Digital Commons Network^™

Expression Pattern And Regulation Of Genes Differ Between Fibroblasts Of Adhesion And Normal Human Peritoneum, Ujjwal K. Rout, Ghassan M. Saed, Michael P. Diamond

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Injury to the peritoneum during surgery is followed by a healing process that frequently results in the attachment of adjacent organs by a fibrous mass, referred commonly as adhesions. Because injuries to the peritoneum during surgery are inevitable, it is imperative that we understand the mechanisms of adhesion formation to prevent its occurrence. This requires thorough understanding of the molecular sequence that results in the attachment of injured peritoneum and the development of fibrous tissue. Recent data show that fibroblasts from the injured peritoneum may play a critical role in the formation of adhesion tissues. Therefore, identifying changes …

The Relationships Between Depression And Other Outcomes Of Chronic Illness Caregiving, Pao-Feng Tsai, Mary M. Jirovec

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Many caregivers with chronically ill relatives suffer from depression. However, the relationship of depression to other outcomes of chronic caregiving remains unclear. This study tested a hypothesized model which proposed that hours of care, stressful life events, social support, age and gender would predict caregivers' outcomes through perceived caregiver stress. Depression was expected to mediate the relationship between perceived stress and outcomes of chronic caregiving (physical function, self-esteem, and marital satisfaction).

Methods

The sample for this secondary data analysis consisted of 236 and 271 subjects from the Americans' Changing Lives, Wave 1, 1986, and Wave 2, 1989, data …

Sequential Super-Stereotypy Of An Instinctive Fixed Action Pattern In Hyper-Dopaminergic Mutant Mice: A Model Of Obsessive Compulsive Disorder And Tourette's, Kent C. Berridge, J Wayne Aldridge, Kimberly R. Houchard, Xiaoxi Zhuang

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Excessive sequential stereotypy of behavioral patterns (sequential super-stereotypy) in Tourette's syndrome and obsessive compulsive disorder (OCD) is thought to involve dysfunction in nigrostriatal dopamine systems. In sequential super-stereotypy, patients become trapped in overly rigid sequential patterns of action, language, or thought. Some instinctive behavioral patterns of animals, such as the syntactic grooming chain pattern of rodents, have sufficiently complex and stereotyped serial structure to detect potential production of overly-rigid sequential patterns. A syntactic grooming chain is a fixed action pattern that serially links up to 25 grooming movements into 4 predictable phases that follow 1 syntactic rule. New …

A Randomized, Controlled Trial Of In-Home Drinking Water Intervention To Reduce Gastrointestinal Illness, John M. Colford, Timothy J. Wade, Sukhminder K. Sandhu, Catherine C. Wright, Sherline Lee, Susan Shaw, Kim Fox, Susan Burns, Anne Benker, M. Alan Brookhart, Mark Van Der Laan, Deborah A. Levy

Journal Articles: Epidemiology

Trials have provided conflicting estimates of the risk of gastrointestinal illness attributable to tap water. To estimate this risk in an Iowa community with a well-run water utility with microbiologically challenged source water, the authors of this 2000-2002 study randomly assigned blinded volunteers to use externally identical devices (active device: 227 households with 646 persons; sham device: 229 households with 650 persons) for 6 months (cycle A). Each group then switched to the opposite device for 6 months (cycle B). The active device contained a 1-microm absolute ceramic filter and used ultraviolet light. Episodes of "highly credible gastrointestinal illness," a …

Effect Of Genetic Variation On The Formation Of Hepatocarcinogenic Metabolites Of Trichloroethylene Using Chloral Hydrate Studies (An Interdisciplinary Approach), Apryl Bronley-Delancey

MUSC Theses and Dissertations

Trichloroethylene (TCE) is listed with the EPA as a suspected human carcinogen and is ubiquitous in the environment (US EPA 1992). Chloral hydrate (CH) is a sedative drug and a cytochrome P450 (CYP 450)-derived metabolite of TCE (Klaassen 2001). Chloral hydrate is metabolized in the liver to the rodent hepatocarcinogen trichloroacetate (TCA) by aldehyde dehydrogenase (ALDH), and to the non-carcinogenic metabolite trichloroethanol (TCEOH) by alcohol dehydrogenase (ADH) (Klaassen 2001). Both ALDH and ADH are polymorphic in humans which can presumably predict the disposition of chloral hydrate into the carcinogenic vs. non-carcinogenic pathways. The likelihood is then raised that subpopulations of …

What Is The Safety And Efficacy Of Biobrane Versus Silver Sulfadiazine In The Treatment Of Low Body Surface Area Partial-Thickness Burns?, Gregory Wanner

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: To determine how the synthetic skin substitute Biobrane compares to silver sulfadiazine (SSD, silvadine) in the treatment of patients with low body surface area partial thickness burns.

