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Articles 2431 - 2460 of 18359
Full-Text Articles in Entire DC Network
Design And Demonstration Of An Inertial-Stabilized Single-Axis Headlamp For Mobile Systems, Thomas Avery Allsup
Design And Demonstration Of An Inertial-Stabilized Single-Axis Headlamp For Mobile Systems, Thomas Avery Allsup
Mechanical and Aerospace Engineering Dissertations - Archive
The introduction of adaptive headlamps has added left and right movement of the headlamps to enhance the vision of the driver during a turn at night. Adaptive headlamps also allow up and down motion of headlamps in either two discrete positions with low and high beams based on vehicle speed and oncoming traffic lights or using the vehicle suspension measurement to adjust headlamp beam angles in any angle between low and high. Using the vehicle suspension ignores the roadway influence on where the headlamps should be positioned to illuminate the roadway for the driver. This dissertation develops governing equations and …
Advances And Applications In Ultrasound-Switchable Fluorescence Imaging, Liqin Ren
Advances And Applications In Ultrasound-Switchable Fluorescence Imaging, Liqin Ren
Bioengineering Dissertations - Archive
Cancer diagnosis is a prerequisite for further medical therapy and treatment. Near-infrared (NIR) fluorescence imaging is a desirable modality without invasiveness and nonionizing radiation. However, fluorescence suffers from a strong light scattering in tissues, leading to a low spatial resolution and low sensitivity in centimeter-deep tissue (limited to several millimeters). To enhance spatial resolution and avoid the high scattering of conventional fluorescence imaging in deep tissue, ultrasound-switchable fluorescence (USF) imaging has emerged as a highly promising technique for biomedical imaging and research. The principle of improving spatial resolution in USF imaging is to confine the fluorescence emission from thermosensitive fluorophores …
Development Of Multiscale And Multidimensional Light Sheet Microscopy For Image-Based Modelling Of Organogenesis, Tanveer Ashwini Ashwini Teranikar
Development Of Multiscale And Multidimensional Light Sheet Microscopy For Image-Based Modelling Of Organogenesis, Tanveer Ashwini Ashwini Teranikar
Bioengineering Dissertations - Archive
Behavioral analysis of individual cells, in the form of structural phenotypes arising in response to mechanical stimuli or genomic alterations as small molecule intermediates of disease, are instrumental for understanding organogenesis. In this regard, dynamic cell tracking or temporal changes in cell shape, area and size are vital for modelling tissue interactions. However, optical diffraction limits imposed by lenses, hinders high resolution volume reconstruction of microscale biological processes and subcellular organelles. Thereby, isotropic intensity is restricted to limited focal volumes, reducing imaging distance to less than 1 mm for high magnification. To combat this, Light Sheet Microscopes (LSM) have emerged …
“Increasing Renewable Energy Potential Of Landfill Gas By Electrocatalytic Conversion Of Carbon Dioxide To Methane At Low Temperature.”, Asma Akter Rony
“Increasing Renewable Energy Potential Of Landfill Gas By Electrocatalytic Conversion Of Carbon Dioxide To Methane At Low Temperature.”, Asma Akter Rony
Civil Engineering Dissertations - Archive
The conversion of carbon dioxide into methane at a low temperature has great potential to reduce current international environmental issues like global warming and will create new sources of renewable energy. The overall goal of this research is to increase renewable energy production from landfill gas using an unconventional process – electrocatalytic methanation of carbon dioxide – which has not been implemented for landfill gas yet. The electrocatalytic methanation follows the Waseda process, which applies an electric field in the presence of a Ruthenium-supported cerium oxide (CeO2) catalyst. The specific objectives of this research were: 1. To explore the impact …
Automated Usability Evaluation Utilizing Log Files And Data Mining Techniques., Sima Shafaei
Automated Usability Evaluation Utilizing Log Files And Data Mining Techniques., Sima Shafaei
