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Expression Of Zeb Factors In Oral Squamous Cell Carcinoma., Saira Ahmed

Electronic Theses and Dissertations

Objectives: The ZEB family of transcription factors (ZEB1 and ZEB2) have been demonstrated to play a role in metastatic progression of several cancers, and may also influence the initial transformation and generation of cancer stem cells. However, the expression pattern of ZEB proteins in the development of oral squamous cell carcinoma has not been investigated. The purpose of this study was to define changes in expression and subcellular localization of the ZEB family in both precancerous lesions and different grades of OSCC. Materials and Methods: Seventy-nine tongue biopsies were subjected to immunohistochemistry and immunofluorescence to determine the expression and subcellular …

Development And Psychometric Testing Of An Instrument To Compare Career Choice Influences And Perceptions Of Nursing Among Healthcare Students, Sok Ying Liaw, Ling Ting Wu, Violeta Lopez, Yeow Leng Chow, Siriwan Lim, Eleanor Holroyd, Khoon Kiat Tan, Wenru Wang

School of Nursing & Midwifery, East Africa

Background: With the availability of more healthcare courses and an increased intake of nursing students, education institutions are facing challenges to attract school leavers to enter nursing courses. The comparison of career choice influences and perception of nursing among healthcare students can provide information for recruitment strategies. An instrument to compare the influences of healthcare career choice is lacking. The purpose of this study is to develop and evaluate the psychometric properties of an instrument to compare the influences of healthcare career choice with perceptions of nursing as a career choice.

Methods: The study was conducted in two phases. In …

Opossum Apobec1 Is A Dna Mutator With Retrovirus And Retroelement Restriction Activity, Terumasa Ikeda, Mayuko Shimoda, Diako Ebrahimi, John L. Vandeberg, Reuben S. Harris, Atsushi Koito, Kazuhiko Maeda

School of Medicine Publications

APOBEC3s (A3s) are single-stranded DNA cytosine deaminases that provide innate immune defences against retroviruses and mobile elements. A3s are specific to eutherian mammals because no direct homologs exist at the syntenic genomic locus in metatherian (marsupial) or prototherian (monotreme) mammals. However, the A3s in these species have the likely evolutionary precursors, the antibody gene deaminase AID and the RNA/DNA editing enzyme APOBEC1 (A1). Here, we used cell culture-based assays to determine whether opossum A1 restricts the infectivity of retroviruses including human immunodeficiency virus type 1 (HIV-1) and the mobility of LTR/non-LTR retrotransposons. Opossum A1 partially inhibited HIV-1, as well as …

The Effects Of Hyperhomocysteinemia On Hypertension In Adults, Kimberly Ford

Nursing Capstones

No abstract provided.

Curcumin And Turmeric Modulate The Tumor-Promoting Effects Of Iron In Vitro., Donald J Messner, Todd Robinson, Kris V Kowdley

Articles, Abstracts, and Reports

Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in T51B cells, a non-neoplastic rat liver epithelial cell line. Purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with iron overload (IC

Tingkat Prokrastinasi Akademik Siswa Sekolah Menengah Pertama Muhammadiyah 9 Yogyakarta, Martika Laely Munawaroh, Said Alhadi, Wahyu Nanda Eka Saputra

Jurnal Kajian Bimbingan dan Konseling

Academic procrastination is one of problems that may occur among junior high school students. This study aims to describe the level of academic procrastination of junior high school students in Sekolah Menengah Pertama Muhammadiyah 9 Yogyakarta. This research uses descriptive quantitative research. The results of this study showed that 17,2% of subjects have high academic procrastination, 77,1% of them have the moderate one, and 5,7% of them have the low one. Based on those results, it is recommended for the next researcher to use Solution-Focused Brief Counseling in reducing academic procrastination in SMP Muhammadiyah 9 Yogyakarta.

Inflammatory Potential Of Diet, Weight Gain, And Incidence Of Overweight/Obesity: The Sun Cohort, Alyson Haslam, Sara Wagner Robb, James R. Hébert, Hanwen Huang, Michael David Wirth, Nitin Shivappa, Mark H. Ebell

Faculty Publications

Objective

The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person’s diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition.

Design

Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models.

Setting

Ten cancer screening centres across the USA.

