Digital Commons Network^™

Studying The Production Of Nanocelluloses, Shohzodbek Abduvahobovich Rashidov, Elmurod Abduqodirovich Egamberdiev, Sadritdin Maxamatdinovich Turabdjanov

Technical science and innovation

Nanoscience is a broad field that includes nanophysics and nanochemistry. Nanotechnologies are aimed at obtaining nanoparticles with new properties and creating materials and devices based on them. This is one of the modern trends in the development of science in the 21st century.

Based on the study of information about nano-sized materials, the mechanisms of their production and changes in their properties, we will consider the technology for producing nanocellulose from organic substances, i.e. from cellulose. The article describes a technology that examines devices for producing nanocellulose and the principles of their operation, as well as a combined method of …

Modeling The Effects Of Retinal Thinning And Oxidative Stress During Space Travel, Dillon Weatherston, Dylan Nelson, Justin Jones, Elizabeth Vargis

Utah Space Grant Consortium

Spaceflight causes both physical and chemical changes within the subretinal tissue, particularly the retinal pigment epithelium (RPE) and Bruch’s membrane. Changes such as layer thinning and increases in oxidative stress are both implicated in vision loss caused by spaceflight. While these changes can lead to cell death, the mechanistic impact that these changes have on retinal function are unknown. To isolate the physical alterations to the subretinal tissue caused by space travel, we utilized a tunable in vitro model of Bruch’s membrane and primary porcine RPE cells. Initial results showed that while thinner models can be constructed, they are difficult …

Optimization Of Animal Hair Preparation For Scanning Electron Microscopy (Sem), Cristina De La Vieja Medina, Samuel Tobler, Wendy Schatzberg

Utah Space Grant Consortium

This study investigates the best method to prepare animal hair samples for scanning electron microscopy (SEM). The main objective is to identify the most effective method to clean, cut, and position the hair to achieve a better image of the hair without external elements. Various cleaning methods were explored, but the best option was a 15-minute sonication in water followed by a 24-hour immersion in a 90% ethanol-10% methanol mixture. Samples were placed with different types of glue to ensure the hair remained stable. A diamond blade was used to cut the hairs but did not provide the desired results …

Artemia In Space, Holbrook Hawkes, Elizabeth Blackburn, Bonnie K. Baxter

Utah Space Grant Consortium

The panspermia hypothesis poses that life originated in space. To test this hypothesis, a model organism capable of withstanding the extreme conditions of space must be used. The brine shrimp genus Artemia represents species of extremophilic zooplankton with adaptations to survive extreme temperatures (-273˚°C to 90˚°C), hydrogen sulfide-reducing environments, HZE particles, oxidation, desiccation, ion exposure, electromagnetic radiation, and anoxia (Skoultchi and Morowitz, 1964; Clegg, 1978; van Stappen, 1996, 2002; Willsie and Clegg, 2001; Clegg and Trotman, 2002; MacRae, 2016). Artemia are so hardy in part due to their ability to produce oviparous encysted embryos instead of live nauplii that can …

Earth Observation Satellite Data Reveals Correlations Between Temperature, Turbidity, And Chlorophyll-A In Utah Lake, Kaylee B. Tanner

Utah Space Grant Consortium

No abstract provided.

The Role Of Monitoring The Partial Pressure Of Oxygen In Urine For Early Detection Of Acute Kidney Injury, Lars Lofgren, Kai Kück, Natalie Silverton

Utah Space Grant Consortium

Acute kidney injury (AKI) is defined as an abrupt decrease in renal function due to structural injury. AKI has a large effect on critical care patients due to a relatively high occurrence and association with poor outcomes. Currently, the diagnostic tools that we have, serum creatinine and urine output, are delayed indicators of the presence of injury and simply capture the drop in renal function. However, there is evidence that renal hypoxia plays a role in the development of most forms of AKI. Furthermore, there is a correlation between the partial pressure of oxygen in urine (PuO₂) and …

Presence Of Atheromatous Plaques And Theirs Effects On The Blood Flow, Belhocine Mostefa Bm, Amrani Hichem Ah, Fedaoui Kamel Dr, Mazouz Hammoudi Mh

Emirates Journal for Engineering Research

The paper utilizes a finite element method to study both the blood flow and atheromatous plaques. Specifically, the COMSOL finite element package is employed to achieve a fluid model. COMSOL is a powerful finite element tool commonly used in various research and industrial domains to study multiphysics problems. The focus of the investigation is on the geometric aspects of the atheromatous plaques. The study considers different forms and arrangements of stenosis, taking into account the irregularities formed by various shapes of the plaques and the resulting flow patterns. The key findings of the research suggest that the pressure and velocity …

