Social and Behavioral Sciences Commons^™

Wild Type And Tangier Disease Abca1 Mutants Modulate Cellular Amyloid-Beta Production Independent Of Cholesterol Efflux Activity, Kim S. Woojin, Andrew F. Hill, Michael L. Fitzgerald, Mason W. Freeman, Genevieve Evin, Brett Garner

Faculty of Science - Papers (Archive)

Cerebral amyloid-β (Aβ) deposition is a critical feature of Alzheimer’s disease. Aβ is derived from the amyloid-β protein precursor (AβPP) via two sequential cleavages that are mediated by β-secretase and the γ-secretase complex. Such amyloidogenic AβPP processing occurs in lipid raft microdomains of cell membranes and it is thought that modulating the distribution of lipids in rafts may regulate AβPP processing and Aβ production. Certain ATP-binding cassette (ABC) transporters regulate lipid transport across cell membranes and, as recent studies reveal, within membrane microdomains. ABCA1 also regulates Aβ metabolism in the brain although its direct impact on AβPP remains an open …

The Sydney Playground Project: Popping The Bubblewrap - Unleashing The Power Of Play: A Cluster Randomized Controlled Trial Of A Primary School Playground-Based Intervention Aiming To Increase Children's Physical Activity And Social Skills, Anita C. Bundy, Geraldine A. Naughton, Paul Tranter, Shirley Wyver, Louise A. Baur, Wendy Schiller, Adrian E. Bauman, Lina Engelen, Jo Ragen, Tim Luckett, Anita Niehues, Gabrielle Stewart, Glenda Jessup, Jennie Brentnall

Faculty of Social Sciences - Papers (Archive)

Background In the Westernised world, numerous children are overweight and have problems with bullying and mental health. One of the underlying causes for all three is postulated to be a decrease in outdoor free play. The aim of the Sydney Playground Project is to demonstrate the effectiveness of two simple interventions aimed to increase children's physical activity and social skills. Methods/Design This study protocol describes the design of a 3-year cluster randomised controlled trial (CRCT), in which schools are the clusters. The study consists of a 13-week intervention and 1 week each of pre-and post-testing. We are recruiting 12 schools …

Association Between Physical Activity And Motor Skills And Coordination In Portuguese Children, Luis Lopes, Vitor Pires Lopes, Rute Santos, Beatriz Pereira

Faculty of Social Sciences - Papers (Archive)

Nowadays, there is growing evidence in literature that Health benefits from regular physical activity (PA). The variance in PA among children is caused by a number of factors including their motor abilities and coordination. The aim of the study was to analyse the relation between usual PA and gross motor abilities and motor coordination in children aged 6 to 7 years. The sample comprised 21 children, aged in average 6,38±0,50 years. Physical activity was accessed by accelerometry, gross motor abilities by using the Test of Gross Motor Development (TGMD-2) and motor coordination by using the Körperkoordination Test für Kinder (KTK). …

Metabolic Risk Factors, Physical Activity And Physical Fitness In Azorean Adolescents: A Cross-Sectional Study, Carla Moreira, Rute Santos, Jose Cazuza De Farias Junior, Susana Vale, Paula Clara Santos, Luisa Soares-Miranda, Ana I. Marques, Jorge Mota

Faculty of Social Sciences - Papers (Archive)

Background

The prevalence of metabolic syndrome has increased over the last few decades in adolescents and has become an important health challenge worldwide. This study analyzed the relationships between metabolic risk factors (MRF) and physical activity (PA) and physical fitness (PF) in a sample of Azorean adolescents.

Methods

A cross-sectional school-based study was conducted on 417 adolescents (243 girls) aged 15-18 from the Azorean Islands, Portugal. Height, weight, waist circumference, fasting glucose, HDL-cholesterol, triglycerides, and blood pressure were measured. A sum of MRF was computed, and adolescents were classified into three groups: no MRF, one MRF and two or more …

Seasonal Differences In Physical Activity And Sedentary Patterns: The Relevance Of The Pa Context, Pedro Silva, Rute Santos, Gregory Welk, Jorge Mota

Faculty of Social Sciences - Papers (Archive)

