Digital Commons Network^™

Search Full Text Options Here 3 Of 3 Heat-Mitigated Design And Lorentz Force-Based Steering Of An Mri-Driven Microcatheter Toward Minimally Invasive Surgery, Martin Francis Phelan Iii, Mehmet Efe Tiryaki, Jelena Lazovic, Hunter Gilbert, Metin Sitti

Faculty Publications

Catheters integrated with microcoils for electromagnetic steering under the high, uniform magnetic field within magnetic resonance (MR) scanners (3-7 Tesla) have enabled an alternative approach for active catheter operations. Achieving larger ranges of tip motion for Lorentz force-based steering have previously been dependent on using high power coupled with active cooling, bulkier catheter designs, or introducing additional microcoil sets along the catheter. This work proposes an alternative approach using a heat-mitigated design and actuation strategy for a magnetic resonance imaging (MRI)-driven microcatheter. A quad-configuration microcoil (QCM) design is introduced, allowing miniaturization of existing MRI-driven, Lorentz force-based catheters down to 1-mm …

The Effects Of Negative Life Events On Pessimistic Future Outlook: Mediating Effects Of Anxiety And Behavior, Kia Harris

Honors Capstones

No abstract provided.

An Investigation Of How Previous Diagnoses Affect The Developmental Functioning Of Children At Risk For Autism Spectrum Disorder, Michaela Brown

LSU Master's Theses

Research has shown that children with autism spectrum disorder (ASD) often have co-occurring medical and/or psychiatric disorders. This current study aimed to investigate how previous diagnoses, which may become comorbidities of ASD if diagnosed, affect the developmental functioning of children presenting as at risk for ASD compared to those presenting with no risk. Developmental areas such as communication, motor, adaptive, cognitive and social, as well as overall developmental functioning, were considered in the analysis. 11,970 children under the age of three were studied. Results found that the presence of previous diagnoses significantly predicted developmental functioning, particularly in the motor functioning …

Heteroaggregation Of Lignin-Zein Nanoparticles: Effects Of Relative Size And Concentration, Yada Chulakham

LSU Master's Theses

Nanotechnology has become an advanced tool for manufacturing materials of the future. As the size of a material is reduced to a nanoscale, its surface area to volume ratio increases drastically, and its surface property becomes size dependent. This allows scientists to make use of unique properties that nanomaterials have to offer to create novel materials that otherwise could not have been achieved in meter-scale materials. As more industrial companies have planned to incorporate different types of nanomaterials into their products, it is undeniable that some of these nanomaterials will be released to the environment. Such possibility has led to …

Diabetes Status Modifies The Association Between Different Measures Of Obesity And Heart Failure Risk Among Older Adults: A Pooled Analysis Of Community-Based Nhlbi Cohorts, Kershaw V. Patel, Matthew W. Segar, Carl J. Lavie, Nitin Kondamudi, Ian J. Neeland, Jaime P. Almandoz, Corby K. Martin, Salvatore Carbone, Javed Butler, Tiffany M. Powell-Wiley, Ambarish Pandey

Clinical Research Faculty Publications

Background: Obesity and diabetes are associated with a higher risk of heart failure (HF). The interrelationships between different measures of adiposity-overall obesity, central obesity, fat mass (FM)-and diabetes status for HF risk are not well-established. Methods: Participant-level data from the ARIC study (Atherosclerosis Risk in Communities; visit 5) and the CHS (Cardiovascular Health Study; visit 1) cohorts were obtained from the National Heart, Lung, and Blood Institute Biologic Specimen and Data Repository Information Coordinating Center, harmonized, and pooled for the present analysis, excluding individuals with prevalent HF. FM was estimated in all participants using established anthropometric prediction equations additionally validated …

Fibrogenesis And Adipogenesis In Farm Animals And Rodents, Chaoyang Li

LSU Doctoral Dissertations

In this dissertation, we aimed to provide additional insight into the mechanisms of fibrogenesis and adipogenesis based on different animal models to help the discovery of new treatments in cardiovascular disease, beef breeding strategies, and feed nutrition modifications.

