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Signer-Independent Sign Language Recognition With Feature Disentanglement, İnci̇ Meli̇ha Baytaş, İpek Erdoğan May 2024

Signer-Independent Sign Language Recognition With Feature Disentanglement, İnci̇ Meli̇ha Baytaş, İpek Erdoğan

Turkish Journal of Electrical Engineering and Computer Sciences

Learning a robust and invariant representation of various unwanted factors in sign language recognition (SLR) applications is essential. One of the factors that might degrade the sign recognition performance is the lack of signer diversity in the training datasets, causing a dependence on the singer’s identity during representation learning. Consequently, capturing signer-specific features hinders the generalizability of SLR systems. This study proposes a feature disentanglement framework comprising a convolutional neural network (CNN) and a long short-term memory (LSTM) network based on adversarial training to learn a signer-independent sign language representation that might enhance the recognition of signs. We aim to …


Barriers To Mental Health Treatment Among U.S. Army Aviation Personnel, Aric James Raus May 2024

Barriers To Mental Health Treatment Among U.S. Army Aviation Personnel, Aric James Raus

Doctoral Dissertations and Projects

Safe and effective Army aviation operations require a clear focus from all involved. Yet, after more than two decades of U.S. combat aviation operations, little is known about the barriers experienced by aviators when considering mental health evaluation and treatment. An extensive literature review found no published studies examining mental health treatment hesitance among Army Aviation personnel or the perceived acceptability of self-help treatment options. This study identifies the relationships between age, gender, and aviation career specialty on the self-disclosed instrumental, attitudinal, and stigma-based barriers to care among U.S. Army aviation personnel. Additionally, the research determines relationships between the population’s …


Advancing Simultaneous Extraction And Sequential Single-Particle Icp-Ms Analysis For Metallic Nanoparticle Mixtures In Plant Tissues, Lei Xu, Xingmao Ma, John Yang, Joel G. Burken, Paul Ki-Souk Nam, Honglan Shi, Hu Yang May 2024

Advancing Simultaneous Extraction And Sequential Single-Particle Icp-Ms Analysis For Metallic Nanoparticle Mixtures In Plant Tissues, Lei Xu, Xingmao Ma, John Yang, Joel G. Burken, Paul Ki-Souk Nam, Honglan Shi, Hu Yang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Engineered Nanoparticles (ENPs) Have Been Increasingly Used in Agricultural Operations, leading to an Urgent Need for Robust Methods to Analyze Co-Occurring ENPs in Plant Tissues. in Response, This Study Advanced the Simultaneous Extraction of Coexisting Silver, Cerium Oxide, and Copper Oxide ENPs in Lettuce Shoots and Roots using Macerozyme R-10 and Analyzed Them by Single-Particle Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Additionally, the Standard Stock Suspensions of the ENPs Were Stabilized with Citrate, and the Long-Term Stability (Up to 5 Months) Was Examined for the First Time. the Method Performance Results Displayed Satisfactory Accuracies and Precisions and Achieved Low Particle Concentration …


Research On Simulation Methods For Forest Fire Extinguishing Using Water Mist, Bing Xiang, Xiaohong Dong, Yang Li May 2024

Research On Simulation Methods For Forest Fire Extinguishing Using Water Mist, Bing Xiang, Xiaohong Dong, Yang Li

Journal of System Simulation

Abstract: As a highly hazardous natural disaster, the occurrence and spread of forest fires are usually affected by a variety of complex factors such as climate, terrain, vegetation, combustible materials, etc., which makes it difficult to accurately simulate the spread and extinguishing process of forest fires. The spread of forest fires and the process of water mist fire extinguishing are physically modele. The spread model adopts a tree module structure to simulate the pyrolysis reaction of tree burning, and considers the effects of temperature, wind field,mass loss rate and other factors on the spread of tree burning.In the fire extinguishing …


A Robust Decision-Making Model For Medical Supplies Via Selecting Appropriate Unmanned Aerial Vehicle, Amira Salam, Mai Mohamed, Rui Yong, Jun Ye May 2024