Subjects

Participants were those included in the screening arm …

Addressing Cardiovascular Disease Risk In Hungarian American Populations: A Cultural Exploration Of Transdisciplinary Health Promotion, Nicholas Laszlo, Basil H. Aboul-Enein, Josh Bernstein, Joanna Kruk

Health & Wellness Department Faculty Publications and Research

Hungarian Americans share a unique culture of food traditions associated with their value system and way of life. Researchers, health care providers, and nutrition professionals counseling and treating a Hungarian-American population should develop a baseline of cultural understanding to achieve successful and long-lasting behavior change outcomes. The leading causes of death among Hungarians include ischemic heart disease (21.3%), stroke (13.4%), and cirrhosis (5.8%); all are directly or indirectly attributed to a traditional Hungarian diet coupled with a sedentary lifestyle. Health behaviors among Hungarian Americans can be partially explained by the Health Belief Model’s value-expectancy construct. Understanding cultural expectations and their …

Coccolithoviruses: A Review Of Cross-Kingdom Genomic Thievery And Metabolic Thuggery, Jozef I. Nissimov, António Pagarete, Fangrui Ma, Sean Cody, David D. Dunigan, Susan A. Kimmance, Michael J. Allen

Nebraska Center for Virology: Faculty Publications

Coccolithoviruses (Phycodnaviridae) infect and lyse the most ubiquitous and successful coccolithophorid in modern oceans, Emiliania huxleyi. So far, the genomes of 13 of these giant lytic viruses (i.e., Emiliania huxleyi viruses—EhVs) have been sequenced, assembled, and annotated. Here, we performed an in-depth comparison of their genomes to try and contextualize the ecological and evolutionary traits of these viruses. The genomes of these EhVs have from 444 to 548 coding sequences (CDSs). Presence/absence analysis of CDSs identified putative genes with particular ecological significance, namely sialidase, phosphate permease, and sphingolipid biosynthesis. The viruses clustered into distinct clades, based on their DNA polymerase …

Structured Study Abroad Enhances Intercultural Competence, Lata A. Krishnan, Christi Masters, Horane Holgate, Cong Wang, Charles A. Calahan

Teaching and Learning in Communication Sciences & Disorders

Participation in a service-learning (SL) study abroad (SA) program has been shown to enhance cultural competence (Krishnan, Richards & Simpson, 2016) as measured via the Public Affairs Scale (PAS; Levesque-Bristol & Cornelius-White, 2012). The purpose of this study was 1) to evaluate students’ development of intercultural competence using the Intercultural Development Inventory (IDI®), a tool specifically designed for this purpose, and 2) to evaluate whether intentionally escalating culturally focused developmental experiential learning together with existing course content would increase cultural competence more than program participation alone. Thirty female and one male student participated over three years of the SL SA …

Emerging Roles Of Xenobiotic Detoxification Enzymes In Metabolic Diseases, Michael C. Petriello, Jessie B. Hoffman, Andrew J. Morris, Bernhard Hennig

Superfund Research Center Faculty Publications

Mammalian systems have developed extensive molecular mechanisms to protect against the toxicity of many exogenous xenobiotic compounds. Interestingly, many detoxification enzymes, including cytochrome P450s and flavin-containing monooxygenases, and their associated transcriptional activators [e.g. the aryl hydrocarbon receptor (AhR)], have now been shown to have endogenous roles in normal physiology and the pathology of metabolic diseases. This mini-review will focus on two such instances: the role of flavin-containing monooxygenase 3 (FMO3) in the formation of the cardiometabolic disease biomarker trimethylamine-N-oxide (TMAO) and the role of AhR as a sensor of endogenous ligands such as those generated by the gut microbiota. Understanding …

Evaluation Of [14c] And [13c]Sucrose As Blood-Brain Barrier Permeability Markers, Mohammad K. Miah, Ekram A. Chowdhury, Ulrich Bickel, Reza Mehvar

Pharmacy Faculty Articles and Research

Non-specific quantitation of [¹⁴C]sucrose in blood and brain has been routinely used as a quantitative measure of the in vivo blood-brain barrier (BBB) integrity. However, the reported apparent brain uptake clearance (K_in) of the marker varies widely (∼100 fold). We investigated the accuracy of the use of the marker in comparison with a stable isotope of sucrose ([¹³C]sucrose) measured by a specific LC-MS/MS method. Rats received single doses of each marker, and the K_in values were determined. Surprisingly, the K_in value of [¹³C]sucrose was 6-7 fold lower than that …

Recurrent Rearrangements Of The Myb/Sant-Like Dna-Binding Domain Containing 3 Gene (Msantd3) In Salivary Gland Acinic Cell Carcinoma, Nicholas Barasch, Xue Gong, Kevin A. Kwei, Sushama Varma, Jewison Biscocho, Kunbin Qu, Nan (Tori) Xiao, Joseph S. Lipsick, Robert J. Pelham, Robert B. West, Jonathan R. Pollack

