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Articles 87211 - 87240 of 96574
Full-Text Articles in Entire DC Network
Molecular Cloning And Characterization Of A Porcine Ul16 Binding Protein (Ulbp)-Like Cdna, Carmen N. Garcia-Borges, Bounleut Phanavanh, Sarika Saraswati, Richard A. Dennis, Mark D. Crew
Molecular Cloning And Characterization Of A Porcine Ul16 Binding Protein (Ulbp)-Like Cdna, Carmen N. Garcia-Borges, Bounleut Phanavanh, Sarika Saraswati, Richard A. Dennis, Mark D. Crew
United States Public Health Resources
UL16 binding proteins (ULBPs) are ligands for the NK cell activating receptor NKG2D. A cDNA encoding a porcine ULBP-like protein (PULBP) was cloned and the predicted amino acid sequence exhibited 35–52% identity to human ULBPs. Southern blot analysis suggested that there is only one ULBP-like gene in the pig genome. Transcripts of PULBP and another potential NKG2D ligand, MIC2, were detected by RT-PCR in a wide range of tissues. Recombinant PULBP-Fc and human ULBP2-Fc fusion proteins were made and used to examine PULBP binding to porcine PBMCs and a human NK cell line (NKL cells). PULBP-Fc bound to a subpopulation …
Effect Of Cirrhosis On Antibiotic Efficacy In A Rat Model Of Pneumococcal Pneumonia, Laurel C. Preheim, Keith M. Olsen, Mei Yue, Mary U. Snitily, Martha J. Gentry-Nielsen
Effect Of Cirrhosis On Antibiotic Efficacy In A Rat Model Of Pneumococcal Pneumonia, Laurel C. Preheim, Keith M. Olsen, Mei Yue, Mary U. Snitily, Martha J. Gentry-Nielsen
United States Public Health Resources
A rat model was used to study the effects of cirrhosis on antibiotic therapy of pneumococcal pneumonia. Cirrhotic and control male Sprague-Dawley rats were infected transtracheally with type 3 Streptococcus pneumonia. Treatment began 18 h later with phosphate-buffered saline (PBS), azithromycin (50 mg/kg), trovafloxacin (50 mg/kg), or ceftriaxone (100 mg/kg) injected subcutaneously twice daily for 5 days. Antibiotic concentrations were measured by high-performance liquid chromatography. Azithromycin, trovafloxacin, and ceftriaxone were all equally effective at preventing mortality in both cirrhotic and normal rats. Free fraction area under the curve to minimum inhibitory concentration ratio (AUC/MIC) and maximum calculated serum concentration …
Rat Sinusoidal Liver Endothelial Cells (Secs) Produce Pro-Fibrotic Factors In Response To Adducts Formed From The Metabolites Of Ethanol, Geoffrey M. Thiele, Michael J. Duryee, Thomas L. Freeman, Michael F. Sorrell, Monte S. Willis, Dean J. Tuma, Lynell W. Klassen
Rat Sinusoidal Liver Endothelial Cells (Secs) Produce Pro-Fibrotic Factors In Response To Adducts Formed From The Metabolites Of Ethanol, Geoffrey M. Thiele, Michael J. Duryee, Thomas L. Freeman, Michael F. Sorrell, Monte S. Willis, Dean J. Tuma, Lynell W. Klassen
United States Public Health Resources
Previous studies with alcohol-associated malondialdehyde–acetaldehyde (MAA)-modified proteins have demonstrated an increase in the expression of adhesion molecules, and the secretion of pro-inflammatory cytokines/chemokines by rat sinusoidal liver endothelial cells (SECs). However, no studies have been initiated to examine the effects of MAA-modified proteins on the expression of the extracellular matrix (ECM) protein, fibronectin and its isoforms. For these studies, SECs were isolated from the liver of normal rats, and exposed to MAA-modified bovine serum albumin (MAA–Alb). At selected time points, the total plasma and cellular fibronectin were determined by Western blot. Injection of rat liver via the mesenteric vein with …
Spatial Management Of Wildlife Disease, Richard Horan, Christopher Wolf, Eli P. Fenichel, Kenneth H. Mathews, Jr.