A Robust Decision-Making Model For Medical Supplies Via Selecting Appropriate Unmanned Aerial Vehicle, Amira Salam, Mai Mohamed, Rui Yong, Jun Ye

Neutrosophic Systems with Applications

Recently, Unmanned Aerial Vehicles (UAVs) have been used in many fields, including the field of health care, especially in delivering the necessary medical equipment and supplies, due to the many advantages they have compared to other traditional methods and the presence of different types of UAVs, to improve healthcare and provide it with the medical supplies and equipment necessary to save the lives of patients. Choosing the appropriate UAV for a specific situation represents a problem facing decision-makers, which is considered a multi-criteria decision-making problem. Since the decision-making process is cumbersome and complex, and deals with uncertainty and ambiguity. In …


Meadowminds: An Ai Literacy Game, Michelle Yavorskiy, Lydia Kim May 2024

Meadowminds: An Ai Literacy Game, Michelle Yavorskiy, Lydia Kim

Computer Science and Engineering Senior Theses

The emergence of artificial intelligence (AI) in our everyday lives has created a need for educating young people of the fundamentals and capabilities of AI in an engaging and effective manner. "MeadowMinds: An AI Literacy Game" aims to address this need by creating a game that simplifies complex machine learning (ML) concepts into an accessible 3D world for middle school students. This project follows a structured, agile development approach, incorporating comprehensive user research and feedback. The objectives of this project included transforming ML concepts, such as clustering and embedding in Large Language Models (LLMs), into interactive gameplay. We utilized various …


Structural Dynamics Of The Human Brain In Vivo From Tagged Mri And Mr Elastography, Jordan De Niro Escarcega May 2024

Structural Dynamics Of The Human Brain In Vivo From Tagged Mri And Mr Elastography, Jordan De Niro Escarcega

McKelvey School of Engineering Graduate Student Theses & Dissertations

The underlying mechanics surrounding vulnerability of human brains in response to impact is critical to our ability to diagnose and treat traumatic brain injury (TBI), but our understanding of brain mechanical behavior is incomplete. Tagged MRI (tMRI) and magnetic resonance elastography (MRE) are two imaging techniques that are used to visualize and quantify deformation fields in human brains in vivo. The objective of this thesis is to gain a better understanding of brain vulnerability, by quantitively analyzing deformation fields extracted from in vivo human imaging studies. This was achieved through the following aims: (1) Extract mode shapes and natural frequencies …


Localized Sustained Release Of Copper Enhances Antitumor Effects Of Disulfiram In Head And Neck Cancer, Juan Wang, Boxuan Li, Remy C. Cooper, Da Huang, Hu Yang May 2024

Localized Sustained Release Of Copper Enhances Antitumor Effects Of Disulfiram In Head And Neck Cancer, Juan Wang, Boxuan Li, Remy C. Cooper, Da Huang, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Drug Repurposing Uses Approved Drugs as Candidate Anticancer Therapeutics, Harnesses Previous Research and Development Efforts, and Benefits from Available Clinically Suitable Formulations and Evidence of Patient Tolerability. in This Work, the Drug Used Clinically to Treat Chronic Alcoholism, Disulfiram (DSF), Was Studied for its Antitumor Efficacy in a Copper-Dependent Manner. the Combination of DSF and Copper Could Achieve a Tumor Cell Growth Inhibition Effect Comparable to Those of 5-Fluorouracil and Taxol on Head and Neck Cancer Cells. Both Bulk Dendrimer Hydrogel and Microsized Dendrimer Hydrogel Particles Were Utilized for the Localized Sustained Release of Copper in the Tumor Site. the …


Toward Intuitive 3d Interactions In Virtual Reality: A Deep Learning- Based Dual-Hand Gesture Recognition Approach, Trudi Di Qi, Franceli L. Cibrian, Meghna Raswan, Tyler Kay, Hector M. Camarillo-Abad, Yuxin Wen May 2024

Toward Intuitive 3d Interactions In Virtual Reality: A Deep Learning- Based Dual-Hand Gesture Recognition Approach, Trudi Di Qi, Franceli L. Cibrian, Meghna Raswan, Tyler Kay, Hector M. Camarillo-Abad, Yuxin Wen