Wayu, the Japanese Black cow, are well-known for their high IMF content, while the Brahman cattle have much less marbling. The development of IMF correlated with the increase in the size and number of IMF adipocytes, which have identified to be derived from a group of progenitor cells known as fibro/adipogenic progenitor (FAP) cells because of their bipotent differentiation ability. Interestingly, the …

Drug Resistance In The Canine Filarial Parasite, Dirofilaria Immitis: Emergence And Clinical Epidemiology In The Lower Mississippi River Alluvial Valley, Cassan Nicole Pulaski

LSU Doctoral Dissertations

Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by practicing veterinarians since 2005 in the Lower Mississippi Delta region. If proven, and not controlled in the early stages, the emergence of ML drug resistance threatens to become a widespread problem in the US that may limit the effectiveness of current preventive drug treatment methods. To validate practice reports, a statewide survey of Louisiana veterinarians was done to define the extent of the problem and identify focal ‘hotspots’ of reported ML LOEs using Geographic Information Systems (GIS) …

Elgin's "Native Tongue": A "Me Too" Universe?, Amir Barati

Tête à Tête: Journal of Francophone Studies

Suzette Haden Elgin’s novel Native Tongue (1984) provides a fascinating critique of the ideologies inscribed into patriarchal language and evokes an extremely valuable linguistic and political awareness. This article will examine the liability of the ways the novel revolts against the patriarchal society via the introduction of a gynocentric linguistic intervention. I claim, Elgin’s novel showcases an invaluable instance of how it is possible for women to revolt against the pillars of patriarchy through manipulations at the gestalt and schematic level of language and most specifically, the bodily metaphoric quality of the English. This proposed transformation of the schematic and …

The Sensible Body Of The Female Reader, Anoosheh Ghaderi

Tête à Tête: Journal of Francophone Studies

No abstract provided.

Transgressing Boundaries Of Identity, Geography And Time In Transmutadxos And La Mucama De Omicunlé, Lucinda Smith

Tête à Tête: Journal of Francophone Studies

The literary works of Rita Indiana (1977) and Yolanda Arroyo Pizarro (1970) are recognised for exposing and challenging hegemonic ideas of identity, sexuality and power. The transgression of boundaries appears time and again in the fiction of both writers, whether these be boundaries of sexual or gender identity, desire, geography, time or even life and death. Using Rita Indiana’s novel La mucama de Omicunlé (2015) and Arroyo’s collection of short stories Transmutadxs (2016), the authors’ representations of such transgressions are the focus of this essay.

Further to addressing similar themes in their texts, both Rita Indiana and Arroyo Pizarro were …

Bodies And Expressions: Exploring The Aesthetics Of Disability Performance Art, Jaya Sarkar

Tête à Tête: Journal of Francophone Studies

No abstract provided.

“Bovarique” Bodies From 19th Century France To 20st Century London, Andisheh Ghaderi, Anoosheh Ghaderi

Tête à Tête: Journal of Francophone Studies

Women’s bodies have always been charged by social associations that aim to control, shape, and discipline women. The frustrations and the ennui caused by sociocultural and political constraints push women to a state of existential crisis and eventually a erasure through biological death. Such vicious cycles had been depicted in the literary works to which Gustave Flaubert’s Madame Bovary (1856) serves as a prominent example. Flaubert’s protagonist, Emma Bovary represents the pathway of a young, provincial, woman to a tragic adulthood filled with banality, emptiness, and despair. Objects, ranging from journals to clothes, are omnipresent in Emma’s life and shape …

Writing Desire On The Lesbian Body: Baudelaire’S Fantasies And Vivien’S Realities, Emily Wieder

Tête à Tête: Journal of Francophone Studies

In The Flowers of Evil [Les Fleurs du Mal (1857)], French poet Charles Baudelaire paints three female bodies: the mistress, the prostitute, and the lesbian. The latter appears in three of one-hundred poems but so captivated Baudelaire that he almost titled the collection The Lesbians. Censors nevertheless condemned the anthology and suppressed two of the lesbian poems. The remaining lesbian poem compares the “damned women” to “thoughtful cattle.” A rare representation of lesbian bodies, this metaphor problematically depicts them as savage.