Spatial Management Of Wildlife Disease, Richard Horan, Christopher Wolf, Eli P. Fenichel, Kenneth H. Mathews, Jr.
Michigan Bovine Tuberculosis Bibliography and Database
The spread of wildlife diseases is a major threat to livestock, human health, resource-based recreation, and biodiversity conservation (Cleaveland, Laurenson, and Taylor). The development of economically sound wildlife disease-management strategies requires an understanding of the links between ecological functions (e.g., disease transmission and wildlife dispersal) and economic choices, and the associated tradeoffs. Spatial linkages are particularly relevant. Yet while ecologists have long-argued that space is important (Hudson et al.), prior economic work has largely ignored spatial issues.
For instance, Horan and Wolf analyzed a case study of bovine tuberculosis (bTB) in Michigan deer, a problem where the disease appears to …
Michigan Bovine Tuberculosis Eradication Project: 2005 Activities Report And Conference Proceedings
Michigan Bovine Tuberculosis Eradication Project: 2005 Activities Report And Conference Proceedings
Michigan Bovine Tuberculosis Bibliography and Database
On June 7 and 8, 2005, the State of Michigan and U.S. Department of Agriculture hosted the ninth annual bovine Tuberculosis (TB) meeting of scientists, with the intent to share research information and provide updates on policies, regulations and activities regarding bovine TB.
This document is a thank you to stakeholders and serves as an annual report offering insight into the finer points of this multi-agency project. The year 2005 has been one of milestones. The Upper Peninsula received TB-Free Status; only one TB positive farm was found during routine surveillance testing; and the disease prevalence rate in Deer Management …
The Un And The Responsibility To Practice Public Health, David P. Fidler
The Un And The Responsibility To Practice Public Health, David P. Fidler
Articles by Maurer Faculty
No abstract provided.
Pathogenesis Of Intracranial Aneurysms, Brian Vala Nahed
Pathogenesis Of Intracranial Aneurysms, Brian Vala Nahed
Yale Medicine Thesis Digital Library
Introduction: Intracranial aneurysms (IA) are a common neurological problem, the rupture of which frequently constitutes a catastrophic neurological event. While the pathogenesis is largely unknown, it is believed that both genetic and environmental factors work in concert to some degree within patients. Our goal was to take a comprehensive approach to understanding the pathogenesis of IA by identifying factors leading to the formation, growth and rupture of IA. Methods: Since 1994, we have recruited patients and families with IA into the Yale Brain Aneurysm Database. Information regarding aneurysm characteristics (size, location, number), patient characteristics (age, medical, and social history), and …
Introduction, Melanie Santiago
Introduction, Melanie Santiago
Journal of Health Care Law and Policy
No abstract provided.
The 800 Pound Gorilla Sleeps: The Federal Government's Lackadaisical Liability And Compensation Policies In The Context Of Pre-Event Vaccine Immunization Programs, Michael Greenberger
The 800 Pound Gorilla Sleeps: The Federal Government's Lackadaisical Liability And Compensation Policies In The Context Of Pre-Event Vaccine Immunization Programs, Michael Greenberger
Journal of Health Care Law and Policy
No abstract provided.
Old Legacies And New Paradigms: Confusing "Research" And "Treatment" And Its Consequences In Responding To Emergent Health Threats, Gail H. Javitt
Old Legacies And New Paradigms: Confusing "Research" And "Treatment" And Its Consequences In Responding To Emergent Health Threats, Gail H. Javitt
Journal of Health Care Law and Policy
No abstract provided.
Inoculation Inventions: The Interplay Of Infringement And Immunity In The Development Of Biodefense Vaccines, Cynthia M. Ho
Inoculation Inventions: The Interplay Of Infringement And Immunity In The Development Of Biodefense Vaccines, Cynthia M. Ho
Journal of Health Care Law and Policy
No abstract provided.
Some Right Jabs And Back In The Ring: Lessons Learned From The Phase I Civilian Smallpox Program, Elin Gursky, Avani Parikh
Some Right Jabs And Back In The Ring: Lessons Learned From The Phase I Civilian Smallpox Program, Elin Gursky, Avani Parikh
Journal of Health Care Law and Policy
No abstract provided.
