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Calix[4]Arene Structure And Function In Sensors, Deuteration Of Cystine Derivatives, And Purification Of Pyrimidine-Based Antibiotics, Ryan P. Madigan

Chemistry & Biochemistry Dissertations - Archive

Calixarenes are cyclic oligomers known for their unique molecular architecture that provides a versatile platform for applications in supramolecular chemistry. These molecules have exceptional binding ability to cations in solution, while also having multiple methods for tunability to change selectivity of cation. When coupled with fluorescent molecules, this serves as a binding domain which can be tuned to develop highly selective chemosensors. Neutrinoless double beta decay is a proposed particle phenomenon in which two neutrons spontaneously convert to two protons and eject 2 electrons, without the ejection of two neutrinos. In a model system, Xenon can be utilized as the …

Solution Combustion Synthesis And Characterization Of Fumarolic Mineral Dolerophanite, Copper (Ii) Oxide Sulfate, Eric J. Cyganowski

Chemistry & Biochemistry Theses - Archive

Dolerophanite Cu₂OSO₄ is a rare mineral found almost exclusively in the fumaroles of volcano systems and is sensitive to temperature and humidity conditions. It has a monoclinic C2/m crystal structure characterized by two-dimensional layers composed of sulfate anions dispersed amongst copper (II) oxide backbones. There has been recent interest in dolerophanite due to the magnetic properties of its Kagome-like lattice as well as its potential use as a photocatalyst or Li-ion battery electrode. Literature on the material however has been limited by the available synthesis strategies. As such, this thesis work presents a novel strategy …

Content Analysis Of The Omani Sciences Textbooks Of Grades (5-8) In The Light Of Timss 2019 Requirements, Raed Abdelkarim, Youssef A. Al Barami, Sobhy A. Soliman, Alaa Aladini

Journal of Educational and Psychological Studies

Abstract: The current study aimed to determine the requirements of Trends of International Mathematics and Science Study (TIMSS 2019) and to find out the extent to which the content of science textbooks for grades (5-8) in the Sultanate of Oman includes the requirements of (TIMSS 2019). Only the content dimension has been taken into account when conducting the content analysis. The study population includes all science books from the fifth to the eighth grade for the academic year 2021-2022. The study identified and organized the requirements in the study tool, and after confirming its validity and reliability, the analysis was …

Weaving Empire: The Role Of Wool, The Subjugated, The Enslaved, And The Convicted In Building The British Empire, 1699-1860, Lisa Y. Gabbert

History Dissertations - Archive

A bright red woolsack comprised of wool clippings from across England sits prominently in the House of Lords. King Edward III originally commissioned the cushion for the Speaker to sit upon while conducting Parliamentary business to signify the importance of the commodity. In 1699, as British trade and territorial interests expanded, Parliament issued the Wool Act. It outlined the expectations and limitations of wool production and exchange in British controlled territories. While the British economy benefitted from commodities such as tobacco, sugar, and cotton which was largely produced by convict and enslaved laborers in its colonies, wool remained an essential …

Understanding The Origin Of Parthenogenesis Via Crossing And Crispr Gene Editing In Daphnia Pulex, Thinh Pham

Biology Dissertations - Archive

Daphnia has been used as a key model system for studying ecological changes, evolution, and genomics for the past few decades due to its rapid turnover time in reproduction. The organism possesses two fascinating modes of reproduction: obligate parthenogenesis and cyclical parthenogenesis. This dissertation delves into the intricate reproductive strategies of Daphnia pulex, focusing on hybrid F1s from different reproductive modes. The first aim is to investigate 31 hybrid F1s generated from obligate parthenogenesis (OP) and cyclical parthenogenesis (CP) parental lines. Transcriptomic analysis reveals misexpression patterns and regulatory divergences, highlighting meiosis-related genes like CDC6 as potential parthenogenesis regulators. The …

Exploring Ecological Drivers Of Evolution Of The Brain, Cognition, And Behavior, Meghan Korte

