Digital Commons Network^™

Our Envirome, Spring/Summer 2019, Issue 40

Sustain Magazine

No abstract provided.

Emergent Behavior Development And Control In Multi-Agent Systems, David W. King

Theses and Dissertations

Emergence in natural systems is the development of complex behaviors that result from the aggregation of simple agent-to-agent and agent-to-environment interactions. Emergence research intersects with many disciplines such as physics, biology, and ecology and provides a theoretical framework for investigating how order appears to spontaneously arise in complex adaptive systems. In biological systems, emergent behaviors allow simple agents to collectively accomplish multiple tasks in highly dynamic environments; ensuring system survival. These systems all display similar properties: self-organized hierarchies, robustness, adaptability, and decentralized task execution. However, current algorithmic approaches merely present theoretical models without showing how these models actually create hierarchical, …

Organically Modified Inorganic Nanoparticles For Halochromic Ionophores And Nucleic Acids, William Johnston

Doctoral Dissertations

In this dissertation, four nanoparticle reaction schemes were developed as substrates for halochromic dyes or nucleic acids. The reaction schemes include the use of two substrates: silica nanoparticles and halloysite nanotubes. The protocols can incorporate silica (SiO2) nanoparticles and halloysite aluminosilicate (AlO2SiO2) nanotubes due to the presence of silane groups on the surface of either substrate. The reaction schemes are presented along with detailed protocols which were written to facilitate both reproducibility and to serve as an aid to further study and for easy modification of the protocol to suit a researcher's needs. The data is discussed in the materials …

Modeling Extreme Heat Events Using Global Reanalysis Data: An Assessment Of Current Climate Data And The Need For Improved Weather Station Data In Tennessee, John Reasons

Electronic Theses and Dissertations

Wet Bulb Globe Temperature (WBGT) is used to assess categorical heat stress risk factors for individuals working in outdoor environments and to provide guidelines for work/rest ratios and water intake. The variables required to compute WBGT are used by meteorologists for many purposes and are available through the Copernicus Program which was implemented by European Centre for Medium-Range Weather Forecasts (ECMWF) to provide users access to ECMWF Re-Analysis (ERA) historical database. WBGT values for Tennessee during National Weather Service (NWS) issued excessive heat warnings were calculated to determine the need for additional advisories based on WBGT guidelines. Monthly average WBGT …

Tools To Improve Interruption Management, Matthew R. Munns

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

Interruptions carry a high cost, especially to software developers. To prevent unnecessary interruptions, several technologies are being explored that can help manage the timing of interruptions, such as displaying the interruptibility of a worker to their peers. Relatively simple algorithms utilizing computer interaction data have been created and used successfully in the workplace, while technology using bio-metric emotion recognition to detect the interruptibility of a user is also being developed.

A Pbpk Model Of Low-Concentration Vitamin D Supplementation In The Absence Of Sunlight, Colton Sawyer

Biology and Medicine Through Mathematics Conference

No abstract provided.

Why High-Level Attention Constantly Oscillates: System-Based Explanation, Griselda Acosta, Eric Smith, Vladik Kreinovich

Departmental Technical Reports (CS)

In many situations like driving, it is important that a person concentrates all his/her attention at a certain critical task -- e.g., watching the road for possible problems. Because of this need to maintain high level of attention, it was assumed, until recently, that in such situations, the person maintains a constantly high level of attention (of course, until he or she gets tired). Interestingly, recent experiments showed that in reality, from the very beginning, attention level oscillates. In this paper, we show that such an oscillation is indeed helpful -- and thus, it is necessary to emulate such an …

Prediction Models For Descreasing Visual Acuity In Wig Makers, Nur Ulfah, Siti Harwanti, Ngadiman Ngadiman

Kesmas

One of the occupational diseases that can arise for workers with high accuracy is a decrease in their visual acuity. Therefore, it is necessary to study the risk factors of decreasing visual acuity in workers with high accuracy, such as in wig makers. This study aimed to examine the correlation between age, working period, lighting intensity, fatigue, and nutritional status with visual acuity, and to observe the main risk factors that can be used as a reference for predicting decreasing visual acuity. This study was an observational study that used a cross-sectional design. The population number for this study was …

The Potential Of Organ On Chip Technology For Replacing Animal Testing, Malcolm Wilkinson

Human Clinical Trials Collection

The term organ on a chip is used to describe the latest stage of development of in vitro cell culture technology. Figure 26.1 shows its steady development since the 1960s. Each step forward has improved our ability to model human-clinical response to new drugs or therapies and has enabled safety risk assessment of existing cosmetics, personal care products, or other chemicals in the environment. Scientific evidence that the predictive power of in vitro tests is superior to the use of animals will trigger a major shift in the way that medical research, in many areas, is carried out. In this …

