Digital Commons Network^™

A Theory Of Veteran Identity, Travis L. Martin

Theses and Dissertations--English

More than 2.6 million troops have deployed in support of the wars in Iraq and Afghanistan. Still, surveys reveal that more than half feel “disconnected” from their civilian counterparts, and this feeling persists despite ongoing efforts, in the academy and elsewhere, to help returning veterans overcome physical and mental wounds, seek an education, and find meaningful ways to contribute to society after taking off the uniform. This dissertation argues that Iraq and Afghanistan War veterans struggle with reassimilation because they lack healthy, complete models of veteran identity to draw upon in their postwar lives, a problem they’re working through collectively …

Food Protein-Based Core-Shell Nanocarriers For Oral Drug Delivery Applications: (Influence Of Shell Composition On In Vitro And In Vivo Functional Performance Of Zein Nanocarriers, Md Saiful Islam

Electronic Theses and Dissertations

Oral delivery is the most preferred route for drug administration. Oral drug delivery is limited by poor physicochemical properties of drugs and physiological barriers in the gastrointestinal tract. To this end, there is a need for developing new carrier systems to enhance the oral bioavailability of poorly absorbed molecules. Food-grade biopolymers are attractive materials for developing drug delivery carriers’ due to their unique properties and proven safety. Six different core-shell nanocarriers were prepared using food-grade biopolymers including zein-casein (ZC) nanoparticles, zein-lactoferrin (ZLF) nanoparticles, zein-β-lactoglobulin (ZLG) nanoparticles, zein-whey protein isolate (ZWP) nanoparticles, zein-pluronic-lecithin (ZPL) nanoparticles and zein-PEG (ZPEG) micelles. The study …

Synergism Of Quercetin And Sodium Butyrate For Controlling Growth Of Glioblastoma, Matthew Alan Taylor

Theses and Dissertations

Glioblastoma multiforme (GBM), or simply glioblastoma, is the most common and aggressive primary brain tumor, with a prevalence of approximately 20,000 new cases per year in the United States and a 3-year survival rate of just 2%. Quercetin (QCT) is a dietary flavonoid that can be found in common foods such as red kidney beans, cilantro, and onions. Despite little evidence showing any benefits through dietary intake of QCT, various studies show its promising anti-cancer results in vitro. In glioblastoma, QCT is able to cause significant amounts of apoptosis through a variety of mechanisms. These include activation of caspase-9 and …

Evaluation Of The Regional Drug Deposition Of Nasal Delivery Devices Using In Vitro Realistic Nasal Models, Mandana Azimi

Theses and Dissertations

The overall objectives of this research project were i) to develop and evaluate methods of characterizing nasal spray products using realistic nasal airway models as more clinically relevant in vitro tools and ii) to develop and evaluate a novel high-efficiency antibiotic nanoparticle dry powder formulation and delivery device. Two physically realistic nasal airway models were used to assess the effects of patient-use experimental conditions, nasal airway geometry and formulation / device properties on the delivery efficiency of nasal spray products. There was a large variability in drug delivery to the middle passages ranging from 17 – 57 % and 47 …

Effect Of Calcium Citrate In Calcium Carbonate Nanoparticles On Hk-2 Cells In Acidic Environment, Tipagorn Udomsinsirikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Metabolic acidosis exerts several cellular and tissue dysfunctions, such as increases mineral bone and protein degradation, induces inflammation, oxidative stress and cell death. These complications lead to multiple organ failure, including chronic kidney disease. Sodium bicarbonate and Shohl's solution are commonly used to treat metabolic acidosis. However, these agents cause frequent gastrointestinal adverse effects. Hence, we invented the new calcium carbonate nanoparticles to use as a drug delivery system for carrying citrate to renal cell which we hypothesize to reduce adverse effects of metabolic acidosis. We studied the physical characteristics and pharmacological effects of calcium citrate nanoparticle (Cacit) and calcium …

Tablet App For Child Cognitive Assessment In Low And Middle Income Countries, Patricia A. Francis-Lyon, Yasser Attiga, Rashmi Manjunath, Uma Ramasubramanian, Vaishali Chaudhuri, Tri Nguyen, Xiangyi Xu

Nursing and Health Professions Faculty Research and Publications

No abstract provided.