Engineering Faculty Articles and Research

Dual-hand gesture recognition is crucial for intuitive 3D interactions in virtual reality (VR), allowing the user to interact with virtual objects naturally through gestures using both handheld controllers. While deep learning and sensor-based technology have proven effective in recognizing single-hand gestures for 3D interactions, research on dual-hand gesture recognition for VR interactions is still underexplored. In this work, we introduce CWT-CNN-TCN, a novel deep learning model that combines a 2D Convolution Neural Network (CNN) with Continuous Wavelet Transformation (CWT) and a Temporal Convolution Network (TCN). This model can simultaneously extract features from the time-frequency domain and capture long-term dependencies using …


Multi-Scale Analysis Of The Structure-Mechanics Relationship Of Mycelium-Based Bio-Composites, Libin Yang May 2024

Multi-Scale Analysis Of The Structure-Mechanics Relationship Of Mycelium-Based Bio-Composites, Libin Yang

Dissertations - ALL

The construction industry faces significant challenges due to the environmental impact of traditional materials like steel and concrete, whose production is energy-intensive and contributes to environmental pollution. This issue is exacerbated by the growing global demand for construction materials, driven by an increasing population. Concurrently, the agricultural and wood industrial sectors produce vast byproducts, such as straw, husk, coir, sawdust, and wood chips. They are often considered as wastes and disposed of through methods like burning. Such a reckless treatment releases greenhouse gases that further lead to environmental degradation. Mycelium, the vegetative part of fungi, presents a natural, promising solution …


Fate, Composition And Formation Of Unknown N-Nitrosamines In Wastewater And Wastewater-Impacted Waters, Changcheng Pu May 2024

Fate, Composition And Formation Of Unknown N-Nitrosamines In Wastewater And Wastewater-Impacted Waters, Changcheng Pu

Dissertations - ALL

N-Nitrosamines form as byproducts during oxidative water treatment or occur as impurities in consumer and industrial products. N-Nitrosamines and their precursors pose significant concerns for water utilities exploiting wastewater-impacted water supplies, as many N-nitrosamines are potential human carcinogens and have genotoxicity. To date, research on N-nitrosamines in environmental engineering has primarily focused on the occurrence, sources, formation, and control of N-nitrosodimethylamine (NDMA) in the broad context of drinking water and wastewater treatment. However, NDMA and the few other N-nitrosamines of current interest only constitute a fraction of the larger pool of total N-nitrosamines (TONO) in source waters and wastewater, while …


Past And Future Predictions Of Climate Change And Urbanization Effects On The Carbon, Nitrogen, And Water Dynamics In Northeastern Forest Ecosystems, Linghui Meng May 2024

Past And Future Predictions Of Climate Change And Urbanization Effects On The Carbon, Nitrogen, And Water Dynamics In Northeastern Forest Ecosystems, Linghui Meng

Dissertations - ALL

Human activities have significantly influenced the structure and function of forest ecosystems in the northeastern US. Urbanization directly reduces forest area and alters forest functions. Forest growth, health, and function can also be affected by climate change, atmospheric carbon dioxide (CO2) concentrations, and air pollution including ground-level ozone (O3) and atmospheric nitrogen (N) deposition. Critical questions for research and environmental management are: How will urbanization, climate change, and air pollution interact to influence the function of forest ecosystems, and how will changes in these environmental drivers alter the function of forests in the future? In this dissertation, I simulate the …


Investigation Of Hydropathy Of Proteins, Lipid-Modified Proteins, And Self-Defensive Biomaterials, Jingjing Ji May 2024

Investigation Of Hydropathy Of Proteins, Lipid-Modified Proteins, And Self-Defensive Biomaterials, Jingjing Ji

