Digital Commons Network^™

Cryptococcus Neoformans Serotype Groups Found In Clinical And Environmental Isolates, John Clauson

Masters Theses & Specialist Projects

Cryptococcus neoformans is an encapsulated yeast responsible for severe meningoencephalitis. The importance of epidemiological studies on cryptococcosis has increased since the beginning of the AIDS epidemic. C. neoformans exists in two varieties containing four serotypes, C. neoformans var. neoformans (serotypes A and D) and C. neoformans var. gattii (serotypes B and C). Locally C. neoformans var. neoformans has been associated with pigeon feces during those months having an average temperature of 64.2°F j(17.8°C) and above. Clinical and environmental isolates of C. neoformans obtained from regional hospitals and environmental samplings, respectively, have been grouped into their variety status utilizing canavanine-glycine-bromthymol blue …

Reasonable Children, Michael Pritchard

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society - May 19, 1993.

Common Elements In Interleukin 4 And Insulin Signaling Pathways In Factor-Dependent Hematopoietic Cells., Ling-Mei Wang, Achsah D. A D Keegan, Weiqun Li, Gustav E. Lienhard

Dartmouth Scholarship

Interleukin 4 (IL-4), insulin, and insulin-like growth factor I (IGF-I) efficiently induced DNA synthesis in the IL-3-dependent murine myeloid cell lines FDC-P1 and FDC-P2. Although these factors could not individually sustain long-term growth of these lines, a combination of IL-4 with either insulin or IGF-I did support continuous growth. The principal tyrosine-phosphorylated substrate observed in FDC cells stimulated with IL-4, previously designated 4PS, was of the same size (170 kDa) as the major substrate phosphorylated in response to insulin or IGF-I. These substrates had phosphopeptides of the same size when analyzed by digestion with Staphylococcus aureus V8 protease, and each …

Isokinetic Measurement Of Sagittal Plane Trunk Strength In Older Adults, Ralph L. Bidwell, Jill E. Thauvette, Patrick A. Townshend

Masters Theses

The purpose of this study was to collect normal flexion and extension trunk strength values for a population of individuals between the ages of 50 and 70 years of age. Twelve female and eight male volunteers in generally good health were tested in a seated position using a Biodex isokinetic dynamometer. Each performed five reciprocal maximal efforts of concentric flexion-extension cycles at the three isokinetic speeds of 60, 120 and 180{dollar}\sp\circ{dollar}/s. Raw and body weight adjusted data for peak torque and total work were analyzed. Results suggest strength decreases with age and that extension strength is greater than flexion strength. …

Ms211: Dbase For The Invitational Conference In Houston, Armin Weinberg

Works on Radiation Effects: 1990-2020

This appears to be the master database of the folks invited to our International Conference hosted by TMH, BCM, THMRF etc. in 1993? It is a treasure trove of those we initially invited from both Israel, Japan, former USSR (Russia, Ukraine, etc.) and of course USA! It has phone and institutional affiliations, flights, etc. See more at Armin Weinberg, PhD Papers and its finding aid.

Dentalgram - Vol. 07, No. 04, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• LLU on TV
• Student missions
• Student conduct
• AADS/IADR
• Faculty doings
• School song
• Library journals
• Women's study
• Sports season
• Welcome
• Congratulations
• Beach vespers
• "Flo" warning
• Appreciation corner
• In sympathy
• Birthdays

Relations Between Social Skills And High-Risk Sexual Interactions Among Adolescents, Douglas W. Nangle, David J. Hansen

Department of Psychology: Faculty Publications

Researchers have begun to employ social-skills training in efforts to change the sexual behavior of adolescents. However, despite the promise of social-skills training, little is known about how social skills are related to the sexual practices of adolescents. The present article reviews the current literature and proposes a conceptual framework for understanding the relations between social skills and sexual behavior of adolescents by (a)examining the relationship between sexual activity and social skills, (b) examining the development of sexual-interaction skills and deficits, (c) summarizing what is currently known about the relations between social skills and sexual behavior, (d) discussing current issues …

Sequence Specificity Of The Core-Binding Factor, Irena N. Melnikova, Barbara E. Crute, Shuwen Wang, Nancy A. Speck

Dartmouth Scholarship

The core-binding factor (CBF) binds the conserved core motif in mammalian type C retrovirus enhancers. We analyzed the phosphate contacts made by CBF on the Moloney murine leukemia virus enhancer by ethylation interference assay. The phosphate contacts span 9 bp centered around the consensus core site. To examine the sequence preferences for CBF binding, we employed the technique of selected and amplified binding sequence footprinting (T. K. Blackwell and H. Weintraub, Science 250:1104-1110, 1990). The consensus binding site for CBF defined by selected and amplified binding sequence footprinting is PyGPyG GTPy.

