Digital Commons Network^™

Diurnal, Seasonal, And Vertical Changes In Photosynthetic Rates In Cinamomum Camphora Forests In Subtropical China, Zhiqiant Li, Qinxiang Wu, Yuanying Peng, Junjie Lei, Shuguang Liu, Can Mao, Xin Liu, Jun Wang, Wende Yan, Xiaoyong Chen

Faculty Authors and Creators Reception

The increase in the global atmospheric CO2 concentration is expected to increase the productivity of forests, but the dynamic processes of such increased productivity in the forest canopy remain unclear. In this study, diurnal and seasonal variations and vertical changes in photosynthetic rates were investigated in Camphor tree (Cinnamomum camphora) forests in subtropical China. The effect of photosynthetically active radiation (PAR) and CO2 concentrations on photosynthetic rates were also examined in the studied forests. Results showed the diurnal patterns of photosynthesis exhibited two peaks on sunny days, but only one peak on cloudy days. The daily average photosynthetic rate on …

Digitalization Of Toxicology: Improving Preclinical To Clinical Translation., Brian R Berridge, Szczepan W Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L Robertson

Faculty Research 2024

Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day. Safety liabilities are a significant contributor to development attrition where the costliest liabilities to both drug developers and patients emerge in late development or post-marketing. Animal studies are an important and influential contributor to the current drug discovery and development paradigm intending to provide evidence that a novel drug candidate can be used safely and effectively in human volunteers and patients. However, translational gaps-such as toxicity in patients not predicted by …

Phosphorus-Independent Role Of Fgf23 In Erythropoiesis And Iron Homeostasis., Min Young Park, Rafiou Agoro, Stanislovas S Jankauskas, Carole Le Henaff, Despina Sitara

Faculty Research 2024

A number of studies have reported an association between phosphorus, red blood cell (RBC) production, and iron metabolism. However, it is difficult to distinguish whether the effect of phosphorus is direct or through the actions of FGF23, and it is not clear whether phosphorus is positively or negatively associated with RBC production. In the present study, we investigated the effects of a) increased phosphorus load and b) phosphorus deficiency on erythropoiesis and iron metabolism in association with FGF23. Mice were fed either a 1.2% or 1.65% phosphorus diet and compared to mice fed a control diet containing 0.6% of phosphorus. …

Protecting Traditional Knowledge And Indigenous Peoples' Rights: The Key To Developing International Environmental Laws That Promote Harmonious Relationships With Nature, Melissa A. Padilla

California Western International Law Journal

No abstract provided.

Early Oligocene Record Of An “Iceberg Alley” In The Weddell Sea From Quartz Sand Microtextural Analysis At Odp Site 696, Victoria Hojnacki, Sandra Passchier

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

The greenhouse to icehouse transition at the Eocene-Oligocene boundary (34 Ma) marked the appearance of continental-scale glaciation in Antarctica. The material recovered from Ocean Drilling Program Site 696 is the only record spanning this major climatic shift in the Weddell Sea region. Using scanning electron microscopy, quartz microtextures in 13 samples across the Eocene-Oligocene transition were analyzed to understand the degree of glacial modification and the transportation history of the >150 µm material. The quartz grains were visually grouped, characterized, and interpreted by grain outline, relief, and surface microtextures. Glacial textures are present throughout the entire interval (34.4–33.2 Ma), with …

Applying Steve Jobs’S Insights On Innovation, Leadership, And Technology Toward An Apple-Inspired Law School, Byron G. Stier

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Sharing The Blame: Using Market Share To Allocate Liability In Opoid Public Nuisance Lawsuits, Molly G. Baldock

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Accommodating Religious Liberty In An Artificially Intelligent Workplace, Michael H. Leroy

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Mechanisms Of Action And Preservation Effects Of Packaging Systems For Mushrooms: Novel Approaches To Preserve Irish Edible Mushrooms, Tigist Tadesse Shonte, Mehraj Fatema Mulla, Lorraine Foley, Shivani Pathania

Articles

Mushrooms support the Irish economy, with a farm gate value of roughly EUR 130 million in 2022 and with 80%–85% of Irish production exported to the United Kingdom. In order to apply cutting edge technologies and offer creative solutions to increase the shelf life of mushrooms, it is essential to understand the mechanisms of action and preservation effects of the current trends in edible mushroom packaging systems. This review summarises the mechanisms of action for nanopackaging, biodegradable packaging, edible coatings, modified atmosphere packaging (MAP), and active packaging in terms of their enzyme activity, antimicrobial activity, antioxidant activity, and rate of …

Feasibility In Embedding Charismatic Leadership Strategies Into Social Work Applications, Lana Grinev

