Digital Commons Network^™

Synthesis Of Small Molecules For The Treatment Of Infectious Diseases, Elena Bray

USF Tampa Graduate Theses and Dissertations

Drug discovery’s impact on modern healthcare cannot be measured. In the past year, the world has watched scientists all around the globe work together to help protect the public from the novel coronavirus pandemic. Although sometimes slow and costly, drug discovery is important for advancing modern society. Drug discovery is at the core of treating diseases and in particular, infectious diseases. In the first chapter an overview of drug discovery will be discussed in a brief manner.

The second chapter will introduce infectious diseases. In modern society, the development of small molecule treatments for treating bacteria, viruses, and fungi has …

The List: Proverbs For Calculus, Bruce H. Pourciau

Journal of Humanistic Mathematics

Topics chosen from first-year calculus illustrate a number of “sayings” or “proverbs,” the first three, for example, being: be awed, like a child; meaning before truth; and act with intention. Many are proverbs for life as well as mathematics.

The Power Of A Double Take: Doubling Back To Show Growth In A Pandemic, Lawrence M. Lesser

Journal of Humanistic Mathematics

The COVID-19 pandemic inspired reflections on the importance and challenges of teaching exponential growth, such as doubling, to varied audiences.

Dynamical Variations Of The Global Covid-19 Pandemic Based On A Seicr Disease Model: A New Approach Of Yi Hua Jie Mu, Xia Wang, Gang Yin, Zengyun Hu, Daihai He, Qianqian Cui, Xiaomei Feng, Zhidong Teng, Qi Hu, Jiansen Li, Qiming Zhou

Department of Earth and Atmospheric Sciences: Faculty Publications

The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused more than 150 million cases of infection to date and poses a serious threat to global public health. In this study, global COVID-19 data were used to examine the dynamical variations from the perspectives of immunity and contact of 84 countries across the five climate regions: tropical, arid, temperate, and cold. A new approach named Yi Hua Jie Mu is proposed to obtain the transmission rates based on the COVID-19 data between the countries with the same climate region over the Northern Hemisphere and Southern Hemisphere. Our results suggest that the …

Transmission Process Prediction Of Novel Coronavirus Based On System Dynamics, Xuepeng Lu, Shang Jiao, Junhui Zhao, Lulu Lü, Zhou Li

Journal of System Simulation

Abstract: The transmission characteristics of novel coronavirus is considered and a new SE4IR2 model based on the principle of system dynamics is proposed. The US epidemic data from June to November is used to set the isolation rate and other parameters, and the SE4IR2 model is used to fit, analyze and predict the development of the epidemic trend in the next stage. The empirical part uses the data from June to November in the United States to achieve the parameters of the SE4IR2 model, obtains the parameter values in December and January through the time series prediction model, and compares …

Structural And Biochemical Characterization Of The Flavin-Dependent Siderophore-Interacting Protein From Acinetobacter Baumannii, Hannah Valentino, David A. Korasick, Tabbetha J. Bohac, Justin A. Shapiro, Timothy A. Wencewicz, John J. Tanner, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Acinetobacter baumannii is an opportunistic pathogen with a high mortality rate due to multi-drug-resistant strains. The synthesis and uptake of the iron-chelating siderophores acinetobactin (Acb) and preacinetobactin (pre-Acb) have been shown to be essential for virulence. Here, we report the kinetic and structural characterization of BauF, a flavin-dependent siderophore-interacting protein (SIP) required for the reduction of Fe (III) bound to Acb/pre-Acb and release of Fe(II). Stopped-flow spectrophotometric studies of the reductive half-reaction show that BauF forms a stable neutral flavin semiquinone intermediate. Reduction with NAD(P)H is very slow (kobs, 0.001 s-1) and commensurate with the rate of reduction by photobleaching, …