Dissertations - ALL

Molecular dynamics (MD) simulations serve as crucial tools for unraveling the underlying physical principles governing the structure and functionality of biological macromolecules. Experimental techniques provide valuable results, but sometimes it is quite difficult to explain phenomena at atomic and molecular levels. MD simulations investigate physical motion of atoms and molecules over microsecond time scale and compute the equilibrium properties. In this work, I investigated the hydropathy of proteins, lipid-modified proteins, and self-defensive biomaterials with atomistic MD simulations and coarse-grained (CG) MD simulations. The method, Protocol for Assigning a Residue's Character on a Hydropathy (PARCH) scale, is developed to characterize and …


Homomeric Tight Junction Strand Assembly Of Claudin Proteins, Patrick Matthew Marsch May 2024

Homomeric Tight Junction Strand Assembly Of Claudin Proteins, Patrick Matthew Marsch

Dissertations - ALL

Tight junctions, a form of cell junction, are utilized throughout the animal kingdom in one way or another. Tasked with facilitating a critical blockade between toxins and vital tissues while also allowing small crucial molecules to pass, the tight junction provides an important line of defense against disease. To build this barrier, various proteins with self-assemble within a cell membrane to then zipper with another cell membrane. The strand-like architecture and size & charge selective pore channels created within the barrier are chiefly governed by the claudin family of proteins. Without claudins present, the tight junction cannot form, and toxic …


Neuro-Symbolic Commonsense Reasoning With Resistance To Data Poisoning: A First-Order Logic And Sub-Symbolic Embeddings Framework, Bryce Shurts, King-Ip Lin May 2024

Neuro-Symbolic Commonsense Reasoning With Resistance To Data Poisoning: A First-Order Logic And Sub-Symbolic Embeddings Framework, Bryce Shurts, King-Ip Lin

Computer Science and Engineering Theses and Dissertations

Commonsense reasoning has long presented a hurdle between conversational agents and their ability to naturally engage with humans in conversation, as the infinitely dimensional nature of a dialogue’s topics presents a significant reasoning challenge in the study of Natural Language Understanding (NLU). Such a system must conceivably be able to act as a generalizable system for evaluating and reasoning about commonsense statements, problems, and queries: in this way, the agent can attempt to quantify the reasonability of a given input. We attempt to address this through the integration of an explainable neuro-symbolic system that leverages Logical Tensor Networks (LTNs) and …


The Effects Of Additive Manufacturing On Canine Hind Limb Repairment Surgery, Annabel Keers May 2024

The Effects Of Additive Manufacturing On Canine Hind Limb Repairment Surgery, Annabel Keers

Honors Theses

The intention of this project is to explore some of the ways that additive manufacturing is affecting veterinary medicine. I will specifically be delving into canine hind limb repairment surgeries, such as cranial cruciate ligament reconstruction. 3D printed prototypes have been utilized in the human medical field for quite a while, and it has inspired such technology to expand into the world of veterinary medicine. Such emerging research is expected to take-off as the pet market grows in size and level of care for the health of our animals.

I took special interest in this field as I will be …


Development Of A Rapid Bacterial Quantification Method Based On Droplet Microfluidics, Shawn Bliss May 2024

Development Of A Rapid Bacterial Quantification Method Based On Droplet Microfluidics, Shawn Bliss

Electronic Theses and Dissertations

The capacity to identify bacteria quickly and accurately is critical for applications such as medical diagnosis, environmental monitoring, and food safety. For instance, sepsis diagnosis requires blood cultures that take as long as 1-5 days, preventing timely intervention and increasing mortality rate. Here, we propose the joint use of microfluidics and a machine learning algorithm for rapid bacterial cell capture and quantification. The combination of high-throughput droplet microfluidics and a support vector machine (SVM) enables analysis and quantification of bacterial samples within as short as 4 hours. We have performed successful encapsulation of pathogenic bacteria such as E. coli, …


Calcium Analysis Of Intercellular Communications Between Alpha Cells And Delta Cells Across The Pancreatic Islet, Shichao Gao May 2024

Calcium Analysis Of Intercellular Communications Between Alpha Cells And Delta Cells Across The Pancreatic Islet, Shichao Gao

