Experimental Analysis of Behavior Commons^™

Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor

Electronic Theses, Projects, and Dissertations

Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT_1A and 5-HT_1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …

Intermittent Sucrose Access: Sweetness Versus Calories, Jarret Folmer, Rudy Eikelboom

Theses and Dissertations (Comprehensive)

Nondeprived rats receiving every 3^rd day access (E3DA) to 4% sucrose solution consume more sucrose on access days compared to rats with everyday access (EDA). Rats receiving EDA or E3DA to 16% sucrose do not consume different amounts, but if placed on every 2^nd day access (E2DA) to 4% sucrose E3DA-group rats consume more than EDA rats (Eikelboom, Hewitt, & Adams, 2022). E3DA affects rats’ value of sucrose but effects appear hidden with high sucrose concentrations. Valyear and Eikelboom (2021) suggested that calorie ceilings limit E3DA-induced consumption with high sucrose, but this ceiling could also be caused by …

The Effects Of Overshadowing In Drosophila Melanogaster With Experimentally Evolved Preference, Jill Lee

Theses

As seen in decades of psychology research, preferences play a major role in driving the decision-making process in both humans and animals. Researchers have advocated for using the technique of experimental evolution as a way to address some of the foundational questions on preferences. These preferences can also affect what is later learned and how well new experiences are learned. Salience is usually mentioned as an important component of what could influence preferences. Animals such as Drosophila melanogaster, that lay eggs without any additional maternal or paternal care, it is important to be selective when deciding where to lay …

Simulated Owl Predation During Foraging Differentially Alters Choice And Fear Behavior Between Sex In Rats, Meghan M. Olsen

Research Psychology Theses

Existing research on the predator cue circuit has indicated there are observed differences between sexes of animals either directly or indirectly exposed to a predator stimulus. Exposure increases predator directed attention, and overrides other motivational systems (hunger, pain, reproductive behavior). Little research has explored whether exposure to predation is associated with differential responses to non-predator related decision-making across a variety of tasks. Therefore, understanding the prioritization of motivational states when a predator stressor is present can aid in understanding sex differences in these processes in both adaptative and maladaptive conditions. To determine how repeated exposure to a predator stressor differentially …

Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert

Select or Award-Winning Individual Scholarship

Buprenorphine, a semi-synthetic opioid prescribed for the treatment of opioid use disorder (OUD), has been suggested as a potential pharmacological treatment for anxiety. Some preclinical and clinical studies provide support for the anxiolytic effects of buprenorphine, but research in this area is scarce, and findings to date have been mixed. The present study was designed to test the hypothesis that buprenorphine alters anxiety-like behavior in C57BL/IJ (B6) mice measured using the elevated zero maze (EZM). Adult, male mice (n=10) were given subcutaneous injections of saline (control) and three doses of buprenorphine (0.3, 1, and 10 mg/kg). One hour following injection, …

Evaluation Of Hippocampal Allostatic Load-Associated Factors In Animal Models Of Post-Traumatic Stress Disorder: Relevance To Human Ptsd, Dennis Parker Kelley

LSU Doctoral Dissertations

Post-traumatic stress disorder (PTSD) is associated with elevated allostatic load, nearly double the risk for metabolic syndrome, reduced hippocampal volume, and contextual memory processing deficits. Emerging evidence suggests that these stress effects may predispose individuals to the development of PTSD, and there is a known relationship between chronic stress and metabolic dysfunction. In this work, we utilized two rat models of PTSD to explore these connections. We used an acute predator odor stressor to investigate the relationship between PTSD-like behaviors and mitochondrial dysfunction in the hippocampus of rats, and we observed that conditioned place avoidance was associated with reduced mitochondrial …

The Effects Of Venlafaxine And Voluntary Exercise On Chronic Unpredictable Stress Induced Anxiety, Marly Mcgowan