Developing Pandemic Comics For Youth Audiences, Judy Diamond, Amy Spiegel, Patricia Wonch Hill, Elizabeth Vanwormer, Judi M. Gaiashkibos, Bob Hall, Aaron Sutherlen, Julia Mcquillan

University of Nebraska State Museum: Staff and Affiliates, Publications

In spring 2020 our team received funding from the Rapid Response Research program of the National Science Foundation to develop comics that would help youth understand the COVID-19 pandemic. Our project built on a decade of expertise creating comics about the biology of viruses. In collaboration with virologists and artists, we developed three comic stories about COVID-19 during the pandemic and posted them on-line during the last half of 2020. The fictional narratives address fundamental issues in biology, virology, and network science, in order to help readers understand the complexities of living through a viral pandemic. The stories focus on …

Distilling Professional Opinion To Gauge Vulnerability Of Guam Avifauna To Brown Treesnake Predation, Robert M. Mcelderry, Eben H. Paxton, Andre V. Nguyen, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

The avifauna of Guam was devastated by the introduction of the Brown Treesnake, and the restoration of native birds would need to address the problem with eradication or suppression of BTS. With eradication of the snake unlikely in the near term, and suppression capabilities limited to specific finite areas, key information for reintroductions is how low BTS abundance will likely need to be for each bird species to be re-established based on their vulnerability to BTS predation. Here, we estimate vulnerability, which can no longer be measured directly, so biologists who are familiar with one or more of seven Guam …

Mathematical Modeling, Analysis, And Simulation Of The Covid-19 Pandemic With Behavioral Patterns And Group Mixing, Comfort Ohajunwa, Padmanabhan Seshaiyer

Spora: A Journal of Biomathematics

Due to the rise of COVID-19 cases, many mathematical models have been developed to study the disease dynamics of the virus. However, despite its role in the spread of COVID-19, many SEIR models neglect to account for human behavior. In this project, we develop a novel mathematical modeling framework for studying the impact of mixing patterns and social behavior on the spread of COVID-19. Specifically, we consider two groups, one exhibiting normal behavior who do not reduce their contacts and another exhibiting altered behavior who reduce their contacts by practicing non-pharmaceutical interventions such as social distancing and self-isolation. The dynamics …

Mapping Heat Vulnerability Index Based On Different Urbanization Levels In Nebraska, Usa, Babak J. Fard, Rezaul Mahmood, Michael Hayes, Clinton M. Rowe, Azar M Abadi, Martha Shulski, Sharon Medcalf, Rachel Lookadoo, Jesse E. Bell

School of Natural Resources: Faculty Publications

Despite similar incidence rates, Heat Vulnerability Index (HVI) in rural areas is under- studied in comparison to urban areas. • The environmental vulnerability variables in rural areas are dissimilar to urban areas, so we applied different variables to calculate them. • We found different organization of socioeconomic variables in calculated HVIs, suggesting separate heat strategies for urbanization levels.

Heatwaves cause excess mortality and physiological impacts on humans throughout the world, and climate change will intensify and increase the frequency of heat events. Many adaptation and mitigation studies use spatial distribution of highly vulnerable local populations to inform heat reduction and …

Experiences And Coping Strategies During The Covid-19 Pandemic Among Fishers And Farmers In The Island Province Of Guimaras, Philippines, Gay Margarett A. Gange, Louie Marie T. Eluriaga, Alice Joan G. Ferrer

Journal of Economics, Management and Agricultural Development

This study describes the experiences and coping strategies related with the COVID-19 threat and the community quarantine policy by the fishers and farmers in the island province of Guimaras. Both food producers faced marketrelated problems such as low demand, low prices of catch and produce, and logistical problems. While the in-kind support (e.g., food provisions) received and adaptive measures (e.g., continued with fishing or adjusted harvest schedule; use of social media or delivery services in marketing) allowed them to get by during the pandemic, there is a need to develop more resilient farming and fishing households. Short-term support can be …