Correlates And Infant Mortality: Sudden Infant Death Syndrome Among Black Women In The United States, Paulette Aubrey

Masters Theses

Often referred to as "cot death" or "crib death," sudden infant death syndrome (SIDS) is the single leading cause of infant death in infants aged 28 days to 1 year of life. Although the exact etiology of SIDS remains unknown, epidemiological studies have identified risk factors associated with higher rates of SIDS. In this study, the relationship between sudden infant death syndrome and maternal education among black women who gave birth in the United States during 1983 was examined.

The population for this study consisted of black infants who were born in 1983 and died before their first birthday. Among …

Characterization Of A Protein That Binds Multiple Sequences In Mammalian Type C Retrovirus Enhancers., Wanwen Sun, Mary M. O'Connell, Nancy A. Speck

Dartmouth Scholarship

Mammalian type C retrovirus enhancer factor 1 (MCREF-1) is a nuclear protein that binds several directly repeated sequences (CNGGN6CNGG) in the Moloney and Friend murine leukemia virus (MLV) enhancers (N. R. Manley, M. O'Connell, W. Sun, N. A. Speck, and N. Hopkins, J. Virol. 67:1967-1975, 1993). In this paper, we describe the partial purification of MCREF-1 from calf thymus nuclei and further characterize the binding properties of MCREF-1. MCREF-1 binds four sites in the Moloney MLV enhancer and three sites in the Friend MLV enhancer. Ethylation interference analysis suggests that the MCREF-1 binding site spans two adjacent minor grooves of …

Isolation Of Interleukin 2-Induced Immediate-Early Genes., Carol Beadling, Kirk W. Johnson, Kendall A. Smith

Dartmouth Scholarship

Clonal expansion of antigen-reactive T lymphocytes is driven by the lymphokine interleukin 2 (IL-2). To further elucidate the mechanisms of IL-2 action, we have utilized a differential hybridization procedure to clone IL-2-induced immediate-early genes from an IL-2-stimulated human T-cell cDNA library. To increase the frequency of IL-2-induced transcripts represented in the library, the protein synthesis inhibitor cycloheximide was included during the 2-hr IL-2 stimulation to superinduce gene expression, and the uridine analogue 4-thiouridine was utilized to enable selective purification of newly synthesized transcripts. From the enriched library, we have isolated eight IL-2-induced genes, six of which represent previously unrecognized human …

Jefferson Alumni Bulletin – Volume Xlii, Number 3, Spring 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLII, Number 3, Spring 1993

Genetic factors behind behavioral disorder are at the center of department research, page 2

Baldwin L. Keyes, ’17: A career through many countries, battles, and specialties, page 5

Baldwin L. Keyes, ’17: A chairman who taught by personal example, page 7

Committee provides guidance on ethical issues that underlie clinical cases, page 9

John E. Deitrick, M.D.: Early appraiser of medical education, page 12

Scientists link nitric oxide to brain damage in neurologic viral diseases, page 14

Study shows Jefferson succeeds in training rural physicians, page 15

Students help organize …

Can An Anesthesia Machine Flush Valve Provide For Effective Jet Ventilation?, S D Gaughan, J L Benumof, G T Ozaki

Faculty, Staff and Student Publications

Transtracheal jet ventilation (TTJV) using a percutaneously inserted intravenous (IV) catheter for the patient who cannot be ventilated or tracheally intubated or, using a jet stylet for changing endotracheal tubes (ETT) in patients for whom subsequent ventilation and/or tracheal reintubation may be difficult, are extremely valuable therapeutic options. The jet ventilation system must have a sufficiently high pressure-oxygen source to drive oxygen through noncompliant tubing and through relatively small IV catheters and/or jet stylets in order to achieve adequate ventilation and oxygenation. There is no evidence that using the common gas outlet of an anesthesia machine by activating the flush …

A Multiple Case Study Of Selected Individuals Who Facilitate The Successful Adoption Of Environmental Public Policy, John H. Austin

Health Services Research Dissertations

The purpose of this study was to determine the personal and professional characteristics of successful individuals who have had a positive influence on the development of public policy concerning the environment. Additionally, which characteristics are most likely to enhance success and determine which of these characteristics might contribute to efforts toward developing public environmental policy in the future were investigated. The purpose was accomplished through the design and implementation of a multiple case study utilizing a qualitative research methodology. The sample for this study included six public servants who were identified as actively involved in affecting the development of public …

