Digital Commons Network^™

Tissue-Specific Heavy Metal Accumulation And Sediment–Mangrove Dynamics In Port Everglades, Florida, Dimitrios Giarikos, Amy Hirons, Jason Gershman, Sophie Welch

SECLER Data

Coastal wetlands near industrialized waterways face increasing heavy metal contamination, yet the role of mangroves as biogeochemical buffers remains poorly understood. This study quantified 16 heavy metals in sediments and red mangrove (Rhizophora mangle) tissues (roots, branches, and leaves) across four sites near Port Everglades, Florida, examining tissue-specific partitioning, contamination patterns, and sediment-to-plant transfer. The South Turning Basin (STB) was the principal contamination hotspot, with geometric mean (GM) concentrations of arsenic (As; 27.8 µg/g) and zinc (Zn; 203 µg/g) exceeding threshold effect levels, while Cu exceeded its probable effect level (PEL; 193 µg/g). Mercury (Hg) exceeded its PEL …

Menstruation Mediating Mental Health: Premenstrual Exacerbation Of Borderline Personality Disorder Symptomatology, Autumn Abbas

Harriet L Wilkes Honors College Theses

Borderline Personality Disorder (BPD) affects up to 6.2% of women, with symptoms predominantly affecting mood and affect, interpersonal relationships, and risk of self-harming behaviors. Like many other psychiatric conditions, interaction of BPD with the menstrual cycle, called premenstrual exacerbation (PME) can occur. Similarly, premenstrual dysphoric disorder (PMDD) affects up to 8% of women, and shares many of the same symptoms. This paper seeks to distinguish between the characteristics of PME of BPD and those of PMDD and explore the effects that BPD can have during the luteal phase of the menstrual cycle. Proposed methods of research to further explore this …

I Lost My Number, Can I Have Yours? Body Image Satisfaction With Sexually Dimorphic Traits Is Associated With Men's Dating Anxiety And Confidence, David A. Frederick, Tania A. Reynolds, Nikoline L. Smart, Justin R. Garcia, David A. Puts

Psychology Faculty Articles and Research

Evolutionary scientists posit that sexual selection processes caused males to develop sexually dimorphic traits to aid them during intrasexual competition and increase their likelihood of being chosen as mates. Evolutionary social sciences have extensively examined women's preferences for traits such as muscle mass and voice pitch, reasoning that these traits serve as cues of men's ability to provide direct benefits (e.g., resources) and indirect (genetic) benefits passed on to offspring. At the same time, body image researchers have extensively focused on the social causes and consequences of men's dissatisfaction with their muscularity and body fat. We connected these two research …

Neural Mechanisms Underlying Jung’S Active Imagination: A Review And Hypothesis, Charles R. Fox

Journal of Conscious Evolution

Active imagination is a key technique of Jungian analysis. Despite its centrality, and its potential importance beyond Jungian psychology to the area of systems neuroscience, psychology, and consciousness studies, there are no known neurological mechanisms underlying this psychological phenomenon. There is a history of using the types of mental imagery used in active imagination to explore consciousness. The development and use of active imagination is briefly reviewed, and a case is developed that the neurology underlying active imagination would be fruitfully explored by considering it a special case of mystical experience. Active imagination primarily uses the right hemisphere processing of …

Developing Best Recommendations For Aerial Application And Chemigation Of Insecticides For Western Bean Cutworm (Striacosta Albicosta Smith) Management In Corn, Andrea Rilakovic

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Western bean cutworm, Striacosta albicosta (Smith), is a univoltine moth in North America, recognized as an economic threat to both corn (Zea mays L.) and dry bean (Phaseolus vulgaris L.). In the Midwest of the United States, S. albicosta can cause severe damage by reducing the quantity and quality of corn ears through larval feeding. Currently, options for Bacillus thuringiensis (Bt) proteins that can effectively control S. albicosta are limited, relying on only one Vip3A effective protein, while other growers use insecticide application via airplanes or center pivot irrigation systems, known as chemigation. Given the importance …

Kajian Dari Perspektlf Hak-Hak Perempuan Tentang Perkawinan Campuran, Mutiara Hikmah

Jurnal Hukum & Pembangunan

Abstract

Effect Of Ta2O5 On The Surface Characteristics And Corrosion Behaviour Of Epd Hydroxyapatite/Chitosan Coating On A Ti6al7nb Alloy, Yasir M. Abdulsahib, Makarim H. Abdulkareem, Ali M. Mustafa