Investigating Phenotypic Severity Associated With Sister Chromatid Cohesion Defects In Human Disease, Stefanie Marie Percival

All ETDs from UAB

INVESTIGATING PHENOTYPIC SEVERITY ASSOCIATED WITH SISTER CHROMATID COHESION DEFECTS IN HUMAN DISEASE STEFANIE M. PERCIVAL GRADUATE BIOMEDICAL SCIENCES ABSTRACT Sister chromatid cohesion (SCC) is a process that utilizes a proteinaceous ring, cohesin, for accurate chromosome segregation. An essential process in S phase termed cohesion establishment is necessary to stabilize cohesin rings around sister chromatids. Mutations in establishment of cohesion homolog 2 (ESCO2), a protein essential for cohesion establishment, cause a developmental disorder called Roberts Syndrome (RBS). Cytogenetic analysis in patients reveals heterochromatic repulsion (HR), a centromeric puffing, indicative of cohesion defects. The severity of phenotypes varies from preterm lethal to …

Walking In Beauty: Responsive And Responsible Health And Healing Among Virginia American Indian People, Amy J. Prorock-Ernest

Theses and Dissertations

Little is systematically known about the collective health and well-being of Virginia American Indian people. This study sought to explore the meaning of health and healing among Virginia American Indian people in the context of a reservation-based, non-federally funded health clinic. Using an emergent approach to qualitative research grounded in a constructivist inquiry paradigm and guided by Indigenous research principles, a total of 24 in-depth, semi-structured interviews were conducted with 17 American Indian service-users of the Clinic. Through an inductive thematic analysis of participant stories, a framework for understanding responsive and responsible health and healing was derived. The framework includes …

Comparative Evaluations Of Tear Secretion In Healthy And Infectious Keratoconjunctivitis Romanov Sheep With Schirmer Tear Test And Phenol Red Thread Tear Test, Mustafa Bariş Akgül, Ni̇hat Şindak, Ali̇ Gülaydin, Doğukan Özen, Serpi̇l Kahya Demi̇rbi̇lek, Kadi̇r Sulu

Turkish Journal of Veterinary & Animal Sciences

The aim of this study is to determine the amount of tear secretion in sheep with infectious keratoconjunctivitis and healthy ones in the Siirt region by Schirmer tear test and phenol red thread tear test. A total of 47 Romanov sheep, consisting of sheep with infectious keratoconjunctivitis (n = 6) and healthy sheep (n = 41), constituted the study material. Phenol red thread tear test followed by Schirmer tear test was performed on both eyes of the animals, properly taken at a control visit on their feet. The Schirmer tear test and phenol red thread tear test values were measured …

Canine Emotions As Seen Through Human Social Cognition, Miiamaaria V. Kujala

Animal Sentience

It is not possible to demonstrate that dogs (Canis familiaris) feel emotions, but the same is true for all other species, including our own. The issue must therefore be approached indirectly, using premises similar to those used with humans. Recent methodological advances in canine research reveal what dogs experience and what they derive from the emotions perceptible in others. Dogs attend to social cues, they respond appropriately to the valence of human and dog facial expressions and vocalizations of emotion, and their limbic reward regions respond to the odor of their caretakers. They behave differently according to the …

Development Of Emulsion-Based Adjuvants For Parenteral Influenza Vaccines, Sakalanunt Lamaisakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Generally, inactivated whole-cell and subunit vaccines are often less antigenic than live-attenuated vaccines, then they require the inclusion of adjuvants to improve immunostimulating activities. In the present study, microemulsion (ME) and nanoemulsion adjuvants were developed to evoke a safety and effective immune response of vaccine antigens. The emulsion systems including vegetable oil and nonionic surfactants have been formulated with or without cationic surfactant, cetyltrimethylammonium bromide (CTAB) and then sterilized by autoclaving. Physical properties, hemolytic activities and biological efficacies of all prepared emulsions were conducted. The results demonstrated that the autoclaving process caused a reduction in droplet size with narrow size …

Experiential Learning: Critical Analysis Of Standardized Patient And Disability Simulation, Laura Vanpuymbrouck, Jenna L. Heffron, Alisa Jordan Sheth, Kim J. The, Danbi Lee

