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ผลของการเปลี่ยนยาจากเอฟาเวียเรนซ์เป็นริลพิวิรีนต่อภาวะตับคั่งไขมันในผู้ป่วยติดเชื้อเอชไอวีที่เป็นโรคตับคั่งไขมันที่ไม่ได้เกิดจากแอลกอฮอล์: การวิจัยเชิงทดลองแบบสุ่มชนิดมีกลุ่มควบคุม, ลัดดารัตน์ ศรีคำ
Chulalongkorn University Theses and Dissertations (Chula ETD)
วัตถุประสงค์: เพื่อเปรียบเทียบการเปลี่ยนแปลงของปริมาณไขมันตับหลังจากเปลี่ยนยาจากเอฟาเวียเรนซ์เป็นริลพิวิรีน ในผู้ป่วยที่รักษาด้วยยาเอฟาเวียเรนซ์ร่วมกับยาต้านไวรัสกลุ่ม NRTI อีก 2 ชนิด เทียบกับผู้ป่วยที่ได้รับยาเอฟาเวียเรนซ์เดิมต่อ วิธีการวิจัย: การศึกษาแบบสุ่มชนิดมีกลุ่มควบคุม สุ่มอาสาสมัครเป็นอัตรา 1:1 เป็นผู้ติดเชื้อเอชไอวีอายุตั้งแต่ 18 ปี และรับยาต้านไวรัสเอฟาเวียเรนซ์ร่วมกับทีโนโฟเวียร์/เอ็มตริไซตาบีน หรืออะแบ็กคาเวียร์/ลามิวูดีน และเป็นโรคตับคั่งไขมันที่ไม่ได้เกิดจากแอลกอฮอล์ แล้วเปลี่ยนยาจากเอฟาเวียเรนซ์เป็นริลพิวิรีน หรือยังให้เอฟาเวียเรนซ์เดิมต่อ โดยก่อนเข้าร่วมวิจัยต้องมีค่าไขมันตับวัดด้วยวิธี CAP มากกว่า 248 เดซิเบล/เมตร ขึ้นไป ผลการศึกษา: อาสาสมัครเข้าร่วมทั้งหมด 30 คน และ 17 คน ถูกสุ่มเข้ากลุ่มเปลี่ยนยาเป็นริลพิวิรีน พบค่ามัธยฐานของความต่างของค่าไขมันตับระหว่างเวลาตั้งต้นและสัปดาห์ที่ 24 ลดลง -20 เดซิเบล/เมตร ในผู้ป่วยกลุ่มเปลี่ยนยา RPV และลดลง -2 เดซิเบล/เมตร ในผู้ป่วยกลุ่มใช้ยาเดิม EFV โดยกลุ่มผู้ป่วยกลุ่มเปลี่ยนยา RPV มีการลดลงของความต่างของค่าไขมันตับมากกว่า แต่ไม่มีความแตกต่างอย่างมีนัยสำคัญทางสถิติ (P = .202) สรุป: การศึกษานี้ แสดงให้เห็นว่าหลังสัปดาห์ที่ 24 ผู้ป่วยติดเชื้อเอชไอวีที่เป็นโรคตับคั่งไขมันที่ไม่ได้เกิดจากแอลกอฮอล์ ที่ได้รับการเปลี่ยนยาต้านไวรัสจากเอฟาเวียเรนซ์เป็นริลพิวิรีน เทียบกับผู้ป่วยที่ได้รับยาต้านไวรัสเป็นเอฟาเวียเรนซ์เดิม ไม่พบความแตกต่างของการเปลี่ยนแปลงของปริมาณไขมันตับ ผลการศึกษาเช่นนี้ อาจเกิดจากขนาดตัวอย่างน้อยกว่าเป้าหมายและต้องการศึกษาขนาดใหญ่มากขึ้น
ผลของการให้โปรตีนเสริมในผู้ป่วยที่ติดเชื้อเยื่อบุช่องท้องต่อการเกิดภาวะแทรกซ้อนจากการติดเชื้อเยื่อบุช่องท้อง, สุรศักดิ์ ใฝ่สัจจะธรรม
ผลของการให้โปรตีนเสริมในผู้ป่วยที่ติดเชื้อเยื่อบุช่องท้องต่อการเกิดภาวะแทรกซ้อนจากการติดเชื้อเยื่อบุช่องท้อง, สุรศักดิ์ ใฝ่สัจจะธรรม
Chulalongkorn University Theses and Dissertations (Chula ETD)
ที่มาของงานวิจัย: ภาวะทุพโภชนาการเป็นปัจจัยเสี่ยงที่สำคัญต่อการเสียชีวิตในผู้ป่วยล้างไตทางช่องท้องที่มีภาวะเยื่อบุช่องท้องอักเสบ ข้อมูลของการให้โปรตีนเสริมในผู้ป่วยที่มีภาวะติดเชื้อเยื่อบุช่องท้องยังค่อนข้างจำกัด ระเบียบวิธีวิจัย: เป็นการศึกษาแบบการทดลองหลายแหล่งวิจัยแบบเปิดที่ศึกษาในศูนย์ล้างไตทางช่องท้องทั้งหมด 9 แห่งในประเทศไทย ที่ศึกษาผู้ป่วยล้างไตทางช่องท้องที่อายุมากกว่าหรือเท่ากับ 18 ปีที่ล้างไตทางช่องท้องและได้รับการวินิจฉัยว่ามีภาวะติดเชื้อเยื่อบุช่องท้อง ร่วมกับมีระดับแอลบูมินในกระแสเลือดต่ำกว่า 3.5 กรัม/ดล. และคัดผู้ป่วยที่ติดเชื้อจากวัณโรค เชื้อรา ติดเชื้อแบบทุติยภูมิ หรือมีภาวะติดเชื้อในกระแสโลหิตรุนแรงออกจากการศึกษา โดยทำการสุ่มผู้ป่วยในอัตรา 1:1 เพื่อเข้าสู่กลุ่มศึกษา และกลุ่มควบคุม ในกลุ่มที่ศึกษาผู้ป่วยจะได้รับโปรตีนเวย์ปริมาณ 30 กรัม/วัน เป็นระยะเวลา 30 วัน โดยที่กลุ่มควบคุมจะไม่ได้รับโปรตีนเสริม ผู้ป่วยในทั้งสองกลุ่มจะได้รับคำแนะนำทางโภชนาการจากนักกำหนดอาหารตามแนวทางการดูแลผู้ป่วยติดเชื้อเยื่อบุช่องท้อง โดยศึกษาผลลัพธ์ของการศึกษาหลักเป็นผลลัพธ์รวมของการเสียชีวิตจากภาวะติดเชื้อเยื่อบุช่องท้องและการติดเชื้อเยื่อบุช่องท้องซ้ำแบบ relapsing และ repeat และผลลัพธ์ของการศึกษารองคือระดับแอลบูมินในกระแสเลือดระหว่างทั้งสองกลุ่ม ผลการศึกษา: ผู้ป่วยทั้งหมด 74 คนจากเดือนมิถุนายน พ.