Archipelago On Lockdown: An Assessment Of The Effects Of The Covid-19 Pandemic On Philippines’ Micro, Small, And Medium Enterprises (Msmes) Across The Food Value Chain, Remund Jordan D. Labios, Dinah Pura T. Depositario, Nohreen Ethel P. Manipol, Renen Szillardo C. De Guzman, Dia Noelle F. Velasco

Journal of Economics, Management and Agricultural Development

The paper examined the effects of COVID-19 pandemic on the Philippines’ MSMEs across the food value chain and the strategies that food-based MSMEs employed to cope with disruptions. A food value chain framework was used to
analyze the food-based MSMEs, focusing on the input and service provision, production/farming, processing, transport and storage, retailing, and consumption. Results revealed the following: (1) different quarantine protocols across provincial and local boundaries contributed to the complexity of transporting inputs and products; (2) limited mobility of manpower contributed to the challenges of continuing business operations; (3) there was an observed increase in new financing programs …

Range-Wide Declines Of Northern Spotted Owl Populations In The Pacific Northwest: A Meta-Analysis, Alan B. Franklin, Katie M. Dugger, Damon B. Lesmeister, Raymond J. Davis, J. David Wiens, Gary C. White, James D. Nichols, James E. Hines, Charles B. Yackulic, Carl J. Schwarz, Steven H. Ackers, L. Steven Andrews, Larissa L. Bailey, Robin Bown, Jesse Burgher, Kenneth P. Burnham, Peter C. Carlson, Tara Chestnut, Mary M. Conner, Krista E. Dilione, Eric D. Forsman, Elizabeth M. Glenn, Scott A. Gremel, Keith A. Hamm, Dale R. Herter, J. Mark Higley, Rob B. Horn, Julianna M. Jenkins, William L. Kendall, David W. Lamphear, Christopher Mccafferty, Trent L. Mcdonald, Janice A. Reid, Jeremy T. Rockweit, David C. Simon, Stan G. Sovern, James K. Swingle, Heather Wise

United States Department of Agriculture Wildlife Services: Staff Publications

The northern spotted owl (Strix occidentalis caurina) inhabits older coniferous forests in the Pacific Northwest and has been at the center of forest management issues in this region. The immediate threats to this federally listed species include habitat loss and competition with barred owls (Strix varia), which invaded from eastern North America. We conducted a prospective meta-analysis to assess population trends and factors affecting those trends in northern spotted owls using 26 years of survey and capture-recapture data from 11 study areas across the owls' geographic range to analyze demographic traits, rates of population change, and occupancy parameters for spotted …

Determination Of Freedom-From-Rabies For Small Indian Mongoose Populations In The United States Virgin Islands, 2019–2020, A. Springer Browne, Hannah M. Cranford, Clint N. Morgan, James A. Ellison, Are Berentsen, Nicholas Wiese, Alexandra Medley, John Rossow, Leanne Jankelunas, Alan S. Mckinley, Claudia D. Lombard, Nicole F. Angeli, Thomas Kelley, Jennifer Valiulus, Bethany Bradford, Valicia J. Burke-France, Cosme J. Harrison, Irene Guendel, Marissa Taylor, Gerard L. Blanchard, Jeffrey B. Doty, David J. Worthington, David Horner, Keith R. Garcia, Joseph Roth, Brett R. Ellis, Kristine M. Bisgard, Ryan Wallace, Esther M. Ellis

United States Department of Agriculture Wildlife Services: Staff Publications

Mongooses, a nonnative species, are a known reservoir of rabies virus in the Caribbean region. A cross-sectional study of mongooses at 41 field sites on the US Virgin Islands of St. Croix, St. John, and St. Thomas captured 312 mongooses (32% capture rate). We determined the absence of rabies virus by antigen testing and rabies virus exposure by antibody testing in mongoose populations on all three islands. USVI is the first Caribbean state to determine freedom-from-rabies for its mongoose populations with a scientifically-led robust cross-sectional study. Ongoing surveillance activities will determine if other domestic and wildlife populations in USVI are …