Journal of Occupational Therapy Education

Current revisions to the accreditation standards for occupational therapy (OT) education include proposed changes to experiential learning. The AOTA Fieldwork/Experiential Learning Ad Hoc Committee recommends that fieldwork Level I experiences be replaced with a new model of experiential education that includes the use of standardized patients and simulation (AOTA, 2017). The purpose of this article is to present critical perspectives about standardized patient simulation and disability simulation to support informed decision-making about the integration of experiential learning in OT professional education. In standardized patient simulation, actors play the roles of clients and important others in therapeutic scenarios; in disability simulation, …

“Mental Health Day” Sickness Absence Amongst Nurses And Midwives: Workplace, Workforce, Psychosocial And Health Characteristics, Scott Lamont, Scott Brunero, Lin Perry, Christine M. Duffield, David Sibbritt, Robyn Gallagher, Rachel Nicolls

Research outputs 2014 to 2021

Aim

To examine the workforce, workplace, psychosocial and health characteristics of nurses and midwives in relation to their reported use of sickness absence described as ‘mental health days’.

Background

The occupational stress associated with the nursing profession is increasingly recognized and nurse/midwifery absenteeism is a significant global problem. Taking a ‘mental health day’ as sickness absence is a common phenomenon in Australian health care. No previous studies have empirically explored the characteristics of nurses and midwives using such sickness absence.

Design

Online cross-sectional survey.

Methods

Survey comprising validated tools and questions on workplace and health characteristics was distributed to nurses …

Cyberbullying And Self-Perceptions Of Students Associated With Their Academic Performance, Maham Muzamil, Gulzar H. Shah

Health Policy & Community Health: Faculty Publications

The aim of this study is to explore the factors influencing students’ academic achievements in secondary school level (grades 09 and 10). Those factors include students’ self-reported psychological and issues (e.g. being bullied through social media) as well as socioeconomic status. Study participants included610 students at senior secondary level (237 male and 363 female) randomly selected from ten different government schools. The schools were randomly selected from the lists provided by their respective Education District Officer (EDO). The data were collected by researchers with the help of teachers. Participants’ were offered as incentives a drawing for a gift certificate. Bivariate …

How Burroughs Plays With The Brain, Or Ritornellos As A Means To Produce Déjà-Vu, Antonio José Bonome

CLCWeb: Comparative Literature and Culture

In his article "How Burroughs Plays with the Brain, or Ritornellos as a Means to Produce Déjà-Vu" Antonio José Bonome discusses how the recurrence and significance of one of William S. Burroughs's most potent refrains, "dim jerky faraway," was inspired by its source text, Paul Bowles's second novel Let It Come Down (1952), where Tangiers-Interzone fuels the unwholesome descent of a US-American expatriate not unlike Bowles or Burroughs himself. "Dim jerky faraway" was used by Burroughs during more than two decades in different contexts, and its textual variations have sparked a mélange of colors, sounds, smells, and feelings oscillating in …

The Effect Of A Culturally Tailored Web-Based Physical Activity Promotion Program On Asian American Midlife Women’S Depressive Symptoms, Wonshik Chee, Sangmi Kim, Xiaopeng Ji, Sooyoung Park, Eunice Chee, Hsiu-Min Tsai, Eun-Ok Im

Asian/Pacific Island Nursing Journal

The benefits of physical activities on depressive symptoms have increasingly been reported in the literature, but the effect through which a Web-based physical activity promotion program alleviates depressive symptoms is not clearly known, especially among ethnic minority midlife women. The purpose of this pilot randomized control study is to examine the preliminary efficacy of the Web-based physical activity promotion program in enhancing the depressive symptoms of Asian American midlife women through increasing physical activity. This study adopted a randomized repeated measures pretest/posttest control group design. This study consisted of two groups of research participants: 18 in an intervention group and …

Rna Sequencing Reveals A Role Of Tonebp Transcription Factor In Regulation Of Pro-Inflammatory Genes In Response To Hyperosmolarity In Healthy Nucleus Pulposus Cells: A Homeostatic Response?, Zariel I. Johnson, Irving M. Shapiro, Makarand V. Risbud

Department of Orthopaedic Surgery Faculty Papers

Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche. Recent studies implicate TonEBP signaling in inflammatory disease and rheumatoid arthritis pathogenesis. However, broader functions of TonEBP in the disc remain unknown. RNA sequencing was performed on NP cells with TonEBP knockdown under hypertonic conditions. 1140 TonEBP-dependent genes were identified and categorized using Ingenuity Pathway Analysis. Bioinformatic analysis showed enrichment of matrix homeostasis and cytokine/chemokine signaling pathways. C-C motif chemokine ligand 2 (CCL2), interleukin 6 (IL6), tumor necrosis factor (TNF), and nitric oxide synthase 2 (NOS2) …