ศ. 2564 ถึงเดือนกุมภาพันธ์ 2565 เข้าร่วมการศึกษาและได้รับการสุ่มไปยังกลุ่มศึกษา 37 คน และกลุ่มควบคุม 37 คน ลักษณะผู้ป่วยในทั้งสองกลุ่มไม่ได้มีความแตกต่างกันอย่างมีนัยสำคัญทางสถิติ จากผลการศึกษาพบว่าผู้ป่วยในกลุ่มศึกษามีอัตราการเสียชีวิตหรือการติดเชื้อเยื่อบุช่องท้องซ้ำแบบ relapsing หรือ repeat ที่ 15 คน (ร้อยละ 41) และ 19 คน (ร้อยละ 51) (hazard ratio 0.84; ช่วงเชื่อมั่นร้อยละ 95 0.43-1.67) แต่พบว่าระดับแอลบูมินในกระแสเลือดในกลุ่มศึกษามีระดับสูงกว่ากลุ่มควบคุมอย่างมีนัยสำคัญเมื่อวิเคราะห์แบบตลอดการศึกษา (P<0.001) โดยมีค่าแตกต่างที่วันที่ 120 เฉลี่ยอยู่ที่ 0.35 กรัม/ดล. (ช่วงเชื่อมั่นร้อยละ 95 0.06-0.64) อาการผิดปกติที่พบในผู้ป่วยไม่แตกต่างในทั้งสองกลุ่ม โดยส่วนมากเป็นอาการระบบทางเดินอาหาร ได้แก่ ถ่ายอุจจาระเหลว อืดแน่นท้อง คลื่นไส้อาเจียน และเบื่ออาหาร สรุปผลการศึกษา: การให้โปรตีนเสริมในผู้ป่วยติดเชื้อเยื่อบุช่องท้องจากการล้างไตทางช่องท้องส่งผลให้ระดับแอลบูมินในกระแสเลือดสูงขึ้นได้อย่างมีนัยสำคัญ อย่างไรก็ตามผลต่อการเปลี่ยนแปลงการเสียชีวิตหรือการติดเชื้อเยื่อบุช่องท้องซ้ำยังไม่พบอย่างชัดเจน จำเป็นต้องการมีการศึกษาเพิ่มเติมในผู้ป่วยที่มากกว่านี้และมีการติดตามผู้ป่วยที่ยาวนานกว่านี้เพื่อศึกษาผลที่แท้จริงต่อไป
History Repeats Itself: Horse Originated Hyperimmune Sera Production Against Sars Cov-2, Ahu Pakdemi̇rli̇, Elvi̇n Çalişkan, Sabri̇ Hacioğlu, Erdem Danyer, Özlem Kardoğan, Züleyha Ergün Kurt, Özcan Yildirim, Hakan Taşkaya, Bora Ündar, Yasemi̇n Sezgi̇n, Gencay Ergi̇n, Hi̇mmet Eki̇ci̇, Ufuk Ülker, Erkan Taçbaş, Şahi̇n Çakir
History Repeats Itself: Horse Originated Hyperimmune Sera Production Against Sars Cov-2, Ahu Pakdemi̇rli̇, Elvi̇n Çalişkan, Sabri̇ Hacioğlu, Erdem Danyer, Özlem Kardoğan, Züleyha Ergün Kurt, Özcan Yildirim, Hakan Taşkaya, Bora Ündar, Yasemi̇n Sezgi̇n, Gencay Ergi̇n, Hi̇mmet Eki̇ci̇, Ufuk Ülker, Erkan Taçbaş, Şahi̇n Çakir
Turkish Journal of Medical Sciences
Background/aim: SARS-CoV-2 disease was announced as a pandemic by The World Health Organization in early 2020. It is still threatening the world population. Here, we aimed to produce hyperimmune sera that contain immunoglobulin G and F(ab')2 fragments sourced from horse antibodies as an urgent response to the pandemic. Materials and methods: SARS-CoV-2 was produced and inactivated with three different methods [formaldehyde (FA), formaldehyde, and binary ethylene amine (FA + BEI), and heat treatment]. After in vitro inactivation control, immunogens were mixed with Freund's adjuvant, thereafter horses (n: 2 for FA, 4 for FA + BEI, 2 for heat inactivation) and …
Association Of Physical Frailty With Cognitive Function And Mood In Older Adults Without Dementia And Depression, Rana Tuna Doğrul, Hacer Doğan Varan, Muhammet Cemal Kizilarslanoğlu, Mustafa Kemal Kiliç, Özgür Kara, Güneş Arik, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Burcu Balam Doğu
Association Of Physical Frailty With Cognitive Function And Mood In Older Adults Without Dementia And Depression, Rana Tuna Doğrul, Hacer Doğan Varan, Muhammet Cemal Kizilarslanoğlu, Mustafa Kemal Kiliç, Özgür Kara, Güneş Arik, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Burcu Balam Doğu
Turkish Journal of Medical Sciences
