Digital Commons Network^™

Numerical Technique For Solving Fractional-Order Of Ivgtt Glucose-Insulin Interaction, M. A. Abdelkawy

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we use a numerical technique to solve fractional nonlinear differential equations systems that arise in Bergman’s minimal model that describe blood glucose and insulin metabolism, after intravenous tolerance testing. Shifted Jacobi -Gauss-Radau collocation (SJ-GR-C) method is developed for approximating the proposed model. The principal target in our technique is to transform the proposed model to a system of algebraic equations. Finally, numerical simulation is introduced to illustrate the analytical results.

Modeling The Spread Of Covid-19 Over Varied Contact Networks, Ryan L. Solorzano

Master's Theses

When attempting to mitigate the spread of an epidemic without the use of a vaccine, many measures may be made to dampen the spread of the disease such as physically distancing and wearing masks. The implementation of an effective test and quarantine strategy on a population has the potential to make a large impact on the spread of the disease as well. Testing and quarantining strategies become difficult when a portion of the population are asymptomatic spreaders of the disease. Additionally, a study has shown that randomly testing a portion of a population for asymptomatic individuals makes a small impact …

Herc5 And The Isgylation Pathway: Critical Modulators Of The Antiviral Immune Response, Nicholas A. Mathieu, Ermela Paparisto, Stephen D. Barr, Donald E. Spratt

Chemistry

Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa tandem ubiquitin-like protein (UBL) that is used by specific E1–E2–E3 ubiquitin cascade enzymes to interfere with the activity of viral proteins. Recent biochemical studies have demonstrated how the E3 ligase HECT and RCC1-containing protein 5 (HERC5) regulates ISG15 signaling in response to hepatitis C (HCV), influenza-A (IAV), human immunodeficiency virus (HIV), SARS-CoV-2 and other viral infections. Taken together, the potent antiviral activity displayed by HERC5 and ISG15 make them promising drug targets for the development …

Modeling Covid-19 Spread Using An Agent-Based Network, Stephen Yh Hung

Master's Theses

Beginning in 2019 and quickly spreading internationally, the Coronavirus disease Covid-19 became the first pandemic that many people have witnessed firsthand along with the severe disruption to their daily lives. A key field of research for Covid-19 that is studied by epidemiologists, biologists, and computer scientists alike is modeling the spread of Covid-19 in order to better predict future outbreaks of the pandemic and evaluate potential strategies to reduce infections, hospitalizations, and deaths.

This thesis proposes a method of modeling Covid-19 spread and interventions for local environments based on different levels of perspective. The goal for this thesis is to …

Evolutionary Generation Of Diversity In Embedded Binary Executables For Cyber Resiliency, Mitchell D. I. Hirschfeld

Theses and Dissertations

Hardening avionics systems against cyber attack is difficult and expensive. Attackers benefit from a "break one, break all" advantage due to the dominant mono-culture of automated systems. Also, undecidability of behavioral equivalence for arbitrary algorithms prevents the provable absence of undesired behaviors within the original specification. This research presents results of computational experiments using bio-inspired genetic programming to generate diverse implementations of executable software and thereby disrupt the mono-culture. Diversity is measured using the SSDeep context triggered piecewise hashing algorithm. Experiments are divided into two phases. Phase I explores the use of semantically-equivalent alterations that retain the specified behavior of …

Comparing Management Programs To Reduce Red–Tailed Hawk Collisions With Aircraft, Brian Washburn, Craig K. Pullins, Travis L. Guerrant, Gregory J. Martinelli, Scott F. Beckerman

United States Department of Agriculture Wildlife Services: Staff Publications

Wildlife-aircraft collisions (wildlife strikes) pose a serious safety risk to aircraft. Raptors (i.e., hawks and owls) are one of the most frequently struck guilds of birds within North America. Although raptors (most notably red-tailed hawks [Buteo jamaicensis]) are commonly managed at most airports and military bases, there is no scientific information available regarding comparisons of the efficacy of raptor management programs for reducing raptor-aircraft collisions. Therefore, we conducted a study to examine the efficacy of 2 raptor hazard management programs implemented at Chicago's O'Hare International Airport (ORD). The first raptor management program (Phase I) occurred during January 2010–June 2013 and …