Electronic Theses and Dissertations
Usability evaluation is one of the essential aspects of software production. This evaluation should be done during the entire life cycle of a software application, from pre-production to production and post-production. However, the collection and evaluation of usability data can be a very challenging, time-consuming, and expensive task to be conducted manually, particularly for certain types of products and working conditions. These challenges may include the need to recruit participants fully engage and motivate them during evaluation, and factor in environmental conditions. Other challenges may include collecting data in real-world environments, especially when the users are geographically dispersed, minimizing evaluator …
Design, Fabrication, And Integration Of Robotic Skin Sensors For Human Robot Interaction., Olalekan Olakitan Olowo
Design, Fabrication, And Integration Of Robotic Skin Sensors For Human Robot Interaction., Olalekan Olakitan Olowo
Electronic Theses and Dissertations
Enhancing physical human-robot interaction in modern robotics relies on refining the tactile perception of robot skin sensors. This research focuses on crucial aspects of the development process, including fabrication techniques, miniaturization, and integration for a more efficient collaborative human-robot interface. The fabrication process of robot skin sensors, designed to mimic human skin, is explored both within and outside cleanroom environments. An enhanced technique is presented to increase fabrication yield and create more miniaturized sensor designs with feature sizes in the tens of microns. These sensors function as piezoresistive arrays using organic polymers like PEDOT: PSS as the pressure-sensing medium. Various …
Resilient, Sustainable, And Secure Systems Support For Ultra-Low-Power Computational Things, Nicole Tobias
Resilient, Sustainable, And Secure Systems Support For Ultra-Low-Power Computational Things, Nicole Tobias
All Dissertations
Wireless battery-free and energy-harvesting devices are expanding the reach and vision of the Internet of Things, where trillions of embedded computational things interconnect ubiquitously around us and inform many different aspects of our everyday lives. Designing these systems without batteries and interconnecting wires lowers maintenance, environmental, and economic costs while also extending device lifetime and deployment opportunities. Over the last decade, research on these ultra-low-power embedded sensors and systems has dramatically increased — enabling new and exciting prospects in many different scientific fields, from smart building and health monitoring applications to animal and activity tracking.
These systems are not without …
Deep Ocean Vehicle Applications And Modifications, Nichole "Nikki" T. Arm
Deep Ocean Vehicle Applications And Modifications, Nichole "Nikki" T. Arm
Master's Theses
This project had two primary goals: (1) to explore opportunities to further a deep-ocean vehicle’s reach using alternative pressure spheres, and (2) to implement an existing deep-ocean vehicle (lander) in active scientific research.
I gained a greater understanding of the limitations and design choices made for existing pressure spheres using Finite Element Analysis (FEA). My simplified FEA model predicted sphere failure for the existing 30% Fiber Glass 70% Nylon injection molded spheres at an external pressure of 3,954psi or 2,690m ocean-depth (only a 7.38% error compared to the tested minimum failure depth), so I determined it a valid model. I …
Amine-Functionalized Lignin-Based Ionomer Nanocomposites For Redox Flow Batteries, Joshua Wilder
Amine-Functionalized Lignin-Based Ionomer Nanocomposites For Redox Flow Batteries, Joshua Wilder
All Theses
As the development of energy storage technologies for renewable energy sources continues to garner attention, vanadium redox flow batteries (VRFBs) have emerged as promising source for grid-scale energy storage. A major component of the VRFB is the ion exchange membrane (IEM), as it serves to physically separate the two liquid electrolytes and also directly impacts the battery’s capacity, efficiency, and cost. The current industry standard IEM, Nafion™, not only accounts for a large portion of the cost of the VRFB but also suffers from poor proton selectivity. Herein, we have synthesized sulfonated poly(ether ether ketone) (SPEEK) composite membranes containing amine …
