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Articles 1681 - 1710 of 13623
Full-Text Articles in Entire DC Network
The Potential Of Dietary Bioactive Compounds Against Sars-Cov-2 And Covid-19-Induced Endothelial Dysfunction, Jack N. Losso
The Potential Of Dietary Bioactive Compounds Against Sars-Cov-2 And Covid-19-Induced Endothelial Dysfunction, Jack N. Losso
Faculty Publications
COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with dysfunctional endothelium. Genetics and environmental factors (epigenetics) are major risk factors for endothelial dysfunction. Individuals with metabolic syndrome are at increased risk for severe SARS-CoV-2 infection and poor COVID-19 outcomes and higher risk of mortality. Old age is a non-modifiable risk factor. All other risk factors are modifiable. This review also identifies dietary risk factors for endothelial dysfunction. Potential dietary …
Event-Triggered Control For Linear Time-Varying Systems Using A Positive Systems Approach, Frederic Mazenc, Michael Malisoff, Corina Barbalata, Zhong Ping Jiang
Event-Triggered Control For Linear Time-Varying Systems Using A Positive Systems Approach, Frederic Mazenc, Michael Malisoff, Corina Barbalata, Zhong Ping Jiang
Faculty Publications
This paper presents a new design for the event-triggered output feedback control of uncertain linear time-varying systems. Departing from the traditional treatments of event-triggered linear time-invariant systems, it is shown that factoring of fundamental solutions as products of solutions of matrix differential equations, together with small-gain arguments and the notions of interval observers and positive systems, lead to a new class of robust event-triggered output-feedback controllers. A key innovation is our use of new event triggers, which use vectors of absolute values instead of the usual Euclidean 2-norms. An illustrative example of a curve tracking system from marine robotics validates …
Glutamic-Oxaloacetic Transaminase 2 (Got2) Reverse Reaction Could Act As A Possible Relief Valve For Mitochondrial Substrate Overload Induced By Glucocorticoids, Humza Pirzadah
Honors Capstones
No abstract provided.
Rnai-Based Screen To Identify Transcription Factors Regulating Small-Vcp Interacting Protein (Svip) Expression In Drosophila Melanogaster, Tiffany Dang
Honors Capstones
No abstract provided.
Exploring The Effect Of Hormetic Stress And Aging On Tubular Lysosome Induction In Caenorhabditis Elegans Nematodes, Sanaa Alam
Honors Capstones
No abstract provided.
New Limit Theorems For Increments Of Birth-And-Death Processes With Linear Rates, Alexander Ya. Kreinin, Vladimir V. Vinogradov
New Limit Theorems For Increments Of Birth-And-Death Processes With Linear Rates, Alexander Ya. Kreinin, Vladimir V. Vinogradov
Journal of Stochastic Analysis
No abstract provided.
Caloric Restriction In Humans Reveals Immunometabolic Regulators Of Health Span, O. Spadaro, Y. Youm, I. Shchukina, S. Ryu, S. Sidorov, A. Ravussin, K. Nguyen, E. Aladyeva, A. N. Predeus, S. R. Smith, E. Ravussin, C. Galban, M. N. Artyomov, V. D. Dixit
Caloric Restriction In Humans Reveals Immunometabolic Regulators Of Health Span, O. Spadaro, Y. Youm, I. Shchukina, S. Ryu, S. Sidorov, A. Ravussin, K. Nguyen, E. Aladyeva, A. N. Predeus, S. R. Smith, E. Ravussin, C. Galban, M. N. Artyomov, V. D. Dixit
Clinical Research Faculty Publications
The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid. CR-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. Expression of the gene Pla2g7 encoding platelet activating factor acetyl hydrolase (PLA2G7) is inhibited in humans undergoing CR. Deletion of Pla2g7 in mice showed decreased thymic lipoatrophy, protection against age-related inflammation, …
Social Media: Good Or Evil?, Prosanta Chakrabarty
Social Media: Good Or Evil?, Prosanta Chakrabarty
Faculty Publications
No abstract provided.