McKelvey School of Engineering Graduate Student Theses & Dissertations

The intricate communication between different cell types within pancreatic islets plays a crucial role in regulating glucose homeostasis. Among these cellular interactions, the interplay between α cells (responsible for glucagon secretion) and δ cells (secreting somatostatin) is particularly intriguing due to the inhibitory effects of somatostatin on glucagon release. Understanding the intercellular interactions between α and δ cells may provide insights into the mechanisms underlying the coordinated regulation of blood glucose levels. In this study, we employed a multi-modal approach combining confocal imaging, image analysis, and correlation network analysis to investigate the spatial relationships and potential functional connections between α …


Pre-Incisional And Multiple Intradermal Injection Of N-Acetylcysteine Slightly Improves Incisional Wound Healing In An Animal Model, Wictor Pascal, Antoni Smolinski, Mateuz Gotowiec, Marta Wojtkiewicz, Albert Stachura, Kaspar Pelka, Michal Kopka, Kyle P. Quinn, Alan E. Woessner, Dariusz Grzelecki, Pavel Wlodarski May 2024

Pre-Incisional And Multiple Intradermal Injection Of N-Acetylcysteine Slightly Improves Incisional Wound Healing In An Animal Model, Wictor Pascal, Antoni Smolinski, Mateuz Gotowiec, Marta Wojtkiewicz, Albert Stachura, Kaspar Pelka, Michal Kopka, Kyle P. Quinn, Alan E. Woessner, Dariusz Grzelecki, Pavel Wlodarski

Biomedical Engineering Faculty Publications and Presentations

The objective of this study was to investigate if delivering multiple doses of N-acetylcysteine (NAC) post-surgery in addition to pre-incisional administration significantly impacts the wound healing process in a rat model. Full-thickness skin incisions were carried out on the dorsum of 24 Sprague-Dawley rats in six locations. Fifteen minutes prior to the incision, half of the sites were treated with a control solution, with the wounds on the contralateral side treated with solutions containing 0.015%, 0.03% and 0.045% of NAC. In the case of the NAC treated group, further injections were given every 8 h for three days. On days …


Variable Design Stent To Prevent Stent Failure In Areas Of High Mobility In Peripheral Artery Disease Patients, Emmie Stevens, Brennan Toepfer, Lexi Graves May 2024

Variable Design Stent To Prevent Stent Failure In Areas Of High Mobility In Peripheral Artery Disease Patients, Emmie Stevens, Brennan Toepfer, Lexi Graves

Honors Theses

As senior biomedical engineering students at the University of Mississippi, we were tasked with a senior project to find an unmet clinical need in the healthcare industry and design a way to solve it. Our team, consisting of Hannah Dunn, Lexi Graves, Emmie Stevens, and Brennan Toepfer, decided to improve upon current stents to create a stent more suited to treating Peripheral Artery Disease (PAD), especially in high-impact areas, such as the back of the knee joint. Stents placed in the back of the knee have a high level of stent failure due to the high movement of the knee …


Spin Coating Multilayer Polymer Films To Improve The Consistency And Longevity Of Interval Drug Release, Katherine Nevils May 2024

Spin Coating Multilayer Polymer Films To Improve The Consistency And Longevity Of Interval Drug Release, Katherine Nevils

Honors Theses

Treatment-resistant depression (TRD) is a clinical diagnosis for patients suffering from major depressive disorder (MDD). An inadequate response to the dosage or duration of antidepressant medication can lead to the diagnosis of TRD. This diagnosis is common in up to 50% of patients with MDD following treatment. Microdosing of classical psychedelics such as lysergic acid diethylamide (LSD) has been shown to have positive cognitive and therapeutic effects on patients with TRD. However, issues of patient compliance to the complex regimen and abuse/diversion of the schedule I controlled substances remain unresolved. The goal of this project is to create an implantable, …


Population At Risk: The Design And Production Of The Pollinator Plaza, Shane Houston Stephens May 2024

Population At Risk: The Design And Production Of The Pollinator Plaza, Shane Houston Stephens

Honors Theses

This report focuses on the development and manufacturing of the Pollinator Plaza, a high-quality bug house created to combat pollinator population loss. According to countless studies, pollinator populations have seen a dramatic decrease in recent years, and this product was developed to address these alarming statistics by providing a suitable habitat for pollinators. A market analysis was used to identify our potential clientele and cost point. This research played an integral part in the design of the Pollinator Plaza, which was developed using AutoCAD software. This design became a reality through the construction of a physical prototype.