Research Involving Children: Regulations, Review Board, And Reform, Rupali Gandhi
Research Involving Children: Regulations, Review Board, And Reform, Rupali Gandhi
Journal of Health Care Law and Policy
No abstract provided.
Faster, Higher, Stronger? Federal Efforts To Criminalize Anabolic Steroids And Steroid Precursors, Adrian Wilairat
Faster, Higher, Stronger? Federal Efforts To Criminalize Anabolic Steroids And Steroid Precursors, Adrian Wilairat
Journal of Health Care Law and Policy
No abstract provided.
Identification Of Neuronal Enhancers Of The Proopiomelanocortin Gene By Transgenic Mouse Analysis And Phylogenetic Footprinting, Flavio S. J. De Souza, Andrea M. Santangelo, Viviana Bumaschny, Marıa Elena Avale, James L. Smart, Malcolm J. Low, Marcelo Rubinstein
Identification Of Neuronal Enhancers Of The Proopiomelanocortin Gene By Transgenic Mouse Analysis And Phylogenetic Footprinting, Flavio S. J. De Souza, Andrea M. Santangelo, Viviana Bumaschny, Marıa Elena Avale, James L. Smart, Malcolm J. Low, Marcelo Rubinstein
Faculty Publications - Department of Biological & Molecular Science
The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus. POMC arcuate neurons play a central role in the control of energy homeostasis, and rare loss of function mutations in POMC cause obesity. Moreover, POMC is the prime candidate gene within a highly significant quantitative trait locus on chromosome 2 associated with obesity traits in several human populations. Here, we identify two phylogenetically conserved neuronal POMC enhancers designated nPE1 (600 bp) and nPE2 (150 bp) located approximately 10 to 12 kb upstream of mammalian POMC transcriptional units. We show that mouse or human genomic regions …
Imposed Constraints On The Smith-Waterman Alignment Algorithm For Enhanced Modeling Of A Single-Molecule Dna Sequencer, Patrick G. Humphrey, Gregory R. Bashford
Imposed Constraints On The Smith-Waterman Alignment Algorithm For Enhanced Modeling Of A Single-Molecule Dna Sequencer, Patrick G. Humphrey, Gregory R. Bashford
Biomedical Imaging and Biosignal Analysis Laboratory
An effort has been underway to develop a system for de novo sequencing of single DNA molecules with very long reads. The system operates by optically detecting the passage of fluorescently tagged DNA bases through a detection zone. A successful system would be revolutionary with respect to speed, read length, cost and minimized laboratory infrastructure. An important part of system development is modeling of the detection process. In particular, predicting the expected error from a set of sequencing parameters is helpful in system design. This paper describes variations on the Smith-Waterman algorithm for subsequence alignment used in a single-molecule detection …
Takagi–Sugeno Fuzzy Modeling Of Skin Permeability, Deepak R. Keshwani, David D. Jones, Rhonda M. Brand
Takagi–Sugeno Fuzzy Modeling Of Skin Permeability, Deepak R. Keshwani, David D. Jones, Rhonda M. Brand
Department of Agricultural and Biological Systems Engineering: Faculty Publications
The skin is a major exposure route for many potentially toxic chemicals. It is, therefore, important to be able to predict the permeability of compounds through skin under a variety of conditions. Available skin permeability databases are often limited in scope and not conducive to developing effective models. This sparseness and ambiguity of available data prompted the use of fuzzy set theory to model and predict skin permeability. Using a previously published database containing 140 compounds, a rule-based Takagi–Sugeno fuzzy model is shown to predict skin permeability of compounds using octanol-water partition coefficient, molecular weight, and temperature as inputs. Model …
Potential Roles Of Follicular Dendritic Cell–Associated Osteopontin In Lymphoid Follicle Pathology And Repair And In B Cell Regulation In Hiv-1 And Siv Infection, Qingsheng Li, Jeffrey D. Lifson, Lijie Duan, Timothy Schacker, Cavan Reilly, John V. Carlis, Jacob D. Estes, Ashley T. Haase
Potential Roles Of Follicular Dendritic Cell–Associated Osteopontin In Lymphoid Follicle Pathology And Repair And In B Cell Regulation In Hiv-1 And Siv Infection, Qingsheng Li, Jeffrey D. Lifson, Lijie Duan, Timothy Schacker, Cavan Reilly, John V. Carlis, Jacob D. Estes, Ashley T. Haase
Qingsheng Li Publications
