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Effects Of Shift Work On Insulin Dependent Diabetics, Rebecca D. Blount

MSN Research Projects

Over 25% of the work force is comprised of insulin-dependent diabetics. The purpose of this descriptive study was to determine the impact of shift work on blood sugar levels in insulin-dependent diabetics. Rogers' Theory of Homeodynamics was the conceptual framework guiding the study. The research question was does rotating shift work have an impact on blood sugar levels in insulin-dependent diabetics. The total sample (N = 40) was selected from 100 insulin-dependent diabetics who work at an industrial plant in midwestern Alabama. Thirty insulin-dependent diabetics who were working rotating shifts and 10 insulin-dependent diabetics who worked regular day shift were …

Bulletin - Summer, 1993, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A sixteen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Simian Immunodeficiency Virus Mutants Resistant To Serum Neutralization Arise During Persistent Infection Of Rhesus Monkeys, Dawn P. Wooley, Catherine Collignon, Ronald C. Desrosiers

Neuroscience, Cell Biology & Physiology Faculty Publications

We previously described the pattern of sequence variation in gp120 following persistent infection of rhesus monkeys with the pathogenic simian immunodeficiency virus SIVmac239 molecular clone (D.P.W. Burns and R.C. Desrosiers, J. Virol. 65:1843, 1991). Sequence changes were confined largely to five variable regions (V1 to V5), four of which correspond to human immunodeficiency virus type 1 (HIV-1) gp120 variable regions. Remarkably, 182 of 186 nucleotide substitutions that were documented in these variable regions resulted in amino acid changes. This is an extremely nonrandom pattern, which suggests selective pressure driving amino acid changes in discrete variable domains. In the present study, …

Interleukin 1-Beta In Symptomatic And Asymptomatic Human Periradicular Lesions, Gerald C. Lim

Loma Linda University Electronic Theses, Dissertations & Projects

Interleukin 1-Beta has been shown to be a potent mediator of bone resorption and has been implicated in resorption in periradicular lesions. In this study we compared the local concentrations of IL-1β in symptomatic and asymptomatic human periradicular lesions. Periradicular tissues from patients with symptomatic and asymptomatic lesions were obtained and stored at -70°C. Pulpal tissues from unerupted third molars and chronically inflamed gingival tissues were also obtained and used as negative and positive controls, respectively. Tissue samples were homogenized, and supernatants were assayed for IL-1β by ELISA. Significantly higher levels of IL-1β were found in symptomatic and asymptomatic lesions …

Increased Collagen-Linked Pentosidine Levels And Advanced Glycosylation End Products In Early Diabetic Nephropathy, Paul J. Beisswenger, Lynn L. Moore, Truls Brinck-Johnsen, Thomas J. Curphey

Dartmouth Scholarship

RATIONALE: Advanced glycosylation end products (AGEs) may play an important role in the development of diabetic vascular sequelae. An AGE cross-link, pentosidine, is a sensitive and specific marker for tissue levels of AGEs. OBJECTIVES: To evaluate the role of AGEs in the development of diabetic nephropathy and retinopathy, we studied pentosidine levels and the clinical characteristics of 48 subjects with insulin-dependent diabetes mellitus. Diabetic nephropathy was classified as normal, microalbuminuria, or gross proteinuria, and retinopathy was graded as none, background, or proliferative. NEWLY OBSERVED FINDINGS: Significant elevation of pentosidine (P = 0.025) was found in subjects with microalbuminuria or gross …

A Curriculum Based On Systems Theory., Ruth L. Schemm, Mary Corcoran, Ellen Kolodner, Roseann C Schaaf

Department of Occupational Therapy Faculty Papers

This paper describes an entry-level curriculum based on systems theory that was designed to promote integrated thinking and a shared image of practice among all of the members of an educational community that included students, faculty, and clinicians. Initiated in 1983, the program integrates occupational therapy theory, critical thinking, and knowledge about person-environmental transactions with traditional medical, biological, psychological, and sociological course work to create a unique educational experience. The curriculum model is based on a spiral learning process that encourages integrated thinking. Furthermore, all concepts are systematically tied to the occupation core, the central theme of the program. Fieldwork …

The Legal Significance Of Gestation, Larry I. Palmer

Faculty Publications

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlii, Number 4, Summer 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLII, Number 4, Summer 1993

The development of surgery for heart disease, page 6

Refining the heart-lung machine, page 9

Training surgical residents, page 10

Counseling in family medicine, page 10

Volunteer care in Swaziland, page 10

Paleoradiology of the prehistoric Australian aborigines, page 11

Vaccine therapy of melanoma, page 12

Biliary radiology and T tube design, page 13

Familial patterns of ovarian carcinoma, page 15

The importance of treating diabetic retinopathy, page 16

Investigators identify key protein causing heart muscle damage after heart attack, page 18

Croce wins Mott Prize, page 19

Westermark given …

Attitudes Of Nursing Personnel Toward Behaviors Of Cognitively Impaired Elders In Long-Term Care Facilities, Janice M. Cooper

MSN Research Projects

The purpose of this descriptive study was to explore the attitudes of nursing personnel toward the behaviors of cognitively impaired elders in L.T.C.F.'s in a rural southeastern state.