Alfaxalone Successfully Immobilizes Small Indian Mongooses (Urva Auropunctata): A Field Report, Caroline C. Sauvé, Yves Rondenay, Are R. Berentsen, Mel J. Rivera-Rodriguez, Patrick A. Leighton

United States Department of Agriculture Wildlife Services: Staff Publications

We investigated intramuscular administration of alfaxalone (5.3–10.0 mg/kg) as an immobilizing agent in free-ranging small Indian mongooses (Urva auropunctata) on the island of St. Kitts, West Indies. From 5–11 January 2020, we successfully immobilized 10 of 11 mongooses. Alfaxalone provided rapid onset (median = 3 min) of immobilization. Mean duration of immobilization was 16.8 ± 3 min. Mean recovery time was 5.6 ± 1 min. There was no effect of dose administered on induction, anesthesia, or recovery times at the dose range used. We concluded that alfaxalone represents an effective alternative to dissociative agents for the immobilization of free-ranging mongooses. …

Strategic Testing Approaches For Targeted Disease Monitoring Can Be Used To Inform Pandemic Decision-Making, James D. Nichols, Tiffany L. Bogich, Emily Howerton, Ottar N. Bjørnstad, Rebecca K. Borchering, Matthew Ferrari, Murali Haran, Christopher Jewell, Kim M. Pepin, William J.M. Probert, Juliet R.C. Pulliam, Michael C. Runge, Michael Tildesley, Cecile Viboud, Katriona Shea

United States Department of Agriculture Wildlife Services: Staff Publications

More than 1.6 million Servere Acute Respiratory Syndrome Cronovirus 2(SARS-COV-2)tests were administered daily in the United States at the peak of the epidemic, with a significant focus on individual treatment. Here, we show that objective-driven, strategic sampling designs and analyses can maximize information gain at the population level, which is necessary to increase situational awareness and predict, prepare for, and respond to a pandemic, while also continuing to inform individual treatment. By focusing on specific objectives such as individual treatment or disease prediction and control (e.g., via the collection of population- level statistics to inform lockdown measures or vaccine rollout) …

An Evaluation Of Body-Grip Trap Trigger Configurations For Reducing River Otter Take Incidental To Beaver Trapping, Alec J. Sundelius, Nicholas Forman, Nathan M. Roberts, Shawn T. Rossler, David B. Ruid, Robert C. Willging

United States Department of Agriculture Wildlife Services: Staff Publications

River otter (Lontra canadensis) populations in North America have been the focus of significant restoration efforts. Wildlife management agencies, concerned about the unintentional take of river otters incidental to beaver (Castor canadensis) trapping, may recommend techniques to avoid capturing river otters. River otter avoidance techniques that are ineffective or diminish trap performance for beavers are undesirable. We conducted a field evaluation in 2015 and 2016 in Wisconsin to assess how two trigger configurations (offset and center) on body-grip traps would affect the incidental capture rate of river otters during beaver trapping. We also evaluated effects of …

The Impact Of Climate Change On Virginia's Coastal Areas, Jonathan L. Goodall, Antonio Elias, Elizabeth Andrews, Christopher "Kit" Chope, John Cosgrove, Jason El Koubi, Jennifer Irish, Lewis L. Lawrence Iii, Robert W. Lazaro Jr., William H. Leighty, Mark W. Luckenbach, Elise Miller-Hooks, Ann C. Phillips, Henry Pollard V, Emily Steinhilber, Charles Feigenoff, Jennifer Sayegh