The Pollinator Plaza’s …


Navigating The Relationships Among Food Waste Practices, Environmental Intentions, And Sustainability Knowledge Of Students, Merri Claire Minshew May 2024

Navigating The Relationships Among Food Waste Practices, Environmental Intentions, And Sustainability Knowledge Of Students, Merri Claire Minshew

Honors College Theses

Colleges and university campuses are among the greatest food wasters in the US due to combined over production and plate waste from consumers. While some schools have developed programs aimed at reducing and sustainably managing food waste, much of it ends up in landfills and produces greenhouse gas emissions. The overall goal of the research was to collect a comprehensive data set on university students’ food waste practices and behavior, environmental and sustainability knowledge, and environmental intentions. For probing relationships among these drivers, a structural equation model and student survey was developed. The survey of 37 questions was collected on …


Revitalizing Turtle Creek Park, Michael Hardyway, Ethan Harm, Abbey Jacoby, Casey Stephenson May 2024

Revitalizing Turtle Creek Park, Michael Hardyway, Ethan Harm, Abbey Jacoby, Casey Stephenson

Final Reports in ENST 411: Environmental Community Projects

We current ENST 411 students, Abbey Jacoby, Michael Hardyway, Ethan Harm, and Casey Stephenson have chosen to work with Jim Knight, East Buffalo Township, the Merrill Linn Land and Waterways Conservancy, and many others in an attempt to revitalize Turtle Creek Park for a plethora of reasons. Three of us are majoring in biology, and two are majoring in environmental science, which makes much of the information and techniques relevant in Turtle Creek applicable to our courses of study. This project included heavy hands on work which allowed us students to leave a memorable and impactful influence on the Lewisburg …


Influence Of Four Veterinary Antibiotics On Constructed Treatment Wetland Nitrogen Transformation, Matthew V. Russell, Tiffany L. Messer, Deborah A. Repert, Richard L. Smith, Shannon L. Bartelt-Hunt, Daniel D. Snow, Ariel P. Reed May 2024

Influence Of Four Veterinary Antibiotics On Constructed Treatment Wetland Nitrogen Transformation, Matthew V. Russell, Tiffany L. Messer, Deborah A. Repert, Richard L. Smith, Shannon L. Bartelt-Hunt, Daniel D. Snow, Ariel P. Reed

Department of Civil and Environmental Engineering: Faculty Publications

The use of wetlands as a treatment approach for nitrogen in runoff is a common practice in agroecosystems. However, nitrate is not the sole constituent present in agricultural runoff and other biologically active contaminants have the potential to affect nitrate removal efficiency. In this study, the impacts of the combined effects of four common veterinary antibiotics (chlortetracycline, sulfamethazine, lincomycin, monensin) on nitrate-N treatment efficiency in saturated sediments and wetlands were evaluated in a coupled microcosm/mesocosm scale experiment. Veterinary antibiotics were hypothesized to significantly impact nitrogen speciation (e.g., nitrate and ammonium) and nitrogen uptake and transformation processes (e.g., plant uptake and …


Bibliometric Review Of The Landscape And Thematic Structure Of Research On Sustainable Mining In Asean, 1942–2022, Nathatai Janjirawatna, Sirisuhk Rakthin, Philip Hallinger May 2024

Bibliometric Review Of The Landscape And Thematic Structure Of Research On Sustainable Mining In Asean, 1942–2022, Nathatai Janjirawatna, Sirisuhk Rakthin, Philip Hallinger

Journal of Sustainable Mining

This bibliometric review addressed the lack of consolidated information on the current state of sustainable mining in the ASEAN region. The review analyzed bibliographic data associated with 539 Scopus-indexed documents on sustainable mining in ASEAN nations published through the end of 2022. Descriptive statistics identified a great disparity in the scope of research on sustainable mining practices across the ASEAN countries. Surprisingly, a significant portion of the extant research on sustainable mining in the region has been authored by scholars from outside of ASEAN. Keyword analyses highlighted several emerging research topics including life cycle assessment, conservation of natural resources, climate …


New York City’S Rising Sea Level And Coastal Erosion: Approaches To Resiliency, Ryder D. Isidro May 2024

New York City’S Rising Sea Level And Coastal Erosion: Approaches To Resiliency, Ryder D. Isidro

Student Theses 2015-Present

No abstract provided.