Process Intensification For Rare Earth Elements Adsorption By Resonant Vibratory Mixing, Oluwatosin Adebayo, Richard Ladouceur, Zainab Nasrullah

Graduate Theses & Non-Theses

The adsorption capacity for six rare earth elements (Lanthanum, Terbium, Neodymium, Dysprosium, Praseodymium, and Holmium) by biochar produced from hemp feedstock was investigated. An innovative approach to enhancing the adsorption of rare earth elements using biochar was studied and investigates the potential of resonant vibratory mixing (RVM) as a process intensification method compared to conventional mechanical mixing for the adsorption process. Hemp hurds as source of biomass was pyrolyzed to produce biochar at a temperature of 4500C for 60 minutes. The biochar was characterized by FTIR (Fourier Transform Infra-red), SEM (Scanning Electron Microscopy), Surpass 3 Electrokinetic solid surface analyzer, and …

Application Of Biochar / Bentonite Based Admixtures In Reinforced Concrete For Corrosion Prevention, Jacob Fleury

Graduate Theses & Non-Theses

Reinforced concrete systems are in many sectors of infrastructure. Due to a combination of elevated compressive strength from the cement and aggregates and tensile strength from the reinforcing steel, reinforced systems are favorable in construction applications where high strength is desired. However, while reinforced concrete is in service, it can be introduced to contaminants that cause corrosion. Contaminants can leach through the porous matrix of the concrete structure and influence initiation of corrosion products on reinforcement. Corrosion is the primary cause for advanced deterioration of concrete structures. Concrete deterioration has promoted research efforts for the protection of future systems. This …

Enabling On-Device Learning Through Hybrid Edge Computing Frameworks, Md Sharif Ahmed

Electrical Engineering Theses

In recent advancement of technology implementing Machine Learning (ML) algorithms with edge devices has gained remarkable popularity. Enabling Machine Learning (ML) in the edge opened new hybrid branch where edge hardware meets with Machine Learning (ML). Day by day devices are becoming more powerful and capable of doing a lot of computation. These powerful computational capabilities created the way of implementing Machine Learning (ML) on small edge devices. There are diverse ways we can implement machine learning models to the edge. For any embedded prototype, implementation of Tiny Machine Learning (TinyML) is making the IoT (Internet of Things) devices intelligent …

Thematic Synthesis: Rethinking Generative Music With Compositional Understanding In Game And Software Development, Jasper Moore Tucker

Dartmouth College Master’s Theses

Generative music, first introduced by composers like Brian Eno and David Cope in the mid-to-late 20th century, has evolved through many stages, with diverse applications across music and technology companies as well as the game industry. However, despite this widespread interest, there remains a notable lack of the foundational understanding of composition and individual expressiveness in current generative systems that was apparent in the work of early composers. This paper advocates for a shift towards prioritizing compositional thought in system design to foster greater diversity and innovation within generative music. To demonstrate this approach, a novel system synthesizing two distinct …

Techno-Economic Optimization Of A Hybrid Energy System With Limited Grid Connection In Pursuit Of Net Zero Carbon Emissions For New Zealand, Daniel Hill, Shafiqur Rahman Tito, Michael Walmsley, John Hedengren

Faculty Publications

As New Zealand moves towards net zero carbon emissions by 2050, multiple factors must be considered including increased electrical load due to electrification, variability of renewable energy generators, required storage capacity, system economics and limitations on grid transmission capacity. Complex and region-specific interactions between the various design choices involved are likely to require an understanding of a range of optimal and near-optimal designs for proposed micro-grid systems as opposed to a single optimal point. This work develops a novel multiscale optimization algorithm for optimization from a univariate capacity optimization approach to a multivariate one. This enhanced algorithm is applied to …

Creating A Bio-Based Circular Economy From Louisiana Sugarcane Byproducts, G. Aita, D. Bhatnagar, G. O. Bruni, M. Deliberto, G. Eggleston, A. Finger, K. Gravois, M. Isied, W. Judice, K. T. Kasson, I. M. Lima, J. L. Purswell, Mena I. Souliman, E. Terrell, B. S. Tubana, H. L. Waguespack Jr., J. J. Wang, P. M. White Jr.