Osteopontin is a multifunctional protein with known roles in bone remodeling, wound healing, and normal and pathological immune responses. We showed in microarray studies that osteopontin gene expression is increased in human immunodeficiency virus type 1 (HIV-1)–infected lymphatic tissues after treatment, and we undertook mapping experiments to study osteopontin’s possible functions in this context. We discovered species-specific colocalization of osteopontin with the follicular dendritic cell (FDC) network in lymphatic tissues in HIV-1 and simian immunodeficiency virus infections, and we found that changes in FDC-associated osteopontin covary with changes in lymphoid follicles during acute and late stages of infection and in …
College Of Optometry Student Handbook 2005-2006, Nova Southeastern University
College Of Optometry Student Handbook 2005-2006, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
On The Utility Of Stochastic Models Of Chronic Obstructive Pulmonary Disease, Rebecca Boehm
On The Utility Of Stochastic Models Of Chronic Obstructive Pulmonary Disease, Rebecca Boehm
MUSC Theses and Dissertations
Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible lung disease characterized by reduced lung function, abnormal inflammatory response, dyspnea, increased sputum production, and costly and debilitating exacerbations. Common treatments for COPD include smoking cessation therapy, short- and long-acting bronchodilators, inhaled corticosteroids, pulmonary rehabilitation, and home oxygen therapy. However, a recent meta-analysis demonstrated that inhaled corticosteroids fail to slow the decline in FEV1, the primary clinical marker of COPD progression. In addition, some evidence exists to suggest that long-term inhaled corticosteroid use may increase bone density loss, leading to osteoporosis. Given that the bone health effects of inhaled corticosteroid …
Latinas And Breast Cancer In The Midwest: Factors Influencing Survivorship, M. Elise Radina, Daniel R. Longo, Jane M. Armer
Latinas And Breast Cancer In The Midwest: Factors Influencing Survivorship, M. Elise Radina, Daniel R. Longo, Jane M. Armer
International Journal of Global Health and Health Disparities
Latinos are the largest ethnic minority group in the U.S. and the Midwest is experiencing the fastest growth in residents of Hispanic descent. Rural health care delivery systems in these areas must therefore respond to changing demographics and provide culturally appropriate service delivery. The incidence rate of breast cancer among Latinas is lower than that among non-Hispanic women; however an increasing number of Latinas are being diagnosed with breast cancer. Despite higher mortality rates from cancer than non-Hispanic women, more Latinas are being treated for breast cancer and are now facing their own unique survivorship experiences This paper addresses factors …
The Role Of The Insecticide Ddt In Breast Cancer, Jared D. Taylor
The Role Of The Insecticide Ddt In Breast Cancer, Jared D. Taylor
International Journal of Global Health and Health Disparities
Breast cancer is by far the most common cancer among black and white females, with approximately 211,000 new cases expected to be diagnosed in the U.S. in 2004 (1). More importantly, incidence has been increasing. Age-adjusted breast cancer incidence in U.S. females rose from the 88.6 per 100,000 in the early 1970s to 109.8 in the early 1990s (2). This represents a 24 percent increase over that time. This trend is only partially explained by the known risk factors for breast cancer, including advancing age, early menarche, late menopause, late age at first parturition and family history. Therefore, researchers have …
Synthesis Of Intermediates Of Receptor-Subtype Selective Lpa Antagonists, Danielle Zafrane
Synthesis Of Intermediates Of Receptor-Subtype Selective Lpa Antagonists, Danielle Zafrane
Theses & Honors Papers
It has been shown that 1-oleoyl lysophosphatid ic acid (LPA; 1-acyl-2-glycerol-3-phosphate) plays a vital role in the progression and proliferation of ovarian cancer. The design and synthesis of LPA receptor selective agonists and antagonists has been the focus of intense research within the last ten years .1 During the Research Experience for Undergraduate s (REU) internship at the University of Virginia 4-bromo-2-(hydroxymethyl)pyridine (intermediate 43) was designed and synthesized based on earlier results. Intermediate 43 was used to modify a current LPA analogue. Modification of current LPA analogues may result in the discovery of potent and metabolically stable LPA antagonists …