The Effect Of Maternal Dietary Habits During Pregnancy On Neonate Leptin Methylation Patterns And Gestational Age, Sean Fitzpatrick

Legacy Theses & Dissertations (2009 - 2024)

The health of a newborn baby is inextricably linked to the health status of its mother and in turn the mother’s diet during pregnancy. Leptin (LEP) is an adipokine hormone involved in metabolism regulation and has been linked fetal development through the hypothalamic-pituitary-adrenal axis (HPA). Prior work suggests that gestational epigenetic alterations the LEP gene may be sensitive to adverse exposures during pregnancy, which in turn could explain variation in neonate outcomes. However, no prior work has examined this possibility explicitly. The objective of this study was to investigate the association between dietary patterns of mothers during pregnancy and their …

A Hybrid Cognitive Architecture With Primal Affect And Physiology, Christopher L. Dancy

Faculty Journal Articles

Though computational cognitive architectures have been used to study several processes associated with human behavior, the study of integration of affect and emotion in these processes has been relatively sparse. Theory from affective science and affective neuroscience can be used to systematically integrate affect into cognitive architectures, particularly in areas where cognitive system behavior is known to be associated with physiological structure and behavior. I introduce a unified theory and model of human behavior that integrates physiology and primal affect with cognitive processes in a cognitive architecture. This new architecture gives a more tractable, mechanistic way to simulate affect-cognition interactions …

Bridging Act-R And Project Malmo, Developing Models Of Behavior In Complex Environments, David M. Schwartz

Honors Theses

Cognitive architectures such as ACT-R provide a system for simulating the mind and human behavior. On their own they model decision making of an isolated agent. However, applying a cognitive architecture to a complex environment yields more interesting results about how people make decisions in more realistic scenarios. Furthermore, cognitive architectures enable researchers to study human behavior in dangerous tasks which cannot be tested because they would harm participants. Nonetheless, these architectures aren’t commonly applied to such environments as they don’t come with one. It is left to the researcher to develop a task environment for their model. The difficulty …

Automatic 13C Chemical Shift Reference Correction Of Protein Nmr Spectral Data Using Data Mining And Bayesian Statistical Modeling, Xi Chen

Theses and Dissertations--Molecular and Cellular Biochemistry

Nuclear magnetic resonance (NMR) is a highly versatile analytical technique for studying molecular configuration, conformation, and dynamics, especially of biomacromolecules such as proteins. However, due to the intrinsic properties of NMR experiments, results from the NMR instruments require a refencing step before the down-the-line analysis. Poor chemical shift referencing, especially for ¹³C in protein Nuclear Magnetic Resonance (NMR) experiments, fundamentally limits and even prevents effective study of biomacromolecules via NMR. There is no available method that can rereference carbon chemical shifts from protein NMR without secondary experimental information such as structure or resonance assignment.

To solve this problem, we …

Pressure Versus Impulse Graph For Blast-Induced Traumatic Brain Injury And Correlation To Observable Blast Injuries, Barbara Rutter

Doctoral Dissertations

"With the increased use of explosive devices in combat, blast induced traumatic brain injury (bTBI) has become one of the signature wounds in current conflicts. Animal studies have been conducted to understand the mechanisms in the brain and a pressure versus time graph has been produced. However, the role of impulse in bTBIs has not been thoroughly investigated for animals or human beings.

This research proposes a new method of presenting bTBI data by using a pressure versus impulse (P-I) graph. P-I graphs have been found useful in presenting lung lethality regions and building damage thresholds. To present the animal …

Spheroid-3d And Monolayer-2d Intestinal Electrochemical Biosensor For Toxicity/Viability Testing: Applications In Drug Screening, Food Safety, And Environmental Pollutant Analysis, Evangelia Flampouri, Shahzad Imar, Kieran O'Connell, Baljit Singh

Articles

The rise of three-dimensional cell culture systems that provide in vivo-like environments for pharmaco-toxicological models has prompted the need for simple and robust viability assays suitable for complex cell architectural structures. This study addresses that challenge with the development of an in vitro enzyme based electrochemical sensor for viability/cytotoxicity assessment of two-dimensional (2D) monolayer and three-dimensional (3D) spheroid culture formats. The biosensor measures the cell viability/toxicity via electrochemical monitoring of the enzymatic activity of nonspecific esterases of viable cells, through the hydrolysis of 1-naphthyl acetate to 1-naphthol. The proposed sensor demonstrated strong correlation (r = 0.979) with viable …

Development, Characterization And Application Of Multi-Detector Flow Injection Systems Based On A Serial Flow Configuration For Simultaneous Multianalyte Determination, Aisha Rashed Al Hameidi Yammahi

