Digital Commons Network^™

Interchange, 1986, V6 N10, Summer, Advocate Health - Midwest

Historical Documents - Combined

The lnterChange newsletter was published monthly for the nursing division of St. Luke's Medical Center. It's purpose was to provide health care and shared governance information and inform nurses of new program benefits and upcoming special events.

Transforming Academic Nursing: Educating Nurses On The Health Challenges Of Climate Change, Clara Granda-Cameron, Lisa Whitfield-Harris

Creating Healthy Work Environments (CHWE)

Background: Climate change is a major public health threat for humanity. Over the coming decades, morbidity and mortality are expected to increase, particularly in vulnerable communities, due to increased heat, poor air quality, undernutrition, and vector-borne diseases. To care for populations who reside in these communities, undergraduate and graduate nursing students must be educated, which requires integrating climate change topics into the nursing curriculum.

Purpose: We piloted a course module about climate change and health and tested its effectiveness as a tool for educating nursing students.

Methods: Using a pre-post intervention design, 192 undergraduate and graduate nursing students enrolled in …

High Frequency Emergency Department Use And Heterogeneity Of Reasons For Attendance By Children And Young People: A Retrospective Cohort Study, Akshay Kumar, Rebecca M Simpson, Kerryn Husk, Graham D Johnson, Chris Burton

Peninsula Medical School

Objective To quantify patterns of emergency department (ED) use over two consecutive 12-month periods among children aged 15 and under, and to assess heterogeneity of reasons for attendance in high-frequency users.Design Population-based retrospective cohort study of routinely collected ED data.Setting EDs in the Yorkshire and Humber region, UK, from 31 March 2014 to 1 April 2017.Patients Children aged 15 and under with ≥1 ED attendance.Main outcome measures Proportion with ≥7 attendances over 2 years and heterogeneity of diagnostic reasons quantified by the Herfindahl index.Results The cohort included 71 143 individuals. Although only 13.6% were high-frequency attenders in the first year, …

The Association Between The Gnb3 Rs5443 C/C Genotype And Obesity Phenotypes In Taiwanese Individuals, Ling-Yi Xiao, Zi-Lun Lai, Yang-Di Su, Szu-Yun Wang, Nia-Jia Zheng, Po- Ren Hsueh

BioMedicine

Background: The prevalence of obesity has increased significantly over the

years, and its health concerns cannot be underestimated. Obesity not only

causes potential mobility limitations in daily life but also increases the risk of

developing cardiovascular diseases, diabetes, cancer and other health

conditions. While an imbalanced diet and lack of exercise are well-known

causes of obesity, genetic patterns also influence its development. Although the GNB3 gene is known to be involved in lipid metabolism and fat cell

differentiation, studies have shown inconsistent associations between a

common single nucleotide polymorphism of GNB3 (c.825C>T, rs5443) and

obesity across different populations. Therefore, …

In Vitro Meat: Unnatural Or Life Saving, Joseph Coplon

Fresh Voices: Composition at Cal Poly

No abstract provided.

Rural Banditry In North Central Nigeria: The Experience Of Women In Affected Communities, Joseph Egidi Igbe, Tersoo Asongo, Evaristus Akpanke Ushie, William Okon Williams, Patrick Owan Bisong

Journal of International Women's Studies

This study examined rural banditry in North Central Nigeria, focusing on women’s experiences in affected communities. The study specifically looked at women’s experiences with poor health, sexual violence, and physical harm caused by rural banditry and militancy in the study area. The study employs Kate Millet’s feminist theory of patriarchal power and structure to frame its theoretical standpoint. Four hundred women informants were selected through stratified random and purposive sampling techniques, and data were obtained using a questionnaire and eight in-depth interviews. Data were analysed using descriptive statistics such as percentages and frequency tables, while simple linear regression was used …

From Soil To Sole: A Rare Case Of Blastomycosis In The Calcaneus, Kelly Fahey, Sharif Denden

Advocate GME

No abstract provided.

Respiratory Syncytial Virus Co-Detection With Other Respiratory Viruses Is Not Significantly Associated With Worse Clinical Outcomes Among Children Aged <2 Years: New Vaccine Surveillance Network, 2016-2020, Justin Z Amarin, Ariana P Toepfer, Andrew J Spieker, Haya Hayek, Tess Stopczynski, Yasmeen Z Qwaider, Laura S Stewart, James D Chappell, Mary Allen Staat, Elizabeth P Schlaudecker, Geoffrey A Weinberg, Peter G Szilagyi, Janet A Englund, Eileen J Klein, Marian G Michaels, John V Williams, Rangaraj Selvarangan, Christopher J Harrison, Leila C Sahni, Vasanthi Avadhanula, Meredith L Mcmorrow, Heidi L Moline, Natasha B Halasa

Faculty, Staff and Students Publications

Background: Risk factors for severe respiratory syncytial virus (RSV) illness include early infancy, premature birth, and underlying medical conditions. However, the clinical significance of respiratory viral co-detection is unclear. We compared the clinical outcomes of young children with RSV-only detection and those with RSV viral co-detection.

