Digital Commons Network^™

Evaluating Differences In Optical Properties Of Indolent And Aggressive Murine Breast Tumors Using Quantitative Diffuse Reflectance Spectroscopy, Joel Rodriguez Troncoso, Umme Marium Mim, Jesse D. Ivers, Santosh K. Paidi, Mason G. Harper, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, David A. Zaharoff, Ishan Barman, Narasimhan Rajaram

Biomedical Engineering Faculty Publications and Presentations

We used diffuse reflectance spectroscopy to quantify tissue absorption and scattering-based parameters in similarly sized tumors derived from a panel of four isogenic murine breast cancer cell lines (4T1, 4T07, 168FARN, 67NR) that are each capable of accomplishing different steps of the invasion-metastasis cascade. We found lower tissue scattering, increased hemoglobin concentration, and lower vascular oxygenation in indolent 67NR tumors incapable of metastasis compared with aggressive 4T1 tumors capable of metastasis. Supervised learning statistical approaches were able to accurately differentiate between tumor groups and classify tumors according to their ability to accomplish each step of the invasion-metastasis cascade. We investigated …

Wastewater Treatment Plants: The Missing Link In Global One-Health Surveillance And Management Of Antibiotic Resistance, Abdolmajid Gholizadeh, Mehdi Khiadani, Maryam Foroughi, Hadi Alizade Siuki, Hadi Mehrfar

Research outputs 2022 to 2026

Introduction: As a global public health crisis, antibiotic resistance (AR) should be monitored and managed under the One-Health concept according to the World Health Organization (WHO), considering the interconnection between humans, animals, and the environment. But this approach often remains focused on human health and rarely on the environment and its compartments, especially wastewater as the main AR receptor. Wastewater treatment plants (WWTPs) not only are not designed for reliving AR but also provide appropriate conditions for enhancing AR through different mechanisms. Methods: By reviewing the research-based statistics on the inclusion of WWTPs in the One-Health/AR program crisis, this paper …

Selective Production Of Levoglucosan (Lg) From Pyrolysis Of Date Pits And Its Catalytic Transformation Into Transportation Fuels, Ala Hamid Higazi

Theses

Levoglucosan (LG) or (1,6-anhydro-β-D-glucopyranose) signifies important sugar derivatives produces in appreciable quantities from thermochemical and biochemical degradation of biomass. It is often regarded as an important platform chemical for the synthesis of value-added products, most notably styrene and furans. The work in this thesis entails two broad aims; to produce LG from pyrolysis of date pits; and then convert the LG into transportation fuels through a hydrodeoxygenation (HDO) reaction. The particular choice of date pits stems from its local relative abundance as a waste biomass. Aiming to further improve the yield of levoglucosan yields from pyrolysis of date pits, pre-treatment …

An Exhaustive Review Of Neutrosophic Logic In Addressing Image Processing Issues, Samia Mandour

Neutrosophic Systems with Applications

Since the importance of images in our lives and the advancements in computer data gathering methods, anyone can collect a large number of images, but most of them cannot be processed manually. Image processing therefore becomes appealing since various types of data may be represented and processed digitally. Image processing has become the most popular processing method, employed in security camera films, healthcare images, images from remote sensors, and naturalistic image/videos because of fast computers and processors. In order to raise cognitive function and speed up decision-making, image processing is crucial to many information access systems. Since ambiguity now permeates …

Machine Learning Based Bioinformatics Analysis Of Intron Usage Alterations And Metabolic Regulation In Adipose Browning, Hamza Umut Karakurt, Pinar Pi̇r

Turkish Journal of Electrical Engineering and Computer Sciences

Adipose tissue is the major energy depot of the body and is considered an endocrine organ. Adipose tissue involves many different cell types, first and foremost, the adipocytes. White adipose cells that store fat and brown adipocytes that take part in lipid oxidation and heat generation are the most common cell types in adipose tissue. Even though brown adipocytes which have a high number of mitochondria and high fat-burning capacity are rare in adults, they are abundant in newborns and rodents. White adipocytes can gain a temporal brown-like character with a process called browning, which can be induced with cold …

Fuzzycsampling: A Hybrid Fuzzy C-Means Clustering Sampling Strategy For Imbalanced Datasets, Abdullah Maraş, Çi̇ğdem Erol