Testing A Bite-Shortened Hook To Minimize Fish Handling In A Recreational Fishery, Holden E. Harris, Brian K. Whalen, Andrew G. Gude, Michael S. Allen

United States Department of Agriculture Wildlife Services: Staff Publications

Discard mortality can make fishing unsustainable, even in catch-and-release or highly regulated fisheries. However, fishing practices and gears that minimize hook injury, handling, and air exposure can considerably improve fitness and survival in released fish. This study tested whether modified hooks could allow anglers to successfully land and then release fish in the water and without handling. Standard, barbless, and bite-shortened hooks were used to catch Spotted Seatrout Cynoscion nebulosus (n > 75 per hook type), and logistic models were used to assess the differences in landing success and hook self-release success by hook type and categorical fish size. Average landing …

Landscape Of Stress: Tree Mortality Influences Physiological Stress And Survival In A Native Mesocarnivore, Jennifer R. Kordosky, Eric M. Gese, Craig M. Thompson, Patricia A. Terletzky, Lorin A. Neuman-Lee, Jon D. Schneiderman, Kathryn L. Purcell, Susannah S. French

United States Department of Agriculture Wildlife Services: Staff Publications

Climate change and anthropogenic modifications to the landscape can have both positive and negative effects on an animal. Linking landscape change to physiological stress and fitness of an animal is a fundamental tenet to be examined in applied ecology. Cortisol is a glucocorticoid hormone that can be used to indicate an animal’s physiological stress response. In the Sierra Nevada Mountains of California, fishers (Pekania pennanti) are a threatened mesocarnivore that have been subjected to rapid landscape changes due to anthropogenic modifications and tree mortality related to a 4-year drought. We measured cortisol concentrations in the hair of 64 …

Risks Of Introduction And Economic Consequences Associated With African Swine Fever, Classical Swine Fever And Foot-And-Mouth Disease: A Review Of The Literature, Vienna Brown, Ryan S. Miller, Sophie C. Mckee, Karina H. Ernst, Nicole M. Didero, Rachel M. Maison, Meredith J. Grady, Stephanie A. Shwiff

United States Department of Agriculture Wildlife Services: Staff Publications

African swine fever (ASF), classical swine fever (CSF) and foot-and-mouth disease (FMD) are considered to be three of the most detrimental animal diseases and are currently foreign to the U.S. Emerging and re-emerging pathogens can have tremendous impacts in terms of livestock morbidity and mortality events, production losses, forced trade restrictions, and costs associated with treatment and control. The United States is the world's top producer of beef for domestic and export use and the world's third-largest producer and consumer of pork and pork products; it has also recently been either the world's largest or second largest exporter of pork …

Economic Losses Of Catfish To Avian Predation: A Case Report, Ganesh Kumar, Shraddha Hegde, David Wise, Charles Mischke, Brian Dorr

United States Department of Agriculture Wildlife Services: Staff Publications

Avian predation in catfish aquaculture has been a persistent issue throughout the history of the industry, and as production has expanded predation from piscivorous birds has intensified. Catfish ponds in the Mississippi River delta (in the Mississippi migratory flyway) provide a constant and readily accessible supply of forage for birds. Intensive foraging by fish-eating birds has led to a specific regulatory policy and numerous on-farm and regional management efforts. However, in 2016, legal challenges lead to recision of some federal policies and uncertainty as to allowable management, resulting in limitations on bird depredation. Estimating the extent of fish losses to …

Regression Methods For Group Testing Data, Michael Stutz

Theses and Dissertations

Group testing is an efficient method of disease screening, whereby individual specimens (e.g., blood, urine, etc.) are pooled together and tested as a whole for the presence of disease. A common goal is to use data arising from these testing protocols to better understand the relationship between disease status and potential risk factors (e.g., age, symptom status, etc.). Numerous statistical methodologies have been developed for this purpose, most of which are built within the framework of a generalized linear model. Recent authors have suggested the inadequacy of such regression methods to capture the true functional relationships when nonlinear effects are …