Civil Engineering Faculty Publications and Presentations

Sugarcane (Saccharum officinarum) is Louisiana's number one row crop. Growing and processing sugarcane produces significant amounts of byproducts, including bagasse, crop residue, molasses, filter-press mud, and boiler fly ash. These products represent an important opportunity to generate value-added and specialty products and enhance sugarcane's sustainability by facilitating a circular economy, where agricultural by-products are reused instead of disposing them (linear economy), in order to reduce resource use and energy demand. Examples of value-added products range from biochar, construction materials, animal feed, biofuels, nanoparticles, and fertilizer. Paramount to the success of the bio-based circular economy is creating useful products that are …

Identification Of Compounds That Cause Axonal Dieback Without Cytotoxicity In Dorsal Root Ganglia Explants And Intervertebral Disc Cells With Potential To Treat Pain Via Denervation, Fei San Lee, Uyen N. Nguyen, Eliza J. Munns, Rebecca A. Wachs

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Low back pain, knee osteoarthritis, and cancer patients suffer from chronic pain. Aberrant nerve growth into intervertebral disc, knee, and tumors, are common pathologies that lead to these chronic pain conditions. Axonal dieback induced by capsaicin (Caps) denervation has been FDA-approved to treat painful neuropathies and knee osteoarthritis but with shortterm efficacy and discomfort. Herein, we propose to evaluate pyridoxine (Pyr), vincristine sulfate (Vcr) and ionomycin (Imy) as axonal dieback compounds for denervation with potential to alleviate pain. Previous literature suggests Pyr, Vcr, and Imy can cause undesired axonal degeneration, but no previous work has evaluated axonal dieback and cytotoxicity …

Near-Collapse Of The Geomagnetic Field May Have Contributed To Atmospheric Oxygenation And Animal Radiation In The Ediacaran Period, Wentao Huang, John A. Tarduno, Tinghong Zhou, Mauricio Ibañez-Mejia, Laércio Dal Olmo-Barbosa, Edinei Koester, Eric G. Blackman, Aleksey V. Smirnov, Gabriel Ahrendt, Rory D. Cottrell, Kenneth P. Kodama, Richard K. Bono, David G. Sibeck, Yong Xiang Li, Francis Nimmo, Shuhai Xiao, Michael K. Watkeys

Michigan Tech Publications

Earth’s magnetic field was in a highly unusual state when macroscopic animals of the Ediacara Fauna diversified and thrived. Any connection between these events is tantalizing but unclear. Here, we present single crystal paleointensity data from 2054 and 591 Ma pyroxenites and gabbros that define a dramatic intensity decline, from a strong Proterozoic field like that of today, to an Ediacaran value 30 times weaker. The latter is the weakest time-averaged value known to date and together with other robust paleointensity estimates indicate that Ediacaran ultra-low field strengths lasted for at least 26 million years. This interval of ultra-weak magnetic …

Manufacturing Silicone In-House For The Creation Of Customized Neurovascular Blood Vessel Mimics, Jacob Wilbert Perisho

Master's Theses

The Tissue Engineering Lab at California Polytechnic State University San Luis Obispo focuses on creating tissue-engineered Blood Vessel Mimics (BVMs) designed for the preclinical testing of neurovascular devices. These BVMs are composed of silicone models, representing anatomically accurate neurovasculatures, that are sodded with vascular cell types and then cultivated in bioreactors (which maintain physiologic conditions). These silicone models are currently sourced externally from industry partners, so the primary goal of this thesis was to develop the means and methods for the Tissue Engineering Lab to manufacture silicone models in-house.

The first aim of this thesis was to develop and explore …

Evaluating Tissue Morphology In The Context Of Varied Initial Fabrication Conditions, Cassidy Caffin

Biomedical Engineering Undergraduate Honors Theses

Cardiovascular diseases have been the leading cause of death for years. This includes myocardial infarctions (MI) where blood flow to the myocardium is restricted. This causes damage to cardiac muscle due to insufficient oxygen. There are multiple ways to treat patients following an MI with the most common involving assorted medication. However, there are limited medications that can be used for treating patients following MIs, and the FDA’s decreasing approval rate for new cardiac drugs will not dramatically improve the range of options. The lead-up to drug candidate rejection by the FDA can involve drugs exhibiting promising preliminary research that …

Machine Learning And Geostatistical Approaches For Discovery Of Weather And Climate Events Related To El Niño Phenomena, Sachi Perera

