Digital Commons Network^™

Act-5 Is An Essential Caenorhabditis Elegans Actin Required For Intestinal Microvilli Formation, A. J. Macqueen, J. J. Baggett, N. Perumov, R. A. Bauer, T. Januszewski, L. Schriefer, J. A. Waddle

Open Access Publications

No abstract provided.

The Type Iα Inositol Polyphosphate 4-Phosphatase Generates And Terminates Phosphoinositide 3-Kinase Signals On Endosomes And The Plasma Membrane, Ivan Ivetac, Adam D. Munday, Marina V. Kisseleva, Xiang-Ming Zhang, Susan Luff, Tony Tiganis, James C. Whisstock, Tony Rowe, Phillip W. Majerus, Christina A. Mitchell

Open Access Publications

No abstract provided.

A Model Of The Statistical Power Of Comparative Genome Sequence Analysis, Sean R. Eddy

Open Access Publications

No abstract provided.

A Surface Groove Essential For Viral Bcl-2 Function During Chronic Infection In Vivo, Joy Loh, Qiulong Huang, Andrew M. Petros, David Nettesheim, Linda F. Van Dyk, Lucia Labrada, Samuel H. Speck, Beth Levine, Edward T. Olejniczak, Herbert W. Virgin Iv

Open Access Publications

No abstract provided.

Pgc-1alpha Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control And Hepatic Steatosis, Teresa C. Leone, John J. Lehman, Brian N. Finck, Paul J. Schaeffer, Adam R. Wende, Sihem Boudina, Michael Courtois, David F. Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O. Holloszy, Denis M. Medeiros, Robert E. Schmidt, Jeffrey E. Saffitz, E. D. Abel, Clay F. Semenkovich, Daniel P. Kelly

Open Access Publications

No abstract provided.

Evidence For Domesticated And Wild Populations Of Saccharomyces Cerevisiae, Justin C. Fay, Joseph A. Benavides

Open Access Publications

No abstract provided.

College Of Osteopathic Medicine Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Prevalence Of Type 2 Diabetes Among Minority Groups, Patricia Elizabeth Sanchez

Theses Digitization Project

The purpose of this study was twofold. First, the study evaluated Loma Linda University Medical Center's (LLUMC) Diabetes Treatment Center's (DTC) effectiveness in providing diabetes education and services to high risk minority populations. Second, the results of the study helped the DTC determine the need for expanding its present efforts in the form of community health prevention services to San Bernardino County residents.

Medical Technology: Contexts And Content In Science And Technology, Michael A. De Miranda, Mark Doggett, Jane T. Evans

Architectural and Manufacturing Sciences Faculty Publications

No abstract provided.

Providing Effective Counseling To Substance Abusers Through The Use Of Biopsychosocialspiritual Strategies, Rachel Phillips

Graduate Research Papers

The field of substance abuse has had a history of relapse. Both In-Patient and Out-Patient Treatment facilities have experienced the "revolving door" effect (Walton, Blow, and Booth, 2001). D.R. Laws found in research he conducted that 80% of the patients treated, relapsed 12 months after treatment and two-thirds of the relapses were within 90 days of treatment (Laws, 1999). The federal government has begun questioning the validity of these programs in light of skyrocketing costs for substance abuse treatment (Craig, 2004). Clinicians have begun to examine the cost effectiveness of their current treatment modalities. This paper will provide an overview …

Convergence Analysis Of Mcmc Method In The Study Of Genetic Linkage With Missing Data, Diana Fisher

Theses, Dissertations and Capstones

Computational infeasibility of exact methods for solving genetic linkage analysis problems has led to the development of a new collection of stochastic methods, all of which require the use of Markov chains. The purpose of this work is to investigate the complexities of missing data in pedigree analysis using the Monte Carlo Markov Chain (MCMC) method as compared to the exact results. Also, we attempt to determine an association between missing data in a familial pedigree and the convergence to stationarity of a descent graph Markov chain implemented in the stochastic method for parametric linkage analysis.

In particular, we will …

Effect Of Dna Base Modification On Polymerase Chain Reaction Efficiency And Fidelity, Jan A. Sikorsky

Theses, Dissertations and Capstones

Polymerase stop assays, used to quantify DNA damage, assume single lesions are sufficient to block thermostable DNA polymerase progression. To explore this assumption, 90 base oligonucleotides containing normal or modified DNA bases were amplified using real-time PCR. Data implied that the PCR efficiency was influenced to differing degrees depending on which base lesion was present on the input oligonucleotide; specifically, while reactions with templates containing a single 8-oxo-7,8-dihydro-2í-deoxyguanosine (8-oxodG) were not noticeably altered, the presence of a single 8-oxo-7,8-dihydro-2í-deoxyadenosine, an abasic site, or a cis-syn thymidine dimer (TT dimer) dramatically delayed amplification. In addition, the presence of two tandem 8-oxodGs …

The Effects Of Parental Alcoholism On Children, Ryan A. Flaherty

Graduate Research Papers

Research has examined the effects of parental alcoholism on children and adolescents. This paper will address the different ways teens are affected by parental alcoholism, identifying medical, emotional, and social dangers, while also trying to link specific aspects of parental alcoholism with each harmful effect. In looking at the negative effects that parental alcoholism has on the parents and children, this paper will also examine whether children become victims and suffer, or become resilient and persevere. This paper will also look at physical, social, emotional, behavioral and family structure concerns as they relate to children with alcoholic parents.