The Isolation And Identification Of Polyphenolics From Grape Seeds And Their Activity Towards Specific Cell Lines, Joseph A. Reddy

Chemistry & Biochemistry Theses & Dissertations

Grape seed extract is being marketed in France for cardiovascular use and skin care. The active constituents of both these drugs are certain polyphenols called procyanidins. A similar seed extract has now been obtained from Virginia Chardonnay grape seeds. Ten of the major components in this extract have been isolated in their pure form by the semi-preparative HPLC separation on a YMC ODS-AQ (Octadecylsilane-AQ) column. The ODS-Aq column has been shown to have a better resolving capacity compared to the Spherisorb ODS (Octadecylsilane) column previously described in the literature. This has been attributed to the ODSAQ support which has both …

Evaluation Of The Gross Anatomy Seasonal Changes Function And Histology Of The Perineal Gland In The Hispid Cotton Rat, Sigmodon Hispidus, Julie Anne Winchell

Biological Sciences Theses & Dissertations

The perinea! gland in the hispid cotton rat, Sigmodon hispidus, is a seasonally cyclic, subcutaneously located organ which is associated with the reproductive system. On gross dissection, the gland possesses a strong attachment to the penis with only loose fascia! connections to the rectum and surrounding muscle and skin. Histologic exam confirms this connection to the reproductive tract and shows the organ to be a compound tubuloacinar gland with a projection leading into the penis. The cyclic hypertrophy and regression of the gland closely parallels that of the testes and seminal vesicles indicating that this cyclicity may be under …

Department Of Radiology-Annual Report-July 1, 1992 To June 30, 1993, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1992 to June 30, 1993. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 85 pages.

On The Relative Importance Of Floral Color, Shape, And Nectar Rewards In Attracting Pollinators To Mimulus, Steven D. Sutherland, Robert K. Vickery Jr.

Great Basin Naturalist

Pollinator preferences were observed for the six species of section Erythranthe of the genus Mimulus using greenhouse-grown plants placed in a meadow in the Red Butte Canyon Natural Area, Salt Lake County, Utah. The principal pollinators were hummingbirds and bumble bees. Hummingbirds preferred the species with the most reflexed tubular flowers regardless of color, whereas bumblebees preferred pink. lavender, or yellow flowers to red flowers regardless of shape. Results for the six species were confirmed by observations of F₂ hybrid recombinant plants selected such that flower color could be held constant and flower shape varied and vice versa.

Dentalgram - Vol. 07, No. 06, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Senior pictures
• Admin appointments
• Reflections
• IDP banquet
• Ortho congratulations
• CDA winners
• Farewell to seniors
• Honors convocation
• Free tuition money
• DFF schedule
• Student conduct
• Graduation stats
• Faculty doings
• SB Sun reprint
• Rideshare winner
• Patients may donate
• Hygiene farewell
• Parking lot sale
• Lost & found
• ...and more

Toxics Use Reduction: Pro And Con, Francine Laden, George M. Gray

RISK: Health, Safety & Environment (1990-2002)

With the Massachusetts Toxics Use Reduction Act as an example, important issues related to the goals and effectiveness of TUR are examined. The benefits as claimed by proponents are contrasted with shortcomings outlined by opponents in point-counterpoint style. Ultimately, the authors call for more balanced analysis.

Helping To Harm? The Ethical Dilemmas Of Managing Politically Sensitive Data, Sylvie C. Tourigny

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society - March 19, 1993.