Relationship Between Parent Satisfaction Regarding Partnerships With Professionals And Age Of Child, Jean Ann Summers, Lesa Hoffman, Janet Marquis, Ann Turnbull, Denise Poston

Department of Psychology: Faculty Publications

In the past, the assessment of families’ satisfaction with the quality of their partnerships with the professionals who serve their children has been restricted to specific programs or age groups, precluding investigation of the relationship between parents’ perspectives on satisfaction and the importance of partnership components for children at different ages. Differences in policies, service models, and family needs at different life-cycle stages suggest a need to understand how satisfaction might differ among parents of children of different ages. In this study, 147 parents completed the Beach Center Family-Professional Partnership Scale to describe the perceived importance of and satisfaction with …

Vertebrate Gld2 Poly(A) Polymerases In The Germline And The Brain, Labib Rouhana, Liaoteng Wang, Natascha Buter, Jae Eun Kwak, Craig A. Schiltz, Tania Gonzalez, Ann E. Kelley, Charles F. Landry, Marvin Wickens

Biological Sciences Faculty Publications

Cytoplasmic polyadenylation is important in the control of mRNA stability and translation, and for early animal development and synaptic plasticity. Here, we focus on vertebrate poly(A) polymerases that are members of the recently described GLD2 family. We identify and characterize two closely related GLD2 proteins in Xenopus oocytes, and show that they possess PAP activity in vivo and in vitro and that they bind known polyadenylation factors and mRNAs known to receive poly(A) during development. We propose that at least two distinct polyadenylation complexes exist in Xenopus oocytes, one of which contains GLD2; the other, maskin and Pumilio. GLD2 protein …

Demographic Characteristics And Academic Measures As Predictors Of Success On The American Society For Clinical Pathology (Ascp) Medical Technologist Certification Examination, Marcia Ann Kilsby

Dissertations

Purpose. This study was undertaken to address the utility of demographic characteristics and academic measures as predictors of success for the American Society for Clinical Pathology Board of Registry Medical Technologist Certification Examination (Certification Examination) Total Score and six Subscores and to find predictive models with relevance to an ethnically and racially-diverse student population.

Method. The research population was the graduates of the Andrews University Program for Clinical Laboratory Sciences. The 233 subjects were from 53 different birth countries. The relationships between Certification Examination scores and both demographic characteristics and academic measures were analyzed by chi square, analysis o f …

Intuitive Decision Making And Leadership Style Among Healthcare Executives In The United States, Cherie Whiting

Dissertations

The purpose of this two-phased, sequential, exploratory, mixed-methods study was to survey a sample of Fellows in the American College of Healthcare Executives in the United States and then interview selected individuals who scored in the highly intuitive category on the intuition survey to explore how they made intuitive decisions. In the first phase, quantitative research questions addressed the relationship between leadership style and the potential to make intuitive decisions, as well as the relationship and interaction between the potential to make intuitive decisions and age, gender, and size of company. In the second phase, qualitative interviews were used to …

Gender Differences In The Self-Efficacy Of African Americans With Type Ii Diabetes: A Secondary Analysis Of A Chronic Disease Self-Management Program, Haley Erica Shead

Masters Theses

African Americans with type II diabetes must possess the self-efficacy to manage and cope with the chronic illness in order to prevent further decline in physical and psychosocial health. This secondary analysis of data examined gender differences in self-efficacy with the theoretical frameworks of Lazarus (1993), Bandura (1971), and Bandura and Bussey (1999). There were no significant differences found between the mean scores on the Self-Efficacy for Managing Chronic Disease 6-Item Scale (Lorig, 1999) for the subgroups of males and females. Other variables such as years diagnosed with diabetes, family members with diabetes, and HbA_1c levels were not related …

Ceftriaxone Or Hiv Associated Angio-Oedema? Case Report, William Macharia, C. Mbaabu, L. Wachira, S.O.M. Muhudhia, G. Moniz