Separation And Quantification Of Queuine-Modified And Unmodified Transfer Rna Isoacceptors, Jorge Miguel Pereira De Oliveira Da Silva Santos

Chemistry & Biochemistry Theses & Dissertations

The discovery of a base-exchange modification in the first position of the anticodon of four transfer RNA (tRNA) isoacceptor families has been shown to be correlated with a decrease in the rate of cell division in several tumorigenic tissues. This fact led to the hypothesis that wobbling in the anticodon might be a control point wich mediates the rate of translation. A suitable method for separation of different tRNA isoacceptor families had to be created in order to generate a means for quantitatively measuring degrees of this base modification in tRNA. Radio labelled amino acids were used to charge tRNA …

Longitudinal Study Of Plasma And Erythrocyte Selenium Levels In Type I Diabetic Children During Development And Treatment Of Ketoacidosis, Pi-Hsia Fan

Chemistry & Biochemistry Theses & Dissertations

Most studies on the biological activity of selenium have focused on its role at the active site in the ubiquitous enzyme, glutathione peroxidase (GSH-Px) which catalyzes the removal of hydrogen peroxide and organic hydroperoxides (1). A connection between selenium deficiency and a wide range of diseases in animals and humans has been reviewed (2). Development of various forms of human cancer (3), failure of the immune system (4), as well as some cardiovascular diseases (5) have been reported or suspected to correlate with selenium deficiency. However, the physiological function of selenium in these different diseases is not fully understood, and …

Competitive Enzyme Immunoassay By Polyclonal Antibodies Against Organophosphorus Pesticides, Kuo-Lan Wen

Theses and Dissertations in Biomedical Sciences

Organophosphorus compounds (OPs) comprise one of the major classes of pesticides in use today because they are highly effective and less toxic. Because of their extensive use, there is a need for monitoring OPs in water and vegetables. Gas chromatography (GC) is the usual method for OPs screening, but it is time-consuming and has the high cost of instrumentation. The goal of this project was to find an easy method which was sensitive and had less instrumentation required to test OPs.

Microwells and microtubes were utilized as the solid-phase immobilization for the development of an enzyme immunoassay for OPs. A …

Ohio Academy Of Medical History Annual Meeting Program, March 27, 1993, Ohio Academy Of Medical History

Annual Conference Programs

This one page program is from the annual meeting of the Ohio Academy of Medical History held on March 27, 1993. The program details the events and presentations of the meeting.

Dentalgram - Vol. 07, No. 03, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• DH phonathon
• New periodontic screening
• School With a Heart
• Table clinic winners
• Student fellowships
• Boards, Part II
• Mission trips
• Student representatives
• Faculty doing
• Accreditation visit
• Retirement planned
• Clinic productivity
• Research profile
• Strategic planning
• Office supplies
• Appreciation
• In sympathy

The Tight Skin Mouse: Demonstration Of Mutant Fibrillin-1 Production And Assembly Into Abnormal Microfibrils, Cay M. Kielty, Michael Raghunath, Linda D. Siracusa, Michael J. Sherratt, Reiner Peters, C. Adrian Shuttleworth, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

Mice carrying the Tight skin (Tsk) mutation harbor a genomic duplication within the fibrillin-1 (Fbn 1) gene that results in a larger than normal in-frame Fbn 1 transcript. In this study, the consequences of the Tsk mutation for fibrillin-containing microfibrils have been examined. Dermal fibroblasts from Tsk/+ mice synthesized and secreted both normal fibrillin (approximately 330 kD) and the mutant oversized Tsk fibrillin-1 (approximately 450 kD) in comparable amounts, and Tsk fibrillin-1 was stably incorporated into cell layers. Immunohistochemical and ultrastructural analyses of normal and Tsk/+ mouse skin highlighted differences in the gross organization and distribution of microfibrillar arrays. Rotary …

Update - March 1993, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Loma Linda offers Masters of Arts in Biomedical and Clinical Ethics and assists Claremont with Theological degree

[ Depo-Provera: Contraceptive Dream or Nightmare? ]
-- A Gynecologist's Perspective
-- Some Catholic Moral Reflections

-- Doctor of Philosophy at Claremont

Extending Continuous Versus Discontinuous Conditioned Stimuli Before Versus After Unconditioned Stimuli, Melody Albert, Sean Ricker, Rick A. Bevins, John J.B. Ayres