Turkish Journal of Electrical Engineering and Computer Sciences

Classification model with imbalanced datasets is recently one of the most researched areas in machine learning applications since they induce to the emergence of low-performing machine learning models. The imbalanced datasets occur if target variables have an uneven number of examples in a dataset. The most prevalent solutions to imbalanced datasets can be categorized as data preprocessing, ensemble techniques, and cost-sensitive learning. In this article, we propose a new hybrid approach for binary classification, named FuzzyCSampling, which aims to increase model performance by ensembling fuzzy c-means clustering and data sampling solutions. This article compares the proposed approaches' results not only …

Towards A Virtual Reality Visualization Of Hand-Object Interactions To Support Remote Physical Therapy, Trudi Di Qi, Louanne Boyd, Scott Fitzpatrick, Meghna Raswan, Franceli L. Cibrian

Engineering Faculty Articles and Research

Improving object manipulation skills through hand-object interaction exercises is crucial for rehabilitation. Despite limited healthcare resources, physical therapists propose remote exercise routines followed up by remote monitoring. However, remote motor skills assessment remains challenging due to the lack of effective motion visualizations. Therefore, exploring innovative ways of visualization is crucial, and virtual reality (VR) has shown the potential to address this limitation. However, it is unclear how VR visualization can represent understandable hand-object interactions. To address this gap, in this paper, we present VRMoVi, a VR visualization system that incorporates multiple levels of 3D visualization layers to depict movements. In …

De Las 7 Bolas De Dragón A Los 7 Reinos De Poniente: Viajando Por La Ficción Para Transformar La Realidad, Vania C. Tovilla

Journal of Roleplaying Studies and STEAM

resumen

El libro es una muestra de la experiencia y dedicación que tiene Issac Pérez López, quien con más de veinte años de práctica en la creación de entornos lúdicos nos sumerge en una suerte de juego donde al leer sus páginas a través de un lenguaje coloquial y cercano. . a la realidad de los docentes del “Cole” nos ejemplifica y ayuda a comprender un poco más los conceptos y pasos que involucran el término “gamificación”.

Podría ser considerado un libro de autoayuda potenciado (en el buen sentido) para los docentes que se están integrando al mundo de los …

Occlusive Membranes For Guided Regeneration Of Inflamed Tissue Defects., Woojin Choi, Utkarsh Mangal, Jin-Young Park, Ji-Yeong Kim, Taesuk Jun, Ju Won Jung, Moonhyun Choi, Sungwon Jung, Milae Lee, Ji-Yeong Na, Du Yeol Ryu, Jin Man Kim, Jae-Sung Kwon, Won-Gun Koh, Sangmin Lee, Patrick T J Hwang, Kee-Joon Lee, Ui-Won Jung, Jae-Kook Cha, Sung-Hwan Choi, Jinkee Hong

Henry M. Rowan College of Engineering Departmental Research

Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration …

Intelligent Healthcare: Evaluation Potential Implications Of Metaverse In Healthcare Based On Mathematical Decision-Making Framework, Ibrahim Elhenawy, Sara Fawaz Al-Baker, Mona Mohamed

Neutrosophic Systems with Applications

The Metaverse has the ability to restructure and change the manner in which individuals connect with one another as well as the activities that they carry out on a daily basis. One definition of a Metaverse describes it as "a virtual, digital, and three-dimensional universe formed by the integration of various cutting-edge technologies and virtual places." In this piece, we will explore the potential applications of the Metaverse in the medical field. Our conversations on the notion of the Metaverse and the primary technologies that make it possible are both thought-provoking and in-depth. In this article, we study and analyze …

Evaluation Of Cyber Insecurities Of The Cyber Physical System Supply Chains Using Α-Discounting Mcdm, Rehab Mohamed, Mahmoud M. Ismail

Neutrosophic Systems with Applications

Recently, supply chains (SCs) are applying information technology to enable data sharing among suppliers, instant access to information, and complete tracking of products. With more cybersecurity risks present, such as theft of information, service interruptions, and financial resources risks, the vulnerability of systems is increased. The management of supply chain cybersecurity, which encompasses information systems, software, and infrastructure, is the emphasis of the supply chain's safety measure. There are several serious danger that attack supply chain systems. Most SC Cybersecurity procedures are used to reduce the threats posed by vulnerabilities to those processes. Researchers have mostly concentrated on supply chain-related …

Integration Of Algae And Biomass Processes To Synthesize Renewable Bioproducts For The Circular Economy, Jessica Martin