Microfluidic Paper-Based Analytical Device (Μpad) For Determining Hydroquinone In Facial Whitening Cream Using Phloroglucinol Reagent, Hermin Sulistyarti, Paradhita Ayu Puspitaloka, Boyfannie Ivan Putra, Rurini Retnowati, Herman Tolle

Makara Journal of Science

A microfluidic paper-based analytical device (µPAD) is developed in this work to analyze hydroquinone in facial whitening creams using phloroglucinol. The µPAD features a hydrophobic barrier for detection and was fabricated using a wax printer with Whatman chromatographic paper. Detection was achieved by colorimetry based on the formation of an orange hydroquinone–phloroglucinol complex. The colored reaction product formed on the detection zone of the µPAD was scanned, and the images obtained were processed with Image-J software to determine their color intensity (RGB value). Optimization of the process conditions was conducted to achieve sensitive measurements. The optimum conditions yielding maximum sensitivity …

Weather And Crime: New York State, Yuna Kim

Student Theses

The present study assesses the degree to which temperature affects the crime rates in all 62 counties in the State of New York. Five different crimes (i.e., robbery, aggravated assault, burglary; larceny, and motor vehicle theft) for the year 2019 were selected from the Division of Criminal Justice Services of New York to be examined. The current study examined whether the rate of these crimes was associated with the changes in weather, with the assumption that higher weathers would lead to higher property and violent crimes, when controlling for the effect of various control variables. The findings suggest that the …

Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease And Implications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz

Department of Paediatrics and Child Health

Background/aim: Since the outbreak of the COVID-19, numerous therapies to counteract this severe disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 patients and the methodologies of ongoing clinical trials are explored.
Materials and methods: A systematic search adhering to PRISMA guidelines was conducted in PubMed, Cochrane Central, medRxiv, and bioRxiv using the following keywords: “Tocilizumab,” “Actemra,” “COVID-19.” An additional subsearch was conducted on Clinicaltrials.gov to locate ongoing tocilizumab trials.
Results: A total of 13 studies were included in the meta-analysis comprising 2120 patients. The treatment group had lower mortality compared to the control group (OR = 0.42, …

Covid-19: A One Health Issue, Karen Gruszynski

Cumberland Mountain Naturalist

COVID-19 has very rapidly become part of modern societal lexicon as the disease highlights the importance understanding zoonotic diseases and the impact they can have on human life. With a 177million human cases and 3.82million deaths globally at the time of this publication, the "One Health" nature of the disease has had a lasting impact across the planet. As the disease spread rapidly, it highlighted the dissemination of information through social media and other sources. With this in mind, Dr. Gary Vroegindewey, Director for One Health at LMU-CVM, put forth the idea to have students collect and summarize information about …

Editorial Board

Karbala International Journal of Modern Science

No abstract provided.

Adapting An Agent-Based Model Of Infectious Disease Spread In An Irish County To Covid-19, Elizabeth Hunter, John D. Kelleher

Articles

The dynamics that lead to the spread of an infectious disease through a population can be characterized as a complex system. One way to model such a system, in order to improve preparedness, and learn more about how an infectious disease, such as COVID-19, might spread through a population, is agent-based epidemiological modelling. When a pandemic is caused by an emerging disease, it takes time to develop a completely new model that captures the complexity of the system. In this paper, we discuss adapting an existing agent-based model for the spread of measles in Ireland to simulate the spread of …

Contemporary Challenges And Opportunities For The Management Of Bird Damage At Field Crop Establishment, Christophe Sausse, Alice Baux, Michel Bertrand, Elsa Bonnaud, Sonia Canavelli, Alexandra Destrez, Page E. Klug, Lourdes Olivera, Ethel Rodriguez, Guilllermo Tellechea, Sebastian Zuil