Paediatrics and Child Health, East Africa

Angio-oedema may be hereditary or acquired and is characterised by episodes of potentially life threatening localised tissue oedema and swelling resulting from deficiency of compliment pathway C1 esterase inhibitor. Acquired angio-oedema is about ten times less frequent than the hereditary type and has been associated with immune-deficiency disorders, malignancies and exposure to specific medications and food substances. We present a case of seven year old, human immune-deficiency virus positive girl, who developed gross swelling of the tongue and neck while on treatment for pneumococcal meningitis with ceftriaxone. Difficulties in arriving at a definitive diagnosis of angio-oedema in a resource poor …

Punishment And Rehabilitation Views Of Social Work Majors And Non-Social Work Students: An Exploratory Study, Eric G. Lambert, Sudershan Pasupuleti, Reva I. Allen

Journal of the South Carolina Academy of Science

No abstract provided.

Mutation Analysis By The Use Of Temporal Temperature Gradient Gel Electrophoresis, Özgül M. Alper, Güven Lüleci̇, Lee-Jun C. Wong

Turkish Journal of Medical Sciences

ALPER^1, Güven LÜLECİ^1, Lee-Jun C. WONG^2 ^1 Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya - Turkey ^2 Georgetown University Medical Center Institute for Human and Molecular Genetics, Washington, DC - USA

A Comparison Of Three High Performance Liquid Chromatographic (Hplc) Methods For Measurement Of Plasma Total Homocysteine, Emi̇n Özgür Akgül, Erdi̇nç Çakir, Ömer Özcan, Hali̇l Yaman, Cumhur Bi̇lgi̇, Mehmet Kemal Erbi̇l

Turkish Journal of Medical Sciences

Homocysteine (tHcy) has been in routine use in many centers after this amino acid was reported as an independent risk factor for cardiovascular, cerebrovascular and peripheral vascular diseases. Many high-performance liquid chromatographic (HPLC) methods including a commercially available kit (Chromsystems) were reported for measuring tHcy in biologic samples. Although the commercial kits are believed to have higher precision, sensitivity and accuracy as well as practical and fast, it may cause high prices by increased test ordering. In this study we aimed to compare two different low-cost methods which had similar advantages with commercial kit as a reference method. In the …

Les Aspects Éthiques De L'Utilisation Des Bioindicateurs En Santé Au Travail, Chantal Caux, Claude Viau, Louise Guilbert, David J. Roy

Rapports de recherche scientifique

Les bioindicateurs et la santé au travail…

Certains travailleurs, dans le cadre de leurs activités professionnelles, sont exposés à des produits potentiellement néfastes pour leur santé. Afin de nous aider à comprendre le lien entre les expositions à ces produits et les maladies qui peuvent apparaître, il peut être utile et même nécessaire d’utiliser des bioindicateurs d’exposition, d’effets, ou encore de susceptibilité. Les premiers (bioindicateurs d’exposition) sont la mesure, dans le sang, l’urine ou l’air expiré dans un premier cas, du produit auquel les travailleurs sont exposés ou encore, dans un deuxième cas, de sous-produits résultant de la transformation de …

Management Of Occupational Manganism: Consensus Of An Experts' Panel, Claude Ostiguy, Paul Asselin, Sylvain Malo, Daniel Nadeau, Philippe Dewals

Rapports de recherche scientifique

Cliquez ici pour la version française de ce rapport

Contexte

Au cours des dernières années, plusieurs travailleurs exposés aux fumées de manganèse ont développé des symptômes évoquant un manganisme d’origine professionnelle. La CSST (la Commission de la santé et de la sécurité du travail), qui est l’organisme d’indemnisation de la province de Québec, faisait face à une situation dans laquelle elle ne disposait pas de techniques normalisées pour la prévention primaire, secondaire et tertiaire du manganisme, menant à la possibilité d’un différend médico-légal, de même qu’à la possibilité d’iniquité pour les travailleurs et les employeurs.