Biology Dissertations - Archive

Evolutionary theory proposes that increases in brain size confer cognitive and behavioral benefits that offset the expensive investment in brain tissue. However, few studies have examined the relationship between brain size, cognition, and behavior within species. The majority of research has focused on cross-species comparisons, thus there is a need for empirical research within species examining how contrasting ecological pressures select for cognitive and behavioral benefits and how these may evolve in tandem with changes in brain size. My dissertation addresses this gap by examining: 1) Whether selection on brain size is linked to improvements in cognitive ability; 2) How …

Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin

Biology Dissertations - Archive

Mycobacteria encompass many pathogenic species known to cause severe disease in humans. A well-known example is Mycobacterium tuberculosis (Mtb), the causative agent of the lung disease tuberculosis, which kills millions of humans worldwide yearly. Pathogenic mycobacteria like Mtb are challenging to treat because of their innate ability to adapt to environmental stress. Their unique cell physiology and conserved stress responses allow them to combat biological insults, regulate growth, and regulate genes involved in stress; all these responses increase tolerance to antibiotics. The current therapies to treat mycobacterial infections are lengthy and, at times, unsuccessful, partly due to antibiotic tolerance. A …

A New Model For Polar Growth In Mycobacteria: The Role Of Wag31 And Mmpl3 In Cell Wall Synthesis, Neda Habibi Arejan

Biology Dissertations - Archive

The disease Tuberculosis (TB) is caused by the pathogen Mycobacterium tuberculosis and was the cause of over one million deaths worldwide in 2023 (World Health Organization, 2023). TB treatment is difficult due to antibiotic tolerance and emerging resistance in Mtb strains. Mycobacterial cells have different regulatory mechanisms that allow them to adjust to myriad environmental stressors: these responses often lead to antibiotic tolerance. Therefore, studying responses to stress will lead to insights about antibiotic tolerance and treatment failure. Here, we specifically study two essential mycobacterial proteins, Wag31 and MmpL3, involved in cell wall metabolism. We show that Wag31 has distinct …

Friends With Benefits: How Picking The Right Partner Pays Off, Patrick T. Stillson

Biology Dissertations - Archive

Animals are highly dependent on microbial symbionts for nutrient supplementation, parasite protection, toxin resistance, and more. While these microbes are important, these associations have the potential to shift from mutualistic to parasitic across environments and over time. Eight insect families from the hemipteran infraorder Pentatomomorpha have evolved a highly specialized relationship with bacteria in the genus Caballeronia. The symbiont is a free-living microbe, acquired from the environment each generation during early host development. By manipulating environmental conditions, I used the bug-Caballeronia model 1) to investigate whether symbionts with greater growth rates at high temperatures prevent hosts from experiencing …

Role Of Extracytoplasmic Function (Ecf) Sigma Factors In The Survival And Symbiosis Of Nitrogen-Fixing Bradyrhizobium Under Desiccation Stress And Comparative Analysis Of Desiccation-Tolerant Rhizobial Isolates, Mohammad Kamruzzaman

Biology Dissertations - Archive

Rhizobia are soil bacteria that facilitate biological nitrogen fixation (BNF) through a symbiotic relationship with legumes such as soybeans. As an eco-friendly alternative to chemical nitrogen fertilizers, rhizobial inoculants can enhance plant growth and yield. However, they face various stresses, including drought (i.e., desiccation). Rhizobia can manage desiccation stress by accumulating trehalose, a disaccharide produced by genes such as otsA, otsB, and treS. Extracytoplasmic function (ECF) sigma factors sense external signals and regulate these desiccation-related genes during the stress. Previous studies have highlighted the importance of EcfG in response to desiccation stress and symbiosis. Based on the protein sequence …

A Perceptual Investigation Of Speech Rhythm Based On A Continuum Of Durational Change, Matthew Benton

Linguistics & TESOL Dissertations - Archive

Speech rhythm is a complicated prosodic feature of spoken languages. Being a suprasegmental feature, it is not a clear cut difference between tonal (Chinese) and non-tonal (English) languages. The popularization of defining languages in terms of their speech rhythms was popularized in the mid 1900’s. Terms like syllable-timed and stress-timed were coined and ever since then there has been much debate on what is a speech rhythm and why particular languages have different rhythms. While speech rhythm was initially a study based on how a listener perceived a spoken language, it became much more focused on measurements and attempts to …