The Future Of Teratology Research Is In Vitro, Jarrod Bailey, Andrew Knight, Jonathan Balcombe

Experimentation Collection

Birth defects induced by maternal exposure to exogenous agents during pregnancy are preventable, if the agents themselves can be identified and avoided. Billions of dollars and manhours have been dedicated to animal-based discovery and characterisation methods over decades. We show here, via a comprehensive systematic review and analysis of this data, that these methods constitute questionable science and pose a hazard to humans. Mean positive and negative predictivities barely exceed 50%; discordance among the species used is substantial; reliable extrapolation from animal data to humans is impossible, and virtually all known human teratogens have so far been identified in spite …

Ld50 Testing Of Botulinum Toxin For Use As A Cosmetic, Martin L. Stephens, Michael Balls

Experimentation Collection

In 2003, the Fund for the Replacement of Animals in Medical Experiments (FRAME) revealed that the potency of botulinum toxin for use as a popular wrinkle treatment is assessed by using the LD50 Test. The endpoint in this mouse-based testing is death through suffocation. In 2004, The Humane Society of the United States (HSUS) sought to work with Allergan, the US-based manufacturer of Botox® Cosmetic, and the U.S. Food and Drug Administration (FDA), on ways to refine, reduce, and replace this LD50 testing. This article summarises The HSUS’s campaign in the United States and provides an update on FRAME’s continuing …

Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey

Laboratory Experiments Collection

There is much current debate surrounding the use of non-human primates (NHPs) in medical research and drug development. This review, stimulated by calls for evidence from UK-based inquiries into NHP research, takes a critical view in order to provide some important balance against papers supporting NHP research and calling for it to be expanded. We show that there is a paucity of evidence to demonstrate the positive contribution or successful translation of NHP research to human medicine, that there is a great deal of often overlooked data showing NHP research to be irrelevant, unnecessary, even hazardous to human health and …

Tgf-Beta1 And Serum Both Stimulate Contraction But Differentially Affect Apoptosis In 3d Collagen Gels, Tetsu Kobayashi, Xiangde Liu, Hui Jung Kim, Tadashi Kohyama, Fu-Qiang Wen, Shinji Abe, Qiuhong Fang, Yun Kui Zhu, John R. Spurzem, Peter Bitterman, Stephen I. Rennard

Journal Articles: Pulmonary & Critical Care Med

Apoptosis of fibroblasts may be key for the removal of cells following repair processes. Contraction of three-dimensional collagen gels is a model of wound healing and remodeling. Here two potent inducers of contraction, TGF-beta1 and fetal calf serum (FCS) were evaluated for their effect on fibroblast apoptosis in contracting collagen gels. Human fetal lung fibroblasts were cultured in floating type I collagen gels, exposed to TGF-beta1 or FCS, and allowed to contract for 5 days. Apoptosis was evaluated using TUNEL and confirmed by DNA content profiling. Both TGF-beta1 and serum significantly augmented collagen gel contraction. TGF-beta1 also increased apoptosis assessed …

The Effects Of Childhood Obesity On Self-Esteem, Heather L. Paxton

Theses, Dissertations and Capstones

Obesity is a growing health problem affecting children in the United States. The prevalence of obesity has increased dramatically over the past 10 years across virtually all populations and age groups. Recent data suggest that 15 percent of U.S. children are severely overweight or obese (National Center for Health Statistics, 2002) . Obese children are at risk for significant health problems, but also face many psychological and social consequences, including low self-esteem. Children who are obese face an increased risk of emotional problems lasting well into adulthood. Factors such as peer rejection, weight-related teasing, and internalized social standards play a …

Chronic Wasting Disease Of Elk: Transmissibility To Humans Examined By Transgenic Mouse Models, Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine I. O'Rourke, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Pertersen, Man-Sun Sy, Shu G. Chen, Pierluigi Gambetti

Zoonotics and Wildlife Disease: Publications

Chronic wasting disease (CWD), a prion disease affecting free-ranging and captive cervids (deer and elk), is widespread in the United States and parts of Canada. The large cervid population, the popularity of venison consumption, and the apparent spread of the CWD epidemic are likely resulting in increased human exposure to CWD in the United States. Whether CWDis transmissible to humans, as has been shown for bovine spongiform encephalopathy (the prion disease of cattle), is unknown. We generated transgenic mice expressing the elk or human prion protein (PrP) in a PrP-null background. After intracerebral inoculation with elk CWD prion, two lines …

Prenatal Malnutrition And Risk Of Schizophrenia, Andria Timmer

International Journal of Global Health and Health Disparities

Characterized by delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, schizophrenia is a severe mental disorder that is estimated to have a lifetime risk of one percent (Liu et al., Allen 2002). Prevalence rates in different countries range from 0.2-2.0 percent with an average incidence rate of 28.1 per 100,000 remaining stable across a wide range of cultures, climates and ethnic groups (Thomas 2000). In the United States, at any given time there may be two to three million people who either have schizophrenia or are at risk of developing it (Allen 2002). The disease usually manifests itself in late …