Student Publications

Purpose – The purpose of this paper is to determine whether charismatic leadership strategies can be successfully implemented within structures, systems and tasks for social workers to increase case management successes, particularly client well-being, given that the six key charismatic leadership traits align with presented professionally bound ethical expectations. Design/methodology/approach – A short generic qualitative review was done over fifteen publications, emphasizing the effects of charismatic leadership in domestic and foreign occupational domains. Findings – Methodological, thematic and theoretical analyses show that charismatic leadership strategies are active in relevant social work domains with positive participant impacts. Practical implications – The …

Nanoscale Interaction Of Endonuclease Ape1 With Dna, Sridhar Vemulapalli, Mohtadin Hashemi, Yingling Chen, Suravi Pramanik, Kishor Bhakat, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

Apurinic/apyrimidinic endonuclease 1 (APE1) is involved in DNA repair and transcriptional regulation mechanisms. This multifunctional activity of APE1 should be supported by specific structural properties of APE1 that have not yet been elucidated. Herein, we applied atomic force microscopy (AFM) to characterize the interactions of APE1 with DNA containing two well-separated G-rich segments. Complexes of APE1 with DNA containing G-rich segments were visualized, and analysis of the complexes revealed the affinity of APE1 to G-rich DNA sequences, and their yield was as high as 53%. Furthermore, APE1 is capable of binding two DNA segments leading to the formation of loops …

Coumarin-Based Aldo-Keto Reductase Family 1c (Akr1c) 2 And 3 Inhibitors, Sravan Jonnalagadda, Ling Duan, Louise F. Dow, Geetha P. Boligala, Elizabeth A. Kosmacek, Kristyn Mccoy, Rebecca E. Oberley-Deegan, Yashpal Singh Chhonker, Darryl J. Murry, C. Patrick Reynolds, Barry J. Maurer, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

A series of 7-substituted coumarin derivatives have been characterized as pan-aldo-keto reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved in drug resistance development. 7-hydroxy coumarin ethyl esters and their corresponding amides have high potency for AKR1C3 and AKR1C2 inhibition. Coumarin amide 3 a possessed IC50 values of 50 nM and 90 nM for AKR1C3 and AKR1C2, respectively, and exhibits 'drug-like' metabolic stability and half-life in human and mouse liver microsomes and plasma. Compound 3 a was employed as a chemical tool to determine pan-AKR1C2/3 inhibition effects both as a …

Discovery Of An Aldo-Keto Reductase 1c3 (Akr1c3) Degrader, Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is the most common mutation of the AR receptor that confers resistance to clinical androgen receptor signalling inhibitors in castration-resistant prostate cancer. AKR1C3 interacts with ARv7 promoting stabilization. Herein we report the discovery of the first-in-class AKR1C3 Proteolysis-Targeting Chimera (PROTAC) degrader. This first-generation degrader potently reduced AKR1C3 expression in 22Rv1 prostate cancer cells with a half-maximal degradation concentration (DC₅₀) of 52 nM. Gratifyingly, concomitant degradation of ARv7 was …

N.U.R.T.U.R.E: Neutralizing Unsafe Risks Through Unique Responsive Environmental Care, Clara Durante, Easton Duppins, Feven Eskinder, Hiba Mohammed, Faith Niranoluwa

DC Health and Academic Prep Program (DC HAPP)

Environmental factors can be distinguished by physical, chemical, biological, behavioral, and socioeconomic categories. Each category has its own individual effect on human health. These environmental factors play a critical role in determining the health outcomes of pregnancies, influencing both maternal and fetal well-being. This project aims to empower pregnant women by providing comprehensive support and education on mitigating environmental risks. Environmental factors have a significant impact on pregnancy outcomes, specifically among women from lower socioeconomic status (SES) background. Low SES is linked with increased exposure to harmful environmental toxins, high stress levels, limited access to healthcare, which contribute to pregnancy …

Research Priorities For Childhood Apraxia Of Speech: A Long View, Patricia Mccabe, Molly Beiting, Elaine R. Hitchcock, Edwin Maas, Amy Meredith, Angela T. Morgan, Nancy L. Potter, Jonathan L. Preston, Laura Moorer, Pooja Aggarwal, Kirrie Ballard, Laura Baskall Smith, Nicole F. Caballero, Kathryn Cabbage, Julie Case, Susan Caspari, Karen V. Chenausky, Shina Cook, Ewa Grzelak, Maryane Gomez, Aubrie Hagopian, Chantelle Highman, Anne Hodits, Jenya Iuzzini-Seigel, Jillian Levos-Carlson, Barbara A. Lewis, Patricia Mayro, Jyutika Mehta, Gabrielle Miller, Kimberly D. Mory, Elizabeth Murray, Megan S. Overby