Faculty Publications

As part of HJ47/SJ47 (2020), the Virginia General Assembly directed the Joint Commission on Technology and Science (JCOTS) to study the “safety, quality of life, and economic consequences of weather and climate-related events on coastal areas in Virginia.” In pursuit of this goal, the commission was to “accept any scientific and technical assistance provided by the nonpartisan, volunteer Virginia Academy of Science, Engineering, and Medicine (VASEM). VASEM convened an expert study board with representation from the Office of the Governor, planning district commissions in coastal Virginia, The Port of Virginia, the Virginia Economic Development Partnership, state universities, private industry, and …

Needles In A Haystack: How Pooling Can Control Error Rates In Noisy Tests, Arockia David Roy Kulandai, J. Stella, John Rose, Thomas Schwarz

Computer Science Faculty Research and Publications

Testing many individuals for a reasonably rare condition using imperfect, time consuming, and expensive tests can be facilitated by pooling. Pooling groups samples from different individuals that are then tested for the existence of a pathogen. An individual is diagnosed as a carrier if a threshold of the tests to which the individual contributed samples is positive. Our assumptions dictate a testing strategy that is not adaptive, with the exception of retesting positively diagnosed persons individually. Pooling is a standard proposal to stretch the supply of test kits. We show that it can also be used to control the false …

Methods For Extending Biomedical Reference Ontologies And Interface Terminologies For Ehrr Text Annotation, Vipina Kuttichi Keloth

Dissertations

Biomedical ontologies and terminologies are a cornerstone in various electronic health record systems (EHRs) for encoding information related to diseases, diagnoses, treatments, etc. Ontologies in general represent entities (concepts) and events along with all interdependent properties and relationships in an efficient way to facilitate easy access, retrieval and sharing. With the landscape of medicine rapidly changing, biomedical ontologies and terminologies need to rapidly evolve to support interoperability, medical coding, record keeping, and healthcare activities in general, and to facilitate interdisciplinary research. Extending ontologies by identifying new and missing concepts plays a vital role in the maintenance of ontologies to keep …

Brown Treesnake Mortality After Aerial Application Of Toxic Baits, Scott M. Goetz, Eric T. Hileman, Melia G. Nafus, Amy A. Yackel Adams, Amanda R. Bryant, Robert N. Reed, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

Quantitative evaluation of control tools for managing invasive species is necessary to assess overall effectiveness and individual variation in treatment susceptibility. Invasive brown treesnakes (Boiga irregularis) on Guam have caused severe ecological and economic effects, pose a risk of accidental introduction to other islands, and are the greatest impediment to the reestablishment of extirpated native fauna. An aerial delivery system for rodent‐based toxic baits can reduce brown treesnake abundance and heterogeneity among individuals may influence bait attraction or toxicant susceptibility. Previous baiting trials have either been simulated aerial treatments or relied on slightly different bait capsule compositions and the results …

Attitudes Concerning Sexual Behavior Towards Risky Sexual Behavior Of Sexual Transmitted Infections Among Male Adolescents In Indonesia, Helda Helda, Nurul Muchlisa

Kesmas

There has been an increase of sexually transmitted infections (STIs) such as HIV/AIDS worldwide, especially in Indonesia. Several studies on adolescent behavior, especially the male as the main predictor, reported increased in STIs’ cases due to risky sexual behavior. This study aimed to show the relationship between attitudes, sexual behavior, and the risks of STIs among male adolescents in Indonesia based on the Indonesia Demographic and Health Survey (IDHS) data in 2017. This cross-sectional study involved 10,547 male adolescents using the total sampling method according to the inclusion and exclusion criteria. Data were analyzed using a complex sample logistic regression …

Stock Markets Performance During A Pandemic: How Contagious Is Covid-19?, Yara Abushahba

Theses and Dissertations

Background and Motivation: The coronavirus (“COVID-19”) pandemic, the subsequent policies and lockdowns have unarguably led to an unprecedented fluid circumstance worldwide. The panic and fluctuations in the stock markets were unparalleled. It is inarguable that real-time availability of news and social media platforms like Twitter played a vital role in driving the investors’ sentiment during such global shock.

