Digital Commons Network^™

A Protocol For Occupational Therapists Working With Returning War Veterans, Suzanne Lunski

Occupational Therapy Capstones

No abstract provided.

The Effectiveness Of Semi-Rigid Custom Made Foot Orthotics In Correcting Abnormal Foot Positions, Kimberly Austin, Chris Gietzen, Bonnie Nostdahl, John Sayler

Physical Therapy Scholarly Projects

Researchers have been trying to understand the complexity of foot biomechanics for over 100 years, and this has lead to an increase in more sensitive technology. Abnormal foot biomechanics are commonly corrected using orthotics. Pressure mapping systems, such as the Force Sensitive Application (FSA) and Teckscan, are becoming more prevalent in both clinical settings and in research to assist clinicians in making proper fitting orthotics. FSA allows clinicians the ability to measure the amount of pressure on patients' feet with and without orthotics. The purpose of this study is to determine the effectiveness of semi-rigid custom foot orthotics in correcting …

Electromyographic (Emg) Analysis Of Trunk Muscles At The Point Of Puck Contact During Slap And Wrist Shots Of Female Ice Hockey Athletes, Lon Donald, Kristi Kjellgren, Jodi Young, Michael Young

Physical Therapy Scholarly Projects

The number of female hockey players has increased significantly in the last decade. The first recorded female hockey game was in Ottawa in 1889. Since that time, hockey has spread into the United States .. Today, USA Hockey, Inc. reports 40,000 registered females and the Canadian Hockey Association has 55,000 female hockey players. Despite the rising popularity of the sport among females, there is little research specifically related to female hockey players.

Golf, tennis, and hockey swings utilize similar rotational components about the trunk. Trunk rotation is controlled and produced by the erector spinae, external oblique and rectus abdominus muscles. …

An Electromyography (Emg) Study Of Two Dynamic Surfaces: Hippotherapy And Swiss Ball, Melissa J. Metcalf, Roslyn J. Muller, Tanya L. Schimek, Erica H. Wheeler

Physical Therapy Scholarly Projects

The use of horseback riding as a therapeutic intervention has been used since the fifth century, B.C.1 It has been proposed that the physical benefits of horseback riding include: improved posture, balance, muscle strength, decreased spasticity, improved gait patterns, and coordination. Unfortunately, at the current time, hippotherapy, the use of horses in physical therapy intervention, has been poorly documented due to little objective research. The purpose of this study was to provide an objective measure of children's postural muscle activity through the use of electromyography (EMG) and electrogoniometry on two dynamic surfaces. Data was analyzed for differences in postural muscle …

I Connect Therefore I Am: Connectivity And Networking In Bodies, Technologies, Communities, And Selves, Anthony Lambert

Reconstruction: Studies in Contemporary Culture

[First paragraph]

The notion of connection refers to both metaphorical and material practices informing our understandings of the flows of energy and information within human bodies, communities, geographies, and technological networks. Cranny-Francis offers a definition of connection which accounts for the term's significance in the contexts of both Cultural Studies and multimedia literacy:

It refers to the ways in which texts generate meanings through their relationship with other texts, to the development of multimedia technologies that are characterized by their connectivity (the web, the net), and to the ways in which meanings are generated crucially by the connection between texts …

Effects Of Ultrasonic Scaling And Hand-Activated Scaling On Tactile Sensitivity In Dental Hygiene Students, Danielle L. Ryan, Michele Darby, Susan L. Tolle, Deborah Bauman, Dayanand Naik

Dental Hygiene Faculty Publications

Purpose. This study was conducted to determine if tactile sensitivity varies in dental hygiene students who use the ultrasonic scaler, as compared to those who scale with hand-activated instruments.

Methods. A two-group, randomized subjects, pretest-posttest design was carried out mid-semester for five weeks on 40 first-year dental hygiene students who met the inclusion criteria of this study and who agreed to participate. A convenience sample of 40 consenting, first-year dental hygiene students were randomly assigned to one of two groups (experimental or control). After establishing a baseline tactile sensitivity score with the Vibratory Sensory Analyzer (VSA), experimental group subjects used …

Urokinase And Urokinase Receptor In The Urinary Tract Of The Dog, Trina Racquel Bailey