Senior Independent Study Theses

Anxiety disorders can impair cognition and emotional control, particularly in the face of novel situations, which is concerning due to the high prevalence of such diagnoses. Exposure to unpredictable chronic stress can provide a way to induce anxiety-like behaviors in rodents by disrupting the stress response systems, including the HPA axis and autonomic nervous system. Pharmacological treatments, including SNRIs like venlafaxine, and voluntary exercise are both anxiolytic treatments that can alleviate the impacts of chronic stress. Using unpredictable chronic stress to mimic the human condition, and exposure to venlafaxine and exercise to mitigate the stress, the open field and elevated …

A Monte Carlo Simulation Of Rat Choice Behavior With Interdependent Outcomes, Michelle A. Frankot

Graduate Theses, Dissertations, and Problem Reports

Preclinical behavioral neuroscience often uses choice paradigms to capture psychiatric symptoms. In particular, the subfield of operant research produces nested datasets with many discrete choices in a session. The standard analytic practice is to aggregate choice into a continuous variable and analyze using ANOVA or linear regression. However, choice data often have multiple interdependent outcomes of interest, violating an assumption of general linear models. The aim of the current study was to quantify the accuracy of linear mixed-effects regression (LMER) for analyzing data from a 4-choice operant task called the Rodent Gambling Task (RGT), which measures decision-making in the context …

Pushing It To The Limit: Determining Asian Elephant (Elephas Maximus) Olfactory Sensitivity And Discrimination Through A Behavioral Choice Task, Matthew S. Rudolph

Theses and Dissertations

Elephants have shown remarkable olfactory capabilities. Their sense of smell impacts their foraging choices, behavior, and ultimately, survival. Being able to detect a target odor can allow elephants to locate specific resources, identify threats, and find receptive conspecifics. Previous studies have shown that elephants can consistently detect target odors, but have not identified the limits of this detection. Thus, to investigate the extent of elephants’ odor detection capabilities, we tested Asian elephants in a two-step odor discrimination task. First, we investigated whether elephants could detect odors at varying levels of dilution after a training procedure, and then whether they could …

Sugar Glider (Petaurus Breviceps) Behavior In Red Vs Blue Lighting, Elisa Hillman

Honors Thesis

Sugar gliders are an exotic pet that is increasing in popularity in households as well as in zoos. One challenge that caregivers have to manage is their nocturnal circadian rhythm. In order for people to view or interact with sugar gliders during their active time, many zoos will reverse their diurnal cycle with lights. The discovery of intrinsically photosensitive retinal ganglion cells (ipRGCs) which seems to have an increased sensitivity to blue light and how these cells affect the hypothalamic suprachiasmatic nucleus (SCN) and circadian rhythm has led to an increase in awareness on the health effects of being exposed …

Corticostriatal Pathway Inactivation And Connections To Associative Learning With Nicotine Stimulus In Rats, Anna Kalinowski

Honors Theses and Capstones

The main concern of this study is looking into the neural mechanisms of associative learning with a nicotine stimulus. The goal of this study was to find out if inactivating the corticostriatal pathway through DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) inhibited goal-tracking behavior in rats. In this experiment, rats underwent two surgeries. One was to inject DREADDs into the infralimbic cortex and the other in the dorsomedial caudate-putamen (dmCPu). Rats were initially trained on levers through water deprivation. Once they reached the criterion, they moved on to the self-administration phase. After the rats were trained in self-administration sessions …

Variation In Personality Among Semi-Wild Myanmar Timber Elephants, Sateesh Venkatesh

Theses and Dissertations

This study examines two personality traits: exploration and neophobia, which could influence human-elephant conflicts. Thirty-one semi-wild elephants were tested over two trials using a custom novel puzzle tube containing three tasks and three rewards. Our studies show that elephants do vary significantly between individuals in both exploration and neophobia.