Purpose:The purpose of this thesis is to study how the investor sentiment in relation to COVID-19 pandemic influenced stock markets globally and how stock markets globally are integrated and contagious. We analyze COVID-19 sentiment through the Twitter posts and investigate its …

Larvicidal Potency Of Dioscorea Sansibarensis Leaf Extract Against Vector Mosquitoes: Anopheles Gambiae S.S. And Culex Quinquefasciatus, Anitha Philbert

Tanzania Journal of Science

Mosquitoes are responsible for transmission of illnesses of public health importance including malaria, lymphatic filariasis, dengue, chikungunya, and many other diseases caused by viruses. Vector control using synthetic insecticides has been the cornerstone for management of vector-borne diseases. However, the chemical based interventions have not been sustainable due to emergency of resistance against insecticides among disease vectors. Plant based mosquitocidal products can be potential alternative tools in vector control. Therefore, the present study aimed at exploring the larvicidal properties of Dioscorea sansibarensis leaf extract against malaria and lymphatic filariasis vectors; Anopheles gambiae s.s. and Culex quinquefasciatus. The larvicidal activities of …

The Determinants Of Stunting For Children Aged 24-59 Months In Kulon Progo District 2019, Chatrine Aprilia Hendraswari, Yuliasti Eka Purnamaningrum, Tri Maryani, Yani Widyastuti, Sakinah Harith

Kesmas

This study pertains to stunting in children in Indonesian with z-scores of less than -2 Standard Deviation (SD) and less than -3 SD. The preliminary study results showed the highest prevalence of stunting to be 22.6%, at the Temon II Primary Health Care in Kulon Progo District. The study aimed to assess the determinants of stunting children aged 24–59 months. This study was conducted from September 2018–May 2019. The design of this study was analytical observational with study design case-control. The sample was 60 children aged 24–59 months. The method utilized proportional sampling, whereas the data analysis applied chi-square and …

Empowering Health Cadres To Support Drug-Resistant Tuberculosis (Dr-Tb) Patient To Enroll In Treatment, Esty Febriani, Adik Wibowo, Neeraj Kak, Hala Jassim Al Mossawi

Kesmas

Tuberculosis (TB) remains a big challenge globally, while the involvement of health cadres’ constitutes one of the key strategies for the TB program in Indonesia. These roles were further expanded to providing support to DR-TB patients. This study was a qualitative study, conducted in 2015 to explore the various factors which influence the performance of health cadres’ in supporting DR-TB patients to enroll in treatment. A total of 39 informants consisting of 24 health cadres, three nurses, four DR-TB patients, and three family members, two peer support, a head of primary health care, and two TB staffs from the District …

Landscape Genetics Of American Beaver In Coastal Oregon, Clinton W. Epps, Vanessa M. Petro, Tyler G. Creech, Rachel S. Crowhurst, Matthew J. Weldy, Jimmy D. Taylor

United States Department of Agriculture Wildlife Services: Staff Publications

American beaver (Castor canadensis) have been translocated for population restoration, reduction of human‐wildlife conflict, and enhancement of ecosystem function. Yet few studies have assessed dispersal of beaver, making it difficult to determine at what scale translocations are appropriate. Genetic studies can provide inferences about gene flow, and thus dispersal. We used a landscape genetic approach to evaluate whether landscape features influenced gene flow among beaver in the Coast Range of western Oregon, USA, using samples collected April–September 2014. We collected genetic samples from live‐captured (n=232), road‐killed (n=2) and trapper‐provided (n=58) tissue samples and genotyped them at 10 microsatellite loci. We …

Association Of Hypothermia With Increased Mortality Rate In Sars-Cov-2 Infection, Naaz Fatteh, Glen E. Sutherland, Radleigh Santos, Rita Zeidan, Alexandra P. Gastesi, Christopher D. Naranjo

Mathematics Faculty Articles

Objective

We observed patients to have variable temperatures. The objective of the study was to identify if hypothermia in a patient infected with SARS-CoV-2 is associated with a higher than expected mortality.