Computational and Data Sciences (PhD) Dissertations

El Nino and La Nina are worldwide environmental phenomena brought about by repetitive changes in the water temperature of the Pacific Ocean. Even though the El-Nino impact focuses on a smaller area in the Pacific Ocean near the Equator, these developments have global repercussions, where temperature and precipitation are influenced across the globe, causing droughts and floods simultaneously. In this dissertation, we first derived a drought vulnerability index for the Nile basin, identifying regions with high and low drought risk under ENSO conditions. Next, we evaluated the coherence and periodicity of the ENSO signal to detect its implications on MENA …

High-Altitude Ballooning And Payload Design, Matthew Smith

Honors College Theses

The Icarus project began in 2017 where a team performs high-altitude balloon (HAB) launches to conduct atmospheric and payload design research. The project involves sending a data-collecting payload containing recording equipment to high altitudes (~100,000 feet). This paper outlines the Icarus project as well as the efforts to design a payload that will remain stable throughout flight while also protecting the equipment housed within the payload shell. SOLIDWORKS computer-aided design (CAD) software was used to design a unique payload system. The payload parts were manufactured with PLA filament using a Prusa MK4 3D printer. The secondary goal of this thesis …

Design Of Small-Scale Milk Processing Facility, Luke Bond, Robert Stenzel, Ry Steffen, John Van Nieuwenhuyse, Rossana Villa-Rojas, Terry Howell Jr., Tami M. Brown-Brandl, Forrest Kievit

Department of Agricultural and Biological Systems Engineering: Masters Project Reports

This project was intended to investigate the feasibility of a proposed modular dairy processing facility collocated with a small dairy on the University of Nebraska–Lincoln’s Innovation Campus. Priority was placed upon cost savings for equipment to be used in processing. Process flow diagrams, floor plans, production schedules, risk assessments, and plans for wastewater treatment were all developed to address the needs of the plant should it be built. A Monte Carlo simulation was conducted to evaluate the timeline for breaking even financially, resulting in the potential for a payback period of 4.5 years. The 4.5-year payback period was based on …

Investigating The Presence Of Patented In Vitro Models For Cancer-Nerve Crosstalk Methods, Christoff Hauptmann

Biomedical Engineering Undergraduate Honors Theses

The purpose of this research project is to investigate the presence of patented in vitro models for perineural invasion (PNI) and tumor innervation, the two most prominent modes of cancer-nerve crosstalk that play an active role in cancer initiation and progression. PNI occurs through a positive feedback loop in which cancer cells invade passive nerves to metastasize. Tumor innervation is the process where tumor cells attract nearby nerves to the tumor microenvironment (TME) for tumor growth and metastasis. These crosstalk paths have been established for many types of cancer and result in poor patient prognosis. Recently, in vitro models have …

Evaluation Of The Efficiency Of Muscle-Specific Promoters To Express Non-Endogenous Proteins In Skeletal Muscle, Gabrielle Bulliard, Made Harumi Padmaswari, Christopher E. Nelson

Biomedical Engineering Undergraduate Honors Theses

Gene therapies are emerging as powerful tools for treating genetic diseases and cancers, offering the potential for a permanent cure. Hemophilia B, affecting approximately 6,000 men in the U.S., results from a deficiency in coagulation factor IX protein (FIX), which is crucial for blood clotting. A substantial portion of patients, over 40%, suffer from severe hemophilia B, experiencing spontaneous, prolonged bleeding. Current prophylactic treatments involve frequent coagulation factor infusions, yet a curative approach would alleviate this burden. Gene editing technologies like CRISPR-Cas systems show promise for correcting genetic mutations, but the diverse nature of factor IX gene (F9) …

An Assessment Of Methane Cracking Technologies For Hydrogen Production And Reduction Of Greenhouse Gases, Alisa E. Pjetrovic

2024 Spring Honors Capstone Projects - Archive

Methane reformation and methane pyrolysis involve separating, or cracking, the components of methane, leading to the production of hydrogen gas, and in the case of pyrolysis, solid carbon. Because methane is known as a leading cause of climate change, these technologies are gaining attention as the global community moves to address methane as a greenhouse gas. This study aims to assess, through a systematic literature review, the current state-of-the-art methane cracking technologies based on seven technology criteria: hydrogen production capability, environmental impact, value of carbon produced, reaction stability, operating temperature requirements, energy requirements, and Technology Readiness Level (TRL). This study …

Novel Designs Of Soft Tactile Sensor And Robot Finger Manipulator Based On Optical Fibers., Seokyoung Han