Engineering and Technology Journal

The Ti6Al7Nb alloy is widely used as an orthopedic implant in biomedical applications. Despite its excellent corrosion resistance and mechanical properties, metallic wear particles and metal ion release occur over long spans. In order to improve the surface properties of the Ti alloy and develop its clinical use, electrophoretic deposition has been applied to enhance the surface characteristics of the Ti alloy. In this study, a hydroxyapatite-chitosan nanocomposite coating was applied on the Ti6Al7Nb implant alloy surface with varying tantalum oxide contents of 0, 10, 30, and 50 wt.% at a direct current of 60 V for 6 minutes. Hydroxyapatite …

Usaha Negara Dalam Menghadapi Kerusakan Lingkungan Hidup Yang Terjadi Di Luar Yurisdiksi Nasional, Leonardo Bernard

Jurnal Hukum & Pembangunan

Abstract

Dampak Berlakunya Trips Agreemen Terhadap Pelaksanaan Konvensi Keanekaragaman Hayati, F.X. Adji Samekto

Jurnal Hukum & Pembangunan

Abstract

Proposed Evidence-Based Practice Guidelines For Using Esmolol To Blunt The Sympathetic Stress Response To Laryngoscopy And Intubation, Maya Kurdi

Doctor of Nursing Practice Scholarly Projects

Direct laryngoscopy (DL) and endotracheal intubation (ETI) are standard procedures performed during general anesthetic induction, which provoke a sympathetic stress response that can result in intraoperative hemodynamic instability. Traditional agents like lidocaine and fentanyl, commonly used to mitigate the stress response, have limitations and can lead to adverse effects. Recent literature suggests that esmolol, an ultra-short-acting, cardio-selective beta-1 adrenergic receptor antagonist, may be an effective alternative due to its rapid onset, short duration, and minimal side effects. This final scholarly project (FSP) aims to develop evidence-based practice guidelines for using esmolol as an adjunctive induction agent. A systematic literature review …

Two Sides Of The Same Cycle: Understanding The Experiences Of Domestic Violence Survivors And Perpetrators, Avery M. Blevins

Honors Theses

Domestic violence has been a prevalent concern throughout society for many years but has recently begun to cumulate awareness from policymakers, people in the community, and individuals in service professions. There have been various changes made to the way that we define and understand domestic violence which has further led to the need to explore and educate on this concern. This paper aims to understand the experiences of both survivors and perpetrators that led to such violent circumstances. This creates a more multifaceted understanding of domestic violence and aids in implementing effective resources to both prevent and intervene in violent …

Soma: Exploring Touch As Performance And Performance As Therapy, Erica Pamson

Expressive Therapies Theses

This project investigated the role of touch within a performative context and its potential as a creative intervention within Expressive Arts Therapy. Grounded in phenomenology and intersubjectivity, the study draws on Expressive Arts Therapy (EXAT) and Performance Art frameworks that position meaning as emerging through embodied, co-created experience. Existing literature identifies touch as a primary mode of perception and communication, essential to both physical and emotional well-being, while also noting its increasing absence and regulation within contemporary Western culture. Performance art literature further highlights the body as both medium and site of relational exchange, often dissolving boundaries between performer and …

Fiber Consumption Of Three Lemur Species With Varying Dietary Specializations, Dylan Daniels

Honors Capstones

Fiber is an important macronutrient as a source of energy for maintaining animal health. My research question is what is the fiber content of foods consumed by lemur species with different dietary specializations (Propithecus diadema, Eulemur fuvlus, and Hapalemur griseus) and are there seasonal changes? 172 plant foods were collected in Tsinjoarivo, Madagascar during the resource-abundant and lean season. I analyzed these samples using the neutral detergent fiber method, which simulates digestion and measures insoluble fiber. Knowing how much fiber lemurs consume and how they adapt to seasonal variation in the food supply will allow for restorative actions to be …

Assessing The Risk Of Low Energy Availability In Ncaa Division Iii Female Soccer Players, Emma C. Sturts

Masters Theses/Capstone Projects

Low Energy Availability (LEA) can occur when an athlete’s energy intake is insufficient to meet the physiological demands of training as well as normal physiological functions. Female soccer players may be at an increased risk of developing LEA due to the high exercise energy expenditure paired with decreased energy intake. The purpose of this study is to assess the prevalence of LEA among Division III female soccer players. Division III female soccer players (n = 11) completed the Low Energy Availability in Females Questionnaire (LEAF-Q). 45.5% (n = 5) of the participants were classified as “At Risk” for LEA. Of …

A New Subspecies Of Papilio Indra (Papilionidae) From The West Desert Of Utah, Usa, Wayne H. Whaley, Alexander A. Jason, Todd L. Stout