Background/aim: Physical frailty is thought to be related with a decline in cognitive function, mood, and social activities, especially in patients with depression and dementia. It is not clear whether or not physical frailty is associated with an impairment in cognitive function and mood in patients without dementia and depression. In this study, we evaluated the association of physical frailty with cognitive function and mood in geriatric patients without dementia and depression. Material and methods: In this study, 612 patients aged 65 years and over were evaluated. Physical frailty was assessed by using Fried criteria. Furthermore, comprehensive geriatric assessment was …
Factors Influencing The Length Of Stay In The Palliative Care Unit In Patients Dischargedhome: Results From A Tertiary Hospital In Turkey, Hi̇lal Zengi̇n, İlker Taşçi
Factors Influencing The Length Of Stay In The Palliative Care Unit In Patients Dischargedhome: Results From A Tertiary Hospital In Turkey, Hi̇lal Zengi̇n, İlker Taşçi
Turkish Journal of Medical Sciences
Background/aim: Increased length of stay (LOS) in the palliative care unit (PCU) is a serious burden to the patients and the health care system. The predictors of longer LOS in a PCU have not been reported so far from Turkey. Our aim in this study was to evaluate the factors associated with the LOS in the PCU of a tertiary hospital. Materials and methods: This cross-sectional analysis of a retrospective cohort evaluated adult patients' medical records admitted to the PCU between 2017 and 2019. The main inclusion criteria were 4 or more days of palliative unit stay and being discharged …
1,25-Dihydroxyvitamin D3 Regulates T Helper And B Lymphocyte Responsessubstantially In Drug-Naive Primary Sjögren's Syndrome Patients' Mononuclear Cells, Deni̇z Genç, Merve Sezer Kürkçü, Burcu Günaydin, Emi̇ne Fi̇gen Tarhan
1,25-Dihydroxyvitamin D3 Regulates T Helper And B Lymphocyte Responsessubstantially In Drug-Naive Primary Sjögren's Syndrome Patients' Mononuclear Cells, Deni̇z Genç, Merve Sezer Kürkçü, Burcu Günaydin, Emi̇ne Fi̇gen Tarhan
Turkish Journal of Medical Sciences
Background/aim: A correlation between vitamin D deficiency and primary Sjögren's syndrome (pSS) has already been described. The limited data has been reported regarding the pathological relevance of vitamin D in primary Sjögren's syndrome. In this study, the peripheral blood mononuclear cells were cocultured with 1,25-dihydroxyvitamin D3 to determine the modulatory effect of vitamin D3 on T and B lymphocyte phenotypes in pSS. Materials and methods: Venous blood samples were collected from 11 patients in the treatment phase and 9 drug-naive pSS patients. Peripheral blood mononuclear cells (PBMC) were isolated and separately cultured in the presence and absence of 1,25- dihydroxyvitamin …
Can Omentin-1 Be A Prognostic Marker In Surgical Intensive Care Patients?, Yücel Gülteki̇n, İsmai̇l Bi̇ri̇, Afi̇g Gojayev, Selen Yilmaz Işikhan, Oytun Portakal Akçi̇n, Yusuf Alper Kiliç
Can Omentin-1 Be A Prognostic Marker In Surgical Intensive Care Patients?, Yücel Gülteki̇n, İsmai̇l Bi̇ri̇, Afi̇g Gojayev, Selen Yilmaz Işikhan, Oytun Portakal Akçi̇n, Yusuf Alper Kiliç
Turkish Journal of Medical Sciences