The aim of this pilot study was to characterize seasonal variationin the moderate to vigorous physical activity (MVPA) and sedentarybehavior of Portuguese school youth, and understand theinfluence of activity choices and settings. The participants inthis study were 24 students, aged 10-13 years. Accelerometersmeasured daily PA over 7 consecutive days, in different seasonsMay - June and January - February. In summer, boys accumulatedmore minutes in MVPA (928 minutes/week) than girls(793 minutes/week). In winter the pattern was reversed withgirls accumulating more activity than boys (736 minutes/weekvs. 598 minutes/week). The repeated measures ANOVA revealedsignificant effects for season (F = 5.98, p = 0.023) …

Evaluation Of Physical Activity Programmes For Elderly People - A Descriptive Study Using The Efqm' Criteria, Ana I. Marques, Maria J. Rosa, Pedro Soares, Rute Santos, Jorge Mota, Joana Carvalho

Faculty of Social Sciences - Papers (Archive)

Background: In the past years, there has been a growing concern in designing physical activity (PA) programmes for elderly people, because evidence suggests that such health promotion interventions may reduce the deleterious effects of the ageing process. Quality is an important issue when designing a PA programme for older people. Some studies support the Excellence Model of the European Foundation for Quality Management (EFQM) as an operational framework for evaluating the quality of an organization. Within this context, the aim of this study was to characterize the quality management models of the PA programmes developed by Portuguese Local Administration to …

Evaluation Of Physical Activity Programmes For The Elderly - Exploring The Lessons From Other Sectors And Examining The General Characteristics Of The Programmes, Ana I. Marques, Pedro Soares, Luisa Soares-Miranda, Carla Moreira, Antonio Oliveira-Tavares, Paula Clara-Santos, Susana Vale, Rute Santos, Joana Carvalho

Faculty of Social Sciences - Papers (Archive)

Background

In Portugal, there are several physical activity (PA) programmes for elderly people developed by the local government. The importance of these programmes has been increasing since the evidence has shown that this type of health promotion interventions may reduce the deleterious effects of the ageing process. However, no study has already identified the general characteristics of these programmes nor if they use any scheme to assess the quality of the service provided. A widely-used scheme is the EFQM Excellence Model, which will be in the core of our present work. Thus, the main aims of this preliminary study were …

A Proposed Adaptation Of The European Foundation For Quality Management Excellence Model To Physical Activity Programmes For The Elderly - Development Of A Quality Self-Assessment Tool Using A Modified Delphi Process, Ana I. Marques, Leonel Santos, Pedro Soares, Rute Santos, Antonio Oliveira-Tavares, Jorge Mota, Joana Carvalho

Faculty of Social Sciences - Papers (Archive)

Background There has been a growing concern in designing physical activity (PA) programmes for elderly people, since evidence suggests that such health promotion interventions may reduce the deleterious effects of the ageing process. Complete programme evaluations are a necessary prerequisite to continuous quality improvements. Being able to refine, adapt and create tools that are suited to the realities and contexts of PA programmes for the elderly in order to support its continuous improvement is, therefore, crucial. Thus, the aim of this study was to develop a self-assessment tool for PA programmes for the elderly. Methods A 3-round Delphi process was …

Declining Physical Activity Levels As An Unintended Consequence Of Abolishing Mandatory Campus Service Fees, Sandra C. Jones, Lance R. Barrie

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective: This study investigates the effect of the introduction of voluntary student unionism and subsequent increase in campus facility fees on engagement in physical activity on campus. Participants: Participants were 1,904 students from a large regional NSW (Australia) university across 3 time periods (926 in 2005, 504 in 2006, and 474 in 2007). Methods: Students completed a survey across the 3 time periods, responding to questions about physical activity levels, use of on-campus and off-campus facilities, and barriers to facility use. Results: Participation in physical activity at university facilities was low overall, and declined substantially between 2005 and 2007, with …

Beat It: Diabetes Lifestyle And Physical Activity Program - The Effects And Affordability Of A 12-Week Community Based, Physical Activity Program For People With Or At Risk Of Diabetes, Bronwyn Penny, Joel Tuccia, Marc A. Brown

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

The Unit Of Analysis In Is Theory: The Case For Activity, Helen Hasan, Sumayya Banna