Methods: We conducted active, population-based surveillance of children with medically attended fever or respiratory symptoms at 7 US medical centers (1 December 2016-31 March 2020). Demographic and clinical data were collected through parental interviews and chart abstractions. Nasal swabs, with or without throat swabs, were systematically tested for RSV and 6 other common respiratory …

Aurora St. Luke's Today, 2008 Jan 4-10, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: Employee newsletter published weekly, with information about what's happening at St. Luke's, as well as Metro Region goals and system-wide initiatives.

St. Luke's Today, 2004 Oct 29-Nov 4, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: Employee newsletter published weekly, with information about what's happening at St. Luke's, as well as Metro Region goals and system-wide initiatives.

St. Luke's Today, 2004 Dec 24-2005 Jan 6, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: Employee newsletter published weekly, with information about what's happening at St. Luke's, as well as Metro Region goals and system-wide initiatives.

St. Luke's Today, 2003 Oct 31-Nov 6, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: Employee newsletter published weekly, with information about what's happening at St. Luke's, as well as Metro Region goals and system-wide initiatives.

St. Luke's Today, 2003 July 25-31, Advocate Health - Midwest

Historical Documents - Combined

Aurora St. Luke's Medical Center, Milwaukee, WI: Employee newsletter published weekly, with information about what's happening at St. Luke's, as well as Metro Region goals and system-wide initiatives.

Pd-L1 Is An Intrinsic Switch For Natural Killer Cell-Mediated, Trail-Dependent Antiviral Function., Kayla Frank, Himani Sharma, Efthymios Motakis, Nooshin Nourbakhsh, Shawn Abeynaike, Tridu R Huynh, Cheryl A Jones, Scott K Johnson, S Mark Tompkins, Silke Paust

Faculty Research 2026

Each year, influenza A virus (IAV) infection of the lung causes half a million deaths worldwide. Patients with compromised immunity experience distinct influenza pathogenesis; however, most IAV-related research is done with wild-type mice or people who are otherwise healthy. We utilize a model of immunocompromised recombination-activating gene 1 (Rag1)-knockout (KO) mice to discover natural killer (NK) cell activation and regulation mechanisms during IAV infection. The treatment of IAV-challenged Rag1-KO mice with a monoclonal antibody (mAb) targeting programmed death ligand 1 (PD-L1) triggers NK cell-intrinsic signaling of PD-L1 and significantly delays lethality. This treatment upregulates tumor necrosis factor-related apoptosis-inducing ligand on …

Evidentiary Standards For Newly Approved Antibiotics For Uncomplicated Urinary Tract Infections, Rosa Rodriguez-Monguio, Enrique Seoane-Vazquez, John H. Powers Iii

Pharmacy Faculty Articles and Research

Importance: Uncomplicated urinary tract infections (uUTIs) are among the most common bacterial infections and are typically treated with existing oral antibiotics. In 2024–2025, the FDA approved two new oral agents, sulopenem etzadroxil/probenecid and gepotidacin, via expedited review pathways, for the treatment of uUTIs. Objective: To assess the clinical significance and regulatory evidence supporting FDA approval of sulopenem/probenecid and gepotidacin for uUTI, and to analyze the adherence of pivotal phase III trials to regulatory standards for approval and FDA guidelines. Design, Setting, and Participants: Comparative descriptive analysis of publicly available data from phase 3 randomized, double-blind, active-controlled clinical …

Increasing Ketamine Administration In Children's Hospitals For Youth With Sickle Cell Disease., Ashley M. Jenkins, Erin Hendry, Alexandra Power-Hays, Marin Valentino, Matthew Hall, Kathyrn Kyler, James W. Antoon, Sonya Tang Girdwood, Jennifer Goldman, Armand N. Morel, Timothy J. Savage, Lucas E. Orth, Natasha M. Archer

Manuscripts, Articles, Book Chapters and Other Papers

Ketamine is recommended as an opioid-sparing adjunct for sickle cell disease (SCD)-related pain management. Little is known regarding its use in hospitalized youth with SCD. We aimed to describe trends in ketamine administration and examine associations between ketamine administration and outcomes in hospitalized youth with SCD. We conducted a cross-sectional, multicenter study examining hospital admissions for youth with SCD from 44 children's hospitals in the United States from 2016 to 2023. Youth aged ≥6 months with SCD were identified using International Classification of Diseases tenth revision codes. Exposures included age, sex, race, payor, childhood opportunity index, hydroxyurea administration, and concomitant …