Enhancing Electromigration Reliability In Solder Interconnects Through Microstructure Control And Thermomechanical Failure Mechanisms In Thin Metal Lines Under Surge Current Conditions, Hariram Mohanram

Material Science and Engineering Dissertations - Archive

The relentless miniaturization of semiconductor devices has intensified reliability challenges in electronic packaging, particularly for solder interconnects and thin metal lines. This dissertation investigates two critical failure mechanisms—electromigration (EM) and thermomechanical fatigue (TMF)—and explores strategies to mitigate these effects. Electromigration, driven by high-density current-induced atomic migration, significantly impacts solder interconnects. This study examines the role of Under-Bump Metallization (UBM) and solder microstructure in improving EM reliability. Findings reveal that thicker UBMs delay void nucleation and enhance EM resistance, while the absence of UBM leads to failure through vertical void propagation. Additionally, grain orientation, particularly the c-axis alignment in Sn grains, …

Optimal Control Frameworks For A Class Of Epidemiological And Oncological Models, Asma Ali H Alghamdi

Mathematics Dissertations - Archive

In this thesis, we employ optimal control frameworks in two distinct contexts: Human immunodeficiency virus (HIV) and esophageal cancer. For HIV, we introduce a comprehensive data-driven nonlinear optimization framework designed for personalized therapies. This framework utilizes a deterministic in-host nonlinear ordinary differential equation (ODE) model and formulates two optimization problems using individual patient data. The first problem focuses on estimating patient-specific parameters through constrained optimization, while the second problem determines optimal combination therapies to reduce viral load to undetectable levels. Several numerical experiments suggest that our framework can provide a robust and effective optimal dosages with lower toxicity levels to …

Evaluating Factors Influencing Wound Healing: A Mixture Cure Rate Model Approach, Anoushka Khayar

Mathematics Theses - Archive

The study focuses on healing of chronic wound. A cure rate and probabilities of patients are calculated and visualized byusing Proportional Hazards Mixture Cure (PHMC) Model. This study reveals that alkaline wounds tend to heal slower than non-alkaline wounds, with significant differences between male and female patients. To be specific, males generally exhibit slower wound healing in both alkaline and non-alkaline conditions compared to females. This study also reveals the need for future research into biological, environmental and social factors, such as hormonal imbalance, living conditions and caregiver support among the patients.

Statistical Analysis On The Effects Of Environmental Factors On Bridge Condition Rating In Texas, Mohammad Wasif Quadri

Civil Engineering Theses - Archive

The development of predictive models for bridge deterioration is crucial for ensuring the longevity and safety of transportation infrastructure. Bridge condition degradation is heavily influenced by environmental conditions. This research integrates various environmental variables such as rainfall, humidity, air temperature, coastal influence, and freezing effects to generate environmental risk scores. These scores help in developing environmental risk zones within the Texas region. Deck condition ratings from the National Bridge Inventory (NBI) database are used to develop deterioration models using linear regression and the Markov method. The results highlight the impact of different environmental risk zones on bridge degradation patterns and …

The Establishment And Sustainment Of Trauma-Informed Culture Perspectives Of Trauma-Sensitive Principals In Elementary Public Schools, Elizabeth R. Foreman

Educational Leadership & Policy Studies Dissertations - Archive

The COVID-19 pandemic brought much awareness to the public education system and the role it plays in alleviating the adverse effects of childhood trauma. However, extant literature has focused mainly on classroom-level interventions rather than school-wide interventions implemented by school leadership. This study examines the perspectives of trauma-sensitive principals in public elementary schools on implementing TIPs. The research questions that guided this study are as follows: What are elementary principals' perceptions regarding implementing school-wide TIPs? What are the leadership approaches of principals in trauma-informed schools? Two findings were identified: (1) principals proactively establish a trauma-informed culture, and (2) principals sustain …