All Dugoni School of Dentistry Faculty Articles

Pathogenic gene fusions have been identified in several histologic types of salivary gland neoplasia, but not previously in acinic cell carcinoma (AcCC). To discover novel gene fusions, we performed whole-transcriptome sequencing surveys of three AcCC archival cases. In one specimen we identified a novel HTN3-MSANTD3 gene fusion, and in another a novel PRB3-ZNF217 gene fusion. The structure of both fusions was consistent with the promoter of the 5' partner (HTN3 or PRB3), both highly expressed salivary gland genes, driving overexpression of full-length MSANTD3 or ZNF217. By fluorescence in situ hybridization of an expanded AcCC case series, we observed MSANTD3 rearrangements …

Emerging Strategies Of Targeting Lipoprotein Lipase For Metabolic And Cardiovascular Diseases, Werner J. Geldenhuys, Li Lin, Altaf S. Darvesh, Prabodh Sadana

Clinical and Translational Science Institute

Although statins and other pharmacological approaches have improved the management of lipid abnormalities, there exists a need for newer treatment modalities especially for the management of hypertriglyceridemia. Lipoprotein lipase (LPL), by promoting hydrolytic cleavage of the triglyceride core of lipoproteins, is a crucial node in the management of plasma lipid levels. Although LPL expression and activity modulation is observed as a pleiotropic action of some the commonly used lipid lowering drugs, the deliberate development of drugs targeting LPL has not occurred yet. In this review, we present the biology of LPL, highlight the LPL modulation property of currently used drugs …

Reproductive Health And Human Rights: Lessons From Ireland, Tanya Saroj Bakhru

Journal of International Women's Studies

The years between 2008-2013 were a period of economic austerity and ideological turmoil in Ireland. Alongside the tragic death of Savita Halappanavar, a woman who died in 2012 due to complications resulting from her refused request for an abortion in an Irish hospital, economic, political and ideological forces converged to promote a tipping point in the demand for full sexual and reproductive rights for women in Ireland. Within this temporal moment, a “convergence of various economic, political and ideological forces that make possible the emergence of specific kinds of practices” (Barndt, 2008, p. 36), the Irish Family Planning Association …

The Slow Food Movement: A 'Big Tent' Ideology, Mark N. Wexler, Judy Oberlander, Arjun Shankar

Journal of Ideology

The Slow Food Movement (SFM) has been characterized as a reminder of the centrality of the kitchen in the “good old days”. It has also been referred to as a poor use of science posing as a rallying point for the beleaguered middle class trying to reclaim psychological territory lost to the fast-paced commercialization of what was once private or leisure time. This paper argues that both these criticisms contain more than a kernel of truth. However, each misses the mark when it comes to explaining the relative successes of SFM. In this paper, we explore SFM’s basic ideological premises. …

Tsu Faculty Research Database-Jan 2017, David Owerbach

Office of Research Institutional Research and Scholarship

Research interests and selected publications from 230 Texas Southern University faculty have been updated in Jan 2017. Faculty from Public Affairs, the College of Science, Engineering and Technology, the College of Pharmacy and Health Sciences, the College of Education, the College of Business, the College of Liberal Arts and Behavioral Sciences, the Law School and the School of Communications are included.

The Effects Of Patient Characteristics On Clinician’S Adherence To Preventive Practice Guidelines, Deshana A. Collett Ph.D,Pa-C, Kenneth M. Tyler Ph.D.

Journal of Health Disparities Research and Practice

ABSTRACT

BACKGROUND: The existence of health disparities confirms that not all patients, regardless of differences in patient demographics, are provided quality healthcare (Agency of Health Care Research and Quality, 2003). Moreover, research suggests that health disparities may be present due to the inadequate delivery of medical services (S. Haist, J. Wilson, M. Lineberry, & C. Griffith, 2007; Van Ryn, Burgess, Malat, & Griffin, 2006). The differences in the delivery of care and services to ethnic minorities and those of low socioeconomic status warrant examining the role healthcare providers play in the causation of these health disparities (Smedley, Stith, & Nelson, …

Relationship Of Associated Cardiovascular Risk Factors And Chronic Kidney Disease With Participants Enrolled In The National Kidney Foundation Of Hawai'i Kidney Early Detection Screening (Keds) Program, Merle R. Kataoka-Yahiro, Victoria Page, Dongmei Li

Journal of Health Disparities Research and Practice

Objective The objective of this study was to further examine the relationship of associated cardiovascular risk factors and chronic kidney disease (CKD) with a large cross-sectional sample of Native Hawaiians, Japanese, Chinese, Filipino, and White participants who were enrolled in the National Kidney Foundation of Hawai'i Kidney Early Detection Screening (KEDS) program.