Global-To-Local Dependencies In Phosphorus Mass Flows And Markets: Pathways To Improving System Resiliency In Response To Exogenous Shocks, Justin Baker, Nathan Schunk, Matt Scholtz, Ashton Merck, Rebecca Muenich, Paul Westerhoff, James J. Elser, Owen W. Duckworth, Luke Gatiboni, Minhazul Islam, Anna-Maria Marshall, Rosangela Sozzani, Brooke K. Meyer May 2024

Global-To-Local Dependencies In Phosphorus Mass Flows And Markets: Pathways To Improving System Resiliency In Response To Exogenous Shocks, Justin Baker, Nathan Schunk, Matt Scholtz, Ashton Merck, Rebecca Muenich, Paul Westerhoff, James J. Elser, Owen W. Duckworth, Luke Gatiboni, Minhazul Islam, Anna-Maria Marshall, Rosangela Sozzani, Brooke K. Meyer

Biological and Agricultural Engineering Faculty Publications and Presentations

Uneven global distribution of phosphate rock deposits and the supply chains to transport phosphorus (P) make P fertilizers vulnerable to exogenous shocks, including commodity market shocks; extreme weather events or natural disasters; and geopolitical instability, such as trade disputes, disruption of shipping routes, and war. Understanding bidirectional risk transmission (global-to-local and local-to-global) in P supply and consumption chains is thus essential. Ignoring P system interdependencies and associated risks could have major impacts on critical infrastructure operations and increase the vulnerability of global food systems. We highlight recent unanticipated events and cascading effects that have impacted P markets globally. We discuss …


Design And Application Of Phase-Separating Peptides In Cytosolic Drug Delivery, Huihao Wang May 2024

Design And Application Of Phase-Separating Peptides In Cytosolic Drug Delivery, Huihao Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

This research investigates the design and application of phase-separating peptides for direct cytosolic drug delivery. Novel peptides (GHGXY)4, with variable amino acids, were synthesized using microwave-assisted chemistry to enhance phase separation and membrane fusion. In vitro experiments utilizing advanced imaging techniques demonstrated the peptides' capability to form coacervates and facilitate direct cargo, DNA, mRNA, and protein, delivery into the cytosol, bypassing traditional cellular barriers. The study also explores the role of inhibitor Bafilomycin and NH4Cl in phase-separating peptides functionality, offering significant insights into their delivery mechanisms. This research underscores the potential of phase-separating peptides in improving therapeutic delivery strategies.


Nodes For Modes: Nodal Honeycomb Metamaterial Enables A Soft Robot With Multimodal Locomotion, Yusuf Dikici, Kathryn Daltorio, Ozan Akkus May 2024

Nodes For Modes: Nodal Honeycomb Metamaterial Enables A Soft Robot With Multimodal Locomotion, Yusuf Dikici, Kathryn Daltorio, Ozan Akkus

Faculty Scholarship

Soft-bodied animals, such as worms and snakes, use many muscles in different ways to traverse unstructured environments and inspire tools for accessing confined spaces. They demonstrate versatility of locomotion which is essential for adaptation to changing terrain conditions. However, replicating such versatility in untethered soft-bodied robots with multimodal locomotion capabilities have been challenging due to complex fabrication processes and limitations of soft body structures to accommodate hardware such as actuators, batteries and circuit boards. Here, we present MetaCrawler, a 3D printed metamaterial soft robot designed for multimodal and omnidirectional locomotion. Our design approach facilitated an easy fabrication process through a …