Real-Time Analysis Of Aerosol Size Distributions With The Fast Integrated Mobility Spectrometer (Fims), Daisy Wang
Real-Time Analysis Of Aerosol Size Distributions With The Fast Integrated Mobility Spectrometer (Fims), Daisy Wang
McKelvey School of Engineering Graduate Student Theses & Dissertations
The Fast Integrated Mobility Spectrometer (FIMS) has emerged as an innovative instrument in the aerosol science domain. It employs a spatially varying electric field to separate charged aerosol particles by their electrical mobilities. These separated particles are then enlarged through vapor condensation and imaged in real time by a high-speed CCD camera. FIMS achieves near 100% detection efficiency for particles ranging from 10 nm to 600 nm with a temporal resolution of one second. However, FIMS’ real-time capabilities are limited by an offline data analysis process. Deferring analysis until hours or days after measurement makes FIMS' capabilities less valuable for …
A Framework Of Flow Models For The Development And Testing Of Cardiovascular Devices, Megan Laughlin
A Framework Of Flow Models For The Development And Testing Of Cardiovascular Devices, Megan Laughlin
Graduate Theses and Dissertations
Cardiovascular disease (CVD) is the leading cause of death worldwide and its treatment continues to improve due to the advancement of innovative cardiovascular medical devices. In vitro and in silico models serve to replicate the in vivo environment for the development and testing of these devices prior to using animals for testing, and eventually humans in clinical trials. However, limitations related to these models exist in multiple areas including general, cardiac, and venous applications. Specifically, current gaps have been identified with customizable, tissue-mimicking phantoms (general), 2D Blood Speckle Imaging (BSI) (cardiac) and a bioprosthetic venous valve (venous). This dissertation focuses …
Assessing The Effectiveness Of Nuclear Security Training And Education In Ghana, Michael Nii Sanka Ansah, Boris Stepanov Pavlovich, Paul Atta Amoah, David Okoh Kpeglo, Simon Adu, Bright Kwame Afornu
Assessing The Effectiveness Of Nuclear Security Training And Education In Ghana, Michael Nii Sanka Ansah, Boris Stepanov Pavlovich, Paul Atta Amoah, David Okoh Kpeglo, Simon Adu, Bright Kwame Afornu
International Journal of Nuclear Security
Growing attention is being given to nuclear power across several African countries, including in Ghana. The world is depending on nuclear energy as a reliable and efficient means of energy generation. Ghana as a country is developing nuclear energy; thus, equal attention must be directed toward nuclear safety and security. Ghana is gradually developing interest in and is devoting substantial required resources to educating and training on nuclear security to meet the standards required by international bodies. Institutions such as the Nuclear Safety and Security Centre and the School of Nuclear and Allied Sciences of the Ghana Atomic Energy Commission …
Design And Modeling Of A Hybrid-Electric Drone System For Conversion, Mark Atttaalla
Design And Modeling Of A Hybrid-Electric Drone System For Conversion, Mark Atttaalla
Electrical Engineering
With the increased use of unmanned aerial vehicles (UAVs), the need for long range high capacity (>1kg) drones has also increased. While these drones do exist, they use complicated and complex technology that proportionately increases the price and barrier to entry for these drones. The goal of this paper is to look at different designs for hybrid electric drones, model the series-hybrid design, and create a low-cost alternative drone that uses off the shelf components. A primary purpose for this document is to present the information required to recreate a similar
Eeg Classification While Listening To Murottal Al-Quran And Classical Music Using Random Forest Method, Heni Sumarti, Fahira Septiani, Agus Sudarmanto, Wahyu Caesarendra, Rizki Edmi Edison
Eeg Classification While Listening To Murottal Al-Quran And Classical Music Using Random Forest Method, Heni Sumarti, Fahira Septiani, Agus Sudarmanto, Wahyu Caesarendra, Rizki Edmi Edison
