American Studies Commons^™

Synthesis Of Small Molecule Inhibitors Of Janus Kinase 2, Phosphodiesterase Iv, Gabaa And Nmda Receptors: Investigation Of Mcmurry, Mannich And Chemoenzymatic Strategies, Meghanath Gali

USF Tampa Graduate Theses and Dissertations

Stilbenoids possess a wide range of biological properties such as, anticancer, antiplatelet aggregation, antiestrogenic, antibacterial, antifungal and antiatherogenic, etc. Owing to these therapeutic values, a great deal of attention attracted in the synthesis of derivatives of stilbenes. During the course of the study, G6 a novel stilbenoid was discovered, through high throughput screening, to be a potent inhibitor of mutated JAK2-V617F. The mutated JAK2 variant has been implicated in various myeloproliferative disorders (MPDs) including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) has been targeted by therapeutics. Chapter 2 describes the synthesis of analogs of the stilbenoid G6 …

Kujichagalia! Self-Determination In Young African American Women With Disabilities During The Transition Process, La Tonya L. Gillis

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to examine the role that self-determination played in the transition process for young African American women with disabilities who exited high school with a special diploma and participated in a local transition program. Factors under study included the young women's autonomy, self-regulation, psychological empowerment, and self-realization (Wehmeyer, 1996).

This examination of the perceptions of the transition process of young African American women with disabilities involved in-depth interviews with five young women and their parent or guardian. Additionally, The Arc's Self-Determination Scale (ASDS) and the Parent Self-Determination Practice Survey (PSDPS) were administered to determine the …

Feasibility Of Wastewater Reuse For Fish Production In Small Communities In A Developing World Setting, Joshua James Girard

USF Tampa Graduate Theses and Dissertations

Eradicating poverty, malnutrition, and the burden of disease have been included as three of the major issues facing the world. The United Nation member countries, having set forth the Millennium Development Goals, have committed themselves to solving these problems. Two major factors which affect solutions to these problems are increasing water stress and implementing improved sanitation. Integration of tilapia aquaculture and reuse of wastewater has been suggested as a solution which addresses both of these factors. The objective of this study is to examine the feasibility, and explore the benefits and drawbacks, to implementing small community wastewater fed (WWF) aquaculture …

The Role Of Hiv-1 Proteins In Alzheimer's Disease Pathology, Brian Nelson Giunta

USF Tampa Graduate Theses and Dissertations

Prevalence of HIV-associated cognitive impairment is rising, the worst form of which is HIV-associated dementia (HAD). The disease is fuiled by a chronic innate type pro-inflammatory response in the brain which is highly dependent upon the activation of microglia. We first created an in vitro model of HAD composed of cultured microglial cells synergistically activated by the addition of IFN-gamma and the HIV-1 coat glycoprotein, gp120. This activation, as measured by TNF-alpha and NO release, is synergistically attenuated through the alpha7nAChR and p44/42 MAPK system by pretreatment with nicotine, and the cholinesterase inhibitor, galantamine. As these medications have been FDA …

The Impact Of Managed Care On The Utilization And Distribution Of Inpatient Surgical Procedures With Demonstrated Volume And Outcome Endogeneity, Linda Stephens Gipson

USF Tampa Graduate Theses and Dissertations

Purpose

This study is designed to determine whether managed care has had an influence on the number and distribution of procedures with demonstrated volume and outcome endogeneity in Florida healthcare markets; in addition, methods are developed to determine which measures of managed care activity best predict the impact of managed care in health care markets.

Rationale

A retrospective population based cohort design is used capitalizing on the variability among Florida markets between 1995 and 1999, a period which captured the full business life cycle of managed care plans statistical areas and competing hospitals (market share) over time. Multiple regression models …

Embodied Energy Assessment Of Rainwater Harvesting Systems In Primary School Settings On La Peninsula Valiente, Comarca Ngobe Bugle, Republic Of Panama, Kaitlin Elinor Green

USF Tampa Graduate Theses and Dissertations

The United Nations Millennium Development goals aim to make improvements in access to potable water. In the Bocas del Toro region of Panama, rainwater harvesting systems are making that goal more attainable. Rainwater harvesting, especially in rural, difficult access areas, may be a viable water source improvement that will allow a greater population to access improved water. This study uses the Carnegie Mellon University Economic Input-output Life Cycle Assessment tool to assess the embodied energy of plastic and ferrocement rainwater harvesting systems in rural Panama. Rainwater harvesting systems are assessed as source improvement technologies that increase access to potable water. …

"The Wound And The Voiceless: The Insidious Trauma Of Father-Daughter Incest In Six American Texts", Christine Lynn Grogan

USF Tampa Graduate Theses and Dissertations

Cathy Caruth's pioneering study of trauma and the posttraumatic forges a connection between the psychoanalytic theory of traumatic experience and the literary as such. Since trauma defies linguistic processing, she explains, the language used to describe it will always be figural. For this reason Caruth privileges imaginative literature, with its highly mediated nature, as a means of representing the otherwise "unclaimed" experience of trauma. Her influential reflections inform a crucial direction within trauma studies: the search for a narrative voice that articulates trauma effectively.