Faculty of Commerce - Papers (Archive)

In the field of IS, researchers use and adapt existing theories to make sense of their data. They also build new theory from their research findings. The way theory is used, adapted or created usually assumes a certain unit of analysis, which could be the artefact, the system, the organisation, the user, the developer, the team or something else. In this paper we propose that ‘activity’ should also be considered as a suitable unit of analysis for theory in IS since the purpose of any information systems is to facilitate activities of use. To support this proposition, we describe tenets …

Blending Complexity And Activity Frameworks For A Broader And Deeper Understanding Of Is, Helen M. Hasan, A Kazluaskas, Kathryn P. Crawford

Faculty of Commerce - Papers (Archive)

A new age of significance and opportunity for Information Systems (IS) is upon us driven by current developments in the use of digital artifacts. In this paper we endeavor to make sense of contemporary IS, as well as possible future directions of IS, by bringing together the notions of complexity and activity within two theoretical frameworks, namely the Cynefin framework and contemporary uses of Activity Theory. We describe activity as a holistic unit of analysis within the Complicated and Complex Domains of the Cynefin framework. This will enable us to make sense of tool-mediated IS activities in those Domains. Our …

Sitting Time And Body Mass Index, In A Portuguese Sample Of Men: Results From The Azorean Physical Activity And Health Study (Apahs), Rute Santos, Luisa Soares-Miranda, Susana Vale, Carla Moreira, Ana I. Marques, Jorge Mota

Faculty of Social Sciences - Papers (Archive)

The aim of this study was to verify the relation between body mass index (BMI) and sitting time in a sample of 4,091 Azorean men. BMI was calculated from self-reported weight and height. Total physical activity (PA) time and total sitting time were assessed with the IPAQ (short version). Linear Regression analysis showed that total sitting time (hours/day) was positively associated with BMI (B = 0.078; p < 0.001) after adjustments for age, meal frequency, alcohol and tobacco consumptions, island of residence, education level and total PA time. Although the cross sectional design precludes us from establishing causality, our findings emphasize the importance of reducing sedentary behavior to decrease the risk of obesity.

Citrate Synthase Activity Does Not Account For Age-Related Differences In Maximum Aerobic Performance In House Sparrows (Passer Domesticus), William A. Buttemer, C Bech, Mark A. Chappell

Faculty of Science - Papers (Archive)

We measured basal (BMR) and peak metabolic rates (PMR) in juvenile and adult House Sparrows. Juvenile birds had significantly higher BMR, but lower PMR than adult birds, despite having statistically indistinguishable body masses. We then evaluated the relation between PMR and masses of central and peripheral organs and found that pectoral muscle mass best correlated with PMR in both groups, accounting for about 35% of the variation in PMR. Because citrate synthase (CS) has such major importance in affecting the first committed step in the tricarboxylic acid cycle, we characterized CS activity levels In extracted muscles to see if this …

Board Composition, Board Activity And Ownership Concentration, The Impact On Firm Performance, Shiguang Ma, Gary Tian

Faculty of Commerce - Papers (Archive)

This paper provides a parallel investigation on the impact of board composition, board activity and ownership concentration on the performance of listed Chinese firms. We find that independent directors enhance firm performance effectively than other board factors. The frequency of shareholder meetings, rather than board meetings, is positively associated with firm value. Tradable share ownership concentration has a positive and linear relationship with firm value, while state and total share ownership concentration represent U(V) shapes. Importantly, companies with the highest levels of both total share and tradable share ownership concentration have a greater firm values than companies with the highest …

The Cd-Loop Of Pai-2 (Serpinb2) Is Redundant In The Targeting, Inhibition And Clearance Of Cell Surface Upa Activity, Blake J. Cochran, Lakshitha P. Gunawardhana, Kara L. Perrow, Jodi A. Lee, Sergei A. Lobov, Marie Ranson

Faculty of Science - Papers (Archive)

Background: Plasminogen activator inhibitor type-2 (PAI-2, SERPINB2) is an irreversible, specific inhibitor of the urokinase plasminogen activator (uPA). Since overexpression of uPA at the surface of cancer cells is linked to malignancy, targeting of uPA by exogenous recombinant PAI-2 has been proposed as the basis of potential cancer therapies. To this end, reproducible yields of high purity protein that maintains this targeting ability is required. Herein we validate the use in vitro of recombinant 6 × His-tagged-PAI-2 lacking the intrahelical loop between C and D alpha-helices (PAI- 2 ΔCD-loop) for these purposes.