The Taxonomic Report of the International Lepidoptera Survey

Papilio indra bonnevillensis is a new described subspecies partly based on taxonomic rearrangement of its larval host plant reproductive phenology relative to Wasatch Range nominate P. indra. It is geographically isolated in Utah’s West Desert from populations of ssp. nevadensis to the west and ssp. calcicola to the south. In addition to phenological differences compared to these two subspecies, it merits description based on host Lomatium depauperatum which recently speciated from L. grayi, neither of which is used as host by other subspecies of P. indra. The evolution of new host L. depauperatum is …

Neurodiversity In The Workplace: Organizational Approaches To Supporting Neurodiverse Employees, Madison Vasquez

M.S. in Leadership

Despite growing conversation around neurodiversity in the workplace, many organizations lack clear understanding and structured strategies to support neurodivergent employees. This study examines existing research on how organizations can more effectively support neurodiverse employees across the employee lifecycle. Using a qualitative literature review, this study addresses the research question by examining literature on neurodiversity within workplace contexts. This includes investigating common representations of neurodiversity and reviewing the strengths and challenges of neurodiverse individuals, including those who have autism, ADHD, and other forms of neurodivergence. The study also reviews workplace barriers, support strategies, and organizational outcomes identified across the literature. Key …

The Effect Of Stress Hormones On Memory Formation And Academic Performance, Emma L. Hooks

Senior Honors Theses

With chronic stress becoming increasingly prevalent in academic settings, researchers have identified significant effects on learning and academic performance. Cortisol, a glucocorticoid hormone, is released following the activation of the hypothalamic-pituitary-adrenal (HPA) axis and plays a vital role in the stress response. Although acute increases in cortisol can improve attention and memory, sustained activation of the stress response can impair memory, executive functioning, and academic performance. This thesis draws on neuroscience, psychology, and education research to examine how chronic cortisol exposure affects the hippocampus and prefrontal cortex, and how the effects manifest in learning and academic performance, particularly in developmental …

Tropomyosin-Related Kinase Receptor Type B Agonism In Geographic Atrophy-The Translational Challenges From Preclinical Data To A First-In-Human Trial, David Brown, Oliver Zeitz, Clare Bailey, Sunir J. Garg, Karl Csaky, James Talks, Sobha Sivaprasad, Peter M. Benz, Rolf Herrmann, Remko A. Bakker, Sebastian Bandholtz, Ankit Mittal, Qihong Huang, Serge Kosobokovs, Gudrun Simons, Andrea Giani, Jochen Huber, Martin Gliem

Wills Eye Hospital Papers

OBJECTIVE: To report results of the first-in-human trial of intravitreal tropomyosin-related kinase receptor type B (TrkB) agonist BI 754132 in participants with geographic atrophy (GA). To discuss BI 754132 clinical data in the context of the preclinical findings and their translation into human data.

DESIGN: An open-label, uncontrolled, nonrandomized phase I trial (NCT04002310) assessing the safety, tolerability, and pharmacokinetics of BI 754132 in participants with GA supported by preclinical data.

PARTICIPANTS: Participants with GA recruited between July 2019 and August 2022 in the United States and UK.

METHODS: Clinical trial comprising a single rising dose (SRD) part (n = 15) …

Comparing The Effectiveness Of Neb Precrtm Repair Mix And Nxgen T4 Dna Ligase For Repairing Degraded Dna For Pcr Forensic Applications, Karolena Zvokel

Honors Theses

This study investigated the comparison between using PreCRTM mix (New England Biolabs) and T4 DNA Ligase (New England Biolabs) to repair degraded forensic whole blood DNA samples for PCR amplification. Degraded DNA presents a significant challenge in forensic STR analysis due to reduced amplification efficiency and allele imbalance. Whole blood samples were extracted, quantified, and artificially degraded using UV exposure. Samples were introduced to multiple treatments, including no damage no repair (NDNR), damage no repair (DNR), PreCRTM repair, T4 DNA ligase treatment, and combined repair approaches. Amplified products were analyzed using capillary electrophoresis, and peak height ratios (PHR) were used …

Employing Zebrafish To Understand Genetic Drivers Of Epilepsy-Related Comorbid Behaviors, Chinwendu Ononuju, Kharma Hall, Olivia Beatty, Scott C. Baraban, Colleen Carpenter-Swanson

Biology Faculty Publications

Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contribute more significantly to overall disease burden than the seizures themselves. To improve quality-of-life (QOL) for these children, treatment options should be selected that control seizures and ameliorate comorbidities. Unfortunately, such therapeutics remain largely elusive. Addressing this issue requires suitable preclinical models. Here we used CRISPR-generated zebrafish with single-gene mutations linked to pediatric epilepsy and applied clinically-relevant behavioral assays to study the effects of these mutations. Using high-throughput locomotion-based assays, we uncovered errors in …