Exploration Of Factors Affecting Nurse Faculty Use Or Resistance To Online Education, Lisa M. Harless

Nursing Theses and Dissertations

The substantial increase in online nursing program enrollment demands that nurse educators be adept in the delivery of online education; however, a significant challenge exists in how to deliver practice-based nursing education in the online environment. Teaching online requires a change in the traditional role of the educator accompanied by the effective use of online learning technologies. Some studies suggest that faculties remain pessimistic to online delivery of education and do not participate, yet few objectively examine variables that influence resistance or use. Included in this dissertation are two manuscripts. The first manuscript defines resistance and addresses prominent concerns associated …

Attitudes, Beliefs, And Factors Affecting Nurse Opioid Administration, Analisa Pearson

Nursing Capstones

No abstract provided.

Impact Of A Student-Scheduled Child Care Program On Parents' Educational Goals, Barbara Carter

Administrative Issues Journal

The purpose of this study is to examine what, if any, impact a Student-scheduled Child Care (SSCC) program had on the families of students completing their higher education goals at a college in the southwestern region of the United States. Student completion rate is a concern for most college and university administrators. Research conducted by the Gates foundation determined that over three quarters of former students surveyed felt that they would have graduated if the college or university had offered child care (Johnson, Ott, & DuPont, 2011). This correlational and descriptive research study revealed what student families thought about the …

Cultural Sensitivity In Healthcare: The New Modern Day Medicine, Daniel Dell'osso

Senior Theses

In healthcare facilities there are many factors that contribute to overall equity, efficiency, and quality of care which if addressed properly can promote justice for all. Patients relying on healthcare facilities come from a variety of races, ethnicities, and cultures as are the employees who provide care for the patients. Diversity is very widespread within the healthcare environment and tolerance as well as acceptance of others is necessary in conducting smooth and efficient care. However, cultural sensitivity and competency seems to continue to be an issue that has been neglected and has severely negatively impacted healthcare centers and its surrounding …

Gastrointestinal Health As A Stimulus For Native American Attraction To Medicinal Asteraceae And Further Implications For Human Evolution, Christopher David Stiegler

Graduate Theses and Dissertations

The Asteraceae, or the daisy family, is the largest family of flowering plants in the world, and its ethnobotanical, medical, and economic value is readily apparent cross-culturally. The aim of this thesis is to examine why constituent genera of the Aster family have remained such an integral part of human medicinal plant knowledge, and thereby to reveal any potential physiological, biological, or evolutionary mechanisms underlining human patterns of use regarding the Asteraceae. The present study focuses specifically on Native American plant knowledge made available by the expansive database in the works Daniel Moerman (Moerman 2003). Frequencies of plant use and …

Using Mouse Models To Define How The P53 R72p Polymorphism Impacts The Adverse Effects Of Doxorubicin And Ionizing Radiation, Emily Dominguez

Dissertations and Theses (Open Access)

The single nucleotide polymorphism (SNP) at codon 72 of the tumor suppressor gene p53 codes for either an arginine (R) or proline (P) (p53 R72P). This SNP may impact how cells respond to genotoxic insult. Studies in cell culture and in tissues from mouse models of the SNP indicate that, in response to gentoxic treatment, the two variants may differentially induce apoptosis and expression of p53 target genes. In epidemiological studies, the P variant is associated with decreased cancer survival and increased risk of side-effects from genotoxic cancer treatment. Genotoxic therapy is still the mainstay of cancer treatment, and doxorubicin …

Thsd1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation In The Pathogenesis Of Intracranial Aneurysm And Subarachnoid Hemorrhage, Teresa Santiago-Sim, Xiaoqian Fang, Morgan L. Hennessy, Stephen V. Nalbach, Steven R. Depalma, Ming Sum Lee, Steven C. Greenway, Barbara Mcdonough, Georgene W. Hergenroeder

School of Medicine Publications

Background and Purpose

A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage (SAH). This study seeks to define a specific gene whose mutation leads to disease.