Methods Data for this cross-sectional study was collected between 2006 and 2009 from the National Kidney Foundation of Hawaii (NKFH). Nine hundred and fifteen participants who attended the NKFH KEDS program were 18 years and older, and residents of the State of Hawaii. Data included demographic information, clinical …

Patient Safety In The Ambulatory Oncology Environment: A Teamstepps® Journey, Tammi Phelps Hick

Nursing Theses and Capstone Projects

Problem: Children have reported that pain and anxiety were the most difficult part of hospitalization, and under treatment of pain and anxiety can have short and long term effects on health outcomes. Most healthcare professionals recognize a link between emotional health and physical health, but this may be especially true for pediatric patients who may not be able to marshal adequate coping skills due to their developmental age. Providing age appropriate alternatives, such as distraction therapy, may result in less invasive treatments for pediatric patients. Distraction therapy is an effective non-pharmacological intervention that is often under-utilized in the acute care …

Anti-Cancer Effects Of Tocotrienols In Nsclc, Lichchavi Raj Raj

Wayne State University Dissertations

Lung cancer is one of the leading causes of death among cancers, with non-small cell lung cancer (NSCLC) accounting for 80-85% of all lung cancers and a five-year survival rate of 5 % at stage IIIB. Delta-tocotrienol (δT) including other tocotrienol isomers has been shown to exhibit anti-tumor activity via inhibition of different signaling pathways in tumors including NSCLC. Previously we reported that δT reduced cell invasion via inhibition of the Notch-1 and NF-κb pathway.

Matrix metallopeptidase 9 (MMP9) dependent cell migration and invasion are key processes in cancer metastasis. Hence, its suppression is a promising strategy for cancer therapeutics. …

The Microbial Ecosystem Of Beer Spoilage And Souring: Competition And Cooperation In The Age Of Bioinformatics, Andrew Kettring

Electronic Theses and Dissertations

The brewing industry generates $350 billion in revenue in the US annually, representing 1.9% of the gross domestic product. Spoilage is a persistent problem throughout production and distribution that causes economic loss, and is therefore meticulously avoided. Contrarily, artisanal sour beers are necessarily produced by a diverse variety of these spoilage organisms metabolically interacting in symbiosis as a microbial ecosystem. We sought to gain insight into factors driving assembly of microbial communities by testing a long-debated Darwinian hypothesis. A collection of community members were screened in co-culture and novel bioinformatics tools were developed to predict observed interactions. A fundamental understanding …

Nurse Perceived Barriers To Effective Nurse-Client Communication, Sara J. Brandenburg

Honors Undergraduate Theses

Successful client care depends on effective nurse-client communication. It is essential in meeting clients' needs, providing quality care, and maximizing positive client outcomes. The intent of this thesis was to explore nurse perceived barriers to effective nurse-client communication. A literature review was conducted and nine articles were identified as addressing nurse perceived barriers to communication. Four major barriers were identified: nurse comfort and knowledge, environment, time, and culture and language. Research on interventions to address nurses' perceptions of barriers to effective nurse-client communication may provide a better understanding of communication barriers and address issues created by ineffective communication with clients.

Synaptotagmin C2b Ca2+-Binding Loops Impose Distinct Exocytosis Phenotypes, Michael W. Schmidtke

Wayne State University Theses

Regulated exocytosis from chromaffin cells in the adrenal medulla plays a critical role in maintaining organismal homeostasis. In the absence of stress, these cells release physiologically relevant substances into the blood stream only in limited quantities, whereas stressful conditions result in a rapid deluge of signaling molecules used, for example, to increase heart rate and pain tolerance. Although the cellular mechanisms governing the switch from low-level to stress-induced secretion are not well understood, recent evidence has implicated the exocytotic Ca2+-sensing protein Synaptotagmin (Syt) in this role.