Methods

We reviewed 331 charts from patients hospitalized with SARS-CoV-2 between March 9 to April 20, 2020.

Results

The probability of death was 2.06 times higher for those with hypothermia than those without [95% C.I. (1.25, 3.38)]. In ventilated patients, there were 32 deaths. Of those, 75% had been hypothermic. In a prior review of 10,000 non-SARS-CoV-2 patients with sepsis, the mortality rate in patients with hypothermia was …

Spring 2021

Scientia

From the Dean: A Decade of Purpose and Progress; Lab Notes: Alumna Wins Gordon Bell Special Prize, New Scholarships, Vaccination Site Volunteers; Women in Science Lecture, National Institutes of Health Grants, "Unequal Cities" Research; All Hands on Deck: Inspired pandemic approaches showcase interdisciplinary acumen in action; Unlocking Potential: Christopher Beasley thinks psychology is key to academic transformation for the formerly incarcerated; Puzzle Master: Bridget Tenner goes to pieces solving problems in cutting-edge mathematics

Analyzing Empirical Quality Metrics Of Deep Learning Models For Antimicrobial Resistance, Huy H. Nguyen, Sanjay Pillay, Allison Roderick, Hao Wang, John Santerre

SMU Data Science Review

Antimicrobial Resistance (AMR) is a growing concern in the medical field. Over-prescription of antibiotics as well as bacterial mutations have caused some once lifesaving drugs to become ineffective against bacteria. However, the problem of AMR might be addressed using Machine Learning (ML) thanks to increased availability of genomic data and large computing resources. The Pathosystems Resource Integration Center (PATRIC) has genomic data of various bacterial genera with sample isolates that are either resistant or susceptible to certain antibiotics. Past research has used this database to use ML algorithms to model AMR with successful results, including accuracies over 80%. To better …

Short Term Safety, Immunogenicity, And Reproductive Effects Of Combined Vaccination With Anti-Gnrh (Gonacon) And Rabies Vaccines In Female Feral Cats, Shiri Novak, Boris Yakobson, Shir Sorek, Liat Morgan, Smadar Tal, Ran Nivy, Roni King, Lauren Jaebker, Douglas C. Eckery, Tal Raz

United States Department of Agriculture Wildlife Services: Staff Publications

Overpopulation of free-roaming cats is a major problem leading to negative impacts on animal health and welfare, public nuisance, transmission of zoonotic diseases, and well-documented harm to wildlife. Surgical sterilization had failed to provide a practical solution to free-roaming cats’ overpopulation under field conditions; therefore, efficient and safe non-surgical immunocontraception methods are aspired. Rabies is a deadly virus that may infect people and animals. However, the safety and efficacy of combined vaccination with anti-GnRH and rabies vaccines in feral cats, which often suffer from disrupted health conditions and experienced high stress level, has never been studied. Therefore, our objective was …

Short Term Safety, Immunogenicity, And Reproductive Effects Of Combined Vaccination With Anti-Gnrh (Gonacon) And Rabies Vaccines In Female Feral Cats, Shiri Novak, Boris Yakobson, Shir Sorek, Liat Morgan, Smadar Tal, Ran Nivy, Roni King, Lauren Jaebker, Douglas C. Eckery, Tal Raz

United States Department of Agriculture Wildlife Services: Staff Publications

Overpopulation of free-roaming cats is a major problem leading to negative impacts on animal health and welfare, public nuisance, transmission of zoonotic diseases, and well-documented harm to wildlife. Surgical sterilization had failed to provide a practical solution to free-roaming cats' overpopulation under field conditions; therefore, efficient and safe non-surgical immunocontraception methods are aspired. Rabies is a deadly virus that may infect people and animals. However, the safety and efficacy of combined vaccination with anti-GnRH and rabies vaccines in feral cats, which often suffer from disrupted health conditions and experienced high stress level, has never been studied. Therefore, our objective was …