But how should we think about trauma that is not a singular "event" but a chronic …

Relationship Between Cancer-Related Fatigue And Depression: A Pilot Study, Gloria Michelle Guess

USF Tampa Graduate Theses and Dissertations

Fatigue is one of the most bothersome symptoms reported by patients diagnosed with cancer, and research indicates that the majority of patients receiving chemotherapy report symptoms of fatigue. Fatigue can have an effect on quality of life; therefore, it is essential that healthcare providers gain a better understanding and recognition of fatigue.

Fatigue can also be a symptom of depression. Depression is another prominent symptom reported by patients diagnosed with cancer. Unfortunately, there are similarities between the symptoms of depression and fatigue making it difficult for health care providers to distinguish between the two. This study utilizes the subscale of …

The Mediating Role Of Social Support And Fulfillment Of Spiritual Needs In End Of Life Care, Kimberley A. Gryglewicz

USF Tampa Graduate Theses and Dissertations

End of life (EOL) caregiving can be a daunting and challenging endeavor as caregivers adjust to the ever-changing care demands associated with dying. Increased personal care, assisting with symptom and medication management, and attending to the emotional and spiritual needs of the dying person require caregivers to learn new tasks and to assume new roles such as social worker, nurse, and chaplain. As families continue to play an essential role in meeting the health care needs of their dying loved ones, it is imperative for social workers to understand the complexities of the end of life caregiving experience in order …

Internships In Public Relations And Advertising: The Nature Of The Experience From The Student's Perspective, Catherine Ann Gugerty

USF Tampa Graduate Theses and Dissertations

This qualitative content analysis examines the nature of experience of public relations and advertising interns. Three decades of scholarly inquiry into the internship experience has provided little insight into the actual experience of the interns themselves. Yet what is learned directly from their individual experience can provide both educators and professionals valuable insight for enhancing the learning process. The following study is a qualitative content analysis of journals and focus groups of undergraduates enrolled in public relations and advertising internships/practicums. The interns' experience follows four themes: (1) the perception of importance; (2) perceived learning benefits; (3) influence of supervisors; and …

Evaluating Lethal And Sub-Lethal Effects Of Catch-And-Release Angling In Florida's Central Gulf Coast Recreational Atlantic Tarpon (Megalops Atlanticus) Fishery, Kathryn Yvonne Guindon

USF Tampa Graduate Theses and Dissertations

Atlantic tarpon are sought after because of their fighting ability on various tackle and support a popular, lucrative and predominantly catch-and-release recreational fishery in Florida. They are not commercially harvested or consumed by the general public, therefore assessing effects of catch-and-release angling on tarpon survival is critical to a sustainable fishery. Tarpon caught on artificial breakaway jig and traditional live bait fishing charters in Boca Grande Pass (n=42) and trips from the recreational fishery of Tampa Bay (n=40) were tagged with ultrasonic transmitters and tracked up to 6 hours immediately following release to estimate post-release mortality. Of the 82 tagged …

Energy Recovery Devices In Seawater Reverse Osmosis Desalination Plants With Emphasis On Efficiency And Economical Analysis Of Isobaric Versus Centrifugal Devices, Mageed Jean Guirguis

USF Tampa Graduate Theses and Dissertations

With huge demands for potable water in regions lacking fresh water sources such as surface or ground water, various potential technologies have been explored for eliminating water shortage. Seawater emerged as a potential source and a major lifeline for such water-deprived areas. The development of seawater reverse osmosis (SWRO) technology proved to be a groundbreaking innovation, making it easier to extract pure water from seawater. Ever since its inception, SWRO technology has taken many leaps towards the development of energy efficient and high yielding systems. The reduction in energy consumption of desalination plants that were based on the SWRO technology …

Electronic Structure Characterization Of Nanocrystalline Surfaces And Interfaces With Photoemission Spectroscopy, Sebastian Gutmann

USF Tampa Graduate Theses and Dissertations

In this study, photoemission spectroscopy (PES) was used to investigate the electronic properties of nanocrystalline titanium dioxide (TiO₂), zinc oxide (ZnO), and cadmium selenide (CdSe). Electrospray deposition technique enabled the preparation of thin films in vacuum from a dispersion prepared outside the vacuum chamber. This method also allowed the step-wise formation of interfaces and the monitoring of the evolution of the electronic structure with intermittent PES characterization.