Results: We show that PAI-2 ΔCD-loop …

Effects Of Shoe Heel Height On Loading And Muscle Activity For Trans-Tibial Amputees During Standing, Xiaohong Jia, Rencheng Wang, Winson Lee

Faculty of Engineering and Information Sciences - Papers: Part A

This study accesses the effects of shoe heel heights on loading, muscle activity, and plantar foot pressure of trans-tibial amputees during standing. Five male subjects with unilateral trans-tibial amputation volunteered to participate in this study. Three pairs of shoes with zero, 20 mm, and 40 mm heel heights were used. The loading line of the prosthetic side, the plantar foot pressure, and the surface electromyography (EMG) of 10 muscles were simultaneously recorded. With increasing shoe heel heights during standing, the loading line of the prosthetic side shifted from the anterior to the posterior side of the knee center, the peak …

Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie

Faculty of Health and Behavioural Sciences - Papers (Archive)

In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …

Evaluating The Impact Of The Environment On The Physical Activity Levels Of People With Dementia In Aged Care Facilities, Loren Devries, Victoria Traynor, Nancy Humpel

Faculty of Health and Behavioural Sciences - Papers (Archive)

To evaluate the impact of the environment on the physical activity levels of people with dementia living in residential aged care facilities

Antimycobacterial Activity Of Cinnamate-Based Esters Of The Triterpenes Betulinic, Oleanolic And Ursolic Acids, Tanud Tanachatchairatana, John B. Bremner, Ratchanaporn Chokchaisiri, Apichart Suksamrarn

Faculty of Science - Papers (Archive)

Betulinic acid, oleanolic acid and ursolic acid have been modified at the C-3 position to cinnamate-based esters and in vitro antimycobacterial activity against Mycobacterium tuberculosis H₃₇Ra has been determined. The results indicated that modification of the parent structures of betulinic acid, oleanolic acid and ursolic acid to the p-coumarate and, in the case of the latter two triterpenes, the ferulate ester analogues resulted in high antimycobacterial activity. Structure–activity relationships within the lupane, oleanane and ursane analogues and between these triterpenes are discussed.

Ict Devices As Ubiquitous Tools For Information Seeking Activity, Joseph A. Meloche, Helen M. Hasan

Faculty of Commerce - Papers (Archive)

This paper investigates the use of current and developing ubiquitous digital devices and the way that they impact on, and are integrated into, use by groups within the community for information seeking. Three cases are presented involving ubiquitous use of the mobile phone, USB memory devices, and a wireless groupware system. The study considers the need for ongoing research to inform, direct and study the innovative use, appropriation and development of such tools. The primary methodological framework that is applied is activity theory, as it allows dasiatoolpsila to be examined in light of purposeful activity in the context of their …

Do Australian Primary School Environments Affect Children's Playground Physical Activity Levels?, Anne-Maree Parrish, Donald Iverson, Kenneth Russell, Heather Yeatman

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background Evidence is growing on the benefit of physical activity to improve well-being following a cancer diagnosis. This study examined changes in physical activity from pre to post diagnosis and explored this relationship with quality of life and depression. Methods Participants were recruited by posters and by letter of invitation. The questionnaire was completed by 59 prostate and 32 breast cancer survivors. Results Physical activity decreased by 72 minutes per week from pre to post diagnosis, although 20.9% reported having increased activity post diagnosis. Over 30% were considered depressed. Breast cancer participants who increased physical activity post diagnosis reported higher …

Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson

Faculty of Health and Behavioural Sciences - Papers (Archive)

INTRODUCTION: The regulation of extracellular proteolytic activity via the plasminogen activation system is complex, involving numerous activators, inhibitors and receptors. Previous studies on monocytic and colon cell lines suggest that plasmin pre treatment can increase plasminogen binding, allowing the active enzyme to generate binding sites for its precursor. Other studies have shown the importance of pre formed receptors such as annexin II heterotetramer. However, few studies have utilised techniques which exclusively characterise cell surface events and these mechanisms have not been investigated at the breast cancer cell surface. METHODS: We have studied plasminogen binding to MCF 7 in which uPAR …