Student Knowledge Of Sexual Assault Resources, Kali Forden

Murray State Theses and Dissertations

Despite the changes in policy and the endorsement of mandatory reporting among college students over time, less than half of survivors of sexual assault report the incident to police or university officials (Cantor et al., 2020). Further, while there is little research on the subject, Moore and Baker (2016) found that a student’s residence can influence whether they report a sexual assault. This project sought to extend this research to determine whether a student’s residence and knowledge of available resources effects the likelihood to report a hypothetical sexual assault. Additionally, it sought to determine the relationship between reporting a sexual …

The Federal Future Of Medication Abortion, Michelle S. Simon

Elisabeth Haub School of Law Faculty Publications

A majority of Americans believe that there should be a right to abortion, at least in some cases. Yet a vocal and determined minority has its sights set on a complete ban on all abortions everywhere in the United States. In many states, these anti-abortion activists have achieved their goal through new laws and limitations enacted in the wake of the Supreme Court's 2022 decision in Dobbs. Anti-abortion advocates are also challenging the Food and Drug Administration's regulatory approval of mifepristone, one of the drugs used in medication abortion (also known as medical abortion). The FDA had initially approved mifepristone …

Displacing Climate Precarity, Camila Bustos, Julia Neusner

Elisabeth Haub School of Law Faculty Publications

In this Essay, we explore these questions and present a two-part argument. In Parts II and III, we argue that because climate change is exacerbating other drivers of displacement, it is seldom possible to attribute movement to any single factor or to categorize movement conclusively as voluntary or involuntary. Therefore, expanding pathways to safety for all people on the move is the best approach to protect those displaced, directly or indirectly, by climate change and environmental disasters. In Part IV, we argue that, despite attribution and definitional challenges with regard to climate-related mobility, documenting and assessing the role of climate …

Two-Year Clinical Performance Of The Indirect Resin Composite Restorations In Endodontically Treated Teeth With Different Cavity Preparation Designs: A Randomized Clinical Trial., Mohamed Fouad Haridy, Hoda Omar Fouda, Hend Sayed Ahmed, Shehabeldin Saber, Maha Elbaz, Olfat Hassanien, Ahmed Abuelezz

Dentistry

No abstract provided.

United States Court Of Appeals For The Tenth Circuit, Abigail Frische, Eleanor C. Hasenbeck

Water Law Review

No abstract provided.

Strategic Enforcement: A Shift From Analytic To Systemic Thinking And Strategy, Raul Virella

Full-Text Theses & Dissertations

In 2021, the State of New Jersey mandated a shift from nearly seventy years of linear, complaint-based enforcement of labor laws to a strategic enforcement approach that recognizes the complex and dynamic nature of the workplace. This dissertation explores how members of the New Jersey Division of Wage and Hour Compliance transitioned their thinking and practices to align with this new approach. A 15-item survey was distributed via email to a sample of 94 members from the Division of Wage and Hour Compliance and the Office of Strategic Enforcement and Compliance, focusing on two research questions.

The first research question …

A Systems Informed Approach To The Complex Challenges Of The Industrial Hemp Industry In Pennsylvania, John Ervin

Full-Text Theses & Dissertations

Utilizing systems thinking methodologies and tools, this dissertation explores the complex growth and development challenges faced by the industrial hemp industry in Pennsylvania. Identified were key stakeholders, regulatory barriers, and market forces influencing the industry revealing a misalignment of goals and a lack of stakeholder collaboration as significant impediments. Legal and regulatory frameworks, supply-demand imbalances, and ineffective partnerships emerged as critical factors impacting the industry's future. Recommendations to address misalignments include fostering stakeholder collaboration, improving public-private partnerships, and utilizing interactive planning to address systemic issues to enhance the industry's growth potential.