Two isoforms of Syt are expressed in chromaffin cells (Syt-1 and Syt-7), and each …

Chromosomal Findings And Sequence Analysis Of Target Exons Of Calcium-Sensingreceptor (Casr) Gene In Patients With Sagliker Syndrome, Erdal Tunç, Osman Demi̇rhan, Yahya Sağliker, İsmai̇l Yildiz, Nuray Paylar, Ali̇ İrfan Güzel

Turkish Journal of Medical Sciences

Background/aim: Sagliker syndrome (SS) develops as a continuation of chronic kidney disease and secondary hyperparathyroidism conditions. It was thought that there are some genetic predisposition factors leading to SS. The calcium-sensing receptor (CaSR) is essential for calcium homeostasis in the body. We aimed to examine SS patients for chromosome aberrations (CAs) and CaSR gene abnormalities in exons 2 and 3. Materials and methods: Twenty-three patients and 23 control subjects were admitted to Balcalı Hospital of the Medical Faculty of Çukurova University in Turkey between 2009 and 2011. Chromosomal analysis was performed according to standard cytogenetic methods. Full sequencing of exons …

Exploring The Impact Of Service Learning In Haiti On The Cultural Competence Of Otd Students, Nathan Short, Heather Y.Z. St. Peters

Journal of Occupational Therapy Education

As society trends towards increased cultural diversity, the need for cultural competence in the field of occupational therapy (OT) becomes more acute. Immersion in another culture within the curriculum offers the student an opportunity to put their knowledge into practice and recognize the need to competently interact with members of another culture. This study explored the impact of a service learning trip to Haiti, providing seating and mobility services, on all four factors of cultural intelligence (CQ; i.e., metacognitive CQ, cognitive CQ, motivational CQ, behavioral CQ) for occupational therapy doctoral (OTD) students. Using the cultural intelligence scale (CQS), a one-group …

Certain Dyes As Pharmacologically Active Substances In Fish Farming And Other Aquaculture Products, Eric Verdon, Wendy C. Andersen

United States Food and Drug Administration: Publications

The last 40 years have brought enormous changes to the aquaculture industry. The farming of fish and of seafood products has been continuously increasing from 3.9% by weight in 1970 to 36% in 2006 according to theWorld Health Organization (WHO) and Food and Agriculture Organization (FAO) of the United Nations.¹ The global trend of aquaculture development gaining importance in total fish supply has remained uninterrupted. Farmed food fish contributed a record 42.2% of the total 158 million tonnes of fish produced by capture fisheries and aquaculture in 2012 (Figure 9.1). This compares with just 13.4% in 1990 and 25.7% …

Self-Efficacy And Cultural Competency Assessment Of The Associate Degree Nursing Student, Deborah Smith Hartman

Walden Dissertations and Doctoral Studies

Effective nursing care can be threatened when nurses are not culturally attuned with their patients. Associate degree nursing (ADN) students receive information about diverse ethnicities in the nursing curriculum, but it may not be sufficient to provide the expertise necessary to care for patients of various cultural backgrounds. The purpose of this quantitative study was to explore the 2nd year ADN students' levels of cultural competence and their perceptions of self-efficacy in working with Caucasian, African American, Native American, Hispanic, and Asian ethnicities. The study used a cross-sectional survey design to determine if a relationship existed between the students' reported …

Nucleotide Excision Repair: Impacts Of Environmental Carcinogens And Its Role In Cancer Susceptibility In Appalachian Kentucky, Nathaniel C. Holcomb

Theses and Dissertations--Toxicology and Cancer Biology

Lung cancer is a particularly devastating disease, accounting for the most deaths among all cancer types in the United States. Despite a reduction in the country’s smoking rates, cigarette smoking remains the number one risk factor for lung cancer. Additionally arsenic exposure, which occurs primarily through contaminated drinking water in the U.S., is associated with increased lung cancer incidence. The nucleotide excision repair (NER) pathway is critical for maintenance of genomic fidelity, removing DNA lesions that could otherwise promote DNA mutations and drive carcinogenesis. Tobacco smoking introduces significant amounts of DNA damage and produces characteristic DNA mutations found in lung …

Impact Of A Sepsis Coordinator On Patient Outcomes Of Adult Patients With Sepsis, Angela B. Smith

Doctor of Nursing Practice Projects

The impact of sepsis is a significant health problem with estimations of 3 million cases of severe sepsis annually and a resultant 750,000 deaths in the United States (Gaieski, Edwards, Kallan & Carr, 2013). The implementation of a Sepsis Coordinator was developed at a local acute care facility to identify areas of opportunities in the care of sepsis patients, facilitate processes to identify patients at risk for sepsis, educate the multidisciplinary team on new and existing evidence and measure and monitor outcome data. This study evaluates the impact of a Sepsis Coordinator on hospital mortality, length of stay and evidence-based …