A Cultural-Historical Activity Theory Approach To Users, Usability And Usefulness, Helen M. Hasan

Faculty of Commerce - Papers (Archive)

This paper takes an historical overview of the field of Human-Computer Interaction. Itdescribes how the cognitive psychology emphasis on user involvement in systemsdevelopment of the 1980s reached its limit by the early 1990s. At this point the focus shifted onto support for the tasks of users using computer-based systems in real contexts, a focus that ideally suits the mobile, ubiquitous and social technologies of the new millennium. The Cultural-Historical Activity Theory provides an appropriate framework for understanding this phenomenon and is adopted in this paper to present the work, over a seven year period, of a usability laboratory grounded in …

Mimicking Phosphorylation Of Alphab-Crystallin Affects Its Chaperone Activity, Heath W. Ecroyd, Sarah Meehan, J Horwitz, Andrew Aquilina, J L Benesch, C V Robinson, Cait Macphee, John Carver

Faculty of Science - Papers (Archive)

No abstract provided.

Scaling Of Na+, K+-Atpase Molecular Activity And Membrane Fatty Acid Composition In Mammalian And Avian Hearts, Anthony J. Hulbert, Paul Else, Kurt Haga, Nigel Turner

Faculty of Health and Behavioural Sciences - Papers (Archive)

We have examined Na⁺,K⁺‐ATPase molecular activity and membrane fatty acid composition in the heart of six mammalian and eight avian species ranging in size from 30 g in mice to 280 kg in cattle and 13 g in zebra finches to 35 kg in emus, respectively. Na⁺,K⁺‐ATPase activity scaled negatively with body mass in both mammals and birds. In small mammals, the elevated enzyme activity was related to allometric changes in both the concentration and molecular activity (turnover rate) of Na⁺,K⁺‐ATPase enzymes, while in small birds, higher Na …

A Contextual Approach To Design And Development Of Interfaces For Search Engines, Using Activity Theory As The Basis For Informing Design Decisions, Joseph A. Meloche, Li Cheng

Faculty of Commerce - Papers (Archive)

The goal of this study is to support the design of more effective search engines. The research presented in this chapter investigates the design of search engines in the context of information seeking
activities. This study is also informed by Activity Theory and considers Information Seeking to be a Keystone Activity. This improvement in search engine design takes into consideration the context of users, and elicits and captures users' explicit and implied requirements. The study uses Q-methodology to elicit the subjective understanding of the participants thought the phases provided by the methodology. This entails collecting, sorting and analysis of detailed …

A Campus Portal Development Methodology To Match Stakeholder Activity, Tharitpong Fuangvut, Helen M. Hasan

Faculty of Commerce - Papers (Archive)

Although introduced less than seven years ago, a Campus Portal (CP) can be considered as an emerging technological innovation within higher education institutions. A large number have already adopted the concept and are currently implementing some type of portal to extend the services of their Web site and information systems to support the activities of institutional stakeholders, especially students. There is some literature recommending sets of characteristics and functionality for successful CPs, in particular personalisation and customisation. However there is a lack of evidence on which aspects of core attributes lead to the failure of a portal to satisfy user …

An Allometric Comparison Of Microsomal Membrane Lipid Composition And Sodium Pump Molecular Activity In The Brain Of Mammals And Birds, Anthony J. Hulbert, Paul Else, Nigel Turner

Faculty of Health and Behavioural Sciences - Papers (Archive)

Previous research has shown that the lipid milieu surrounding membrane proteins may be an important factor in determining their activity. To investigate this we have examined sodium pump molecular activity and microsomal membrane lipid composition in the brain of five mammalian and eight avian species ranging in size from 30 g mice to 280 kg cattle and 13 g zebra finches to 35 kg emus, respectively. Sodium pump (Na⁺,K⁺-ATPase) activity was higher in the smaller species and showed a significant allometric decline with body mass in both the mammals (μmol P_i h^-1 mg wet …