Osteohistological Assessment Of Edmontosaurus Radii From The Liscomb Bonebed, Prince Creek Formation, North Slope, Alaska, Emma Griffin

Student Research Poster Presentations 2024

Hadrosaurs were one of the most diverse dinosaur groups in the Late Cretaceous period and are known for their numerous articulated skeletons and monodominant bonebeds (Wosik et al., 2020). They are more commonly known as duck-billed dinosaurs and are found globally including latitudinal extremes such as the artic and Antarctica. Edmontosaurus, a genus of hadrosaur, are herbivores and are very large growing up to 8,000 pounds. Edmontosaurus were known to travel in herds as a defense mechanism and were one of the last non-avian dinosaurs living during the late Campanian stage through the end of the Maastrichtian stage, right up …

Science Teachers’ Initial Use Of Ngss Science Practices In Diverse Classrooms, Amy Tankersley, Elizabeth Hasseler, Elizabeth B. Lewis, Lyrica Lucas, Brandon Helding

Department of Teaching, Learning, and Teacher Education: Faculty Publications

In the landscape of U.S. education, the widespread adoption of the Next Generation Science Standards (NGSS) offers a unique vantage point for researchers to better understand teacher-, school- and classroom-level factors that advance reform initiatives in science classrooms. Addressing a gap in current knowledge, our study probes how secondary science teachers implement one dimension of NGSS - the science practices (SPs). Our data collection encompasses teacher interviews and meticulous observations of science lessons, coded for NGSS science practices (SPs) and inquiry-based teaching. Embracing a methodologically rich approach, our study employs both qualitative and quantitative data collection and analysis. Quantitatively, we …

State Discretion Is Not Enough: The Case For A Constitutional Right To Fetal Personhood, Mary Clare Walters

University of Memphis Law Review

No abstract provided.

Machine Learning To Identify Structural Motifs In Asphaltenes, Arun K. Sharma, Selsela Arsala, James Brady, Madison Franke, Shelby Franke, Supreet Gandhok, Simon-Olivier Gingras, Ana Gomez, Katelyn Huie, Kayla Katz, Samantha Kozlo, Mateo Longoria, Levi Molnar, Nathaly Peña, Sarina Regis

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Asphaltenes are organic compounds that aggregate in crude oil with two dominant molecular architectures: archipelago and continental. Continental architectures possess a single uniform island structure composed of aromatic rings in contrast to archipelago architectures with aromatic cores interconnected through aliphatic chains. The structural composition of asphaltenes varies globally due to geographical differences, posing challenges in their classification due to a lack of uniformity. This study is the first known exploration of using image-based supervised machine learning, particularly the ResNet-50 neural network, for the binary classification of asphaltenes into continental and archipelago motifs. 255 continental and archipelago models underwent structural augmentations …

8th Cauthen Seminar (2024) Program, Cauthen-Seminar

Veterinary Science Presentations

Contained here is the complete program for the 8th Annual Cauthen Seminar held at the Gluck Equine Research Center.

The Cauthen seminar series was started in 2017 as a tribute and memorial to respected and beloved farrier and teacher, “Tex” Cauthen, developed to encourage the sharing of best practices, technology, research, experience, and insight among all communities in the equine industry, from owners, farriers, track managers, veterinarians, and jockeys.

The annual series has been hosted at the Gluck Equine Research Center at the University of Kentucky in Lexington, KY along with a live broadcast as a Zoom webinar, offered free …

Navigating Religious Attitudes Towards Assisted Reproductive Technology, Gretchen Ruschman

Gaines Fellow Senior Theses

As global infertility rates increase, the growing utilization of assisted reproductive technology (ART), specifically in vitro fertilization (IVF), has introduced a range of ethical concerns. Religious beliefs play a crucial role in shaping societal norms and guiding individual ethical deliberation, which is also true in navigating the ethical framework surrounding ART. Therefore, it is important to acknowledge the role of religion in shaping perspectives on ART and explore the role of religion in ethical decision-making on an individual and a community scale. This study explored different religious perspectives on ethical issues surrounding the current state and potential future advancements of …

Personal Narratives As Mechanisms To Explore The Stem Undergraduate Research Experience, Isha Chauhan

Gaines Fellow Senior Theses

STEM (science, technology, engineering, and mathematics) has popularly been labeled as reliant on objective analysis, while, conversely, humanities are rooted in engaging human virtue and creating connections between people. A particularly interesting piece of the humanities is storytelling, which allows people of unique backgrounds to develop creative connections to their work. In this way, STEM and the humanities are united by personal experience and the ability to convey such. This connection can be demonstrated through the STEM undergraduate experience, which has been greatly underrepresented in the form of personal narratives. With the format of personal narratives being conducive to discussion …