Yet this “Other” exemplifies the baudelairean poetic ideal. By crafting Beauty, the Poet immortalizes his corpus. As the …

Developmental Functioning Of Infants And Toddlers With Neurodevelopmental Disorders, Megan Callahan

LSU Master's Theses

Autism spectrum disorder (ASD), epilepsy, and cerebral palsy (CP) are some of the most common neurodevelopmental disorders among children with prevalence rates of 1.85% (Maenner et al., 2020), 1.2% (Zack & Kobau, 2017), and between 0.21 and 0.31% (Christensen et al., 2013), respectively. These neurodevelopmental disorders are highly comorbid with each other and with other disorders, such as intellectual disability (ID). While previous research has investigated developmental functioning in these neurodevelopmental disorders, it has primarily focused on only two at a time and in older children or adults. The current study aimed to investigate developmental functioning in these neurodevelopmental disorders …

Design And Fabrication Of A Low-Cost, Portable, Battery-Operated Surface Enhanced Raman Scattering (Sers) Optical Device, Blessing Adewumi

LSU Doctoral Dissertations

Raman Spectroscopy is a time-honored, non-invasive method for analyzing and identifying the molecular composition of materials. However, unenhanced Raman Spectroscopy has extremely low sensitivity which limits its sensing capability. SERS brings rough nano-metallic surfaces in contact with the material molecules to enormously enhance the Raman signals.

The sensitivity of SERS can be exploited in probe applications where the spectrometer needs to be brought near the specimen. For example, a long optical fiber coupled to a SERS device can be used to characterize and identify easy-to-reach cancerous tissues in organisms. Unfortunately, background signals in a long fiber can easily mask any …

Microplastics Through The Lens Of Colloid Science, Ahmed Al Harraq, Bhuvnesh Bharti

Faculty Publications

Microplastics are sub-millimeter-sized fragments of plastics and a relatively new class of pollutant increasingly found in the environment. Due to their size and surface area to volume ratio, the physicochemical characteristics of microplastics can diverge from those of their macroscopic counterparts. This is partly why it is challenging to understand their origin, analyze their behavior, and predict their fates in the environment compared to large pollutants. We believe that adopting a view of microplastics as a colloid provides a holistic framework that connects their physical properties and surface chemistries with observations of their dynamics in the environment. In particular, we …

Ecology Of Periphyton In A Subtropical River Floodplain, Kamela De Gallardo

LSU Doctoral Dissertations

The Atchafalaya River Basin (ARB) in southcentral Louisiana, USA, is a large and biologically diverse floodplain surrounding the Atchafalaya River (AR), which is the largest distributary of the Mississippi River, receiving 30% of the combined daily discharge of the Mississippi and Red Rivers. Annual flooding facilitates exchange between the AR and its floodplain and is thought to give rise to the high productivity of the river-floodplain system. Primary production within the aquatic ARB is driven by periphytic algae, phytoplankton, and aquatic macrophytes, however, very little is known about periphytic algal assemblages in floodplain systems. In this study, artificial substrates were …

Dynamic Correlation Estimators For Bivariate Brownian And Geometric Brownian Motions, Majnu John, Yihren Wu

Journal of Stochastic Analysis

No abstract provided.

Designing A Clinical Study With Dietary Supplements: It's All In The Details, Z. Elizabeth Floyd, David M. Ribnicky, Ilya Raskin, Daniel S. Hsia, Jennifer C. Rood, Bill J. Gurley

Division of Basic Science Faculty Publications

A successful randomized clinical trial of the effect of dietary supplements on a chosen endpoint begins with developing supporting data in preclinical studies while paying attention to easily overlooked details when planning the related clinical trial. In this perspective, we draw on our experience studying the effect of an ethanolic extract from Artemisia dracunculus L. (termed PMI-5011) on glucose homeostasis as a potential therapeutic option in providing resilience to metabolic syndrome (MetS). Decisions on experimental design related to issues ranging from choice of mouse model to dosing levels and route of administration in the preclinical studies will be discussed in …

Moisture-Tolerant And Operationally Simple Synthesis Of Synthetic Polypeptides And Polypeptoids By Ring-Opening Polymerization Of N-Thiocarboxyanhydrides, David Siefker