Hydrological Seasonality And Nutrient Stoichiometry Control Dissolved Organic Matter Characterization In A Headwater Stream, Siyue Li, Jiachen Luo, Y. Jun Xu, Liuqing Zhang, Chen Ye
Hydrological Seasonality And Nutrient Stoichiometry Control Dissolved Organic Matter Characterization In A Headwater Stream, Siyue Li, Jiachen Luo, Y. Jun Xu, Liuqing Zhang, Chen Ye
Faculty Publications
Dissolved organic matter (DOM) is a diverse and highly complex mixture of organic macromolecules, and thus plays a central role in aquatic ecosystems. However, responses of components and sources of DOM to hydrological processes and trophic levels (nutrient stoichiometric ratios) are poorly understood, particularly in monsoonal headwater streams of Asia that are vulnerable to catchment physical characteristics. In this study, the excitation - emission matrix florescence spectroscopy coupled with parallel factor analysis (EEM-PARAFAC) was used to explore the DOM characters in a headwater stream, where seasonal rainfalls and nutrient levels vary largely. The EEM-PARAFAC modelling identified one autochthonous protein-like fluorescence …
The Number Of Tree Species On Earth, Roberto Cazzolla Gatti, Peter B. Reich, Javier G.P. Gamarra, Tom Crowther, Cang Hui, Albert Morera, Jean Francois Bastin, Sergio De-Miguel, Gert Jan Nabuurs, Jens Christian Svenning, Josep M. Serra-Diaz, Cory Merow, Brian Enquist, Maria Kamenetsky, Junho Lee, Jun Zhu, Jinyun Fang, Douglass F. Jacobs, Bryan Pijanowski, Arindam Banerjee, Robert A. Giaquinto, Giorgio Alberti, Angelica Maria Almeyda Zambrano, Esteban Alvarez-Davila, Alejandro Araujo-Murakami, Valerio Avitabile, Gerardo A. Aymard, Radomir Balazy, Chris Baraloto, Jorcely G. Barroso, Meredith L. Bastian, Philippe Birnbaum, Robert Bitariho
The Number Of Tree Species On Earth, Roberto Cazzolla Gatti, Peter B. Reich, Javier G.P. Gamarra, Tom Crowther, Cang Hui, Albert Morera, Jean Francois Bastin, Sergio De-Miguel, Gert Jan Nabuurs, Jens Christian Svenning, Josep M. Serra-Diaz, Cory Merow, Brian Enquist, Maria Kamenetsky, Junho Lee, Jun Zhu, Jinyun Fang, Douglass F. Jacobs, Bryan Pijanowski, Arindam Banerjee, Robert A. Giaquinto, Giorgio Alberti, Angelica Maria Almeyda Zambrano, Esteban Alvarez-Davila, Alejandro Araujo-Murakami, Valerio Avitabile, Gerardo A. Aymard, Radomir Balazy, Chris Baraloto, Jorcely G. Barroso, Meredith L. Bastian, Philippe Birnbaum, Robert Bitariho
Faculty Publications
One of the most fundamental questions in ecology is how many species inhabit the Earth. However, due to massive logistical and financial challenges and taxonomic difficulties connected to the species concept definition, the global numbers of species, including those of important and well-studied life forms such as trees, still remain largely unknown. Here, based on global ground-sourced data, we estimate the total tree species richness at global, continental, and biome levels. Our results indicate that there are ∼73,000 tree species globally, among which ∼9,000 tree species are yet to be discovered. Roughly 40% of undiscovered tree species are in South …
Inhibition Of Biotin Carboxylase By Three Antibacterial Compounds, Matt Craft
Inhibition Of Biotin Carboxylase By Three Antibacterial Compounds, Matt Craft
LSU Doctoral Dissertations
The rise of antibacterial resistant bacteria is a major problem in the United States of America and around the world. Millions of patients are infected with antimicrobial resistant bacteria each year. Novel antibacterial agents are needed to combat the growing and present crisis. Acetyl-CoA carboxylase (ACC), the multi-subunit complex which catalyses the first committed step in fatty acid synthesis, is a validated target for antibacterial agents. However, there are at present, no commercially available antibiotics that target ACC. Ethyl 4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulfonylamino]benzoate (SABA1) is a compound that has been shown to have antibacterial properties against Pseudomonas aeruginosa and Escherichia coli. SABA1 inhibits …
Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing
Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing
Faculty Publications
New lithium electrolytes compatible with high energy density cells are critical for lithium metal battery applications, but dendrite formation associated with the use of dilute organic electrolytes complicates their realization. High-concentration electrolytes mitigate some of the issues of the electrolytes but introduce additional problems, such as low conductivity and high cost. Hence, pseudo-concentrated electrolytes, wherein a co-solvent is added to a dilute electrolyte, have been presented as a possible alternative to both dilute and concentrated electrolytes. However, the effect that the co-solvent has on the electrolyte properties at both macroscopic and microscopic levels is unknown. Here, a study of the …
Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing
Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing
Faculty Publications
New lithium electrolytes compatible with high energy density cells are critical for lithium metal battery applications, but dendrite formation associated with the use of dilute organic electrolytes complicates their realization. High-concentration electrolytes mitigate some of the issues of the electrolytes but introduce additional problems, such as low conductivity and high cost. Hence, pseudo-concentrated electrolytes, wherein a co-solvent is added to a dilute electrolyte, have been presented as a possible alternative to both dilute and concentrated electrolytes. However, the effect that the co-solvent has on the electrolyte properties at both macroscopic and microscopic levels is unknown. Here, a study of the …
Mass Removal Efficiencies In Water And Consequences After A River Diversion Into Coastal Wetlands: Second Thoughts, R. Eugene Turner, Erik M. Swenson, James M. Lee, Charles S. Milan
Mass Removal Efficiencies In Water And Consequences After A River Diversion Into Coastal Wetlands: Second Thoughts, R. Eugene Turner, Erik M. Swenson, James M. Lee, Charles S. Milan
Faculty Publications
Salinity control, nutrient additions, and sediment supply were directly or indirectly the rationale for a $220 million coastal wetland restoration project (Davis Pond River Diversion) that began in 2002. We sampled Mississippi River water going in and out of the receiving basin from 1999 to 2018 to understand why wetland loss increased after it began. There was a reduction in inorganic sediments, nitrogen (N), and phosphorus (P) concentrations within the ponding area of 77%, 39% and 34%, respectively, which is similar to that in other wetlands. But the average sediment accumulation of 0.6 mm year(-1) inadequately balances the present-day 5.6 …
A Bayesian Phase I/Ii Biomarker-Based Design For Identifying Subgroup-Specific Optimal Dose For Immunotherapy, Beibei Guo, Yong Zang
A Bayesian Phase I/Ii Biomarker-Based Design For Identifying Subgroup-Specific Optimal Dose For Immunotherapy, Beibei Guo, Yong Zang
Faculty Publications
Immunotherapy is an innovative treatment that enlists the patient's immune system to battle tumors. The optimal dose for treating patients with an immunotherapeutic agent may differ according to their biomarker status. In this article, we propose a biomarker-based phase I/II dose-finding design for identifying subgroup-specific optimal dose for immunotherapy (BSOI) that jointly models the immune response, toxicity, and efficacy outcomes. We propose parsimonious yet flexible models to borrow information across different types of outcomes and subgroups. We quantify the desirability of the dose using a utility function and adopt a two-stage dose-finding algorithm to find the optimal dose for each …
Singing Strategies Are Linked To Perch Use On Foraging Territories In Heart-Nosed Bats, Grace C. Smarsh, Ashley M. Long, Michael Smotherman
Singing Strategies Are Linked To Perch Use On Foraging Territories In Heart-Nosed Bats, Grace C. Smarsh, Ashley M. Long, Michael Smotherman
Faculty Publications
Acoustic communication allows animals to coordinate and optimize resource utilization in space. Cardioderma cor, the heart-nosed bat, is one of the few species of bats known to sing during nighttime foraging. Previous research found that heart-nosed bats react aggressively to song playback, supporting the territorial defense hypothesis of singing in this species. We further investigated the territorial defense hypothesis from an ecological standpoint, which predicts that singing should be associated with exclusive areas containing a resource, by tracking 14 individuals nightly during the dry seasons in Tanzania. We quantified the singing behavior of individuals at all perches used throughout the …
Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc
Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc
Faculty Publications
We provide a new global strict Lyapunov function construction for a susceptible, infected, and recovered (or SIR) disease dynamics that includes quarantine of infected individuals and mass vaccination. We use the Lyapunov function to design feedback controls to asymptotically stabilize a desired endemic equilibrium, and to prove input-to-state stability for the dynamics with a suitable restriction on the disturbances. Our simulations illustrate the potential of our feedback controls to reduce peak levels of infected individuals.
