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Neural Substrates Of Impaired Sensorimotor Timing In Adult Attention-Deficit/Hyperactivity Disorder, Eve M. Valera Phd, Rebecca M. C. Spencer, Thomas A. Zeffero Md, Phd, Nikos Makris Md, Phd, Thomas J. Spencer Md, Stephen V. Faraone Phd, Joseph Biederman Md, Larry J. Seidman Phd
Neural Substrates Of Impaired Sensorimotor Timing In Adult Attention-Deficit/Hyperactivity Disorder, Eve M. Valera Phd, Rebecca M. C. Spencer, Thomas A. Zeffero Md, Phd, Nikos Makris Md, Phd, Thomas J. Spencer Md, Stephen V. Faraone Phd, Joseph Biederman Md, Larry J. Seidman Phd
Rebecca M. C. Spencer
Background—Timing abilities are critical to the successful management of everyday activities and personal safety, and timing abnormalities have been argued to be fundamental to impulsiveness, a core symptom of attention-deficit/hyperactivity disorder (ADHD). Despite substantial evidence of timing deficits in ADHD youth, only two studies have explicitly examined timing in ADHD adults, and only at the supra-second time-scale. Also, the neural substrates of these deficits are largely unknown for both youth and adults with ADHD. The present study examined sub-second sensorimotor timing and its neural substrates in ADHD adults. Methods—Using fMRI, we examined paced and unpaced finger tapping in a sample …
Brain Estrogens Rapidly Strengthen Auditory Encoding And Guide Song Preference In A Songbird, Luke Remage_Healey, M. J. Colemand, R. K. Oyamaa, B. A. Schlinger
Brain Estrogens Rapidly Strengthen Auditory Encoding And Guide Song Preference In A Songbird, Luke Remage_Healey, M. J. Colemand, R. K. Oyamaa, B. A. Schlinger
Luke Remage-Healey
Higher cognitive function depends on accurate detection and processing of subtle features of sensory stimuli. Such precise computations require neural circuits to be modulated over rapid timescales, yet this modulation is poorly understood. Brain-derived steroids (neurosteroids) can act as fast signaling molecules in the vertebrate central nervous system and could therefore modulate sensory processing and guide behavior, but there is no empirical evidence for this possibility. Here we report that acute inhibition of estrogen production within a cortical-like region involved in complex auditory processing disrupts a songbird’s ability to behaviorally respond to song stimuli. Identical manipulation of local estrogen levels …