Massage Therapy For People With Hiv, Karen T. Boulanger

International Journal of Global Health and Health Disparities

Massage therapists celebrated along with other complementary and alternative medicine (CAM) practitioners at the release of Eisenberg et al.'s follow-up of a national survey on the trends in the use of CAM in the United States from 1990-1997. Not only did the use of CAM increase from 33.8 percent to 42.1 percent, massage was one of the therapies that increased the most (Eisenberg et al., 1998). In addition, although 71.5 percent of the visits were not covered by any insurance, massage therapy was the second most popular CAM therapy used, accounting for 18.1 percent of the 628.8 million total visits …

Schizophrenia And Alcoholism, Kim Mueser

Presentations

No abstract provided.

Early Oral-Motor Interventions For Pediatric Feeding Problems: What, When And How, C. J. Manno, C. Fox, P. S. Eicher, Mary Louise Kerwin

College of Science & Mathematics Departmental Research

Children with developmental delays often have feeding difficulties resulting from oral-motor problems. Based on both clinical experience and a review of published studies, oral-motor interventions have been shown to be effective in improving the oral function of preterm infants and children with neuromotor disorders, such as cerebral palsy. However, oral-motor problems may be under identified in other populations of children with developmental difficulties. The purpose of this paper is to provide a conceptual framework for understanding oral-motor skill development and problems that can occur in any infant and young child and to review oral-motor treatment techniques and their empirical support.

Ethical Approaches To Gathering Information From Children And Adolescents In International Settings: Guidelines And Resources, Katie D. Schenk, Jan Williamson

HIV and AIDS

This publication provides practical guidance to help program managers and researchers understand and uphold ethical standards when planning and implementing information-gathering activities among children and adolescents, and promotes discussion of ethical issues among people of different backgrounds and training who gather information for different purposes. The publication, which is divided into three parts, is intended to be helpful to anyone who plans, manages, implements, analyzes, or funds any program or research activity that requires gathering information from children and adolescents, including monitoring and evaluation. Part 1 presents key issues that must be considered from the earliest stages of planning and …

Doctor Of Health Science 2005, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Narrative Art Therapy For Families That Have A Child With A Life-Threatening Illness, Andrea A. Seitz

Art Therapy | Master's Theses in Print

Researchers have recognized the importance of meaningful collaboration between family medical and family therapy practitioners. A report published this year (2005) by the American Academy of Pediatrics spells out the need for pediatricians to be cognizant of the entire family’s needs when treating a child. Given the demands on pediatricians it seems almost impossible for them to provide psycho-social support needed by families. Therefore, a partnership between an MFT and a physician is a more realistic alternative. This proposal will offer an intervention model for working with families who have a child with a catastrophic illness. The treatment modality. Narrative …

Health Related Quality Of Life In Sickle Cell Patients: The Pisces Project, Donna K. Mcclish, Lynne T. Penberthy, Viktor E. Bovbjerg, John D. Roberts, Imoigele P. Aisiku, James L. Levenson, Susan D. Roseff, Wally R. Smith

Biostatistics Publications

Background Sickle cell disease (SCD) is a chronic disease associated with high degrees of morbidity and increased mortality. Health-related quality of life (HRQOL) among adults with sickle cell disease has not been widely reported.

Methods We administered the Medical Outcomes Study 36-item Short-Form to 308 patients in the Pain in Sickle Cell Epidemiology Study (PiSCES) to assess HRQOL. Scales included physical function, physical and emotional role function, bodily pain, vitality, social function, mental health, and general health. We compared scores with national norms using t-tests, and with three chronic disease cohorts: asthma, cystic fibrosis and hemodialysis patients using analysis of …

Recruitment Of Gr-1+ Monocytes Is Essential For Control Of Acute Toxoplasmosis, Paul M. Robben, Marie Laregina, William A. Kuziel, L. David Sibley

Open Access Publications

No abstract provided.

Gap Junctions Regulate Extracellular Signal-Regulated Kinase Signaling To Affect Gene Transcription, Joseph P. Stains, Roberto Civitelli

Open Access Publications

No abstract provided.

Predictive Spatial Dynamics And Strategic Planning For Raccoon Rabies Emergence In Ohio, James E. Childs, David L. Smith, Colin A. Russell, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Rabies is an important public health concern in North America because of recent epidemics of a rabies virus variant associated with raccoons. The costs associated with surveillance, diagnostic testing, and post-exposure treatment of humans exposed to rabies have fostered coordinated efforts to control rabies spread by distributing an oral rabies vaccine to wild raccoons. Authorities have tried to contain westward expansion of the epidemic front of raccoonassociated rabies via a vaccine corridor established in counties of eastern Ohio, western Pennsylvania, and West Virginia. Although sporadic cases of rabies have been identified in Ohio since oral rabies vaccine distribution in 1998, …