Predator-Pest Dynamics Of Arthropods Residing In Louisiana Soybean Agroecosystems, Scott T. Lee, Chaoyang Li, Jeffrey A. Davis
Predator-Pest Dynamics Of Arthropods Residing In Louisiana Soybean Agroecosystems, Scott T. Lee, Chaoyang Li, Jeffrey A. Davis
Faculty Publications
Over the past two decades, management practices within Louisiana soybean production have shifted. Successful application of an integrated pest management (IPM) strategy requires an understanding of how these changes have affected predator-pest dynamics. Surveys monitoring foliage-foraging arthropod populations in soybean took place across six locations within Louisiana over six years (2012–2014 and 2015–2018). Temporal associations of pest groups, defoliating and piercing-sucking, and predator groups relating to soybean phenology were observed. Additionally, soybean maturity groups (III, IV, and V) were also evaluated to delineate potential differences. Results indicated higher abundances of piercing-sucking pests compared to defoliating pests across both datasets (2012–2014 …
The Body: Undergraduate Lecture Recital, Cara Ramos
The Body: Undergraduate Lecture Recital, Cara Ramos
Honors Capstones
No abstract provided.
Docking And Molecular Dynamic Of Microalgae Compounds As Potential Inhibitors Of Beta-Lactamase, Roberto Pestana-Nobles, Yani Aranguren-Diaz, Elwi Machado-Sierra, Juvenal Yosa, Nataly J. Galan-Freyle,, Laura X. Sepulveda-Montano, Daniel G. Kuroda, Leonardo C. Pacheco-Londono
Docking And Molecular Dynamic Of Microalgae Compounds As Potential Inhibitors Of Beta-Lactamase, Roberto Pestana-Nobles, Yani Aranguren-Diaz, Elwi Machado-Sierra, Juvenal Yosa, Nataly J. Galan-Freyle,, Laura X. Sepulveda-Montano, Daniel G. Kuroda, Leonardo C. Pacheco-Londono
Faculty Publications
Bacterial resistance is responsible for a wide variety of health problems, both in children and adults. The persistence of symptoms and infections are mainly treated with beta-lactam antibiotics. The increasing resistance to those antibiotics by bacterial pathogens generated the emergence of extended-spectrum beta-lactamases (ESBLs), an actual public health problem. This is due to rapid mutations of bacteria when exposed to antibiotics. In this case, beta-lactamases are enzymes used by bacteria to hydrolyze the beta-lactam rings present in the antibiotics. Therefore, it was necessary to explore novel molecules as potential beta-lactamases inhibitors to find antibacterial compounds against infection caused by ESBLs. …
Whole-Genome Sequencing And Rna-Seq Reveal Differences In Genetic Mechanism For Flowering Response Between Weedy Rice And Cultivated Rice, Richard S. Garcia, Sapphire Coronejo, Jonathan Concepcion, Prasanta K. Subudhi
Whole-Genome Sequencing And Rna-Seq Reveal Differences In Genetic Mechanism For Flowering Response Between Weedy Rice And Cultivated Rice, Richard S. Garcia, Sapphire Coronejo, Jonathan Concepcion, Prasanta K. Subudhi
Faculty Publications
Flowering is a key agronomic trait that influences adaptation and productivity. Previous studies have indicated the genetic complexity associated with the flowering response in a photoinsensitive weedy rice accession PSRR-1 despite the presence of a photosensitive allele of a key flowering gene Hd1. In this study, we used whole-genome and RNA sequencing data from both cultivated and weedy rice to add further insights. The de novo assembly of unaligned sequences predicted 225 genes, in which 45 were specific to PSRR-1, including two genes associated with flowering. Comparison of the variants in PSRR-1 with the 3K rice genome (RG) dataset identified …
Editorial: Proceedings Of The 21st Biennial Southern Silvicultural Research Conference, John L. Willis, Thomas J. Dean
Editorial: Proceedings Of The 21st Biennial Southern Silvicultural Research Conference, John L. Willis, Thomas J. Dean
Faculty Publications
No abstract provided.