Background/aim: A member of the adipokine family, omentin-1 is selectively secreted from visceral fat tissue and the omentum. It has been shown that omentin-1 is involved in the pathogenesis of certain diseases and can be used as a prognostic marker. This study first investigated the prognostic significance of omentin-1 in surgical intensive care patients. In addition, the relationship between omentin-1 and laboratory and clinical parameters commonly used in intensive care units (ICUs) was evaluated. Materials and methods: One hundred and fifty-four patients hospitalized in the surgical ICU were included in the study. Blood samples for omentin-1 were collected from the …
The Effects Of Vitamin D Supplemantation On Prognosis In Patients With Mildobstructive Sleep Apnea Syndrome, Feri̇de Ayyildiz, Hi̇lal Yildiran, Nigar Afandiyeva, Özlem Gülbahar, Oğuz Köktürk
The Effects Of Vitamin D Supplemantation On Prognosis In Patients With Mildobstructive Sleep Apnea Syndrome, Feri̇de Ayyildiz, Hi̇lal Yildiran, Nigar Afandiyeva, Özlem Gülbahar, Oğuz Köktürk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effect of vitamin D on the disease prognosis and biochemical parameters in patients with mild obstructive sleep apnea syndrome (OSAS). Materials and methods: Nineteen adult male individuals (18-65 years) who were diagnosed with mild OSAS after polysomnography and had low vitamin D levels were included in the study. Each week, patients took 50.000 IU Vitamin D3 supplementation for 8 weeks. Polysomnography, biochemical parameters FBG (fasting blood glucose), lipid profile (TG, TC, LDL-C, HDL-C, VLDL-C), calcium, phosphorus, parathormone, calcitonin, serum 25(OH)D, insulin, CRP, TNF-α, IL-6, and IL-10 of patients were evaluated …
Relationship Between C-Reactive Protein To Albumin Ratio And Coronary Artery Calciumscore And Cad-Rads Scores With Coronary Computed Tomography Angiography, Mehmet Aki̇f Erdöl, Kadri̇ye Gayretli̇ Yayla
Relationship Between C-Reactive Protein To Albumin Ratio And Coronary Artery Calciumscore And Cad-Rads Scores With Coronary Computed Tomography Angiography, Mehmet Aki̇f Erdöl, Kadri̇ye Gayretli̇ Yayla
Turkish Journal of Medical Sciences
Background/aim: C-reactive protein (CRP) to albumin ratio (CAR) is predictive marker of systemic inflammatory state in atherosclerotic coronary diseases when compared to predictive value of these two markers separately. We aimed to evaluate the relationship between CAR and the coronary artery calcium (CAC) score, Coronary Artery Disease-Reporting and Data System (CAD-RADS) score in patients' unknown diagnosis of coronary artery disease (CAD) underwent coronary CTA (Computed Tomography Angiography) and were classified by CAD-RADS scores. Materials and methods: A total of 187 patients consecutively referred for the evaluation of their chest pain underwent coronary CTA were included retrospectively. Results: CRP, CAR, and …
The Protective Effect Of Boric Acid On Cholestatic Rat Liver Ischemia Reperfusion Injury, Serkan Güler, Ari̇f Aslaner, Hami̇t Yaşar Elli̇dağ, Şenay Yildirim, Tuğrul Çakir
The Protective Effect Of Boric Acid On Cholestatic Rat Liver Ischemia Reperfusion Injury, Serkan Güler, Ari̇f Aslaner, Hami̇t Yaşar Elli̇dağ, Şenay Yildirim, Tuğrul Çakir
Turkish Journal of Medical Sciences
Background/aim: To evaluate the potential protective effects of boric acid (BA) in experimental cholestatic liver ischemia reperfusion (IR) injury model. Materials and methods: The study included 24 female rats which were divided into 3 groups each containing 8 rats. The control group (Group 1) only received laparotomy. In the IR group (Group 2) biliary tract ligation was applied and 1 week later 45 min ischemia and 1 h reperfusion with relaparotomy without any treatment was implemented. In the treatment BA+IR group (Group 3). 1 week after the biliary ligation intraperitoneal administration of 200 mg/kg BA was given 10 min before …