Time Series Forecasting Of Covid-19 Deaths In Massachusetts, Andrew Disher

Honors Program Theses and Projects

The aim of this study was to use data provided by the Department of Public Health in the state of Massachusetts on its online dashboard to produce a time series model to accurately forecast the number of new confirmed deaths that have resulted from the spread of CoViD-19. Multiple different time series models were created, which can be classified as either an Auto-Regressive Integrated Moving Average (ARIMA) model or a Regression Model with ARIMA Errors. Two ARIMA models were created to provide a baseline forecasting performance for comparison with the Regression Model with ARIMA Errors, which used the number of …

Post Covid-19 Water And Waste Water Management To Protect Public Health And Geoenvironment, Ken Cornell, Arvin Farid

Chemistry and Biochemistry Faculty Publications and Presentations

The coronavirus disease 2019 pandemic has posed severe threats to humans and the geoenvironment. The findings of severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) traces in waste water and the practice of disinfecting outdoor spaces in several cities in the world, which can result into the entry of disinfectants and their by-products into storm drainage systems and their subsequent discharge into rivers and coastal waters, raise the issue of environmental, ecological and public health effects. The aims of the current paper are to investigate the potential of water and waste water to operate as transmission routes for Sars-CoV-2 and the …

Mathematical Models Of Covid-19, Kate Faria

Honors Program Theses and Projects

For more than a year, the COVID-19 pandemic has been a major public health issue, affecting the lives of most people around the world. With both people’s health and the economy at great risks, governments rushed to control the spread of the virus. Containment measures were heavily enforced worldwide until a vaccine was developed and distributed. Although researchers today know more about the characteristics of the virus, a lot of work still needs to be done in order to completely remove the disease from the population. However, this is true for most of the infectious diseases in existence, including Influenza, …

Randomised Trials At The Level Of The Individual, Jay J H. Park, Nathan Ford, Denis Xavier, Per Ashorn, Rebecca F. Grais, Zulfiqar Ahmed Bhutta, Herman Goossens, Kristian Thorlund, Maria Eugenia Socias, Edward J. Mills

Centre of Excellence in Women and Child Health

In global health research, short-term, small-scale clinical trials with fixed, two-arm trial designs that generally do not allow for major changes throughout the trial are the most common study design. Building on the introductory paper of this Series, this paper discusses data-driven approaches to clinical trial research across several adaptive trial designs, as well as the master protocol framework that can help to harmonise clinical trial research efforts in global health research. We provide a general framework for more efficient trial research, and we discuss the importance of considering different study designs in the planning stage with statistical simulations. We …

Assessing The Impact Of Vaccination And Behavior Change On Outbreaks Of Emerging Respiratory Diseases, Mohammed Hameed Alharbi

Mathematics Dissertations - Archive

The purpose of this dissertation is to use mathematical models to evaluate the impact of characteristics of respiratory diseases like influenza and COVID-19 either alone or co-circulating and how might influenza vaccine affect this interplay. First, we assess the effects of matching and mismatching between vaccine strains and circulating strains during the Hajj. Then we evaluate the impact of the proportion of asymptomatic COVID- 19 infections on the magnitude of an epidemic under three different behavior change scenarios. Finally, we model the co-circulation of influenza and COVID-19 to investigate whether the influenza vaccine increases the combined disease burden of influenza …

Liposomes Prevent In Vitro Hemolysis Induced By Streptolysin O And Lysenin, Marcelo Ayllon, Gamid Abatchev, Andrew Bogard, Rosey Whiting, Sarah E. Hobdey, Daniel Fologea

Physics Faculty Publications and Presentations

The need for alternatives to antibiotics in the fight against infectious diseases has inspired scientists to focus on antivirulence factors instead of the microorganisms themselves. In this respect, prior work indicates that tiny, enclosed bilayer lipid membranes (liposomes) have the potential to compete with cellular targets for toxin binding, hence preventing their biological attack and aiding with their clearance. The effectiveness of liposomes as decoy targets depends on their availability in the host and how rapidly they are cleared from the circulation. Although liposome PEGylation may improve their circulation time, little is known about how such a modification influences their …