United States Department of Agriculture Wildlife Services: Staff Publications

Bird damage, from sowing to crop establishment, is an important issue for farmers in many parts of the world. However, reliable and cost-effective solutions remain elusive because management tools and research on the subject are limited. The spatial variability of damage across landscapes and the adaptative behaviour of birds create further challenges. Additionally, the issue must be tackled at the landscape scale and involve a variety of stakeholders with conflicting interests and objectives. We summarize some of the challenges and opportunities identified to face these difficulties and address four major research directions for operational solutions including 1) crop damage assessment, …

Total Synthesis And Antimalarial Activity Of 2-(-Hydroxybenzyl)-Prodigiosins, Isoheptylprodigiosin, And Geometric Isomers Of Tambjamine Myp1 Isolated From Marine Bacteria., Papireddy Kancharla, Yuexin Li, Monish Yeluguri, Rozalia A. Dodean, Kevin A. Reynolds, Jane X. Kelly

Chemistry Faculty Publications and Presentations

Highly efficient and straightforward synthetic routes toward the first total synthesis of 2-(-hydroxybenzyl)-prodigiosins (-), isoheptylprodigiosin (), and geometric isomers of tambjamine MYP1 ((/)-) have been developed. The crucial steps involved in these synthetic routes are the construction of methoxy-bipyrrole-carboxaldehydes (MBCs) and a 20-membered macrocyclic core and a regioselective demethylation of MBC analogues. These new synthetic routes enabled us to generate several natural prodiginines - in larger quantity. All of the synthesized natural products exhibited potent asexual blood-stage antiplasmodial activity at low nanomolar concentrations against a panel of parasites, with a great therapeutic index. Notably, prodiginines and - provided curative in …

Integrated Research To Reduce Poisoning From Oxytropis And Astragalus Spp In U.S.A., Michael H. Ralphs, B. L. Stegelmeier, K. E. Panter, Dale R. Gardner, J. A. Pfister, S. E. Lee, L. F. James, K. C. Mcdaniel, Rebecca Creamer, J. R. Valdez, D. R. Child

IGC Proceedings (1977-2023)

No abstract provided.

The Discrete-Event Modeling Of Administrative Claims (Demac) System: Dynamically Modeling The U.S. Healthcare Delivery System With Medicare Claims Data To Improve End-Of-Life Care, Rachael Chacko

Dartmouth College Undergraduate Theses

The shift of the U.S. healthcare delivery system from the treatment of acute conditions to chronic diseases requires a new method of healthcare system analysis to properly assess end- of-life (EOL) quality throughout the country. In this paper, we propose the Discrete-Event Modeling of Administrative Claims (DEMAC) system, which relies on a hetero-functional graph theory and discrete event-driven framework to dynamically model EOL care on multiple levels. The heat map visualizations produced by the DEMAC system enable the elucidation of not only patient-specific EOL care but also broader treatment patterns among providers and hospitals. As a whole, the DEMAC system …

Global Stability Of Generalized Within-Host Chikungunya Virus Dynamics Models, Taofeek O. Alade, Afeez Abidemi, Cemil Tunç, Shafeek A. Ghaleb

Applications and Applied Mathematics: An International Journal (AAM)

This paper proposes two models of a general nonlinear within-host Chikungunya virus (CHIKV) dynamics. The production, incidence, proliferation and removal rates of all compartments are modeled by general nonlinear functions that satisfy a set of reasonable conditions. The second model takes into consideration two forms of infected host cells: (i) latently infected cells which do not produce the CHIKV, (ii) actively infected cells which generate the CHIKV particles. We show that all the solutions of the models are nonnegative and bounded. The global stability of the steady states of the models is proven by applying Lyapunov method and LaSalle’s invariance …