What Is The Restorative Effect Of Vegf Inhibitor Bevacuzimab Against Subarachnoidhemorrhage In An Experimental Model?, Adnan Yalçin Demi̇rci̇, Yahya Güvenç, Ersi̇n Özeren, Çeti̇n Akyol, Pinar Bayram, Deni̇z Bi̇llur, Sevi̇m Aydin, Hakan Seçki̇n, Kazim Yi̇ği̇tkanli
What Is The Restorative Effect Of Vegf Inhibitor Bevacuzimab Against Subarachnoidhemorrhage In An Experimental Model?, Adnan Yalçin Demi̇rci̇, Yahya Güvenç, Ersi̇n Özeren, Çeti̇n Akyol, Pinar Bayram, Deni̇z Bi̇llur, Sevi̇m Aydin, Hakan Seçki̇n, Kazim Yi̇ği̇tkanli
Turkish Journal of Medical Sciences
Background/aim: This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Materials and methods: Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH+BVZ group (n = 6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ for 2 days after the SAH. Basilar artery diameters were measured with …
An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari
An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the administration of cinnamon extract that is known to be effective in decreasing the high blood glucose and the distribution of NGF and Trk-A receptor in pancreas with immunohistochemistry way. Materials and methods: The experimental groups were defined as control, sham, cinnamon, diabetes, and diabetes-cinnamon. At the end of the experiment, the pancreatic tissue samples were obtained for the rats. The hematoxylin-eosin and triple staining were used to examine histology. The immunohistochemical methods were performed on the sections of pancreatic tissue. In all groups, the body weight and fasting blood glucose …
The Protective Effects Of Anakinra In A Neonatal Rat Model Of Necrotizing Enterocolitis, Hati̇ce Güneş, Sevcan İpek, Sadik Yurttutan, Tuncay Kuloğlu, Fatma İnanç Tolun, Ülkü Kazanci, Adem Doğaner
The Protective Effects Of Anakinra In A Neonatal Rat Model Of Necrotizing Enterocolitis, Hati̇ce Güneş, Sevcan İpek, Sadik Yurttutan, Tuncay Kuloğlu, Fatma İnanç Tolun, Ülkü Kazanci, Adem Doğaner
Turkish Journal of Medical Sciences
Background/aim: Necrotizing enterocolitis (NEC) is a commonly seen life-threatening condition in newborns characterized by ischemic necrosis. This study aimed to investigate anakinra's effects, an interleukin-1 receptor antagonist, on oxidative stress, inflammation, and tissue necrosis in an NEC rat model. Materials and methods: Forty Wistar albino pups were divided into four groups randomly as follows; group 1, control group; group 2, anakinra-treated control group; group 3, NEC group; and group 4, NEC and anakinra treatment group. The rats were given hyperosmolar formula feeding, and they were exposed to hypoxia after cold stress at +4 °C and oxygen in order to create …
High Zinc Content Of Ankaferd Hemostat And Wound Healing Effect, Nazi̇fe Yasemi̇n Ardiçoğlu Akişin, Mehmet Nejat Akar
High Zinc Content Of Ankaferd Hemostat And Wound Healing Effect, Nazi̇fe Yasemi̇n Ardiçoğlu Akişin, Mehmet Nejat Akar
Turkish Journal of Medical Sciences
No abstract provided.