Knowledge Engineering and Data Science
This study is aimed to classify the brain activity of adolescents associated with audio stimuli; murottal Al-Quran and classical music. The raw data were filtered using Independent Component Analisys (ICA) and followed by band-pass filter in Python on the Google Colab Extraction was processed with Power Spectral Density (PSD) and the Random Forest Method in Weka Machine Learning was used for classification. The research results showed the same results between the two types of stimulation, namely the order of brain waves from highest to lowest were delta, alpha, theta and beta. The average brain waves of teenagers when given murottal …
Comparison Of Machine Learning Algorithms For Species Family Classification Using Dna Barcode, Lala Septem Riza, M Ammar Fadhlur Rahman, Yudi Prasetyo, Muhammad Iqbal Zain, Herbert Siregar, Topik Hidayat, Khyrina Airin Fariza Abu Samah, Miftahurrahma Rosyda
Comparison Of Machine Learning Algorithms For Species Family Classification Using Dna Barcode, Lala Septem Riza, M Ammar Fadhlur Rahman, Yudi Prasetyo, Muhammad Iqbal Zain, Herbert Siregar, Topik Hidayat, Khyrina Airin Fariza Abu Samah, Miftahurrahma Rosyda
Knowledge Engineering and Data Science
Classifying plant species within the Liliaceae and Amaryllidaceae families presents inherent challenges due to the complex genetic diversity and overlapping morphological traits among species. This study explores the difficulties in accurate classification by comparing 11 supervised learning algorithms applied to DNA barcode data, aiming to enhance the precision of species family classification in these taxonomically intricate plant families. The ribulose-1,5-bisphosphate carboxylase-oxygenase large sub-unit (rbcL) gene, selected as a DNA barcode locus for plants, is used to represent species within the Amaryllidaceae and Liliaceae families. The experimental results demonstrate that nearly all tested models achieve accurate species classification into the appropriate …
Motion Simulation And Risk Assessment Of Dropped Objects In Offshore Operations, Hanqi Yu
Motion Simulation And Risk Assessment Of Dropped Objects In Offshore Operations, Hanqi Yu
LSU New Orleans Theses and Dissertations
Subsea pipelines are a cost-effective and reliable way to transport hydrocarbons in offshore oil and gas development. However, dropped objects can pose hazards and cause damage to pipelines. This dissertation briefly introduces the hazards and hidden dangers caused by dropped containers, discusses motion simulation methods for different object shapes, and reviews risk assessment procedures for handling dropped objects in offshore operations. Ongoing research at the University of New Orleans' towing tank on dropped container models is also discussed. Using ANSYS Fluent, we simulate trajectories of container models and calculate relevant hydrodynamic coefficients for different dropped angles. We then apply risk …
Recurrent Session Approach To Generative Association Rule Based Recommendation, Tubagus Arief Armanda, Ire Puspa Wardhani, Tubagus M. Akhriza, Tubagus M. Adrie Admira
Recurrent Session Approach To Generative Association Rule Based Recommendation, Tubagus Arief Armanda, Ire Puspa Wardhani, Tubagus M. Akhriza, Tubagus M. Adrie Admira
Knowledge Engineering and Data Science
This article introduces a generative association rule (AR)-based recommendation system (RS) using a recurrent neural network approach implemented when a user searches for an item in a browsing session. It is proposed to overcome the limitations of the traditional AR-based RS which implements query-based sessions that are not adaptive to input series, thus failing to generate recommendations. The dataset used is accurate retail transaction data from online stores in Europe. The contribution of the proposed method is a next-item prediction model using LSTM, but what is trained to develop the model is an associative rule string, not a string of …
Unraveling Water Quality Issues In The Colorado River Basin: Utilizing Remote Sensing Satellite Images, Statistical, And Machine Learning For Improved Monitoring, Godson Ebenezer Adjovu