The work function of nanocrystalline TiO₂ and ZnO was measured with ultraviolet photoemission spectroscopy (UPS) and low-intensity x-ray photoemission spectroscopy (LIXPS). Measurements on environmentally contaminated surfaces revealed an instantaneous and …

Self-Directed Learning Characteristics Of First-Generation, First-Year College Students Participating In A Summer Bridge Program, Jeffrey Drummond Hall

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to advance understanding of self-directed learning characteristics of first-year, first-generation college students participating in a summer bridge program. Understanding the experience of these students in higher education can lead to the development of programmatic and pedagogical strategies to better meet the needs of this at-risk student population.

This study was conducted at the University of South Florida (USF), a large, public research university in Tampa. Participants were recruited from the Freshman Summer Institute (FSI), a summer bridge program for first-generation students at USF.

Theoretical frameworks from higher education and adult education literature merged to …

Design And Testing Of A Motion Controlled Gait Enhancing Mobile Shoe (Gems) For Rehabilitation, Ismet Handzic

USF Tampa Graduate Theses and Dissertations

Persons suffering central nervous system damage, such as a stroke, coma patients, or individuals that have suffered damage to the spinal cord, brainstem, cerebellum, and motor cortex, sometimes develop an asymmetric walking pattern where one leg does not fully swing backward. This uneven gait hinders these individuals in properly and efficiently moving through everyday life.

Previous research in humans and various animals has introduced a split belt treadmill to analyze possible rehabilitation, which can recreate a correct gait pattern by altering the speed of each track. Gait adaptation was achieved by having the split belt treadmill move each leg at …

Statistical Analysis And Mechanistic Modeling Of Water Quality: Hillsborough Bay, Florida, Keith Hackett

USF Tampa Graduate Theses and Dissertations

Nutrient pollution has been identified as a significant threat to U.S. coastal and estuarine water quality. Though coastal and estuarine waters need nutrients to maintain a healthy, productive ecosystem, excess nutrients can lead to eutrophication. There are significant potential negative consequences associated with eutrophication, including loss of habitat, loss of economic activity, and direct threats to human health. Hillsborough Bay experienced eutrophication in the 1960s and 1970s due to a rapidly growing population and associated increases in nutrient pollution. These eutrophic conditions led to more frequent phytoplankton and macroalgae blooms and declines in seagrasses. To address these problems, a series …

Using Multi-Paradigmatic Interventions: Gauging The Possibilities Of Using Culturally Responsive Pedagogy Within A Response To Intervention Framework, Vanessa Hein

USF Tampa Graduate Theses and Dissertations

There exists a highly charged debate about whether or not the Problem Solving/Response to Intervention (PS/RtI) model works alone in lowering the rate of special education referrals for students in an inclusive learning environment. This study seeks to explore the incorporation of a culturally responsive pedagogy (CRP) into the PS/RtI framework, with the assumption that it would assist teachers with PS/RtI implementation as well as enhance their classroom learning environment. Interviews with PS/RtI coaches and elementary school teachers implementing PS/RtI are coded using inductive and deductive strategies, using salient factors of both CRP and PS/RtI as indicators for a comparative …

Framing And The End Of Operation Iraqi Freedom, James Robert Hickman

USF Tampa Graduate Theses and Dissertations

The purpose of this qualitative framing study is to analyze the dominant frames that were reflected in the news coverage of two separate Presidential speeches marking the proposed cessation of combat operations in Operation Iraqi Freedom. In order to determine which frames emerged in the coverage of each speech, a content analysis of 105 articles from 4 national newspapers was conducted. Analysis included the week preceding and the week following each speech in an effort to capture the immediate coverage surrounding each address. The findings suggest that the dominate frames utilized were the economic consequences frame, the responsibility frame and …

Physical Models Of Amyloid Fibril Assembly, Shannon Elizabeth Hill

USF Tampa Graduate Theses and Dissertations

Formation of large fibers and plaques by amyloid proteins is recognized as the molecular hallmark of an increasing number of human disorders, including Parkinson's disease, Alzheimer's disease and even type II diabetes. The broader objective of my research is to unravel the basic mechanisms that initiate and regulate fibril formation by amyloidogenic proteins. This objective is significant because even basic aspects of how fibril formation proceeds from a soluble, monomeric protein to an insoluble amyloid fibril remain much debated. Furthermore, there is increasingly strong evidence suggesting that intermediates of the aggregation process, with properties distinct from those of mature fibrils, …

Park Access And Distributional Inequities In Pinellas County, Florida, Kyle Ray Hirvela

USF Tampa Graduate Theses and Dissertations

Although environmental justice research has traditionally focused on environmental disamenities and health hazards, recent studies have begun to examine social inequities in the distribution of urban amenities such as street trees and parks that provide several direct and indirect health benefits to local residents. This thesis adds to this knowledge by evaluating distributional inequities in both distribution and access to parks in Pinellas County, the most densely populated and one of the most racially segregated counties in Florida. An important objective was to determine if neighborhoods with lower levels of park access are more likely to contain a significantly higher …