Frailty As A Surgical Vital Sign: A Narrative Review Of Risk Stratification And Outcomes In General Surgery, Ambrose Loc T. Ngo, Matthew Tiojanco, Ian Miller, Linda Nguyen, Uyen Tam Nguyen, Carolyn Duong

Student Publications

Frailty has emerged as a critical determinant of perioperative risk, yet it remains underutilized in routine surgical assessment. As the global population ages, an increasing proportion of patients undergoing general surgery present with diminished physiologic reserve that is not adequately captured by traditional risk stratification tools. This narrative review examines frailty as a multidimensional construct and its role as a prognostic marker in general surgery, with the aim of synthesizing current evidence on its biological basis, evaluating commonly used frailty assessment tools, and examining its impact on postoperative outcomes, including morbidity, mortality, length of stay, and discharge disposition. A comprehensive …

Tractor Workflow: A Scalable Nextflow Framework For Local Ancestry-Aware Genome-Wide Association Studies, Nirav N Shah, Taotao Tan, Jessica Honorato-Mauer, Yi-Sian Lin, Adam X Maihofer, Clement C Zai, Pgc-Ptsd Ancestry Working Group, Marcos Santoro, Caroline M Nievergelt, Elizabeth G Atkinson

Faculty, Staff and Students Publications

Motivation: The routine exclusion of admixed individuals from traditional genome-wide association studies (GWAS) due to concerns about spurious associations has limited multi-ancestry genetic discovery. Tractor addresses this issue by incorporating local ancestry into association testing, enabling the identification of ancestry-enriched signals and generating ancestry-specific summary statistics. However, adoption has been constrained by the complexity of prerequisite steps, including phasing and local ancestry inference, which require substantial bioinformatics expertise and introduce key analytical decision points.

Results: We developed a scalable, automated Nextflow workflow that integrates phasing, local ancestry inference, and Tractor association testing into a reproducible end-to-end pipeline. To demonstrate its …

Nuclear Export As A Therapeutic Vulnerability In Zfta-Rela Ependymoma, Siri M Ippagunta, Amir Arabzade, Srinidhi Varadharajan, Erik Emanus, Amanda Bland, Alisha Kardian, Nicholas Laboe, Hua Sun, Tuyu Zheng, Amelia Hancock, Mark Zhai, Emma Caesar, Maxwell Park, Wilda Orisme, Melissa Johnson, Brittany Rodgers, Gregory H Turner, Jeffrey Steinberg, Burgess Freeman, Martine F Roussel, Anang Shelat, Richard Kriwacki, Thomas E Merchant, Benjamin Deneen, Michael D Taylor, Sameer Agnihotri, Shondra Pruett-Miller, Jacob A Steele, Anoop Murthy Kavirayani, David W Ellison, Arzu Onar-Thomas, Giles Robinson, Stephen C Mack, Kelsey C Bertrand

Faculty, Staff and Students Publications

Background: Ependymoma (EPN) is the third most common pediatric brain tumor with no targeted therapies available to patients. In supratentorial ependymoma, the most frequent driver alteration is a gene fusion between ZFTA and RELA (denoted ZR), leads to constitutive localization of ZR in the nucleus. Because ZR is not currently druggable, we tested whether ZR expression leads to aberrant protein interactions that could represent therapeutic vulnerabilities.

Methods: Using CRISPR-Cas9 pooled screening, we identified many novel druggable ZR interacting proteins including XPO1, CARM1, SMARCA4, and CDK1. We focused on the nuclear export protein (XPO1), given the ability of most XPO1 inhibitors …

Annona Muricata (Soursop) And Hematopoiesis: Ethnomedicinal Insights, Immunomodulatory Mechanisms, And Translational Challenges, Fatma Matano, Amiya Patra

Peninsula Medical School

Annona muricata (soursop) is a tropical medicinal plant widely used in traditional medicine across Africa, the Caribbean, and parts of South America. While its ethnomedicinal applications span a range of conditions, including infections, inflammation, and anemia-related symptoms, its potential relevance to hematopoiesis has not been systematically examined. This narrative review synthesizes ethnomedicinal knowledge, phytochemical composition, and experimental evidence to explore the biological plausibility by which A. muricata may indirectly influence hematopoietic processes. Bioactive constituents of A. muricata, including flavonoids, polyphenols, and acetogenins, have demonstrated antioxidant, anti-inflammatory, and immunomodulatory properties in preclinical models. These effects are particularly relevant given the established …