Update - June 1993, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Gerald Winslow to succeed Wil Alexander as Religion Dean and Ethics Chair; Ivan Blazen to teach scripture and ethics
-- Quality-of-Life Is Not a Dirty Word

[ How Secret Should a Patient's Secrets Be? ]
-- Duties to Warn and Reasons for Reticence
-- A Legal Perspective

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1993), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1993 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective: Hospitals’ Sale Signals New Beginnings
• DO/MBA Program: Higher Degrees of Health Care
• Commencement ‘93
• A Glimpse of the Cass of 1993
• Bulletin Board
• Class Acts
• Readership Survey
• Coming Events

Early Adolescent Family Formation, Lisa J. Crockett

Department of Psychology: Faculty Publications

In the United States, adolescent family formation has been considered a major social problem since the late 1970s. The sources of concern are multiple. First, teenage childbearing is associated with risks for the mother and her child, including health problems, reduced life chances, and a greater likelihood of living in poverty. Second, a large and increasing proportion of births to teenagers are nonmarital; this appears to compound these risks. Third, the rate of teenage childbearing in the United States far exceeds those in other Western, industrialized countries (Alan Guttmacher Institute, 1986). The high rate of adolescent pregnancy in the United …

Cloning And Characterization Of Subunits Of The T-Cell Receptor And Murine Leukemia Virus Enhancer Core-Binding Factor., Shuwen Wang, Qing Wang, Barbara E. Crute, Irena N. Melnikova, Susanna R. Keller, Nancy A. Speck

Dartmouth Scholarship

Moloney murine leukemia virus causes thymic leukemias when injected into newborn mice. A major determinant of the thymic disease specificity of Moloney virus genetically maps to the conserved viral core motif in the Moloney virus enhancer. Point mutations introduced into the core site significantly shifted the disease specificity of the Moloney virus from thymic leukemia to erythroid leukemia (N.A. Speck, B. Renjifo, E. Golemis, T.N. Fredrickson, J.W. Hartley, and N. Hopkins, Genes Dev. 4:233-242, 1990). We previously reported the purification of core-binding factors (CBF) from calf thymus nuclei (S. Wang and N.A. Speck, Mol. Cell. Biol. 12:89-102, 1992). CBF binds …

Lithium Phthalocyanine: A Probe For Electron Paramagnetic Resonance Oximetry In Viable Biological Systems., K. J. Liu, P. Gast, M. Moussavi, S. W. Norby, N Vahidi, T Walczak

Dartmouth Scholarship

Lithium phthalocyanine (LiPc) is a prototype of another generation of synthetic, metallic-organic, paramagnetic crystallites that appear very useful for in vitro and in vivo electron paramagnetic resonance oximetry. The peak-to-peak line width of the electron paramagnetic resonance spectrum of LiPc is a linear function of the partial pressure of oxygen (pO2); this linear relation is independent of the medium surrounding the LiPc. It has an extremely exchange-narrowed spectrum (peak-to-peak line width = 14 mG in the absence of O2). Physicochemically LiPc is very stable; its response to pO2 does not change with conditions and environments (e.g., pH, temperature, redox conditions) …

Commencement Program 1993, Loma Linda University

Commencement Programs

CONTENTS

2 | 1993 Events of Commencement

3 | Academic Procession

4 | The Speakers

7 | The Honorees

11 | The Zapara Award

Order of Program

• School of Medicine, 14
• School of Dentistry, 21
• Graduate School, 29
• School of Nursing, 37
• School of Public Health, 41
• School of Allied Health Professions, 48

Aggressive Angiomyxoma Of Vulva, Farrukh Aijaz, Shahid Pervez, Shehnaz Wasti, Sheema H. Hassan

Department of Pathology and Laboratory Medicine

No abstract provided.

Suppressive Effects Of Transforming Factor-Β And Interleukin-10 On The Cytolytic Activity Of Murine Macrophages And Reversal By Cytokines, Chin-Hung Lin

Loma Linda University Electronic Theses, Dissertations & Projects

In this study, the suppressive effects of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) on peritoneal macrophage killing of H238 target cells and the potential for reversal of the immunosuppressive effect by IL-4 and interferon-γ (IFN-γ) were investigated. The responsiveness of naive and peptone-activated macrophages was compared. The cytolytic activity for tumor cells of these effector cells was measured by percent lysis of ³H-thymidine labeled Herpes simplex virus type 2-transformed tumor cells (H238). After 18-24 hours of incubation with TGF-β or IL-10, the cytolytic activity of macro-medium alone. The immunosuppressive effect of TGF-β or IL-10 on non-activated macrophages was …

Thymic Peptide Modulates Glutathione Redox Cycle And Antioxidant Enzymes In Macrophages, Choon Sil Park

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of a 6-kDa thymic peptide (TP) on the oxidative burst of a murine macrophage cell line J774 was determined. TP (12.5-200 μg/ml) was incubated with 5 x 10⁵ J774 cells at 37° C and 5% C0₂ for 18 h and oxidative burst was triggered by zymosan; chemiluminescence was amplified by luminol and measured in an automated luminometer. TP exhibited a concentration-dependent inhibition of oxidative burst. To study the mechanisms involved in TP’s inhibition of oxidative burst, its effect on the glutathione (GSH) redox cycle, GSH biosynthesis, and antioxidant enzymes was investigated. TP was shown to increase …

Book Review, Bradley J. Olson

RISK: Health, Safety & Environment (1990-2002)

Review of: JOHN HARRIS, WONDERWOMAN AND SUPERMAN: THE ETHICS OF HUMAN BIOTECHNOLOGY. (Oxford University Press 1992) [271 pp.] Acknowledgements, further reading, index, introduction, notes. LC 91-23939; ISBN 0-19-2177540-0. [$22.95 cloth. 200 Madison Avenue; New York NY 10016.]