LSU Master's Theses

Urokinase (uPA) and urokinase receptor (uPAR) are present in the urinary tract of people, mice, rats and cows. The presence of urokinase and urokinase receptor in the urinary tract of dogs has not been documented. Documenting the presence of uPA and uPAR in the urinary tract of healthy dogs will help determine the role these proteins play in pathology of the urinary tract in further research. Urine was collected from fifty-four healthy dogs. A fluorescence assay was developed using the fluorogenic substrate Z-Gly-Gly-Arg-AMC, HCl. This assay documented presence of active uPA-like protein in concentrated urine. A direct sandwich ELISA assay …

Estimation Of Subject Specific Icp Dynamic Models Using Prospective Clinical Data, Wayne W. Wakeland, Joe Fusion, B. Goldstein

Complex Systems Faculty Publications and Presentations

We used a prospective clinical trial to generate physiologic data to create subject-specific in silico (computer simulation) models of intracranial pressure dynamics in children with severe traumatic brain injury. The trial included a physiologic challenge protocol with changes in head-of-bed elevation and minute ventilation, applied over multiple iterations to three subjects. Physiologic signals (electrocardiogram, respiration, arterial blood pressure, intracranial pressure [ICP], oxygen saturation) were recorded continuously, along with clinical annotations indicating the precise timing of physiologic challenges. Several parameters within the model of ICP dynamics were estimated for each subject based on the ICP response to the challenges. Estimation was …

Healing During Physician-Patient Consultation, Waris Qidwai, Ss Ali, S Ayub, S Ayub

Department of Family Medicine

OBJECTIVE: To determine the patient perceptions regarding healing during a physician-patient consultation.
DESIGN: A questionnaire-based survey.
PLACE AND DURATION OF STUDY: Family Practice Center of the Aga Khan University Hospital, Karachi, Pakistan, in June 2004.
PATIENTS AND METHODS: A questionnaire was designed that included the demographic profile of patients comprising age, gender, education and occupation as well as questions in line with the study objective. It was administered to 111 patients, visiting outpatient department of the hospital. Participants were explained the study objective, a written consent was taken and full confidentiality was assured.
RESULTS: The mean age of …

Patient Expectations From An Emergency Medical Service, Waris Qidwai, Ss Ali, M Baqi, S Ayub

Department of Family Medicine

BACKGROUND: Patient expectation survey at the Emergency Medical Services can improve patient satisfaction. A need was established to conduct such a survey in order to recommend its use as a quality improvement tool.
METHODS: The study was conducted on patients visiting the Emergency Medical Services, Aga Khan University, Karachi. A questionnaire was used to collect information on the demographic profile, and expectations of patients. The ethical requirements for conducting the study were met.
RESULTS: A hundred patients were surveyed. The majority was relatively young, married men and women, well educated and better socio-economically placed. The majority of the …

‘‘Antedisciplinary’’ Science, Sean R. Eddy

Open Access Publications

No abstract provided.

Ultrasonic Songs Of Male Mice, Timothy E. Holy, Zhongsheng Guo

Open Access Publications

No abstract provided.

A Novel Endogenous Inhibitor Of The Secreted Streptococcal Nad-Glycohydrolase, Michael A. Meehl, Jerome S. Pinkner, Patricia J. Anderson, Scott J. Hultgren, Michael G. Caparon

Open Access Publications

No abstract provided.

Mutant Kinesin-2 Motor Subunits Increase Chromosome Loss, Mark S. Miller, Jessica M. Esparza, Andrew M. Lippa, Fordyce G. Lux Iii, Douglas G. Cole, Susan K. Dutcher

Open Access Publications

No abstract provided.

Dap12 (Karap) Amplifies Inflammation And Increases Mortality From Endotoxemia And Septic Peritonitis, Isaiah R. Turnbull, Jonathan E. Mcdunn, Toshiyuki Takai, R. Reid Townsend, J. Perren Cobb, Marco Colonna

Open Access Publications

No abstract provided.

Outlook Magazine, Spring 2005

Outlook Magazine

No abstract provided.

Outlook Magazine, Winter 2005

Outlook Magazine

No abstract provided.

Outlook Magazine, Fall 2005

Outlook Magazine

No abstract provided.

Emotion Perception In Pre-Kindergarten School Children At Central Institute For The Deaf, Amanda Ruth Shinall

Independent Studies and Capstones

This paper studies the ability of pre-kindergarten students with both normal hearing and impaired hearing to identify emotions in speech through audition only. In addition, the study assesses whether a listener's familiarity with a speaker's voice has an effect on his/her ability to identify the emotion of the speaker.