Exercise Reduces The Protein Abundance Of Txnip And Its Interacting Partner Redd1 In Skeletal Muscle: Potential Role For A Pka-Mediated Mechanism, Alec B. Chaves, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Kelly N.Z. Fuller, Blaise Stearns, Andrew Ludlow, David L. Williamson, Joseph A. Houmard, Jacob M. Haus
Exercise Reduces The Protein Abundance Of Txnip And Its Interacting Partner Redd1 In Skeletal Muscle: Potential Role For A Pka-Mediated Mechanism, Alec B. Chaves, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Kelly N.Z. Fuller, Blaise Stearns, Andrew Ludlow, David L. Williamson, Joseph A. Houmard, Jacob M. Haus
Division of Basic Science Faculty Publications
Thioredoxin-interacting protein (TXNIP) negatively effects the redox state and growth signaling via its interactions with thioredoxin (TRX) and regulated in development and DNA damage response 1 (REDD1), respectively. TXNIP expression is downregulated by pathways activated during aerobic exercise (AE), via posttranslational modifications (PTMs; serine phosphorylation and ubiquitination). The purpose of this investigation was to determine the effects of acute AE on TXNIP expression, posttranslational modifications, and its interacting partners, REDD1 and TRX. Fifteen healthy adults performed 30 min of aerobic exercise (80% V_ O2max) with muscle biopsies taken before, immediately following, and 3 h following the exercise bout. To explore …
Revisiting Forest Certification In Sri Lanka: The Forest Management And Export Wood-Based Manufacturing Sector Perspectives, Priyan Perera, Rajitha Lakshan Rupasinghe, Devin Weerasekera, Richard Vlosky, Rangika Bandara
Revisiting Forest Certification In Sri Lanka: The Forest Management And Export Wood-Based Manufacturing Sector Perspectives, Priyan Perera, Rajitha Lakshan Rupasinghe, Devin Weerasekera, Richard Vlosky, Rangika Bandara
Faculty Publications
There are discussions and debates surrounding forest certification in developing coun-tries. In this study, we surveyed 50 forest-based companies in Sri Lanka (43 wood-based manufacturers and 7 plantation companies) to ascertain their participation in forest certification, current and future forest certification trends, as well as their satisfaction with the performance of Forest Stewardship Council (FSC) certification in its economic, environmental, and social aspects, using an importance–performance analysis (IPA). Study results indicate that certified companies typically focus on exports and supplying raw materials for value-added exporters. The customer demand/signaling mechanism appears to be the primary driver of FSC certification in Sri …
Is Catalase An Effective Additive To Alleviate Oxidative Stress During Cryopreservation Of Zebrafish Sperm At The Repository Level?, Huiping Yang, E. Hu, Jennifer L. Matthews, Zoltan M. Varga, Terrence R. Tiersch
Is Catalase An Effective Additive To Alleviate Oxidative Stress During Cryopreservation Of Zebrafish Sperm At The Repository Level?, Huiping Yang, E. Hu, Jennifer L. Matthews, Zoltan M. Varga, Terrence R. Tiersch
Faculty Publications
The goal of this study was to investigate whether supplementation of cryoprotective medium with catalase (CAT), an antioxidation enzyme, is efficient for zebrafish sperm cryopreservation from the viewpoint of high-throughput genetic repository operations. Three cryoprotectants (10%, v/v), dimethylacetamide (DMA), dimethylformamide (DMF), and methanol were used. The objectives were to evaluate the effects of CAT on sperm motility, plasma membrane integrity, and concentration for: 1) fresh sperm at equilibration up to 60 min; 2) post-thaw sperm after cooling at 10, 20, and 40 °C/min), and 3) post-thaw fertilization and embryo survival rates. Catalase addition did not improve sperm motility, regardless of …
Misleading Or Factually Incorrect Statements In The American Journal Of Clinical Nutrition Perspectives Article By Ludwig Et Al, Adam Drewnowski, Rudolph L. Leibel, Eric Ravussin, Leanne M. Redman, Michael W. Schwartz, Randy J. Seeley, Lori M. Zeltser
Misleading Or Factually Incorrect Statements In The American Journal Of Clinical Nutrition Perspectives Article By Ludwig Et Al, Adam Drewnowski, Rudolph L. Leibel, Eric Ravussin, Leanne M. Redman, Michael W. Schwartz, Randy J. Seeley, Lori M. Zeltser
Clinical Research Faculty Publications
No abstract provided.