Immunocompromise In Gnotobiotic Pigs Induced By Verotoxin-Producing Escherichia Coli (O111:Nm), Jane Christopher-Hennings, Joann A. Willgohs, David H. Francis, Usha A. K. Raman, Rodney A. Moxley, David J. Hurley

School of Veterinary and Biomedical Sciences: Faculty Publications

A verotoxin-producing Escherichia coli serotype O111:NM strain (strain 10049; verotoxin 1 positive) persistently infected experimentally inoculated gnotobiotic pigs, causing attaching-effacing intestinal lesions and chronic diarrhea. Experiments were performed to determine whether persistent infection might be associated with immunocompromise of the host by this organism. Pigs inoculated with this strain had a significant reduction in peripheral blood lymphocytes and lower antibody titers to sheep erythrocytes compared with control pigs. Compared with pigs given a verotoxin-negative pathogenic strain of the same serotype (O111:NM, strain 2430), pigs inoculated with the verotoxin-positive strain had lower peripheral lymphocyte counts and proliferative responses to concanavalin A, …

Sequencing Of Cdna From 50 Unrelated Patients Reveals That Mutations In The Triple-Helical Domain Of Type Iii Procollagen Are An Infrequent Cause Of Aortic Aneurysms., Gerard Tromp, Yuli Wu, Darwin J. Prockop, Swarna L. Madhatheri, Caren Kleinert, James J. Earley, Jiapiao Zhuang, Orjan Norrgård, R. Clement Darling, William M. Abbott, C. William Cole, Pekka Jaakkola, Markku Ryynanen, William H. Pearce, James S.T. Yao, Kari Majamaa, Stanton N. Smullens, Zoran Gatalica, Robert E. Ferrell, Sergio A. Jimenez, Charles E. Jackson, Virginia V. Michels, Michael Kaye, Helena Kuivaniemi

Department of Biochemistry and Molecular Biology Faculty Papers

Detailed DNA sequencing of the triple-helical domain of type III procollagen was carried out on cDNA prepared from 54 patients with aortic aneurysms. The 43 male and 11 female patients originated from 50 different families and five different nationalities. 43 patients had at least one additional blood relative who had aneurysms. Five overlapping asymmetric PCR products, covering all the coding sequences of the triple-helical domain of type III procollagen, were sequenced with 28 specific sequencing primers. Analysis of the sequencing gels revealed only two nucleotide changes that altered the structure of the protein. One was a substitution of threonine for …

Proto-Oncogenes Of Genomic Dna In Normal Thai Domestic Animal, Achariya Sailasuta, Ted Tesaprateep, Boonmee Sunyasootcharee, Susumu Tateyama, Ryoji Yamaguchi, Dai Nosaka, Noriaki Miyoshi

The Thai Journal of Veterinary Medicine

The proto-oncogenes homologous to the c-myc, c-ros-1, c-yes-1, and v-Ki-ras oncogenes of genomic DNAs in buffaloes, dogs, cats and ducks were investigated with Southern blot hybridization. High molecular-weight-genomic DNAs in each of the animals animals contained proto-oncogenes showing more than 65% homology of the proto-oncogenes differed in both number and approximate molecular weight: i.e. one or two bands at 1.6 to 18.0 kilobase (kb) in the c-myc probe, one band at 1.1 to 15.0 kb in the c-ros-1 probe, one to five bands at 0.3 to 18.0 kb in the c-yes-1 probe, and one to five bands at 1.6 to …

Laboratory Health And Safety Compliance Guide For Private Colleges And Universities, Gina Marie Ochs

Theses

Academic laboratories are presented with the unique challenge of ensuring the health and safety of all people involved in daily activities. The Occupational Safety and Health Administration (OSHA) recently enacted the regulation 29 CFR 1910.1450, "Occupational Exposure to Hazardous Chemicals in Laboratories," which applies to all private employers (including colleges and universities). In this work, a guide is developed to assist private colleges and universities comply with applicable governmental regulations and to ensure the health and safety of all individuals involved with laboratory activities.

Academic laboratories warrant special consideration because of the nature of experimentation (variation in research and classroom …