Chemistry Theses

Oxidase enzymes have been used successfully in the analysis of several biochemical species such as glucose, lactate, pyruvate, creatine, creatinine, amino acids, cholesterol and sialic acid, by generating - in a single or consecutive reaction -hydrogen peroxide (H₂O₂) as a signal molecule which is commonly detected amperometrically. Some approaches have been also reported to use more than one enzyme in a given system to achieve multi-analyte determination. This study aims to evaluate a novel approach for n-analyte determination based on n-enzyme reactors (each is loaded with one or more oxidase enzyme) as well as n-1 catalase immobilized …

Semi-Permeable Membrane Experiment For Unsaturated Liquid Permeability Of Building Materials: Potential And Practice, Chi Feng, Hans Janssen

International Building Physics Conference 2018

The unsaturated liquid permeability is a crucial hygric property of porous building materials. Its direct measurement is very challenging however, because currently available experimental protocols are either demanding in test facilities, complicated in data processing, or limited in moisture content range. Inspired by the osmosis phenomenon, we study the possibility to apply semi-permeable membranes for directly measuring the liquid permeability of porous building materials. The key principle is studied profoundly and a simple experimental set-up is constructed. Trial tests on calcium silicate insulation and autoclaved aerated concrete are performed. Results show that the experimental set-up can be used to measure …

Passive Survivability In Residential Buildings During Heat Waves Under Dynamic Exterior Conditions, Timothy Aduralere, Jacqueline Isaacs, David Fannon

International Building Physics Conference 2018

The increased frequency of heat waves around the world has prompted numerous studies to improve building resilience and maintain thermal comfort in the face of extreme conditions. However, previous studies rely on the assumption of steady-state conditions, including external temperature, which limits real-world applicability, demanding a more practical perspective. This paper presents the use of recorded heat wave temperatures for a specified location to simulate the effect of extreme temperatures on the interior temperature of buildings when air conditioning is not used. The objective of this study is to determine how a building becomes uninhabitable during extreme heat and to …

Design And Synthesis Of Circadian Clock Modulators And The Study Of Lov Domain Protein Lkp2 In Arabidosis Thaliana And Brassica Rapa, Aditi Nagar

Chemistry Theses and Dissertations

Circadian rhythms are self-autonomous endogenous clocks synchronized with the rotation of the Earth. With the Earth’s rotation and revolution on its axis, the internal clock undergoes oscillation in the period of ~24 hour and governs day to day activities in most organisms. In humans, it regulates the day to day physiological activities. Today’s modern lifestyle has an impact on health: shift work, jet lag, and irregular eating habits contribute to the misalignment of the endogenous circadian oscillator, thereby, increasing the risk of many metabolic disorders including diabetes, irregular blood pressure, sleep disorders, obesity, depression, and cancer. The primary goal of …

Advancing Risk Assessment: Mechanistic Dose-Response Modelling Of Listeria Monocytogenes Infection In Human Populations, Ashrafur Rahman, Daniel Munther, Aamir Fazil, Ben Smith, Jianhong Wu

Mathematics and Statistics Faculty Publications

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. The utility of characterizing the effects of strain variation and individual/subgroup susceptibility on dose-response outcomes has motivated the search for new approaches beyond the popular use of the exponential dose-response model for listeriosis. While descriptive models can account for such variation, they have limited power to extrapolate beyond the details of particular outbreaks. By contrast, this study exhibits dose-response relationships from a mechanistic basis, quantifying key biological factors involved in pathogen-host dynamics. An …

Cell Size Control In Budding Yeast By Titration Of Regulatory Proteins, John Tyson

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Combined Effects Of Soil Fertility And Soil Amendments On The Growth And Mycorrhizal Associations Of American Ginseng (Panax Quinquefolius), Emily Ann Murray

Masters Theses, 2010-2019

Arbuscular mycorrhizal fungi (AMF) are fungi that form symbiotic associations with 70-90% of plant families. They are known to allow for the extension of the root system as well as an increase in plant size by assisting with the uptake of nutrients such as nitrogen and phosphorus. The role that AMF play in plant health and success has led to the development of commercial inoculum, which is used in agricultural settings. However, soil fertility, and soil amendments are known to affect AMF and plant associations. This study intends to look at how cultivated American Ginseng seedlings are affected by commercial …

Outbreak And Extinction Dynamics In Stochastic Populations, Garrett T. Nieddu

Theses, Dissertations and Culminating Projects

Each piece of work herein examines nonlinear population dynamics using methods from deterministic dynamical systems, stochastic processes and statistical mechanics. This dissertation is the compilation of three independent – but related – pieces of work: the first investigates an isolated population that is capable of maintaining multiple carrying capacities; the second project examines a stochastic Ebola model with a zoonotic disease reservoir; and the third looks at a basic disease-invasion model to characterize outbreak vulnerability and the connectedness of supposedly separate populations.