Using Object-Choice Tasks To Investigate Sensory Perception In Sunda Pangolins (Manis Javanica), Joshua Dipaola

Theses and Dissertations

Pangolins are one of the most heavily poached, yet least understood mammals in the world. In this study, we used an object-choice task to assess the ecological relevance and use of sensory information in Sunda pangolin foraging behavior. This is the first controlled experiment on pangolin behavior to our knowledge.

The Maze Of Personality: Latency And Electric Organ Discharge In A Mormyrid Fish, Gnathonemus Petersii Gunther 1862 (Mormyridae, Teleostei), Abbey C. Lipe

Theses and Dissertations

Personality is individual differences in behavior, consistent across contexts. Among Gnathonemus petersii we investigated, we hypothesized that fish could be grouped by: (1) slow/fast maze performance, (2) low/high electric frequencies, (3) correlated latency and frequency. Our first two hypothesis were not supported. Our third hypothesis was partially supported.

130— Reducing Stereotypic Behavior With A Ketogenic Diet, Anna Beltramini, Andrew Guido, Alicia Bauers, Joe Spano

GREAT Day Posters

Now a popular fad diet, the ketogenic diet (KD) is a high-fat, low-carb diet that for decades has been used for treatment of intractable epilepsy. Recent therapeutic applications of KD in animal models include treatment of dementia, obsessive-compulsive disorder, and autism. These disorders are associated with stereotypic behaviors (repetitive, invariant behaviors with no apparent function) that are life-impairing and stigmatizing. However, little is known about their underlying mechanisms and no effective pharmacological treatments are available. Here, we present a novel application of KD to reduce stereotypic behavior in an inbred strain of mice (FVBN/J) that displays a prominent repetitive circling …

The Midsession Reversal Task With Pigeons: Effects Of A Brief Delay Between Choice And Reinforcement, Megan Ashley Halloran

Theses and Dissertations--Psychology

During a midsession reversal task, the session begins with a simple simultaneous discrimination in which one stimulus (S1) is correct and the alternate stimulus (S2) is incorrect (S1+/S2-). At the halfway point, the discrimination reverses and S2 becomes the correct choice (S2+/S1-). When choosing optimally, a pigeon should choose S1 until the first trial in which it is not reinforced and then shift to S2 (win-stay/lose-shift). With this task pigeons have been shown to respond suboptimally by anticipating the reversal (anticipatory errors) and continuing to choose S1 after the reversal (perseverative errors). This suboptimal behavior may result from a pigeon’s …

Efficacy Of The Feline Temperament Profile In Evaluating Sheltered Cats For Adoption Into Families Of A Child With Autism Spectrum Disorder, Angélique Lamontagne, Rebecca A. Johnson, Gretchen K. Carlisle, Leslie A. Lyons, Jessica L. Bibbo, Colleen Koch, Steven J. Osterlind

Animal Studies Journal

This project was part of the Feline Friends Study, which matches shelter cats with families of children with Autism Spectrum Disorder (ASD) to study children’s social behaviour and cats’ stress. Cats were screened for calm temperament using the Feline Temperament Profile (FTP). The FTP consists of ten phases, with a list of ‘acceptable’ and ‘questionable’ behaviours under each phase. Our aim was to answer the following research questions: What items of the FTP best predict temperament in shelter cats? What are similarities and differences in temperament between cats who qualified or did not qualify for placement? Forty-four shelter cats were …

Behavioural Risks In Female Dogs With Minimal Lifetime Exposure To Gonadal Hormones, Melissa J. Starling, Anne Fawcett, Bethany Wilson, James Serpell, Paul Mcgreevy

Physiology Collection

Spaying of female dogs is a widespread practice, performed primarily for population control. While the consequences of early spaying for health are still being debated, the consequences for behaviour are believed to be negligible. The current study focused on the reported behaviour of 8981 female dogs spayed before 520 weeks (ten years) of life for reasons other than behavioural management, and calculated their percentage lifetime exposure to gonadal hormones (PLGH) as a proportion of their age at the time of being reported to the online Canine Behavioral Assessment and Research Questionnaire (C-BARQ). We found that 23 behaviours differed between entire …

Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander

All NMU Master's Theses

This study attempted to further explore the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able to acquire the discrimination in 19.1 sessions. The clozapine cue partially generalized (63.13% drug lever responding [SEM = ± 18.91]) to the antimalarial drug methylene blue at the 7.5 mg/kg dose, but not to the antimalarial quinacrine. …

Its Skin Is My Skin, Bryan Page

Graduate School of Art Theses

This text examines the complexity of attempting to empathize with bodies that are vastly othered from my own. This broad yet nuanced subject crosses epistemological boundaries and complicates the dualities between both the mind and body, and between the corporeal and the virtual. My desire to better understand the conditions of another’s experience originates from a painful traumatic loss which caused me to feel isolated and incomplete. In response to this suffering, I long to emotionally connect with other beings and create artwork that attempts to bridge the qualia of individual experience.

I am interested in the capacity (or lack …

Bottlenose Dolphin (Tursiops Truncatus) Vocal Responses To Sonar And Spectrally Pink Background Noise, Maria Zapetis

Dissertations

As human populations rise, the level of man-made noise increases globally. Naval sonar and boat traffic are underwater sound sources of particular concern to marine mammal welfare. To better understand the impact of these noise increases on cetaceans, studies can explore animals’ behavioral changes in response to noise. Studies have investigated the ‘dose-response’ relationship between the received sound pressure level of sonar signals and the behavior of cetaceans in the wild, but exposure studies in controlled environments are limited. The studies in this dissertation examined bottlenose dolphin vocal modifications during various experimental noise treatments. Acoustic recordings previously obtained for bottlenose …

Probability Discounting Of Lewis And Fischer 344 Rats: Strain Comparisons At Baseline And Following Acute Administration Of D-Amphetamine, Jenny E. Ozga

Graduate Theses, Dissertations, and Problem Reports

Risky choice can be defined as choice for a larger, uncertain reinforcer over a smaller, certain reinforcer when choosing the smaller alternative maximizes reinforcement. Risky choice is studied using various procedures in the animal laboratory; one such procedure is called probability discounting. There are many variables that contribute to risky decision-making, including biological and pharmacological determinants. The present study assessed both of these variables by evaluating dose-response effects of d-amphetamine on risky choice of Lewis (LEW) and Fischer 344 (F344) rats. The probability-discounting procedure included discrete-trials choices between one food pellet delivered 100% of the time and three food …

Measuring Glutamate And Oxygen In Brain Reward Circuits In Animal Models Of Cocaine Abuse And Decision-Making, Seth Richard Batten

Theses and Dissertations--Psychology

Drug-specific reward and associated effects on neural signaling are often studied between subjects, where one group self-administers drug and a separate group self-administers a natural reinforcer. However, exposure to drugs of abuse can cause long-term neural adaptations that can affect how an organism responds to drug reward, natural reward, and their reward-associated stimuli. Thus, to isolate drug-specific effects it is important to use models that expose the same organism to all of the aforementioned. Multiple schedules provide a means of dissociating the rewarding effects of a drug from the rewarding effects of food within a single animal. Further, drug users …

Bubble Stream Production By Belugas (Delphinapterus Leucas), Megan Slack

Theses

Bubble stream production in belugas has been poorly characterized and its function is not well understood. I examined behavioral states when producing bubble streams (“bubbling”), and when bubbling calls, to determine whether bubbling was significantly associated with a particular call category or behavioral state. Using 19 hours of video and audio recordings collected over a two-day period, I quantified bubble streams of a 4-month old calf and an unrelated adult female housed together. Based on the overall activity budgets and pool of vocalizations for both animals, I calculated the expected counts of bubble streams with and without vocalizations, assuming that …

Development Of Semantic Reference For Location Symbols By Bottlenose Dolphins (Tursiops Truncatus) Using A Two-Way Communication Keyboard, Alyssa Taylor