Musculoskeletal Infection Reporting And Data System (Mski-Rads): Reviewed And Explained, Angela He, Flavio Duarte Silva, Mina Guirguis, Erin F. Alaia, William B Morrison, Avneesh Chhabra

Department of Radiology Faculty Papers

A standardized guideline and scoring system are recommended for the imaging evaluation of musculoskeletal infections on MR imaging. The Musculoskeletal Infection Reporting and Data System (MSKI-RADS) is a recently developed and validated classification system using MR imaging that can be used to classify the severity and extent of musculoskeletal infections, improve radiology-pathology concordance, and outline the corresponding management recommendations. This review article explains MSKI-RADS and discusses the different elements of this system in detail with a review of pertinent literature so that the readers can apply it in their practices. The work outlines the technical considerations for optimal MR imaging …

Secondary Syphilis Case Report: Septic Arthritis And Tendinopathy, Phil Kulpinski

Advocate GME

No abstract provided.

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUND. The SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.

METHODS. We longitudinally profiled SARS-CoV-2–naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).

RESULTS. We discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1–2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was …

A Correlation Between Leptin Hormone And Other Biochemical Parameters In Iraqi Women With Hepatitis C Virus (Hcv) In Thi-Qar Governorate In Iraq, Hadeel Rashid Faraj, Alyaa Majid, Sarah A Sayer

Baghdad Science Journal

Background: chronic hepatitis C virus (HCV) infection is a major health problem. Females of childbearing age who are infected with hepatitis C are exposed to premature aging of the ovaries, which leads to an imbalance in the levels of sex hormones leptin hormone is associated with all stages of reproductive age. The aim of the present study is to observe levels the liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin hormone. Also to evaluate the correlation between ( leptin hormone liver enzyme, Albumin, total bilirubin, estrogen and progesterone ).Methods: Serum liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin …

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUNDThe SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.METHODSWe longitudinally profiled SARS-CoV-2-naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).RESULTSWe discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1-2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was characterized by ISGF3 complex activation and …

Investigation Of Antimicrobial Synergism Of Actinomycin Derivatives From Streptomyces Parvus 35m1 Against Escherichia Coli Atcc 25922, Özge Can, Mustafa Ünver Kurt, Meli̇s Küçüksolak, Ataç Uzel, Erdal Bedi̇r

Turkish Journal of Biology

Background/aim: Limited drug development and increased antibiotic tolerance among Gram-negative bacteria have led researchers to consider combination therapy. Actinomycin derivatives, particularly actinomycin D, exhibit a wide range of bioactivities, including antibacterial effects. However, actinomycin D is less effective against Gram-negative pathogens. Therefore, it is essential to demonstrate the synergy of actinomycin D and its derivatives with clinically known antibiotics against Escherichia coli ATCC 25922 and investigate the effects on cellular morphology.

Materials and methods: Streptomyces parvus 35M1 isolated from coastal sediment in İzmir/Türkiye was identified via genome sequencing. Large-scale (30 L) fermentation followed by chromatographic purification yielded compounds 1 (actinomycin …

The Impact Of Vascular Endothelial Growth Factor, Neutrophil Gelatinase-Associated Lipocalin, And Interleukin-38 Food And Air Allergy Patients Following The Pandemic Of Covid-19 In Iraq, Esraa Hameed Khamees, Zaizafoon N. Nasif

Baghdad Science Journal

Allergies are a common health issue where the immune system reacts to substances in the environment that are normally harmless. This study further investigates the effects of vascular endothelial growth factor (VEGF), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-38 (IL-38), immunoglobulin E (IgE), and the neutrophil-lymphocyte ratio (NLR) in these individuals, offering insight into the probable processes behind allergic responses following the pandemic. The study comprised 120 non-vaccinated females with previous COVID-19 infection. Groups included controls and food and air (F&A) allergic patients, with 60 individuals matched for age and gender. Serum levels of IL-38, VEGF, IgE, and NGLA were assessed using …

A New Prospective Of Colistin Resistance Profile Of Some Staphylococcus Species Isolated From Iraqi Wound Fractured Foot, Zahraa M. Fadhil, Halah H Al-Haideri