Unraveling Water Quality Issues In The Colorado River Basin: Utilizing Remote Sensing Satellite Images, Statistical, And Machine Learning For Improved Monitoring, Godson Ebenezer Adjovu
UNLV Theses, Dissertations, Professional Papers, and Capstones
This research was aimed at exploring innovative and cost-effective tools in understanding the spatiotemporal variability of water quality parameters in the Colorado River Basin (CRB), which includes the Colorado River and major reservoirs and lakes in the USA including Lake Mead. The river which arises in the state of Colorado and empties into the Republic of Mexico at the Gulf of California, is a source of water to seven US states and the Republic of Mexico and provides water to about 40 million people and million acres of farmlands in seven states in the western US and the Republic of …
Investigating A Passive Treatment System For The Removal Of Nutrients From Urban Runoff, Jasminn Gray
Investigating A Passive Treatment System For The Removal Of Nutrients From Urban Runoff, Jasminn Gray
UNLV Theses, Dissertations, Professional Papers, and Capstones
The Environmental Protection Agency recognizes urban runoff as a major contributor of surface water pollution with nutrients as the second largest cause of surface water impairment in the United States. While a water quality standard of 100 lbs/day total phosphorus load allocation for all nonpoint sources is permitted for the Las Vegas Valley (LVV) under the National Pollutant Discharge Elimination System, currently there is not a counterpart standard for nitrogen. With the continued development of the LVV and the depletion of the quantity of water in Lake Mead due to the ongoing drought, the concentrations of phosphorus and nitrogen species …
Engineered Biomass-Derived Carbon Adsorbents For Targeted Contaminant Remediation From Aqueous Environments, Suraj Venkat Pochampally
Engineered Biomass-Derived Carbon Adsorbents For Targeted Contaminant Remediation From Aqueous Environments, Suraj Venkat Pochampally
UNLV Theses, Dissertations, Professional Papers, and Capstones
Porous carbon adsorbents like biochar (BC) are produced from waste biomasses like wood chips, animal litter, nut shells, dried grass, etc. to be used in a multitude of applications like gas capture, soil amendment, water treatment, electrode materials, etc. In water treatment, carbon-based adsorbents have been mainly used to physically or chemically adsorb contaminants depending on the adsorption mechanism. However, BCs in their raw state do not have the capability of absorbing high amounts of contaminants and need to be activated/ modified for the pore network to broaden and adsorb the contaminants with better efficiency.
The scope of this dissertation …
Road Embedded Traffic Actuated Turbine (Retat), Derek Terry Cedillo, Jairo Fernandez Garcia, Alejandro Samaniego, Yosef Towfique
Road Embedded Traffic Actuated Turbine (Retat), Derek Terry Cedillo, Jairo Fernandez Garcia, Alejandro Samaniego, Yosef Towfique
Mechanical Engineering
The Road Embedded Traffic Actuated Turbine (RETAT) project aims to revolutionize sustainable energy solutions by harnessing the power of passing vehicles to generate electricity. This Final Design Review (FDR) encapsulates the evolution of the project, from conceptualization to the tangible realization of the Verification Prototype created by a team of mechanical engineering students. The RETAT boasts an innovative design, incorporating square steel tubing and a unique linear-to-rotational energy conversion mechanism. This report provides a comprehensive overview of the design, implementation, and testing phases, highlighting achievements, challenges, and areas for refinement. As the RETAT project strives to contribute to a cleaner, …
Deficiency Of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality And Lung Injury In Mice, Ailing Ji, Andrea C. Trumbauer, Victoria P. Noffsinger, Luke W. Meredith, Brittany Dong, Qian Wang, Ling Guo, Xiangan Li, Frederick C. De Beer, Nancy R. Webb, Lisa R. Tannock, Marlene E. Starr, Christopher M. Waters, Preetha Shridas
Deficiency Of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality And Lung Injury In Mice, Ailing Ji, Andrea C. Trumbauer, Victoria P. Noffsinger, Luke W. Meredith, Brittany Dong, Qian Wang, Ling Guo, Xiangan Li, Frederick C. De Beer, Nancy R. Webb, Lisa R. Tannock, Marlene E. Starr, Christopher M. Waters, Preetha Shridas