Objectif

Grâce à la définition …

Inhibitory Activity Against Listeria Monocytogenes By Soy-Protein Edible Film Containing Grape Seed Extract, Nisin, And Malic Acid, Brittany Adams, T. Sivarooban, Navam S. Hettiarachchy, M. G. Johnson

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

The frequent outbreaks of food-borne illness necessitate development of intervention strategies, including the use of natural antimicrobials. Listeria monocytogenes is one of the most important bacterial pathogens that recently has caused a significant number of outbreaks. With the aim of finding potent natural agents that can minimize pathogen contamination concerns, this study evaluated the inhibitory activities against L. monocytogenes of grape seed extract (GSE), malic acid (M), nisin (N), and combinations thereof incorporated into soy-protein edible films. Soy-protein films with/without addition of antimicrobial agents (GSE: 1%, Nisin: 10,000 IU/g, Malic acid: 1%, and their combinations) were prepared and evaluated for …

The Effectiveness Of Back Belts As A Control Measure For Occupational Low Back Pain In A Retail Hardware Chain, Nick Merdith

Theses: Doctorates and Masters

The objective of this study was to examine the effect of the mandatory introduction of back belts on the incidence, days lost and cost of occupational low back injuries resulting from manual handling in 11 retail hardware chain. The study was of a non-experimental before-and-after design with all retail employees in Western Australia being included in a retrospective cohort. The pre-intervention period extended for 21 months and included 2,265,933 work hours with 647 full-time equivalent positions, while the intervention period was 32 months for 4,411,352 hours worked and 827 full-time equivalent positions. Workers' compensation claims for all occupational injuries occurring …

Prenatal Diagnosis Of A Trisomy 13 Case Associated With Holoprosencephaly By Ultrasonography And Quantitative Fluorescent Pcr, N. Lale Şatiroğlu Tufan, A. Çevi̇k Tufan, Başak Yildirim, Babür Kaleli̇, C. Nur Semerci̇, Ferda Bi̇r, Füsun Düzcan, Hüseyi̇n Bağci

Turkish Journal of Medical Sciences

ŞATIROĞLU TUFAN^{1,2}, A. Çevik TUFAN^{2,3}, Başak YILDIRIM^4, Babür KALELİ^4, C. Nur SEMERCİ^1, Ferda BİR^5, Füsun DÜZCAN^1, Hüseyin BAĞCI^{1,2} ^1Department of Medical Biology, Center for Genetic Diagnosis, Molecular Genetics Laboratory, Faculty of Medicine, Pamukkale University, Denizli - Turkey ^2Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli - Turkey ^3Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, Denizli - Turkey ^4Department of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, Denizli - Turkey ^5Department of Pathology, Faculty of Medicine, Pamukkale University, Denizli - Turkey

A Compilation Of Homologous Cancer-Related Genes In Humans And Dogs, Julie Susan Brown

Honors Program Theses

The purpose of this study was to find out if spontaneously arising point mutations occurred in canine e-kit and if these mutations contributed to the development of mast cell tumors in dogs. Specimens were collected from 11 dogs after tumors had been surgically removed or the dog had died. The e-kit DNA was amplified using PCR, and the previously established point mutations were searched for (London et al., 1999). The point mutations found in human mast cell lines were not detected in the canine e-kit DNA, but new mutations were observed. These new mutations, observed in 50% of the tumors, …

Biochemical And Molecular Nutrition Blocks As Dietary Supplements In Llamas (Lama Glama) In The Last Third Of The Gestation Period Of The Ceac, Janette Illanes Callejas

Theses and Dissertations

The present work consisted in the use of biochemical and molecular nutrition blocks (BMN) in llamas during the last third of the gestation period, at the Agricultural Experiment Center of Condori (CEAC), located 49 km north of the city of Oruro, and 12 km north of the Caracollo population, in the province of Cercado. For this research work, we used 20 pregnant llamas in the last third of their gestation period, between the ages of 2 and 3 years old, 10 of which belonged to the Khara breed, and 10 to the Thampulli breed. Two corrals of 7 x 7 …

Women's Participation In Disaster Relief And Recovery, Ayse Yonder, Sengul Akcar, Prema Gopalan

Poverty, Gender, and Youth

Too little attention has been given to the gender-differentiated effects of natural disasters, that is, women’s losses relative to men’s, how women’s work time and conditions change (both in terms of care-giving and income-generating work), or how disaster-related aid and entitlement programs include or marginalize affected women. The detailed case studies from three earthquake-stricken areas in India and Turkey that are contained in this issue of SEEDS help fill this information gap. They provide examples of how low-income women who have lost everything can form groups and become active participants in the relief and recovery process. Readers learn how women …

Reciprocal Effects Of Health And Economic Well-Being Among Older Adults In Taiwan And Beijing, Kristine R. Baker, Mary Beth Ofstedal, Zachary Zimmer, Zhe Tang, Yi-Li Chuang