Mitochondrial Dna Mutations, Apoptosis, And The Misfolded Protein Response., Justin L. Mott, Dekui Zhang, Hans Peter Zassenhaus

Journal Articles: Biochemistry & Molecular Biology

Studies of transgenic mice with accelerated accumulation of mtDNA mutations specifically in the heart lead us to propose that apoptotic signaling and cell death is central to the pathogenesis of mtDNA mutations in aging. It is the cellular response to that apoptotic signaling and the organ?s compensatory response to a loss of cells that specify the phenotype of an accumulation of mtDNA mutations. In the heart, cardiomyocytes induce a vigorous anti-apoptotic, pro-survival response to counteract mitochondrial apoptotic signaling. The heart up-regulates contractility of remaining myocytes in order to maintain cardiac output. We hypothesize that mutant mitochondrial proteins originate apoptotic signaling …

Survey Of The Use Of Pedometers And Knowledge Of Caloric Intake And Expenditure, Tera Bahl, Holly Freudenberg, Tara Hynek, Lynae Jost

Physical Therapy Scholarly Projects

Background and Purpose. As the prevalence of obesity continues to rise, medical professionals are searching for ways to combat this epidemic. One of the first steps is to assess the activity levels and eating habits of those who are obese and look for ways to modify these two areas in order to assist the obese individual in achieving a desirable and healthy weight. The purpose of this study is to determine if pedometer use, gender, or body mass influence one's knowledge of caloric consumption and expenditure.

Subjects and Methods. 253 questionnaires were sent out to randomly selected faculty and staff …

The Use Of Time-Resolved Fluorescence Imaging In The Study Of Protein Kinase C Localisation In Cells., Christopher D Stubbs, Stanley W Botchway, Simon J Slater, Anthony W Parker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Two-photon-excitation fluorescence lifetime imaging (2P-FLIM) was used to investigate the association of protein kinase C alpha (PKCalpha) with caveolin in CHO cells. PKCalpha is found widely in the cytoplasm and nucleus in most cells. Upon activation, as a result of increased intracellular Ca2+ and production of DAG, through G-protein coupled-phospholipase C signalling, PKC translocates to a variety of regions in the cell where it phosphorylates and interacts with many signalling pathways. Due to its wide distribution, discerning a particular interaction from others within the cell is extremely difficult. RESULTS: Fluorescence energy transfer (FRET), between GFP-PKCalpha and DsRed-caveolin, was used …

Association Between Coinfection Of Porphyromonas Gingivalis, Actinobacillus Actinomycetemcomitans And Treponema Denticola And Periodontal Tissue Destruction In Chronic Periodontitis, L. L. Chen, Y. M. Wu, J. Yan, W. L. Sun, Y. Z. Sun, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

No abstract provided.

Global Gene Expression Profiling Of Cells Overexpressing Smc3., Giancarlo Ghiselli, Chang-Gong Liu

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: The Structural Maintenance of Chromosome 3 protein (SMC3) plays an essential role during the sister chromatid separation, is involved in DNA repair and recombination and participates in microtubule-mediated intracellular transport. SMC3 is frequently elevated in human colon carcinoma and overexpression of the protein transforms murine NIH3T3 fibroblasts. In order to gain insight into the mechanism of SMC3-mediated tumorigenesis a gene expression profiling was performed on human 293 cells line stably overexpressing SMC3. RESULTS: Biotinylated complementary RNA (cRNA) was used for hybridization of a cDNAmicroarray chip harboring 18,861 65-mer oligos derived from the published dEST sequences. After filtering, the hybridization …

Etiology Of Oral Disease In View Of Microbial Complexity, Anne C. R. Tanner, Jacques Izard

Department of Food Science and Technology: Faculty Publications

The number of different microorganisms recognized in the oral cavity using molecular methods has more than doubled compared with the number isolated using cultural techniques. This finding necessitates a reevaluation of which species may be pathogens in dental infections. Molecular methods used to determine microbial diversity include broad range target Polymerase Chain Reaction with ‘universal primers,’ and cloning amplicons or denaturing gradient gel electrophoresis to separate DNA fragments before sequencing. These molecular methods have clarified and expanded the taxonomy of oral microbial species. Discrepancies between comprehensive molecular and cultural methods suggest that neither method alone can adequately evaluate associations of …

Antigenicity And Immunogenicity Of A Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein, Feng Gao, Eric A. Weaver, Zhongjing Lu, Yingying Li, Hua-Xin Liao, Benjiang Ma, S. Munir Alam, Richard M. Scearce, Laura L. Sutherland, Jae-Sung Yu, Julie M. Decker, George M. Shaw, David C. Montefiori, Bette T. Korber, Beatrice H. Hahn, Barton F. Haynes