Law, Medicine, And Religion: Towards A Dialogue And A Partnership In Biomedical Technology And Decision Making, George P. Smith Ii
Law, Medicine, And Religion: Towards A Dialogue And A Partnership In Biomedical Technology And Decision Making, George P. Smith Ii
Scholarly Articles
Faith, religion, spirituality, and prayer have a current focused outreach and easy parlance in the market places and public squares of the nation. News stories and court cases abound with dramatic challenges to the placement of monuments to the Ten Commandments in public buildings and grounds, the use of God's name in school pledges of allegiance, the teaching of Darwinian or evolutionary science in public education, the role of faith and religion in health care healing, and even the value of affirmations of religious faith on the political hustings. The purpose of this article is to explore the conjunctive and …
Female Genital Cutting Among The Somali Of Kenya And Management Of Its Complications, Guyo W. Jaldesa, Ian Askew, Carolyne Njue, Monica Wanjiru
Female Genital Cutting Among The Somali Of Kenya And Management Of Its Complications, Guyo W. Jaldesa, Ian Askew, Carolyne Njue, Monica Wanjiru
Reproductive Health
The Somali community living in Kenya (and in their native Somalia) has practiced the severest form of female genital cutting (FGC)—infibulation—for centuries. To understand the context within which the practice takes place, and how its complications are managed, the Population Council’s Frontiers in Reproductive Health Program undertook a diagnostic study that confirmed that FGC is a deeply rooted and widely supported cultural practice. Several closely related reasons are used to sustain the practice: religious obligation, family honor, and virginity as a prerequisite for marriage; an aesthetic preference for infibulated genitalia was also mentioned. The study also found that the health …
Master Of Medical Science Graduate Distance Education Program Overview, Nova Southeastern University
Master Of Medical Science Graduate Distance Education Program Overview, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Liberty Or Death: Maryland Improves Upon The Model State Emergency Health Powers Act, Franklin H. Alden Jr.
Liberty Or Death: Maryland Improves Upon The Model State Emergency Health Powers Act, Franklin H. Alden Jr.
Journal of Health Care Law and Policy
No abstract provided.
Informed Consent And Public Health: Are They Compatible When It Comes To Vaccines?, Wendy E. Parmet
Informed Consent And Public Health: Are They Compatible When It Comes To Vaccines?, Wendy E. Parmet
Journal of Health Care Law and Policy
No abstract provided.
Identification Of Cystacanths And Adults Of Oligacanthorhynchus Tortuosa, Macracanthorhynchus Ingens, And Macracanthorhynchus Hirudinaceus Based On Probiscis And Hook Morphometrics, Dennis J. Richardson
Identification Of Cystacanths And Adults Of Oligacanthorhynchus Tortuosa, Macracanthorhynchus Ingens, And Macracanthorhynchus Hirudinaceus Based On Probiscis And Hook Morphometrics, Dennis J. Richardson
Journal of the Arkansas Academy of Science
No abstract provided.
Validation Of An Immunomagnetic-Electrochemiluminescence Detection System For The Detection Of Escherichia Coli 0157 In Food And Comparison With An Iso Standard Method, Eimear Carney
Theses
Rapid and sensitive methods for detecting Escherichia coli 0157 in contaminated food, water and other biological samples are important in limiting and preventing the spread of this pathogen. Traditional culture based methods for bacterial identification and detection can be time consuming and labour intensive. Modem alternative methods should be faster whilst maintaining sensitivity. Immunomagnetic separation (IMS) methodology has been investigated and appears promising for rapid bacterial detection in unrelated food and environmental samples. In this study, a commercial sensor which combined IMS with electrochemiluminescence (ECL) was evaluated for the detection of E. coli 0157 in unrelated food matrices. Emitted signals …