Fetal Us And Mri In Detection Of Craniospinal Anomalies With Postnatal Correlation:Single-Center Experience, İlker Eyüboğlu, Gülseren Di̇nç
Fetal Us And Mri In Detection Of Craniospinal Anomalies With Postnatal Correlation:Single-Center Experience, İlker Eyüboğlu, Gülseren Di̇nç
Turkish Journal of Medical Sciences
Background/aim: To reveal the contribution of magnetic resonance imaging (MRI) to ultrasound (US) in prenatal diagnosis of fetal craniospinal anomalies by retrospectively comparing the prenatal and postnatal findings. Materials and methods: After institutional review board approval, between January 2010 and May 2020, 301 pregnant women, which had a gestational age between 19-37 weeks (mean 26.5 ± 6.1 weeks), diagnosed with cranial and spinal anomalies on fetal US and later on imaged with MRI were evaluated, and in 179 of those cases prenatal imaging findings were compared with postnatal findings. Results: A total of 191 fetal craniospinal anomalies were detected in …
Clinical Implications Of Fungal Isolation From Sputum In Adult Patients With Cystic Fibrosis, İli̇m Irmak, Ebru Damadoğlu, Damla Karadeni̇z Güven, Xursud Huseynova, Ahmet Çağkan İnkaya, Berri̇n Er, Ali̇ Korhan Siğ, Dolunay Gülmez Kivanç, Sevtap Arikan, Di̇lber Ademhan Tural, Deni̇z Doğru Ersöz, Hayri̇ye Uğur Özçeli̇k, Emi̇ne Nural Ki̇per, Ali̇ Fuat Kalyoncu
Clinical Implications Of Fungal Isolation From Sputum In Adult Patients With Cystic Fibrosis, İli̇m Irmak, Ebru Damadoğlu, Damla Karadeni̇z Güven, Xursud Huseynova, Ahmet Çağkan İnkaya, Berri̇n Er, Ali̇ Korhan Siğ, Dolunay Gülmez Kivanç, Sevtap Arikan, Di̇lber Ademhan Tural, Deni̇z Doğru Ersöz, Hayri̇ye Uğur Özçeli̇k, Emi̇ne Nural Ki̇per, Ali̇ Fuat Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: Cystic fibrosis is an autosomal recessive disease with a defect in mucociliary activity that is characterized by recurrent pulmonary infections. Bacterial agents frequently implicated in airway colonization are Haemophilus influenzae, Staphylococcus spp., and Pseudomonas spp. Fungal isolation from sputum is common in adults. However, growth of fungal agent only in sputum culture in patients with cystic fibrosis is insufficient for the diagnosis of fungal diseases. There is limited data about the clinical significance of fungal isolation in sputum cultures. The aim of the study was to investigate the clinical outcomes andsignificance of fungal isolation from sputum samples in adult …
Impact Of Frailty And Ultrasonography-Based Sarcopenia On The Development Ofpostoperative Complications In Gastrointestinal Cancer Patients, Gözde Şengül Ayçi̇çek, Ti̇muçi̇n Erol, Peli̇n Ünsal, Olgun Deni̇z, Osman Abbasoğlu, Meltem Gülhan Hali̇l
Impact Of Frailty And Ultrasonography-Based Sarcopenia On The Development Ofpostoperative Complications In Gastrointestinal Cancer Patients, Gözde Şengül Ayçi̇çek, Ti̇muçi̇n Erol, Peli̇n Ünsal, Olgun Deni̇z, Osman Abbasoğlu, Meltem Gülhan Hali̇l
Turkish Journal of Medical Sciences
Background/aim: Gastrointestinal (GI) system cancers are frequent among older adults and it is still difficult to predict which are at increased risk for postoperative complications. Frailty and sarcopenia are increasing problems of older population and may be associated with adverse outcomes. In this study we aimed to examine the effect of sarcopenia and frailty on postoperative complications in older patients undergoing surgery for GI cancers. Materials and methods: Forty-nine patients admitted to general surgery clinic with the diagnosis of gastrointestinal system cancers were included in this cross-sectional study. Frailty status was assessed using the Edmonton Frail Scale (EFS). Sarcopenia was …
Turkish Validity And Reliability Study Of Type 2 Diabetes Stigma Assessment Scale, Bahar İnkaya, Ezgi̇ Karadağ
Turkish Validity And Reliability Study Of Type 2 Diabetes Stigma Assessment Scale, Bahar İnkaya, Ezgi̇ Karadağ
Turkish Journal of Medical Sciences