LSU Doctoral Dissertations

ABSTRACT

This work aims to develop a new synthetic strategy for synthesizing advanced functional This work aims to develop a new synthetic strategy for synthesizing advanced functional pseudo-peptidic polymers. Pseudo-peptidic polymers mimic poly(glycine) backbone with substituents on either the α-carbon or the nitrogen, appealing properties for various biomedical applications. One of the critical challenges in pseudo-peptidic polymers research is the synthesis of functional pseudo-peptidic polymers under mild conditions. We developed a system based on ring-opening polymerization (ROP) of N-Thiocarboxyanhydrides (NTAs) initiated by primary amines to synthesize polypeptides with a wide range of controlled molecular weights …

Reef Sediments Can Act As A Stony Coral Tissue Loss Disease Vector, Michael S. Studivan, Ashley M. Rossin, Ewelina Rubin, Nash Soderberg, Daniel M. Holstein, Ian C. Enochs

Faculty Publications

Stony coral tissue loss disease (SCTLD) was first observed in 2014 near Virginia Key in Miami-Dade County, Florida. Field sampling, lab experiments, and modeling approaches have suggested that reef sediments may play a role in SCTLD transmission, though a positive link has not been tested experimentally. We conducted an ex situ transmission assay using a statistically-independent disease apparatus to test whether reef sediments can transmit SCTLD in the absence of direct contact between diseased and healthy coral tissue. We evaluated two methods of sediment inoculation: batch inoculation of sediments collected from southeast Florida using whole colonies of diseased Montastraea cavernosa, …

Long-Term Suppression Of Hardwood Regeneration By Chinese Privet (Ligustrum Sinense), Taylor N. Turner, Thomas J. Dean, Jeff S. Kuehny

Faculty Publications

Native hardwood regeneration in the southeast United States is hindered by repeat disturbance events and the presence of invasive species. Our study aimed to determine the ability of native species in an unmanaged urban forest fragment to persist following high winds from hurricane Gustav in 2008 and subsequent salvage logging. In 2009, researchers estimated the density and composition of the regeneration and overstory trees as well as percent crown cover of invasive Chinese privet. Percent Chinese privet cover was visibly high, leading them to believe it may be inhibiting native hardwood establishment. Ten years later in 2019, we returned to …

Role Of International Research Experiences In The Development Of Women Of Color In Chemistry, R D. Davis, L Winfield, D Spivak, Z S. Wilson-Kennedy, R D. Davis

Faculty Publications

As undergraduate students cultivate their scientific knowledge and abilities, several high-impact educational practices such as undergraduate research and global experiences have proven exponentially beneficial for their development and success. Current literature on underrepresented racial and ethnic minorities has focused primarily on the impact of undergraduate research on this subpopulation. However, fewer studies have explored the impact of global research experiences and women of color in international research experiences. Grounded in the theoretical frameworks of Social Cognitive Career Theory, Intersectionality, and Community Cultural Wealth, this present study explored the impact of international undergraduate research experiences on women of color from groups …

Current Methods And Future Directions In Avian Diet Analysis, Brandon D. Hoenig, Allison M. Snider, Anna M. Forsman, Keith A. Hobson, Steven C. Latta, Eliot T. Miller, Michael J. Polito, Luke L. Powell, Samantha L. Rogers, Thomas W. Sherry, David P.L. Toews, Andreanna J. Welch, Sabrina S. Taylor, Brady A. Porter

Faculty Publications

Identifying the composition of avian diets is a critical step in characterizing the roles of birds within ecosystems. However, because birds are a diverse taxonomic group with equally diverse dietary habits, gaining an accurate and thorough understanding of avian diet can be difficult. In addition to overcoming the inherent difficulties of studying birds, the field is advancing rapidly, and researchers are challenged with a myriad of methods to study avian diet, a task that has only become more difficult with the introduction of laboratory techniques to dietary studies. Because methodology drives inference, it is important that researchers are aware of …

Distributed Matrix Tiling Using A Hypergraph Labeling Formulation, Avah Banerjee, Maxwell Reeser, Guoli Ding

Faculty Publications

Partitioning large matrices is an important problem in distributed linear algebra computing, used in ML among others. Briefly, our goal is to perform a sequence of matrix algebra operations in a distributed manner on these large matrices. However, not all partitioning schemes work well with different matrix algebra operations and their implementations (algorithms). This is a type of data tiling problem. In this paper we consider a data tiling problem using hypergraphs. We prove some hardness results and give a theoretical characterization of its complexity on random instances. Additionally we develop a greedy algorithm and experimentally show its efficacy.