Poverty, Gender, and Youth

The objectives of this Population Council study are threefold: 1) to examine whether socioeconomic status disparities in health are found in non-Western settings; 2) to assess whether socioeconomic status gradients in health endure into older ages; and 3) to evaluate the direction of causality between health and socioeconomic status. Findings provide evidence for reciprocal effects of economic well-being and health among older adults in both Taiwan and Beijing. Those with higher levels of economic well-being have lower levels of functional limitation over time, and those with higher levels of functional limitation have lower levels of economic well-being over time. Consistent …

The Impact Of Childhood Mortality On Fertility In Six Rural Thanas Of Bangladesh, Mian Bazle Hossain, James F. Phillips, Thomas K. Legrand

Poverty, Gender, and Youth

This Population Council working paper examines the causal structure of the relationship between child mortality events and subsequent fertility during a time of rapid decline in fertility in Bangladesh. Results lend support to the hypothesis of an insurance effect, while demonstrating that its demographic significance is likely to be less prominent than that of replacement behavior. Findings indicate that the insurance motive remains intact even after total fertility declined to fewer than three children per woman. The well-documented role of gender bias as a determinant of child health and survival is also a factor in child-replacement decisionmaking. Although the rapid …

The Pericentrion: Identification, Characterization, And Function Of A Novel Cpkc-Dependent Compartment, Kevin P. Becker

MUSC Theses and Dissertations

Members of the protein kinase C (PKC) superfamily transduce a myriad of transmembrane signals initiated by the formation of sn-l ,2-diacylglycerol (DAG). As the primary physiological agonist for C] domain containing PKC isoenzymes, DAG functions to regulate the spatial and temporal parameters of PKC activity. It is now recognized that cellular DAG levels can vary from minutes to hours and even days. These observations have suggested a division of PKC functions that correlate to the duration of the cellular DAG signal. In their classical role, cPKCs respond acutely to the short-lived (1-2 min) DAG generated at the plasma membrane by …

The Secret Kappa Lambda Society Of Hippocrates (And The Origin Of The American Medical Association's Principles Of Medical Ethics), Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

This paper relates the neglected history of an idealistic, secret medical fraternity which existed briefly in Lexington, Kentucky, during the first half of the 19th century. It was created for students in the Medical Department at Transylvania University, the fifth US medical school, founded in 1799. One goal of the fraternity was to counter the widespread dissension and often violent quarrels among doctors that characterized American medicine of that period. And to that end, it was among the first to promote Thomas Percival's code of medical ethics in this country. Branches of the fraternity were established in Philadelphia and New …

Method Of Infant Feeding As A Predictor Of Maternal Responsiveness, Emily Eiwen Drake

Theses and Dissertations

Infants need to develop effective, secure attachment to their primary caregivers in the first year of life. Researchers have not been able to identify all the factors that may influence the development of infant attachment. Most of the studies in this area have been done without regard to infant feeding as a potential factor. Maternal responsiveness appears to be key in the child's development of secure attachment behaviors, yet even after decades of research on infant attachment and maternal responsiveness, there is little evidence available to assist with early identification of families at risk and few interventions known to be …

The Incidence And Prevalance Of Cervical Cancer In Vietnamese Women (1993-1995): A Analysis Of Seer Reported Cases, Thuy Do

Theses and Dissertations

Background: Cervical cancer is the third most common reproductive cancer in the U.S. To date, one report concluded that U.S. Vietnamese women had the highest incidence rate (43.0/100,000). The current study examines whether U.S. Vietnamese women are more likely to have cervical cancer in comparison to Whites, Blacks, Hispanics, American Indians, and other Asian subgroups. Methods: SEER data of cervical cancers diagnosed from 1993-1995 (n = 37,790) was utilized. Using SPSS, chi-square statistics assessed whether Vietnamese women were older and more likely to be married or diagnosed at a later stage. Logistic regression assessed the amount of risk race/ethnicity contributes …

Predictors Of Induced Abortion Among Female Youth Center Users In Port-Au-Prince, Haiti, Rachel Barker

Theses and Dissertations

Objective: Induced abortions occur in every country in the world. However sixty percent of the world's women live in countries where abortion is illegal. 19 million pregnancies end in unsafe and/or illegal abortions. Annually, 68,000 women die from unsafe abortions. Legal or not, unsafe abortion is one of the great neglected problems of health care in developing countries like Haiti and is a serious concern to women during their reproductive lives. Methods: The data for this study was collected from youth centers (ages 15-24) and used to estimate percentage distributions of abortion ratios by selected characteristics of women, particularly age …