Background/aim: Stigma has a high incidence and adversely affects people with diabetes. In this context, patients face difficulties such as fear of losing their jobs, travel restrictions, isolation from social life, problems related to mental health, and feeling of wellness. The aim of this study was to investigate the validity and reliability of the stigma assessment scale in individuals with type 2 diabetes. Materials and methods: The study sample consisted of 153 diabetic individuals. The validity of language, content, and construct were examined to evaluate the validity of the type 2 diabetes stigma assessment scale. Cronbach's alpha was used to …
Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş
Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effect of vitamin D supplementation on ambulation and mobility in hospitalized patients undergoing stroke rehabilitation. Materials and methods: This study was conducted retrospectively between September 2020 and October 2020 at Gazi University Faculty of Medicine Physical Medicine and Rehabilitation Department. Seventy-six patients who received inpatient stroke rehabilitation treatment between May 2018 and February 2020 were included in the study. The patients were divided into two groups as those who did and did not take vitamin D supplements. Lower extremity motor function and ambulation status were compared using Brunnstrom recovery stage …
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …
What Is The Main Factor In Predicting The Morbidity And Mortality In Patients Withgastroschisis: Delivery Time, Delivery Mode, Closure Method, Or The Type Of Gastroschisis(Simple Or Complex)?, Mustafa Behram, Süleyman Cemi̇l Oğlak, Seyi̇than Özaydin, Sema Süzen Çaypinar, İlker Gönen, Şeyhmus Tunç, Yusuf Başkiran, İsmai̇l Özdemi̇r
What Is The Main Factor In Predicting The Morbidity And Mortality In Patients Withgastroschisis: Delivery Time, Delivery Mode, Closure Method, Or The Type Of Gastroschisis(Simple Or Complex)?, Mustafa Behram, Süleyman Cemi̇l Oğlak, Seyi̇than Özaydin, Sema Süzen Çaypinar, İlker Gönen, Şeyhmus Tunç, Yusuf Başkiran, İsmai̇l Özdemi̇r
Turkish Journal of Medical Sciences
Background/aim: There are numerous debates in the management of gastroschisis (GS). The current study aimed to evaluate perinatal outcomes and surgical and clinical characteristics among GS patients based on their type of GS, abdominal wall closure method, and delivery timing. Materials and methods: This study was a retrospective analysis of prospectively collected data of 29 fetuses with GS that were prenatally diagnosed, delivered, and managed between June 2015 and December 2019 at the Obstetrics and Pediatric Surgery Clinics of Kanuni Sultan Süleyman Training and Research Hospital. Results: Twenty-three of the patients had simple GS, and six of them had complex …
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
Turkish Journal of Medical Sciences
Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the …
Nutritional Status In Patients With Neuro-Behçet's Disease, Seyda Erdoğan, Mi̇ne Hayri̇ye Sorgun, Müge Kuzu Kumcu, Mustafa Aykut Kural, Sefer Rzayev, Canan Yücesan
Nutritional Status In Patients With Neuro-Behçet's Disease, Seyda Erdoğan, Mi̇ne Hayri̇ye Sorgun, Müge Kuzu Kumcu, Mustafa Aykut Kural, Sefer Rzayev, Canan Yücesan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the nutritional status and risk factors for malnutrition in Behçet's disease (BD) and neuro-Behçet's disease (NBD) patients. Materials and methods: Medical recordings of 74 patients with BD without neurological involvement (BDWoNI), 72 patients with NBD, and 50 patients with other diseases (carpal tunnel syndrome or lumbar discopathy) were analyzed retrospectively. The serum analyses were performed in the inactive period of disease. Chronic malnutrition was defined as low levels of serum albumin (
Decreased Exercise Capacity, Strength, Physical Activity Level And Quality Of Life In Adultpatients With Familial Mediterranean Fever, Nurten Gi̇zem Tore, Fulden Sari̇, Devri̇m Can Saraç, Seli̇n Bayram, Hasan Satiş, Hazan Karadeni̇z, Abdurrahman Tufan, Deran Oskay
Decreased Exercise Capacity, Strength, Physical Activity Level And Quality Of Life In Adultpatients With Familial Mediterranean Fever, Nurten Gi̇zem Tore, Fulden Sari̇, Devri̇m Can Saraç, Seli̇n Bayram, Hasan Satiş, Hazan Karadeni̇z, Abdurrahman Tufan, Deran Oskay
Turkish Journal of Medical Sciences