Kinetics And Connectivity Properties Of Parvalbumin- And Somatostatin-Positive Inhibition In Layer 2/3 Medial Entorhinal Cortex, Fernando R. Fernandez, Guillem Via, Carmen C. Canavier, John A. White

Faculty Publications

No abstract provided.

Biological And Geochemical Proxies In Sediment Cores Reveal Shifts In Marine Predator Population Dynamics Relative To Historic Anthropogenic Exploitation And Recent Climate Change At South Georgia Island Sub-Antarctic, Allyson K. Kristan, Kanchan Maiti, Kelton W. Mcmahon, Michael A. Dance, Michael J. Polito

Faculty Publications

Historical climate change and human exploitation are thought to have played important roles in shaping population dynamics of sub-Antarctic marine predators, such as king penguins (Aptenodytes patagonicus) and Antarctic fur seals (Arctocephalus gazelle). For example, Antarctic fur seals on the sub-Antarctic South Georgia Island were nearly hunted to extinction by humans before the early 1900s. However, records of occupation history pre- and post-anthropogenic stress are often sporadic and challenging to interpret. In this study, we investigated paleoecological proxies in sediment cores from South Georgia Island to examine past marine predator population dynamics in the face of climate change and exploitation …

Isocaloric Low Protein Diet In A Mouse Model For Vanishing White Matter Does Not Impact Isr Deregulation In Brain, But Reveals Isr Deregulation In Liver, Lisanne E. Wisse, Denise Visser, Timo J. Ter Braak, Abdellatif Bakkali, Eduard A. Struys, Christopher D. Morrison, Marjo S. Van Der Knaap, Truus E.M. Abbink

Division of Basic Science Faculty Publications

Objective: Vanishing white matter (VWM) is a genetic brain white matter disorder caused by mutations in eIF2B. eIF2B is central in the integrated stress response (ISR), during which its activity is inhibited by various cellular stresses. VWM is a chronic progressive disease with episodes of rapid neurological deterioration provoked by stresses. VWM patients and VWM mouse models show ISR deregulation in brain, correlating with chronic disease development. ISR inhibition ameliorates the chronic disease in VWM mice. The subacute deteriorations have not been modeled yet. We hypothesized that ISR activation could worsen disease progression in mice and model the episodic neurological …

Obesity: Understanding And Achieving A Healthy Weight, George A. Bray, Catherine M. Champagne

Population and Public Health Science Faculty Publications

Obesity is a chronic, relapsing, stigmatized disease process that is increasing in prevalence, affecting both adults and children. It is the result of a small positive energy imbalance from too much food or too little activity. These underlying causes are influenced by many environmental factors. The food we eat is more than “calories,” and focusing on calories alone may not be as productive as focusing on patterns of eating and the role of sugar and fat in the diet. Obesity increases the risk of many diseases and shortens life span, and weight loss provides benefits in reducing health risks and …

Obesity, Body Composition, And Sex Hormones: Implications For Cardiovascular Risk, Prachi Singh, Naima Covassin, Kara Marlatt, Kishore M. Gadde, Steven B. Heymsfield

Clinical Research Faculty Publications

Cardiovascular disease (CVD) continues to be the leading cause of death in adults, highlighting the need to develop novel strategies to mitigate cardiovascular risk. The advancing obesity epidemic is now threatening the gains in CVD risk reduction brought about by contemporary pharmaceu-tical and surgical interventions. There are sex differences in the development and outcomes of CVD; premenopausal women have significantly lower CVD risk than men of the same age, but women lose this advantage as they transition to menopause, an observation suggesting potential role of sex hormones in determining CVD risk. Clear differences in obesity and regional fat distribution among …