Master's Theses

The ability for humans to communicate with another species has been an aspiration and well documented. One example is through training animals to make associations between a designated cue and conditioned response (Pryor, 1986). Two-way communication, however, in which both species can express wants/needs has been predominantly pursued with apes and dolphins. Studies conducted by Louis Herman demonstrated the capabilities of dolphins to comprehend complex semantic and syntactic commands in an artificial language system (Herman, Richards, & Wolz, 1984). Researchers working with primates have used American Sign Language, a computer keyboard system with discrete lexigrams, and a portable lexigram keyboard …

Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo

All NMU Master's Theses

Tobacco smoking in the United States is used by approximately 25% of adults. Many studies using animal models have suggested that nicotine has rewarding properties. Contrastingly, several studies have also found it to be a weakly reinforcing substance at low and high dose levels. Due to this, other tobacco constituents, such as the monoamine oxidase inhibitor norharmane which is found in tobacco leaf and smoke, may be responsible for tobacco addiction by potentiating the rewarding properties of nicotine. Several studies have attempted to observe this phenomenon, however, monoamine oxidase inhibitors that are not found in tobacco leaf or smoke have …

Identifying The Social Contexts Present For Mouthing Behaviors In Bottlenose Dolphins (Tursiops Truncatus), Erin E. Frick

Dissertations

Much of the research on dolphin communication has focused on the acoustic signals produced in a variety of social contexts. Although acoustic signals are undoubtedly an important aspect of dolphin communication systems, dolphin communication is multifaceted and multimodal (e.g., postural, visual and tactile signals, acoustic cues). The present study examined behaviors that involve the mouth (i.e., mouthing behaviors) in a group of captive dolphins using 2,696 minutes of underwater acoustic and video recordings collected from 2010 – 2014. Target behaviors are described as primarily visual (e.g., open-mouth display), both visual and acoustic (e.g., jaw claps), and tactile (e.g., mouthing, biting). …

Social Influences On Songbird Behavior: From Song Learning To Motion Coordination, Iva Ljubičić

Dissertations, Theses, and Capstone Projects

Social animals learn during development how to integrate successfully into their group. How do social interactions combine to maintain group cohesion? We first review how social environments can influence the development of vocal learners, such as songbirds and humans (Chapter 1). To bypass the complexity of natural social interactions and gain experimental control, we developed Virtual Social Environments, surrounding the bird with videos of manipulated playbacks. This way we were able to design sensory and social scenarios and test how social zebra finches adjust their behavior (Chapters 2 & 3). A serious challenge is that the color output of a …

Is Pecking Aversive To A Pigeon Or Is It Only The Delay To Reinforcement?, Danielle M. Andrews

Theses and Dissertations--Psychology

The principle of least effort suggests that animals should minimize effort to reinforcement. Thus, not pecking should be preferred over pecking. However, pigeons often peck when it is allowed but not required (e.g., fixed time schedules) but pecking may be adventitiously reinforced. In the present experiment, to better compare a schedule of reinforcement that requires pecking with one that requires the absence of pecking, we compared a fixed-interval (FI) schedule in which reinforcement follows the first peck after the interval has elapsed and a differential-reinforcement-of-other behavior (DRO) schedule which requires pigeons abstain from pecking for a similar interval. The delay …

Treatment Analysis Of A Captive Male Jaguar (Panthera Onca), Megan Colleen Morris

UNF Graduate Theses and Dissertations

Large carnivores in human care have been reported to engage in stereotypic behaviors. Such behavior is thought to be correlated with high stress levels, in part, due to captive environments limiting opportunities for functional consequences and environmental stimuli. Moreover, there are several arguments stating that stereotypic behaviors can be indicative of poor welfare, as they can often have severe negative emotional and physical effects on the animal. The first portion of this study included a five-phase treatment analysis which evaluated whether environmental manipulations decrease the frequency of stereotypic behaviors including pacing, over-grooming and tail-sucking exhibited by a single male jaguar …