Background: Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease that causes recurrent attacks of fever, polyserositis, arthritis or skin eruptions, resulting in pain in the abdomen, muscles, joints and chest. All of these might lead to a reduction in exercise capacity, muscle strength, physical activity level (PAL) and quality of life (QoL). Therefore, assesment of these parameters are important. The aim of this study was to assess exercise capacity, muscle strength, PAL, and QoL in patients with FMF as compared to controls. Materials and methods: A total of 40 subjects with FMF and 36 healthy control subjects participated in …
The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber
The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber
Turkish Journal of Medical Sciences
Background/aim: We aimed to determine the presence of subclinical atherosclerosis using carotid intima-media thickness (CIMT) and biochemical parameters in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: Thirty-four patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency on regular glucocorticoid treatment for ≥3 years and 31 healthy subjects were included in the study. The patients were divided into two groups according to the degree of control of the clinic, laboratory, and radiological parameters as a) "uncontrolled" [n= 22; with increased height velocity (HV) standard deviation score (SDS) (≥2 SDS), advanced bone age, serum 17-OH progesterone 0.05]. …
Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner
Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner
Turkish Journal of Medical Sciences
Background/aim: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish agespecific reference values for lymphocyte subsets using updated immunophenotyping panels. Materials and methods: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed …
Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Turkish Journal of Medical Sciences
Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (
The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş
The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş
Turkish Journal of Medical Sciences
Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤ 32 weeks of gestation formed the study group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal …
Serum Growth Differentiation Factor-15 Analysis As A Malnutrition Marker Inhemodialysis Patients, Di̇dem Turgut, Deni̇z İlhan Topcu, Cemi̇le Cansu Alperen, Sidika Esra Baskin
Serum Growth Differentiation Factor-15 Analysis As A Malnutrition Marker Inhemodialysis Patients, Di̇dem Turgut, Deni̇z İlhan Topcu, Cemi̇le Cansu Alperen, Sidika Esra Baskin
Turkish Journal of Medical Sciences
Background/aim: Growth differentiation factor (GDF)-15 is related to inflammation and mortality in many conditions. We aimed to determine if an elevated serum GDF-15 level is related to nutritional status of patients on hemodialysis (HD) and mortality. Materials and methods: Routine HD patients (n = 158) were included in the study and followed for 18 months. Some malnutrition/ inflammation scoring indexes (malnutrition/inflammation score (MIS), controlling nutritional status (CONUT) score, and prognostic nutritional index (PNI)), biochemical parameters, and GDF-15 were used to build Cox regression multivariate models to study the association with mortality. Results: Among the patients, 90 (57 %) had a …
Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz
Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz
Turkish Journal of Medical Sciences
Background/aim: Volume and T2 relaxation time measurements of the skeletal muscle provide quantitative information. We aimed to evaluate the interobserver reliability and the intraobserver reproducibility of measurements of volumes and T2 relaxation times of the quadriceps femoris and the hamstring muscles. Materials and methods: A cross-sectional reliability study was conducted on ten recreational athletes. The images of the quadriceps and the hamstring muscles of both limbs were obtained using a 3.0 Tesla magnetic resonance imaging (MRI) scanner. Two sports medicine specialists measured muscle volumes from a total of 2560 images and T2 relaxation times from a total of 40 images, …