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

This article introduces the Journal of Speech, Language, and Hearing Research Special Issue: Selected Papers From the 2022 Apraxia Kids Research Symposium. The field of childhood apraxia of speech (CAS) has developed significantly in the past 15 years, with key improvements in understanding of basic biology including genetics, neuroscience, and computational modelling; development of diagnostic tools and methods; diversity of evidence-based interventions with increasingly rigorous experimental designs; and understanding of impacts beyond impairmentlevel measures. Papers in this special issue not only review and synthesize the some of the substantial progress to date but also present novel findings addressing critical research …

Effect Of Walleye Fry Stocking On Future Gillnet Cpue, Alexander Barker

Journal of Earth and Life Science

Walleye Sanders vitreus for many states, is a key attractant of anglers from around North America. Due to immense popularity, management efforts have been conducted to maintain Walleye populations, especially in the form of stocking. The purpose of this study is to analyze the effect of Walleye fry stocking on gillnet catch per unit effort (CPUE). A total of 90 lakes were analyzed for this study within three defined regions of Minnesota, 30 from each region. The regions chosen for this study are the Minnesota Department of Natural Resources northern pike Esox lucius regulation regions which consist of the Southern, …

Scoping Review: Health Care Use In Foster Care Children, Karen Mcwaters

Post-Professional Occupational Therapy Doctorate - Innovations in OT Symposium: Transforming Possibilities into Practice

No abstract provided.

2023-2024 Annual Student Assessment Report, Southwestern Oklahoma State University

Assessment Center Reports

Annual Student Assessment Report produced by the SWOSU Assessment Center.

Landscape-Scale Epidemiological Dynamics Of Sars-Cov-2 In White-Tailed Deer, Joshua Hewitt, Grete Wilson-Henjum, Derek T. Collins, Timothy J. Linder, Julianna B. Lenoch, Jonathan D. Heale, Christopher A. Quintanal, Robert Pleszewski, Dillon S. Mcbride, Andrew S. Bowman, Jeffrey C. Chandler, Susan A. Shriner, Sarah N. Bevins, Dennis J. Kohler, Richard B. Chipman, Allen L. Gosser, David L. Bergman, Thomas J. Deliberto, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Understanding pathogen emergence in new host species is fundamental for developing prevention and response plans for human and animal health. We leveraged a large-scale surveillance dataset coordinated by United States Department of Agriculture, Animal and Plant Health Inspection Service and State Natural Resources Agencies to quantify the outbreak dynamics of SARS-CoV-2 in North American white-tailed deer (Odocoileus virginianus; WTD) throughout its range in the United States. Local epidemics in WTD were well approximated by a single-outbreak peak followed by fade out. Outbreaks peaked early in the northeast and mid- Atlantic. Local effective reproduction ratios of SARS-CoV-2 were between …

What Is Known, Unknown, And Needed To Be Known About Damage Caused By Wild Pigs, Kurt C. Vercauteren, Kim M. Pepin, Seth M. Cook, Sophie Mckee, Abigail Pagels, Keely J. Kohen, Ingrid A. Messner, Michael P. Glow, Nathan P. Snow

United States Department of Agriculture Wildlife Services: Staff Publications

Damage assessments provide evidence for initiating and evaluating management programs that protect natural resources and human livelihoods against invasive species. Wild pigs (Sus scrofa) cause extensive damage in their native and non-native ranges, but the extent of current damage and efficacy of management of the damage (i.e., population control of wild pigs, exclusion fencing, etc.) remains poorly described. We conducted a systematic review of physical damage caused by wild pigs to summarize what is known and identify knowledge gaps for damage assessment. Wild pig damage assessments have been overwhelmingly qualitative (84% of studies) and measured differently across studies, …

Tracking Sero-Molecular Trends Of Swine Brucellosis In Hawai'i And The Central Pacific, Thi Hai Au La, Ian A. Mcmillan, Prashant Dahal, Andrew H. Burger, Mahdi Belcaid, Darrin M. Phelps, Samuel M. Goldstein, Vienna R. Brown, Michael H. Norris

United States Department of Agriculture Wildlife Services: Staff Publications

Introduction

Brucellosis is a zoonotic disease of mammals caused by bacterial species of the Brucella genus. The reservoir for disease is typically mammals, with species of Brucella found infecting amphibians, bats, and marine mammals. Brucella spp. can pass directly to humans through contact with infected animals or their products. Brucella spp. can cause chronic debilitating infections in mammals, including humans, and is associated with spontaneous abortions in infected animals, causing reduced fecundity. In Hawai‘i, terrestrial species that could harbor Brucella spp. include swine, cattle, horses, and axis deer among others. The numerous feral swine in Hawai‘i are known to carry …

