Clinical Psychology Commons^™

Does The Apoe-Ε4 Allele Differentially Influence Cognition: A Longitudinal Investigation In Healthy Older Adults At Risk For Alzheimer’S Disease, Aditya Kulkarni

Dissertations, Theses, and Capstone Projects

Background: The apolipoprotein E (APOE) ε4 allele is the strongest susceptibility factor for sporadic, late-onset, Alzheimer’s disease (AD). However, not all persons who carry the ε4 allele show significant cognitive decline, and thus do not progress to dementia. The impact of the ε4 allele on memory decline has been documented primarily in populations already demonstrating cognitive impairment (i.e., those with mild cognitive impairment or dementia), with fewer investigations completed in baseline healthy older adults. Investigations of the ε4 allele and its influence on non-memory domains are also sparse in the literature. Furthermore, these cognitive investigations are typically cross-sectional and …

Hippocampal Volume And The Detection Of Mild Cognitive Impairment In An Older Adult Population: Assessing Performance On Cognitive Screeners Administered In-Person And Electronically, Kristen Fabrizi

Dissertations

The present study investigated how performance on in-person and electronic neuropsychological assessment measures predicted subcortical hippocampal volume and cognitive decline consistent with mild cognitive impairment. It was hypothesized that the Montreal Cognitive Assessment would display better predictive strength than the Cogstate Brief Battery when evaluating subcortical hippocampal volume measured via structural magnetic resonance imaging. It was further hypothesized that the Montreal Cognitive Assessment would be more sensitive to predicting group membership to the diagnostic classification of mild cognitive impairment compared to the Cogstate Brief Battery. The sample included 445 older adult participants selected from the Alzheimer’s Disease Neuroimaging Initiative 3. …

The Relation Between Hyperlipidemia, Hypertension, And Downstream Cognitive And Neuroanatomical Function, Victor James Wasserman

Theses and Dissertations

Objective: Cardiovascular risks (CVR) such as hypertension and hyperlipidemia play a critical role in the emergence of dementia syndromes. Medication to treat CVR may not obviate downstream risk for cognitive change.

Methods: To examine the relation between history of treatment with medications to treat CVR and cognitive outcomes, participants were seen at time points ~7 years apart, completed neuropsychological evaluations, assessed for history of treatment with medication associated with hypertension and hyperlipidemia as indicators of CVR, and classified into 3 groups: Not Treated, Inconsistently Treated, and Consistently Treated. Regression models associating neuropsychological outcome measures of cognition and CVR were explored …

Neuro-Exergaming For Older Adults With Mild Cognitive Impairment (Mci): A Single Bout Of Interactive Physical And Cognitive Exercise (Ipaces V2.5), Alexa Puleio

Honors Theses

Mild Cognitive Impairment (MCI) poses a serious risk to the older population. This disease may be a precursor to a more debilitating dementia, such as Alzheimer’s Disease (AD), and it affects the cognitive abilities as well as overall quality of life of those who suffer from it (Alzheimer’s Association, 2014). Finding preventative ways to combat these neurodegenerative illnesses is imperative for our increasing older population at risk. Prior research has shown benefits to cognition from physical exercise (Colcombe & Kramer, 2003); however, only a fraction of older adults actually achieve recommended levels (Chodzko-Zajko et al., 2009). Some researchers have explored …

Predicting Cognitive Decline In Older Adults, Kimberly M. Baerresen

Loma Linda University Electronic Theses, Dissertations & Projects

The investigator sought to determine which neuropsychological tests are more likely to predict an individual’s cognitive decline (i.e., normal to mild cognitive impairment, mild cognitive impairment to Alzheimer’s disease) two years prior to conversion. A sample of non-decliners (N=109) compared to those who declined (N=24) in cognitive status (i.e., mild cognitive impairment or Alzheimer’s disease) with a mean age of 61.44 (SD=11.29) was examined. Results indicate the Rey-Osterrieth Complex Figure Test, Retention Trial (RCFT Retention; OR=0.93, p=0.005) is a significant predictor of conversion to MCI and the Buschke Delay (OR=0.54, p=0.017) is a significant predictor of conversion to AD. Due …

Predicting Cognitive Decline In Older Adults Through Multi-Voxel Pattern Analysis, Nathan Hantke

Dissertations (1934 -)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is associated with cognitive and structural decline beyond what is seen in normal, healthy aging. Functional magnetic resonance imaging (fMRI) research indicates that prior to the onset of measureable cognitive impairment, individuals at-risk for AD demonstrate different patterns of neural activation than individuals at lower risk. Thus, differences in task-activated fMRI may be beneficial in predicting cognitive decline at a "pre-symptomatic" stage. The present study utilizes multi-voxel pattern analysis (MVPA) of baseline fMRI task-related activation to predict cognitive decline, with the hypothesis that famous and non-famous name task activation will discriminate …

Functional Resting State Connectivity In Individuals At-Risk For Alzheimer's Disease, Alissa M. Butts

Master's Theses (2009 -)

Resting state functional magnetic resonance imaging studies have examined the connectivity between the hippocampus (HIPP) and the posterior cingulate (PC) in individuals with Alzheimer's disease (AD), mild cognitive impairment (MCI), and younger individuals at risk for AD. The present study aimed to examine the functional connectivity between these two memory structures and targets of AD neurodegeneration in cognitively intact elders at risk for AD (positive for ApolipoE protein (ε4) and family history of dementia), MCI, and healthy controls. Seeds and regions of interest were defined in the bilateral hippocampus and posterior cingulate, and the time courses were cross-correlated to generate …