Nebraska Center for Virology: Faculty Publications

Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine development. To decrease the genetic distances between candidate immunogens and field virus strains, we have designed and synthesized an artificial group M consensus env gene (CON6 gene) to be equidistant from contemporary HIV-1 subtypes and recombinants. This novel envelope gene expresses a glycoprotein that binds soluble CD4, utilizes CCR5 but not CXCR4 as a coreceptor, and mediates HIV-1 entry. Key linear, conformational, and glycan-dependent monoclonal antibody epitopes are preserved in CON6, and the glycoprotein is recognized equally well by sera from individuals infected with different HIV-1 …

Antigenicity And Immunogenicity Of A Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein, Feng Gao, Eric A. Weaver, Zhongjing Lu, Yingying Li, Hua-Xin Liao, Benjiang Ma, S. Munir Alam, Richard M. Scearce, Laura L. Sutherland, Jae-Sung Yu, Julie M. Decker, George M. Shaw, David C. Montefiori, Bette T. Korber, Beatrice H. Hahn, Barton F. Haynes

Nebraska Center for Virology: Faculty Publications

Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine development. To decrease the genetic distances between candidate immunogens and field virus strains, we have designed and synthesized an artificial group M consensus env gene (CON6 gene) to be equidistant from contemporary HIV-1 subtypes and recombinants. This novel envelope gene expresses a glycoprotein that binds soluble CD4, utilizes CCR5 but not CXCR4 as a coreceptor, and mediates HIV-1 entry. Key linear, conformational, and glycan-dependent monoclonal antibody epitopes are preserved in CON6, and the glycoprotein is recognized equally well by sera from individuals infected with different HIV-1 …

Cutting Edge: Cd4+Cd25+ Regulatory T Cells Contribute To Gender Differences In Susceptibility To Experimental Autoimmune Encephalomyelitis, Jay Reddy, Hanspeter Waldner, Xingmin Zhang, Zsolt Illes, Kai W. Wucherpfennig, Raymond A. Sobel, Vijay K. Kuchroo

Jay Reddy Publications

Female B10.S mice are highly resistant to proteolipid protein (PLP) 139–151-induced experimental autoimmune encephalomyelitis (EAE) and depletion of PLP 139–151- reactive CD4+CD25+regulatory T (Treg) cells can slightly increase their EAE susceptibility. Although male B10.S mice are moderately susceptible to EAE, we report that depletion of Treg cells in male B10.S mice before immunization with PLP 139–151 renders them highly susceptible to severe EAE with more CNS neutrophil infiltrates than nondepleted controls. Increased susceptibility is associated with an enhanced PLP 139–151-specific T cell response and greater production of IFN-γ, IL-6, and IL-17. Male CD4+CD25+ effector cells depleted of Treg cells proliferate …

Serologic Survey Of Select Infectious Diseases In Coyotes And Raccoons In Nebraska, Richard Bischof, Douglas G. Rogers

School of Veterinary and Biomedical Sciences: Faculty Publications

To obtain data about select zoonotic and other infectious diseases in free-ranging predators in five ecoregions in Nebraska, sera were collected from 67 coyotes (Canis latrans) and 63 raccoons (Procyon lotor)) from November 2002 through January 2003. For coyotes, antibodies were detected against canine distemper virus (CDV, 61%), Francisella tularensis) (32%), Rickettsia rickettsi) (13%), and flaviviruses (48%). None of the coyote sera had antibodies to Borrelia burgdorferi, Brucella canis), or six serovars of Leptospira interrogans). Because serologic cross-reactivity exists among flaviviruses, 14 sera from flavivirus-positive coyotes were also tested for St. Louis …

Quality Laboratory Services – Is It Related To Personal Credentials?, Maria Dannessa Delost

Theses and Dissertations

Performance on proficiency test (PT) surveys provides an objective and consistent evaluation of laboratory quality. The goal of the study, a retrospective review of existing PT results (2003) from six clinical laboratories in northeastern Ohio and western Pennsylvania was to determine the relationship of PT performance to the personnel credentials of the laboratory testing personnel. Predictor variables included the practitioner's major area of study, degree, certification and years of laboratory experience.

The study group consisted of 174 testing personnel and 11,689 proficiency-testing results, of which 11,233 were valid and included in the study. Of the 11,233 results, there were 11,120 …