value, yet few would be ready to accord to experience the irrationally high esteem granted it by the various units, agencies, and boards that govern and deliver higher education in Louisiana. In an educational establishment where “retire-rehire” could almost qualify as the refrain of a top-ten tune, where retreads and reassigned old hands move from juicy appointment to juicier portfolio while youngsters scramble for bread, where middle age is all but marginalized, where “double dipping” may sometimes lead to the ejection of a Commissioner but will usually create happy prosperity …

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Mtbindingsim: Simulate Protein Binding To Microtubules, Julia T. Philip, Charles H. Pence, Holly V. Goodson Jan 2012

Mtbindingsim: Simulate Protein Binding To Microtubules, Julia T. Philip, Charles H. Pence, Holly V. Goodson

Faculty Publications

Summary: Many protein–protein interactions are more complex than can be accounted for by 1:1 binding models. However, biochemists have few tools available to help them recognize and predict the behaviors of these more complicated systems, making it difficult to design experiments that distinguish between possible binding models. MTBindingSim provides researchers with an environment in which they can rapidly compare different models of binding for a given scenario. It is written specifically with microtubule polymers in mind, but many of its models apply equally well to any polymer or any protein–protein interaction. MTBindingSim can thus both help in training intuition about …

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The Oxford Handbook Of Slavery In The Americas, Andrew Sluyter Jan 2012

The Oxford Handbook Of Slavery In The Americas, Andrew Sluyter

Faculty Publications

No abstract provided.

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Amino Acid Differences In Glycoproteins B (Gb), C (Gc), H (Gh) And L(Gl) Are Associated With Enhanced Herpes Simplex Virus Type-1 (Mckrae) Entry Via The Paired Immunoglobulin-Like Type-2 Receptor Α, Sona Chowdhury, Misagh Naderi, Vladimir N. Chouljenko, Jason D. Walker, Konstantin G. Kousoulas Jan 2012

Amino Acid Differences In Glycoproteins B (Gb), C (Gc), H (Gh) And L(Gl) Are Associated With Enhanced Herpes Simplex Virus Type-1 (Mckrae) Entry Via The Paired Immunoglobulin-Like Type-2 Receptor Α, Sona Chowdhury, Misagh Naderi, Vladimir N. Chouljenko, Jason D. Walker, Konstantin G. Kousoulas

Faculty Publications

© 2012 Chowdhury et al; licensee BioMed Central Ltd. Background: Herpes simplex virus type-1 (HSV-1) enters into cells via membrane fusion of the viral envelope with plasma or endosomal membranes mediated by viral glycoproteins. HSV-1 virions attach to cell surfaces by binding of viral glycoproteins gC, gD and gB to specific cellular receptors. Here we show that the human ocular and highly neurovirulent HSV-1 strain McKrae enters substantially more efficiently into cells via the gB-specific human paired immunoglobulin-like type-2 receptor-a (hPILR-α). Comparison of the predicted amino acid sequences between HSV-1(F) and McKrae strains indicates that amino acid changes within gB, …

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