Saha Cardiovascular Research Center Faculty Publications
Serum amyloid A (SAA) is a family of proteins, the plasma levels of which may increase >1000-fold in acute inflammatory states. We investigated the role of SAA in sepsis using mice deficient in all three acute-phase SAA isoforms (SAA-TKO). SAA deficiency significantly increased mortality rates in the three experimental sepsis mouse models: cecal ligation and puncture (CLP), cecal slurry (CS) injection, and lipopolysaccharide (LPS) treatments. SAA-TKO mice had exacerbated lung pathology compared to wild-type (WT) mice after CLP. A bulk RNA sequencing performed on lung tissues excised 24 h after CLP indicated significant enrichment in the expression of genes associated …
Marss: Multi-Agent Reinforcement Learning For Satellite Swarms, Nicholas J. Yielding
Marss: Multi-Agent Reinforcement Learning For Satellite Swarms, Nicholas J. Yielding
Theses and Dissertations
Multi-agent systems and swarms in spacecraft formation flying are of ever-increasing importance in a contested space environment—use of multiple spacecraft to contribute to a cooperative mission potentially increases positive outcomes on orbit, while autonomy becomes an ever more important requirement to reduce reaction time in dynamic situations and lower the burden on space operators. This research explores difficult swarm Guidance Navigation and Control (GNC) scenarios using Deep Reinforcement Learning (DRL). DRL polices are trained to provide guidance inputs to agents in multi-agent swarm environments for completing complex, teamwork focused objectives in geosynchronous orbit. An example scenario is explored for a …
Docai, Riley Badnin, Justin Brunings
Docai, Riley Badnin, Justin Brunings
Computer Science and Software Engineering
DocAI presents a user-friendly platform for recording, transcribing, summarizing, and classifying doctor-patient consultations. The application utilizes AssemblyAI for conversational transcription, and the user interface allows users to either live-record consultations or upload an existing MP3 file. The classification process, powered by 'ml-classify-text,' organizes the consultation transcription into SOAP (Subjective, Objective, Assessment, and Plan) format – a widely used method of documentation for healthcare providers. The result of this development is a simple yet effective interface that effectively plays the role of a medical scribe. However, the application is still facing challenges of inconsistent summarization from the AssemblyAI backend. Future work …
Enhancing Urban Water Quality Through Biological-Chemical Treatment: Aquatic Macroinvertebrate Community And Temporal Chlorophyll-A Response, Matthew Chaffee
Enhancing Urban Water Quality Through Biological-Chemical Treatment: Aquatic Macroinvertebrate Community And Temporal Chlorophyll-A Response, Matthew Chaffee
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
With a growing human population, urbanization is impeding a plethora of natural waterways. Of these, urban ponds play a vital role in nutrient sequestration, flood prevention, and habitat sanctuaries. However, nutrient loading can reduce habitat effectiveness and promote harmful algae blooms. To reduce internal nutrient loads, a biological-chemical treatment strategy consisting of floating treatment wetlands (FTWs) and lanthanum were applied to two urban retention ponds, Densmore and Wilderness Ridge Ponds. To measure effectiveness, chlorophyll-a samples were collected and correlated with Sentinel-2. A novel band algorithm termed 3BR1 produced a strong correlation (R2 = 0.72) to physical chlorophyll-a …
Renovating The Ipmu Via Internet Of Things For Pollutant Emission Estimations In Poultry Facilities, Joshua Dotto
Renovating The Ipmu Via Internet Of Things For Pollutant Emission Estimations In Poultry Facilities, Joshua Dotto
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
The emissions of ammonia (NH3), particulate matter (PM2.5), and carbon dioxide (CO2) are major concerns in poultry facilities. They can pose environmental concerns and nuances. Robust and affordable measurement systems are needed to accurately measure in-barn concentrations and quantify the emissions.