Effects Of Intermittent Fasting On Cardiometabolic Health: An Energy Metabolism Perspective, Manuel Dote-Montero, Guillermo Sanchez-Delgado, Eric Ravussin
Effects Of Intermittent Fasting On Cardiometabolic Health: An Energy Metabolism Perspective, Manuel Dote-Montero, Guillermo Sanchez-Delgado, Eric Ravussin
Clinical Research Faculty Publications
This review summarizes the effects of different types of intermittent fasting (IF) on human cardiometabolic health, with a focus on energy metabolism. First, we discuss the coordinated metabolic adaptations (energy expenditure, hormonal changes and macronutrient oxidation) occurring during a 72 h fast. We then discuss studies investigating the effects of IF on cardiometabolic health, energy expenditure and substrate oxidation. Finally, we discuss how IF may be optimized by combining it with exercise. In general, IF regimens improve body composition, ectopic fat, and classic cardiometabolic risk factors, as compared to unrestricted eating, especially in metabolically unhealthy participants. However, it is still …
Exercise/Physical Activity In Individuals With Type 2 Diabetes: A Consensus Statement From The American College Of Sports Medicine, Jill A. Kanaley, Sheri R. Colberg, Matthew H. Corcoran, Steven K. Malin, Nancy R. Rodriguez, Carlos J. Crespo, John P. Kirwan, Juleen R. Zierath
Exercise/Physical Activity In Individuals With Type 2 Diabetes: A Consensus Statement From The American College Of Sports Medicine, Jill A. Kanaley, Sheri R. Colberg, Matthew H. Corcoran, Steven K. Malin, Nancy R. Rodriguez, Carlos J. Crespo, John P. Kirwan, Juleen R. Zierath
Division of Basic Science Faculty Publications
This consensus statement is an update of the 2010 American College of Sports Medicine position stand on exercise and type 2 diabetes. Since then, a substantial amount of research on select topics in exercise in individuals of various ages with type 2 diabetes has been published while diabetes prevalence has continued to expand worldwide. This consensus statement provides a brief summary of the current evidence and extends and updates the prior recommendations. The document has been expanded to include physical activity, a broader, more comprehensive definition of human movement than planned exercise, and reducing sedentary time. Various types of physical …
The Precision Interventions For Severe And/Or Exacerbation-Prone (Precise) Asthma Network: An Overview Of Network Organization, Procedures, And Interventions, Steve N. Georas, Rosalind J. Wright, Anastasia Ivanova, Elliot Israel, Lisa M. Lavange, Praveen Akuthota, Tara F. Carr, Loren C. Denlinger, Merritt L. Fajt, Rajesh Kumar, Wanda K. O'Neal, Wanda Phipatanakul, Stanley J. Szefler, Mark A. Aronica, Leonard B. Bacharier, Allison J. Burbank, Mario Castro, Laura Crotty Alexander, Julie Bamdad, Juan Carlos Cardet, Suzy A.A. Comhair, Ronina A. Covar, Emily A. Dimango, Kim Erwin, Serpil C. Erzurum, John V. Fahy, Jonathan M. Gaffin, Benjamin Gaston, Lynn B. Gerald, Eric A. Hoffman, Fernando Holguin, Daniel J. Jackson, John James, Nizar N. Jarjour
The Precision Interventions For Severe And/Or Exacerbation-Prone (Precise) Asthma Network: An Overview Of Network Organization, Procedures, And Interventions, Steve N. Georas, Rosalind J. Wright, Anastasia Ivanova, Elliot Israel, Lisa M. Lavange, Praveen Akuthota, Tara F. Carr, Loren C. Denlinger, Merritt L. Fajt, Rajesh Kumar, Wanda K. O'Neal, Wanda Phipatanakul, Stanley J. Szefler, Mark A. Aronica, Leonard B. Bacharier, Allison J. Burbank, Mario Castro, Laura Crotty Alexander, Julie Bamdad, Juan Carlos Cardet, Suzy A.A. Comhair, Ronina A. Covar, Emily A. Dimango, Kim Erwin, Serpil C. Erzurum, John V. Fahy, Jonathan M. Gaffin, Benjamin Gaston, Lynn B. Gerald, Eric A. Hoffman, Fernando Holguin, Daniel J. Jackson, John James, Nizar N. Jarjour
Division of Basic Science Faculty Publications
Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate …
Biomass Slurry Fracture Injection As A Potential Low-Cost Negative Emissions Technology, Brian F. Snyder
Biomass Slurry Fracture Injection As A Potential Low-Cost Negative Emissions Technology, Brian F. Snyder
Faculty Publications
Negative emissions technologies (NETs) are systems which remove carbon dioxide directly from the atmosphere and sequester it in permanent storage and they are required to meet the goals of the Paris Agreement. However, all NETs are limited by biological, physical and economic factors. Here, we model the life cycle emissions, geospatial potential, technoeconomic feasibility of a new NET based on slurry fracture injection, a technique which has been used for decades in the oil and gas industry to dispose of wastes. In the proposed system, called biomass slurry fracture injection (BSFI), biogeneic wastes are injected into fractures created in permeable …