Gender Regrets: Banning Abortion And Gender-Affirming Care, Margot J. Pollans, Noa Ben-Asher

Elisabeth Haub School of Law Faculty Publications

This Article analyzes the use of “regret” in the campaigns to ban GAC and abortion. It identifies two overlapping threads. First, both campaigns against medical care point to protection of patients from future regret as a legitimate state interest justifying restrictions on providing medical care. Second, both rely on concerns about regret to redefine the legal meaning of “informed consent” and make it easier for potential future plaintiffs to prevail in civil suits against providers of medical care. In doing so, both treat the emotion of regret as a distinct injury that may give rise to a range of legal …

Uab Magazine - Fall/Winter 2024, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

99th Henry M. Campbell Moot Court Competition: Final Round, University Of Michigan Law School

Event Materials

Henry Munroe Campbell was a distinguished lawyer who served as legal counsel to the University of Michigan’s Board of Regents for several years.

He was born in 1854, the son of famed Michigan Supreme Court Justice James V. Campbell. He graduated from the University of Michigan in 1876 and later from the University of Michigan Law School. In 1878, he established a law partnership in Detroit with Henry Russell. Over the years, the firm prospered and continues today as the Detroit-based firm Dickinson Wright PLLC.

Campbell became an attorney of considerable eminence in Michigan and was widely regarded as a …

Geological And Environmental Sciences - 2024, Dept. Of Geological And Environmental Sciences

Geological and Environmental Sciences News

• Greetings from the Department Chair
• Thank You to our Donors
• Faculty Updates
• Emeritus Faculty Updates
• MGRRE Updates
• MGS Updates
• Geosciences Advisory Council
• Student Clubs
• Awards and Honors, 2024
• Department Graduates
• Publications 2023–24

The Effects Of Early Developmental Co-Exposure To Alcohol And Nicotine Via E-Cigarettes On Anxiety- And Motor-Related Behaviors In Mice, Carley Cirafesi

West Chester University Master’s Theses

Thirty percent of people who report consumption of alcohol while pregnant simultaneously report consuming nicotine. Prenatal co-exposure to alcohol and nicotine has increased with the popularity of electronic cigarettes due to their presumed safety, yet e-cigarette use may have a greater impact on fetal development than traditional cigarettes. Prenatal exposure to alcohol or nicotine is associated with increased anxiety-related behaviors and impaired motor coordination later in life, yet it is unknown whether prenatal co-exposure to alcohol and nicotine exacerbates these effects, particularly via e-cigarettes. This project examined the effects of co-exposure to alcohol and nicotine via e-cigarettes during early development …

The Party’S Missionaries: The Experiences Of African Students In China During The Twentieth And Twenty-First Centuries

The Graduate Review

No abstract provided.

International Virtual Exchange During And Beyond The Pandemic, Ian Mcintosh

National Collegiate Honors Council Monographs: Chapters

The first goal of this chapter is to describe the virtual class. The second is to demonstrate just how easy such exchanges are when using technology such as the CN (Course Networking), which is like Facebook for academia. This software, plus the use of What’s App for free mobile calling, allowed students from both countries to get to know one another and explore course topics well beyond what can be delivered in a classroom setting. Finally, I will share information on the United Nations Sustainable Development Goals and some of the impressive discoveries made by the students in their respective …

Online Education, Honors, And The Engaged University: Modeling Experiential Learning For Fully Online Students At Fort Hays State University, Kevin S. Amidon, Gregory Atkins

National Collegiate Honors Council Monographs: Chapters

This essay outlines the principles upon which the Fort Hays State University Honors Online initiative will be based and proposes ways of achieving successful honors outcomes in student-centered ways that are appropriate and meaningful to both on-campus and online cohorts. We propose a structure guided by a Community of Inquiry (COI) framework that respects and reflects the social, cognitive, and academic needs of diverse students as individuals and groups. This results in a concentric curricular model in which the student’s academic major field provides a broad, encompassing space for inner fields of co-curricular experiential learning and service. Honors staff work …

Honors Online: Teaching, Learning, And Building Community Virtually In Honors Education: Front And Back Matter, Victoria M. Bryan, Cat Stanfield

National Collegiate Honors Council Monographs: Chapters

Front and back matter from Honors Online: Teaching, Learning, and Building Community Virtually in Honors Education (NCHC, 2024), edited by Victoria M. Bryan and Cat Stanfield.