Electronic Theses and Dissertations

Robotic manipulation is one of the main types of automated labor that humans want to achieve in order to free ourselves from mundane and hazardous tasks. The range of realizations could be very broad, from massive industrial robots to highly advanced medical devices for human healthcare. Given the critical nature of these application spaces, they require robust, safe, and most of all versatile designs. In that direction, one of the most interesting topics is the anthropomorphic robotic manipulator. Since it is inspired by human hands’ function and structure, it is able to achieve the aforementioned system requirements. However, the perfect …

Context Dependent Training Data Selection For Automatic Target Detection., Tylman Michael

Electronic Theses and Dissertations

An Automatic Target Detection (ATD) algorithm is capable of identifying the location of targets of interest captured by Infra-Red imagery in vastly different contexts. ATD is often a precursor in a 2-stage methodology in order to ascertain the location and nature of a target in both military and civilian applications. In order to train an ATD algorithm, a large amount of data from varied sources is required. One drawback of this requirement is that some sources of data may harm the performance of the method in different contexts. This thesis explores utilizing an unsupervised method to identify a subset of …

Multithreaded Applications On The Heterogeneous Research Computing Environment., Sungbo Jung

Electronic Theses and Dissertations

Bioinformatics is a domain that has experienced rapid research growth in recent years, as evidenced by the increasing number of articles in biomedical databases such as PubMed, which adds over a million publications every year. However, this also poses a challenge for researchers who need to find relevant citations for their work. Therefore, developing efficient indexing and searching methods for text data is crucial for Bioinformatics. One key technique for information retrieval is document inversion, which involves creating an inverted index to enable efficient searching through vast collections of text or documents. This Ph.D. research aims to design the research …

Detection Of Hypoxia Via Rgb Imaging, Nathania Nischal

Biomedical Engineering Undergraduate Honors Theses

Colorectal cancer is a common form of cancer, and is heavily researched in murine models. Colonoscopies are often performed in clinical settings to assess the health of the colon, as well as locate and assess the severity of tumors in a non-invasive way. As the quality of the images is dependent on the colonic environment and the light available, it is important to ensure the accuracy of the images via a normalization algorithm. The RGB images procured from these colonoscopies have great potential as a diagnostic tool for physicians, as varying scales of discoloration is common in hypoxic tissue. While …

Computational Predictions Of Heart Failure Drug Effects On Cardiac Fibrosis, Aaron Gardner

Chemical Engineering Undergraduate Honors Theses

The extracellular matrix is a complex system surrounding cells that is crucial to all of the cardiovascular system’s functions. Fibrosis is an excessive accumulation (scarring) of the extracellular matrix. Fibrosis is typically a negative event, and the scarring must be reduced in the heart in order to maintain its functionality. Due to this, simulations are run using the software “Netflux” in order to determine the effects of different heart failure drugs on cardiac fibrosis. The drugs that were simulated were an ACE Inhibitor, BAR Beta Blocker, ARB Blocker, and Entresto. These drugs were simulated over 50 hours at three different …

Design And Fabrication Of Injectable Alginate Hydrogel Microstrands For Mesenchymal Stem Cell Delivery In Salivary Gland Tissue Regeneration, Sujith Chander Reddy Kollampally

Legacy Theses & Dissertations (2009 - 2024)

Fibrosis is a pathological wound healing process, driven by excessive accumulation of extracellular matrix (ECM) following tissue remodeling. Fibrosis occurs in diseased or damaged salivary glands caused by several conditions, such as Sjogren’s syndrome or radiation for head and neck cancers. Having better insight into the cellular and molecular progression of fibrosis will allow us to model new therapeutic approaches as fibrosis prevents salivary gland tissue regeneration and function. Pharmacological, tissue engineering and cell-based regeneration strategies have been widely explored to restore lost salivary gland function. Among cell-based therapies, exploitation of mesenchymal stromal/stem cells (MSC) for salivary gland regeneration has …

Advancements Of A Breast Tissue Marker And Localization System, Azrin Jamison

All Theses

Breast cancer has become the most prominent cancer worldwide in women. Annual mammograms are encouraged for women of high risk to increase early detection allowing for lumpectomies rather than mastectomies to occur. Prior to a lumpectomy, a biopsy must be taken to determine if the tissue is cancerous, and a breast cancer biopsy marker (BBM) is left in the region of possible cancerous tissue. Wire localization has been the gold standard for localizing these BBMs. However, due to the reported patient discomfort and logistical inefficiencies faced by healthcare providers (HCP), non-wire localization solutions have been recently developed. This study aims …