USF Tampa Graduate Theses and Dissertations

Rapid population growth and global industrialization have substantially heightened the demand for fossil-based fuels and products in various sectors of the global economy, including energy production, transportation fuels, and as raw materials for petrochemicals. The intense consumption of fossil fuels has caused immense environmental impacts, especially pertaining to carbon dioxide emissions. Shifting to renewable feedstocks (raw materials) is expected to reduce these emissions by lowering the carbon footprint of fuels and products compared to traditional fossil-derived alternatives. This transition aligns with the goal of creating a sustainable and circular economy, emphasizing efficient resource use, and reducing waste generation through recycling …

Sustainability And Circular Economy Horizon Scan And Needs Analysis, Sadaf Dalirazar, Mark Kelly, Derek Sinnott, James O'Donnell

Reports

The construction industry plays a crucial role in addressing the climate crisis as it is the largest global consumer of raw materials and contributes significantly to global energy consumption and emissions. Considering the world’s continuous population growth and the imperative to address infrastructure and housing demands the construction sector needs to adopt further sustainable strategies in its activities to reduce the pressure on natural resources. In addition, the Architecture, Engineering, and Construction (AEC) sector is responsible for generating substantial amount of waste known as Construction and Demolition Waste (CDW), which is projected to increase due to the future construction developments. …

Evolutionary Conservation And Times Of Action Of Heterochronic Genes, Maria Ivanova

Theses and Dissertations

The heterochronic pathway of C. elegans is the most well-characterized system to date for controlling the sequence and timing of developmental events. However, we still have critical unanswered questions to address. First, little is known about the evolution of the heterochronic pathway, and of developmental timing in general. To determine if the roles of major heterochronic genes are conserved, I made mutants in orthologs of these genes in C. briggsae, using CRISPR/Cas9. My studies revealed a significant drift in the roles of some of the genes, although all of them are still involved in the developmental timing regulation, and several …

An Exploration Of Tissue Specific Impedance Using Microneedle Based Wearable Sensors, Kaitlyn J.H. Read

Nanoscience and Microsystems ETDs

Within this research, I have developed a microneedle-based wearable sensor for plants and fungi, to measure the electrical impedance of different tissues. Electrical impedance measures the physical properties of a material while allowing complex biological systems to be modeled onto a simplified electrical circuit. Microneedles allow for electrical impedance to measure specific tissues without the insulative properties of the cuticle and can be applied to delicate tissues. I have demonstrated the tissue specificity, novel attachment methods, as well as use on both plants and fungi. In chapter 1, I applied microneedle-based impedance to the leaf midrib of a sorghum and …

Carrier Dynamics In Green Iii-Nitride Leds Using Small-Signal Electroluminescence, Xuefeng Li

Optical Science and Engineering ETDs

Solid-state lighting has achieved significant success over the past two decades, but the low quantum efficiency of green LEDs (i.e., the “green gap”) remains a barrier to full red-green-blue (RGB) displays in numerous applications. Combating efficiency reduction in longer-wavelength LEDs requires understanding the relative roles of intrinsic effects (e.g., wave-function overlap, carrier-current density relationship, phase-space filling (PSF)) vs. extrinsic effects (e.g., material degradation due to increased defect density, compositional inhomogeneities, etc.). A systematic study of the carrier dynamics in InGaN/GaN LEDs is very important for understanding the origin of the green gap and for providing solutions to improve the efficiency …

Analyzing Major Elements Of Crash Injury Severity Involving Priority-I Detriments Of Vision-Zero Plan, Muhammad Umer Farooq, Cole Madson, Aemal Khattak

Mid-America Transportation Center: Final Reports and Technical Briefs

Road traffic crashes result in significant economic losses for individuals, their families, and entire nations. These losses stem from the expenses associated with injury treatment, as well as the productivity lost due to fatalities or disabilities caused by these injuries. The 2030 Agenda for Sustainable Development set an ambitious target of halving the global number of fatalities and injuries from road traffic crashes by 2020 and achieving zero deaths by 2030, commonly referred to as the 'Target Zero Plan.' The Target Zero Plan prioritizes traffic safety issues into three distinct levels. The three priority levels are determined based on the …

Integrated Flood Risk Assessment Of Properties And Associated Population At County Scale For Nebraska, Usa, Shivendra Srivastava, Tirthankar Roy