Evaluating The Suitability Of The Berg Balance Scale For Assessing Balance In Diabetes With And Without Prior Covid-19: A Methods-Validation Study, Garima Kaushik Dr, Sheetal Malhan Dr., Apoorva Tiwari Dr, Vishakha Daga Dr

Journal Of Indian Physician Associates

ABSTRACT

Background: Balance impairment in diabetes mellitus is predominantly driven by somatosensory loss secondary to peripheral neuropathy. The Berg Balance Scale (BBS) is widely used to evaluate functional balance, yet it mainly reflects motor performance and may not adequately represent sensory mechanisms. Following COVID-19, additional concerns regarding deconditioning have emerged, but interpretation depends on the measurement tool employed.

Objective: To examine the construct behavior and suitability of the BBS for assessing balance in individuals with diabetes with and without prior COVID-19 infection, and to determine whether the scale reflects known determinants of diabetic imbalance.

Methods: A cross-sectional analysis was conducted …

Exploring Identity Through Clay: A Humanistic Art Therapy Case Study With A Blind Chinese Adoptee, Virginia Jade Leicht

Expressive Therapies Theses

This qualitative case study explored how working with clay in art therapy can help support a blind man’s identity exploration. This paper addresses the problem of many traditional therapeutic approaches within the art therapy realm: They rely too heavily on visual engagement, which can limit the accessibility and opportunities for self-exploration and identity development for those who are blind. The study was grounded in current research and foundational theories based on the humanistic art therapy approach. Clay is considered an accessible medium that engages multiple senses and allows for emotional exploration and meaning making, specifically through tactile and sensory-based engagement …

Inbreeding And The Fall Of The Spanish Habsburg Dynasty, Kira L. Kent

Honors Theses

Inbreeding and the Fall of the Spanish Habsburg Dynasty examines how centuries of consanguineous marriages within the Spanish Habsburg family contributed to the dynasty’s decline and eventual extinction. Focusing on the reign and health of Carlos II of Spain, this study explores how dynastic marriage strategies, which were designed to consolidate political power and preserve royal lineage, ultimately produced severe genetic consequences. This thesis analyzes patterns of intermarriage beginning with Carlos I and continuing through the next four monarchs, highlighting the repeated marriages between close relatives. These practices significantly increased the likelihood of inheriting harmful recessive traits. In addition, this …

Returning To Play: Play-Centered Art Therapy With Parentified Adult Caregivers, Paola Andrea Mendez Carreno

Expressive Therapies Theses

This research investigates the impact of play-centered art therapy on parentified adult caregivers, focusing on how creative interventions utilizing elements of play can support identity development, self-compassion, and relational capacity. The literature indicates that childhood parentification leads to identity loss and burnout, but creative play can foster neuroplasticity and emotional processing by allowing adults to externalize harmful narratives that have been internalized. To explore these concepts, the author conducted four sessions over six weeks with an adult participant at a private outpatient practice in Massachusetts. Play-centered activities included free collaging, puppet-making, and clay modeling, often involving moments of parallel play …

Modulating The Plastisphere: Inhibiting Biofilm Formation Of Vibrio Spp., Kacian Clayton

Harriet L Wilkes Honors College Theses

According to the United Nations Environment Programme (UNEP), approximately 19-23 million tons of plastic are released into the aquatic environment each year. Vibrio spp. are diverse gram-negative bacteria that inhabit these environments, capable of colonizing and forming biofilms on these plastic surfaces. In an age when anthropogenic activity exerts an undeniable influence on ecosystems, elucidating a way to regulate the interactions between plastic and vibrios is essential. In previous studies, Polymyxin B has demonstrated high efficacy against biofilm formation in gram-negative bacteria, including Vibrio cholerae. The purpose of this study is to investigate the efficacy of cyclic lipopeptide antibiotics toward …

Chemometric Analysis Of Dissolved Organic Matter Using Fluorescence, Dani Fellner, Ken Overway

Honors Projects

Univariate spectroscopic techniques have been utilized to measure dissolved organic matter (DOM), but challenges arise in the separation and characterization due to similarities in chemical structures and spectral overlap. Multivariate techniques utilize a combination of known analytes with their unique excitation and emission spectra from fluorescence measurements to quantify amount of each analyte present in the mixture using parallel factor analysis. Tryptophan, tyrosine, and phenylalanine are common amino acids found in environmental samples and can be quantified due to their intrinsic fluorescence qualities. These amino acids can be utilized to estimate the amount of DOM in a sample since proteins …