Methods

More than 500 IA probands and 100 affected families were enrolled and clinically characterized. Whole exome sequencing was performed on a large family, revealing a segregating THSD1 mutation. THSD1 was sequenced in other probands and controls. Thsd1 loss-of-function studies in zebrafish and mice were used for in vivo analyses, and functional studies performed using an in vitro endothelial cell model.

Results

A nonsense mutation in THSD1 (thrombospondin type-1 domain-containing …

Decentralization And Health: Case Studies Of Kenya, Pakistan, And The Philippines, Christina E. Lewis, David Clarke, Jd, Maryam Bigdeli, Phd

CwiC Posters

Decentralization, defined by the World Bank (2001) as, “the transfer of authority and responsibility for public functions from the central government to intermediate and local governments or quasi-­‐independent government organizations and/or the private sector,” is a movement that has gained much traction in recent history. For many countries undergoing decentralization, a major driver has been a desire to increase the role and participation of local governments in the decision-­‐making space. In doing this, it is hoped to create governance structures that are more accountable and responsive to the people. For health, decentralization has been touted as a potential way to …

The Perception For Good Death Of Community Dwelling Japanese And Thailand Respondents, Michiyo Ando, Supawadee Somchit, Mitsunori Miyashita, Laiad Jamjan

Asian/Pacific Island Nursing Journal

Having a “good death” is a very important goal of palliative care, and it is useful for nurses to understand cultural differences in the perception of a good death to propose nursing care. The purpose of this study was to compare the perception of a “good death” among community-dwelling Japanese and Thai people. Three hundred sixty-nine respondents completed the Good Death Questionnaire. The research design was a cross-sectional study. The scores of the Japanese respondents on “good relationships with medical staff,” “being respected as an individual,” and “fighting against cancer” were higher among Thai respondents. On the other hand, “environmental …

Understanding Teamwork In The Provision Of Cancer Care: Highlighting The Role Of Trust, Elizabeth H. Lazzara, Joseph R. Keebler, Soosi Day, Deborah Diazgranados, Minggui Pan, Michael A. King, Shin-Ping Tu

Publications

Team science research has indicated that trust is a critical variable of teamwork, contributing greatly to a team’s performance. Trust has long been examined in health care with research focusing on the development of trust by patients with their health care practitioners. Studies have indicated that trust is linked to patient satisfaction, adherence to treatment, continuity of care, and improved outcomes. We explore the construct of trust using a case example of a patient who received a surgical procedure for a precancerous polyp. We apply the principle of trust to the case as well as present the literature on trust …

Perceived Body Image, Eating Behavior, And Sedentary Activities And Body Mass Index Categories In Kuwaiti Female Adolescents, Lemia H. Shaban, Joan A. Vaccaro, Shiryn D. Sukhram, Fatma G. Huffman

Publications and Research

Background. The State of Kuwait has a growing obesity epidemic in both genders and all age groups; however, obesity rates in the young seem to be rising. Methods.We conducted a cross-sectional survey in 169 Kuwaiti female adolescents attending both private and public schools spanning the six governorates in the State of Kuwait in order to explore female adolescents’ self-image, body dissatisfaction, type of school (private versus public), TV viewing, and computer games and their relationship to body mass index.

Results. Approximately half the students classified as obese perceived their body image to lie in the normal range. Females in the …

College Health Care Providers’ Student-Centered Care, Cheryl Ann Lambert, Julie Donovan

The Qualitative Report

Patient care in the university setting is indelibly connected to college health care providers. College health care providers adapt to a specific set of circumstances unique to the university context in their patient care roles. The authors therefore sought to investigate the patient care phenomenon from college health care providers’ lived experiences. The patient care phenomenon was explored via in-depth interviews with 11 college health care providers at universities in the Midwest and Northeast regions of the United States. The phenomenological theoretical framework of the study revealed five themes of patient care during data analysis: health education, behavioral health, student …

2016 Program, Office Of Academic Affairs

Programs

Eastern Illinois University is a community enthusiastically engaged in intellectual exploration. This includes faculty testing the boundaries of knowledge within their disciplines and the boundaries of how to convey that knowledge to their students. It also includes students, both graduate students joining with their faculty mentors in pressing the disciplinary boundaries, and undergraduate students discovering the front edges of the disciplines under the guidance of their instructors. Today we celebrate the full range of such faculty contributions: journal articles, book chapters, monographs, art works, music compositions, performances in all forms, and a host of others. Funded research contributions also are …