The Intelligent Portable Monitoring Unit (iPMU or PMU3) developed in 2016 was reconstructed into PMU4 to include upgraded NH3 and PM2.5 sensors and wireless connectivity for a low-cost, robust, and accurate air quality monitoring device with contactless data transfer using the concept of Internet of Things (IoT). In addition, a user-friendly …
Application Of Biochar For Antibiotic-Free Nutrient Recovery From Source-Separated Human Urine, Sayeda Ummeh Masrura
Application Of Biochar For Antibiotic-Free Nutrient Recovery From Source-Separated Human Urine, Sayeda Ummeh Masrura
UNLV Theses, Dissertations, Professional Papers, and Capstones
In recent years, the application of biochar as a soil amendment has gained attention as a potential solution for nutrient management and environmental remediation. Biochar, a carbon-rich material produced through the pyrolysis of biomass under oxygen-limited conditions, exhibits unique physicochemical properties making it an effective sorbent for nutrients and contaminants. Its high surface area, porosity, and stability provide an ideal matrix for nutrient retention and release, as well as the immobilization of pollutants. One area of particular interest is the application of biochar for nutrient recovery from source-separated human urine. Source separation of urine has gained momentum as a sustainable …
Optical And Electrical Interfaces For Biological Structures, Mehdi Bandali
Optical And Electrical Interfaces For Biological Structures, Mehdi Bandali
Boise State University Theses and Dissertations
This dissertation presents novel solutions for recording optical and electrical data from biological structures. CHAPTER ONE discusses the 16×16 Time correlated SPAD image array I developed in a 180 nm HV CMOS process for single-molecule localization super-resolution microscopy (SRM). This image array has a maximum frame rate of 80 MHz and a fill factor of 17.4 %. To demonstrate SRM with this imaging array, we localized gold nanoparticle displacement at 40 nm. CHAPTER TWO discusses stimulation artifacts' time and frequency domain characteristics and potential strategies for canceling this interference on neural recording. CHAPTER THREE discusses an artifact-resilient neural recording front-end …
Role Of Mechanical Signaling In Bone Tissue, Scott Aaron Birks
Role Of Mechanical Signaling In Bone Tissue, Scott Aaron Birks
Boise State University Theses and Dissertations
As the global population ages and life expectancy continues to rise, osteoporosis continues to be a growing worldwide health concern. The International Osteoporosis Foundation reports 1 in 3 women over the age of 50 years and 1 in 5 men worldwide will experience osteoporotic fractures in their lifetime, costing between 5 and 6.5 trillion USD annually in Canada, Europe, and the United States alone. The need for preventative measures to reduce age-related bone loss is clear, not only to improve quality of life for countless individuals but also to relieve the economic burden this condition imposes.
Exercise is a proven …
Design And Characterization Of A Novel Eef2k Degrader With Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer, Changxin Zhong, Rongfeng Zhu, Ting Jiang, Sheng Tian, Xiaobao Zhao, Xiaoya Wan, Shilong Jiang, Zonglin Chen, Rong Gong, Linhao He, Jin-Ming Yang, Na Ye, Yan Cheng
Design And Characterization Of A Novel Eef2k Degrader With Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer, Changxin Zhong, Rongfeng Zhu, Ting Jiang, Sheng Tian, Xiaobao Zhao, Xiaoya Wan, Shilong Jiang, Zonglin Chen, Rong Gong, Linhao He, Jin-Ming Yang, Na Ye, Yan Cheng
Markey Cancer Center Faculty Publications
Dysregulated eEF2K expression is implicated in the pathogenesis of many human cancers, including triple-negative breast cancer (TNBC), making it a plausible therapeutic target. However, specific eEF2K inhibitors with potent anti-cancer activity have not been available so far. Targeted protein degradation has emerged as a new strategy for drug discovery. In this study, a novel small molecule chemical is designed and synthesized, named as compound C1, which shows potent activity in degrading eEF2K. C1 selectively binds to F8, L10, R144, C146, E229, and Y236 of the eEF2K protein and promotes its proteasomal degradation by increasing the interaction between eEF2K and the …