Each of these three chapters explore the interplay between interconnected systems, without explicitly modeling the elements that are …

Geometric Design, John Marceaux

Honors Capstones

No abstract provided.

Review Of G. Israel, Meccanicismo. Trionfi E Miserie Della Visione Meccanica Del Mondo, Marco Panza

MPP Published Research

"This is Giorgio's Israel last book, which appeared only a few weeks after his untimely death, in September 2015. For many reasons, it can be considered as his intellectual legacy, since it comes back, in a new and organic way, to many of the research topics to which he devoted his life and his many publications, which include several papers in Historia Mathematica. One of these papers, co-authored with M. Menghini, appeared in vol. 25/4, 1998 and was devoted to Poincaré's and Enriques's opposite views on qualitative analysis, which is a theme also dealt with in this book (pp. 117–122)."

Polysaccharide-Mediated Synthesis Of Melanins From Serotonin And Other 5-Hydroxy Indoles, Koen Vercruysse, Astiney Clark, Noor Alattas, Dylan Brooks, Nafisa Hamza, Margaret Whalen

Chemistry Faculty Research

Aim: As a continuation of our research on the melanin formation from catecholamines, we studied the polysaccharide-mediated oxidation of serotonin and other 5-hydroxy indoles into melanin-like materials. As for the catecholamines, we observed that many polysaccharides promote the oxidation of such compounds, particularly in the presence of Cu²⁺. Methodology: The reactions were monitored using reverse phase-HPLC and size-exclusion chromatography techniques. Melanin-like materials were purified through dialysis and characterized using UV-Vis and Fourier transform IR spectroscopic techniques. Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu²⁺ was found to affect …

Towards A Physio-Cognitive Model Of Slow-Breathing, Chris Dancy

Faculty Conference Papers and Presentations

How may controlled breathing be beneficial, or detrimental to behavior? Computational process models are useful to specify the potential mechanisms that lead to behavioral adaptation during different breathing exercises. We present a physio-cognitive model of slow breathing implemented within a hybrid cognitive architecture, ACT-R/Φ. Comparisons to data from an experiment indicate that the physiological mechanisms are operating in a manner that is consistent with actual human function. The presented computational model provides predictions of ways that controlled breathing interacts with mechanisms of arousal to mediate cognitive behavior. The increasing use of breathing techniques to counteract effects of stressors makes it …

Towards A Physio-Cognitive Model Of The Exploration Exploitation Trade-Off., David M. Schwartz, Christopher L. Dancy

Faculty Conference Papers and Presentations

Managing the exploration vs exploitation trade-off is an important part of our everyday lives. It occurs in minor decisions such as choosing what music to listen to as well as major decisions, such as picking a research direction to pursue. The dilemma is the same despite the context: does one exploit the environment, using current knowledge to acquire a satisfactory solution, or explore other options and potentially find a better answer. An accurate cognitive model must be able to handle this trade-off because of the importance it plays in our lives. We are developing physio-cognitive models to better understand how …

The Investigation Of Lactoferrin Nitration: Quantification, Function, And Inhibition, Amani Yahya Alhalwani

Electronic Theses and Dissertations

Lactoferrin (LF) is an iron-binding glycoprotein of molecular mass ca. 80 kDa that is predominantly found in mammalian body fluids. Lactoferrin is a multifunctional protein that has a wide range of properties such as antibacterial, antiviral, anti-inflammatory, and anti-allergic functions. Tyrosine residues in the protein play a part in many lactoferrin functions. Protein tyrosine nitration modification represents an oxidative and nitrosative stress process which can be caused by the exposure of proteins to oxidants from air pollution or disease. Understanding the way nitrated lactoferrin interacts with the biochemical environment of the body is thus important to the broader goal of …

Design And Development Of Simulation-Based Instruction On Meaningful Use And Interprofessionalism Core Competencies In A Healthcare Team-Based Learning Environment, Elizabeth Oviawe

CCAC Theses and Dissertations

Policymakers and electronic health records (EHR) experts agree that healthcare professionals lack proficiency in meaningful use of EHRs. This competency gap can result in increased medical errors. It is essential for health professions graduates to acquire skill sets that are adaptable to any electronic health information technologies including the EHRs to facilitate work process and information access. Simulation as an instructional method to create transformative learning experiences has shown promise in the medical profession. In simulations, learners are able to engage in real-life scenarios and practice their cognitive, affective, and psychomotor skills in a safe environment.

The goal was to …