Department of Civil and Environmental Engineering: Faculty Publications

Risk assessment of properties and associated population was conducted for the state of Nebraska, leveraging only open-source datasets. The flood risk framework consisted of interactions among drivers, i.e. hazard, exposure, vulnerability, and response, to assess the risks related to properties and associated populations. To quantify hazard on a county scale, we considered properties at risk of flooding based on a flood score (a higher score represents a greater chance of flooding). Exposure was quantified by considering population density at the county level. We quantified vulnerability under four categories: social, ecological, economic, and health. Response, a relatively newer component in flood …

Integrated Flood Risk Assessment Of Properties And Associated Population At County Scale For Nebraska, Usa, Shivendra Srivastava, Tirthankar Roy

Department of Civil and Environmental Engineering: Faculty Publications

Risk assessment of properties and associated population was conducted for the state of Nebraska, leveraging only open-source datasets. The flood risk framework consisted of interactions among drivers, i.e. hazard, exposure, vulnerability, and response, to assess the risks related to properties and associated populations. To quantify hazard on a county scale, we considered properties at risk of flooding based on a flood score (a higher score represents a greater chance of flooding). Exposure was quantified by considering population density at the county level. We quantified vulnerability under four categories: social, ecological, economic, and health. Response, a relatively newer component in flood …

India In Space: Factors Shaping The Indian Trajectory, Harsh V. Pant, Ajey Lele

Space and Defense

By launching its space probe to the Moon, Chandrayaan-1, on 22 October 2008, India joined the United States (U.S.), Japan, Europe, Russia, and China in this accomplishment. The principal goal of the probe was to conduct mapping of the lunar surface, and among the scientific payloads it carried two were from the United States and three from the European Space Agency (ESA). This was a unique mission as it was an attempt to map highresolution, 3-D topography of entire Moon, get mineral composition of surface, and investigate the availability of water and Helium-3. Chandrayaan-1 operated until August 2009, coming to …

Mixed Reality: A Tool For Investigating The Complex Design And Mechanisms Of A Mechanically Actuated Digital Pump, Israa Azzam, Keith Pate, Farid Breidi, Minsoo Choi, Yeling Jiang, Christos Mousas

Purdue University Libraries Open Access Publishing Fund

Digital hydraulics is a discrete technology that integrates advanced dynamic system controls, digital electronics, and machine learning to enhance fluid power systems’ performance, overall efficiency, and controllability. A mechanically actuated inline three-piston variable displacement digital pump was previously proposed and designed. The inline three-piston pump incorporates complex mechanical and hydraulic subsystems and highly coupled mechanisms. The complexity of the utilized subsystems poses challenges when assessing the viability of the conceptual design. Therefore, this work focuses on designing, developing, and implementing a collaborative virtual platform involving a digitized module showcasing the internal mechanical structure of the digital pump utilizing mixed reality …

Attack On The Brain: Neurowars And Neurowarfare, Armin Krishnan

Space and Defense

Is neurotechnology leading nation-states toward a new domain of war? Neuroscience is on the verge of deciphering the human brain. As a result, brains will become a part of the battlefield against which attacks will be directed. As neuroscientist James Giordano argued: “the brain is the next battlespace.” It is foreseeable that this will have tremendous implications for warfare and could amount to a true military revolution in the sense of military historian Williamson Murray: it would completely change the characteristics of conflict, as well as transform state and society.

Addition Of Fibers Derived From Paper Mill Sludge In Paper Coatings: Impact On Microstructure, Surface And Optical Properties, Bilge N. Altay, Burak Aksoy, Anamiqa Huq, Richard Hailstone, Charles P. Klass, Muslum Demir, Scott Williams

Articles

Traditionally, cellulose nanofiber (CNF) production has primarily relied on virgin cellulose sources. Yet, the shift to using paper mill sludge (PMS) as a source for CNF underscores the significance of reusing and recycling industrial byproducts. PMS contains significant amounts of cellulose that can be extracted as a raw material. The purpose of present study is to provide a sustainable approach to PMS utilization as a paper coating additive in the cellulose nanofibrils (CNFPMS) form via simply scalable wire-wound rod coating method. The effect of CNFPMS additive amounts at two coating layers on microstructure and surface properties of coatings such as …

A Bayesian Network-Based Methodology For Improved Bridge Load Rating And Asset Management, Jeffery Mark Roberts

Dissertations and Theses

From the day a new structure is made available for use, to the day that the structure is no longer able to fulfill an intended purpose, structural safety is a vital interest. Managing a portfolio of structures can be a difficult undertaking for an asset manager, particularly if different types of structures are being maintained. The goal is to manage assets in the most efficient manner which can be influenced by, at a minimum, safety and financial concerns.