Department of Psychology: Faculty Publications

Conditioned suppression was used with rats to study the effects of extending conditioned stimuli (CSs) before versus after the delivery of unconditioned stimuli. These extensions are termed B and A extensions, respectively. Within-group designs were used to compare the effects of extending CSs when 2-min parts of those CSs were separated by temporal gaps of 6 min versus a separation of no gap. The results were as follows: (a) B extensions weakened conditioning more than did A extensions, with or without gaps; (b) under some conditions, this asymmetrical effect persisted with extended training; (c) gaps between 2-min parts of a …

Temperature Dependent Coordination Effects In Base-Off Adenosyl And Methylcobalamin By X-Ray Edge Spectroscopy, Mark R. Chance

Faculty Scholarship

Examination of the role of base-off cobalamin species (where the 5,6-dimethylbenzimidazole ligand coordinated to cobalt is detached by protonation of the imidazole nitrogen) in differentiation between homolytic and heterolytic cobalt-carbon bond cleavage mechanisms is a primary step in better understanding B12-dependent enzyme catalysis. X-ray absorption edge spectroscopy provides the first direct structural evidence of five-coordination in base-off adenosyl- and base-off methylcobalamin complexes at room temperature. Integration of 1s-3d pre-edge transitions of the base-off species reveals the dependence of coordination number on temperature. Gradual increases in 1s-3d transition intensities, as the temperature is increased from 180 K to 298 K, reflect …

A Common Mechanism For Influenza Virus Fusion Activity And Inactivation, João Ramalho-Santos, Shlomo Nir, Nejat Düzgüneş, Arsélio Pato De Carvalho, Maria Conceição Pedroso De Lima

All Dugoni School of Dentistry Faculty Articles

The fusion of influenza virus (A/PR/8/34 strain) with PC-12 cells was monitored by a fluorescence assay, and the results were analyzed with a mass-action model which could explain and predict the kinetics of fusion. The model accounted explicitly for the reduction in the fusion rate constant upon exposure of the virus to low pH, either for the virus alone in suspension or for the virus bound to the cells. When the pH was lowered without previous viral attachment to cells, an optimal fusion activity was detected at pH 5.2. When the virus was prebound to the cells, however, reduction of …

Treat It Right : Alternative Wastewater Systems That Protect Water Quality, Brian Kent

Maine Collection

Treat It Right : Alternative Wastewater Systems That Protect Water Quality

Maine Dept. of Environmental Protection : Maine Dept. of Economic & Community Development, February 1993.

"This handbook was prepared by Maine Tomorrow, a consulting firm in Hallowell. Maine. The handbook was researched, written and designed by Brian Kent; the primary editor and research associate was Alison Truesdale, and Wendy Mahoney did the wordprocessing and desk-top printing."

Long-Term Consequences Of Childhood Physical Abuse, Robin Malinosky-Rummell, David J. Hansen

Department of Psychology: Faculty Publications

This article reviews the literature on the long-term consequences of childhood physical abuse. Empirical research is discussed within 7 topic areas: aggressive and violent behavior, nonviolent criminal behavior, substance abuse, self-injurious and suicidal behavior, emotional problems, interpersonal problems, and academic and vocational difficulties. The studies reviewed involve primarily adult populations, although pertinent findings from literature on children and adolescents are briefly summarized. Some variables that affect the relation between physical abuse and long-term consequences are examined. These moderator variables include maltreatment characteristics, individual factors, family factors, and environmental factors. The article ends with suggestions for future research on long-term consequences …

What's Happening: January 13, 1993, Maine Medical Center

What's Happening

No abstract provided.

Dentos 1993, Chicago College Of Dental Surgery

Chicago College of Dental Surgery Yearbooks

No abstract provided.

Health Care Information Systems Management: Structure And Infrastructure, Binshan Lin

Journal of International Information Management

The practice of medicine is inextricably entwined with the management of health care information system (HCIS). Major problems with HCIS are that it has not evolved from the needs of end users, and lacks of an organizational base^ to manage the HCIS in the health care environment. The object of this paper is to examine a direction to effectively support and enhance the health care activities through managing HCIS. An integrated focus is provided through a framework for analyzing the structure and infrastructure of HCIS in hospitals.

Articulations 1993, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj

Yearbooks

University of Medicine and Dentistry of New Jersey (UMDNJ) School of Osteopathic Medicine yearbook for the class of 1993. 104 pages.

Contents: Osteopathic Oath p.1, UMDNJ-SOM Campus p. 2, University Affiliated Medical Centers p. 5, Dean's Message p. 6, Administration/Faculty/Staff p. 7, Class of 1993...A Look Back p. 17, Class Photo p. 32, Graduates p. 33, Class Trip p. 83, Convocation p. 87, Commencement p. 91, Directory p. 95.