Baghdad Science Journal

Sulbactam belongs to β-lactamase inhibitors that are more commonly used for Gram-negative bacteria than Gram-positive bacteria. In this study, nine different species of Staphylococcus (S. aureus, S. epidermidis, S.hominis, S. lentus, S. pseudintermedius, S. lugdunensis, S. haemolyticus, S. sciuri , and S. warneri. were isolated from wounded-fractured feet of Iraqi patients. The spectrum of activity of sulbactam and colistin against all isolates was evaluated. Surprisingly, among S. aureus isolates, 5 (12) isolates were sensitive to colistin, whereas, all bacterial isolates were completely resistant to sulbactam. Here, our study revealed that combining …

Navigating (M)Otherhood: Perception, Practice, & Policy Of Adolescent Pregnancy In The North Coast Of Perú, Mahir Rahman

USF Tampa Graduate Theses and Dissertations

“It’s a vicious circle”, the obstetricians of Huanchaco repeated time and time again after discussing a recently pregnant 13-year-old girl who had just moved to the North Coast of Perú. Adolescent pregnancy is an extremely stigmatized topic in global maternal and child health discourse. Pregnant adolescents are subject to educational policy, clinical protocol, and community practice. While global scholarship emphasizes adolescent pregnancy prevention, limited scholarship focuses on the conditions in which adolescent pregnancy is perceived, discussed, and managed. More importantly, these perspectives are even less documented amongst the North Coast of Perú.

This thesis serves as an ethnographic exploration of …

A Scoping Review On Governing The Commercial Determinants Of Health: Mechanisms, Tools, And Collaborative Approaches, Alyssa S. Khan, Sierra Arnold, Imran Bari, Isabel G. Long, Nino Paichadze

Student Works

Purpose: The commercial determinants of health (CDoH) are the systems, practices, and pathways through which commercial actors drive health and equity. This review aimed to identify CDoH governance approaches, distinguishing between promoted and criticized approaches.

Design/Methodology/Approach: We conducted a systematic scoping review in PubMed and Google Scholar databases. Relevant grey literature was also identified through citation searching and reference list review. Our search strategy combined terms related to economic and commercial determinants of health, governance models, and health outcomes. English-language publications between January 2000 to December 2025 were included. Relevant data from included sources were extracted and then synthesized using …

Adalimumab Therapy For Crohn’S Disease And Axial Spondyloarthritis In Latent Tuberculosis: A Bibliometric-Systematic Literature Review, Nyimas Maida Shofa, Nurike Setiyari Mudjari, Rusdiyana Ekawati, Arianti Arianti, Annisa Zahra Mufida, Budi Widodo, Titong Sugihartono

Sultan Qaboos University Medical Journal

The management of Crohn’s disease (CD) using anti-tumour necrosis factor therapy in tuberculosis (TB)-endemic regions poses major clinical challenges due to the risk of latent TB infection reactivation. This bibliometric–systematic literature review synthesised evidence from 17 peer-reviewed studies (2020–2025) evaluating adalimumab administered with concurrent prophylactic antitubercular therapy. Thematic synthesis and bibliometric mapping using VOSviewer demonstrated that adalimumab achieved 60–85% clinical remission in moderate-to-severe CD and axial spondyloarthritis while enhancing mucosal healing. However, 1–3% of patients developed active TB despite appropriate screening and isoniazid prophylaxis, revealing false-negative diagnostics and partial chemoprophylaxis protection. These findings highlight the need for region-specific frameworks integrating …

Strategies Of Science Denial In Contemporary Politics, Yumi Li

Undergraduate Research and Engagement Symposium

My presentation applies the FLICC acronym to different sources of science denial during the COVID-19 pandemic and Trump's handling of it.

Honest Like A Bear Attack, Clare Magneson

Creative Nonfiction Magazine

No abstract provided.

Igg4-Related Disease Associated With Pearson Syndrome: A Case Of Rapid Decline, Kai-Jing Zhang, Xiao-Juan Lv, Qin-Qin Zhao, Wan-Wan Xu

Journal of Pediatric Infectious Diseases

We report a diagnostically challenging case of a 1-year-old female with refractory thrombocytopenia, sideroblastic anemia, pancreatitis and metabolic decompensation, ultimately attributed to coexisting IgG4-related disease (IgG4-RD) and Pearson syndrome (PS)—a previously undocumented association. Key findings of the case were 1. Treatment resistant thrombocytopenia despite IVIG, corticosteroids, and eltrombopag (transient response only). 2. Elevated IgG4 (840 μg/mL) and pancreatitis thought to be secondary to IgG4-RD. 3. Mitochondrial DNA deletion (m.10052_15604 del, 93.2% heteroplasmy) and ringed sideroblasts secondary to PS. 4. Fatal Metabolic Crisis with hyperlactatemia (peak 8.4 mmol/L) and cardiac failure, underscoring PS's rapid progression. This is the first reported association …