A potential tool for an asset manager or owner is the use of Bayesian Networks (BNs). When a BN is used to …

Organic Electronics In Biosensing: A Promising Frontier For Medical And Environmental Applications, Jyoti Bala Kaushal, Pratima Raut, Sanjay Kumar

Durham School of Architectural Engineering and Construction: Faculty Publications

The promising field of organic electronics has ushered in a new era of biosensing technology, thus offering a promising frontier for applications in both medical diagnostics and environmental monitoring. This review paper provides a comprehensive overview of organic electronics’ remarkable progress and potential in biosensing applications. It explores the multifaceted aspects of organic materials and devices, thereby highlighting their unique advantages, such as flexibility, biocompatibility, and low-cost fabrication. The paper delves into the diverse range of biosensors enabled by organic electronics, including electrochemical, optical, piezoelectric, and thermal sensors, thus showcasing their versatility in detecting biomolecules, pathogens, and environmental pollutants. Furthermore, …

Foundation Of The Superhypersoft Set And The Fuzzy Extension Superhypersoft Set: A New Vision, Florentin Smarandache

Neutrosophic Systems with Applications

We introduce for the first time the SuperHyperSoft Set and the Fuzzy and Fuzzy Extension SuperHyperSoft Set. Through a theorem, we prove that the SuperHyperSoft Set is composed from many HyperSoft Sets.

Integrated Periphyton Biofilters In Marine Recirculating Aquaculture Systems, Adam N. Bell

USF Tampa Graduate Theses and Dissertations

Marine aquaculture is a growing industry that has the potential to reduce eutrophication, overfishing, and loss of biodiversity. Recirculating aquaculture systems (RAS) are a type of aquaculture system that decreases discharge, raises biological control, and conserves water; however, RAS are challenged due to high energy cost, low biodiversity, water quality control, and waste nutrients. Periphyton biofilters are a new technology that allows for feed production, water quality control, microbial diversity, and resource recovery in marine aquaculture systems. The overarching question that this dissertation investigates is, how can periphyton biofilters be integrated into RAS to address the challenges of modern sustainable …

Novel Method Of The Quantification Of Turbulent Fluid Flow In Silicone Artery Phantoms Using Acoustic Analysis, Julia Wong

Master's Theses

Cardiovascular disease is the leading cause of death globally and is responsible for taking 17.9 million lives per year. Despite the use of clinical treatments and detection methods, there remains a large population of individuals that suffer from CVD whose symptoms are left undetected and untreated prior to a life-threatening cardiac event. This highlights a need for an early detection method that can prevent the manifestation and worsening of the disease as well as address limitations of current early detection methods. An area of interest for early detection of CVD is subclinical atherosclerosis, which is the long, early, asymptomatic stage …

Development Of An Angiogenic Tissue-On-A-Chip Microenvironment, Eric Stuehr

Master's Theses

Preclinical testing is necessary to investigate the safety and efficacy of novel therapeutics before moving to clinical trials, yet approximately 90% of these therapies fail once tested in humans. This has led to increased interest in developing robust preclinical models that accurately mimic the complex human in vivo physiology. Microfluidic devices that can introduce dynamic conditions to 3D cell/organoid cultures, also known as tissue-on-a-chip, have emerged as physiologically relevant in vitro preclinical models that can achieve high throughput screening of therapeutics. The research presented here aimed to develop an angiogenic environment within a novel microfluidic device to stimulate formation of …

An Amplification-Free Crispr-Sers Biosensor For Specific, Sensitive And Rapid Detection Of Salmonella Typhimurium In Poultry, Fei Jia, Bingyan Li, Yawen He, Yafang Shen, Juhong Chen, Xingmin Li, Yanbin Li

Biological and Agricultural Engineering Faculty Publications and Presentations

CRISPR (Clustered regularly interspaced short palindromic repeats) has been a cutting-edge biotechnology in both gene editing and biosensing due to its desirable features, such as high base resolution and set-and-forget operation. However, as a nucleic acid detection method, an DNA/RNA amplification procedure is still inevitable in CRISPR biosensors. In this study, a highly-ordered nanopore array SERS substrate, coated with silver nanoparticles, was fabricated and utilized as a platform for the specific detection of Salmonella Typhimurium (S. Typhimurium) without the time-consuming DNA amplification step. The smart sensing strategy was established by introducing an ssDNA labeled with a Raman active molecule …