Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Multivariate Analysis
On The Merits Of Voxel-Based Morphometric Path-Analysis For Investigating Volumetric Mediation Of A Toxicant's Influence On Cognitive Function, Shu-Chih Su, Brian S. Caffo, Lynn E. Eberly, Elizabeth Garrett-Mayer, Walter F. Stewart, Sining Chen, David Yousem, Christos Davatzikos, Brian Schwartz
On The Merits Of Voxel-Based Morphometric Path-Analysis For Investigating Volumetric Mediation Of A Toxicant's Influence On Cognitive Function, Shu-Chih Su, Brian S. Caffo, Lynn E. Eberly, Elizabeth Garrett-Mayer, Walter F. Stewart, Sining Chen, David Yousem, Christos Davatzikos, Brian Schwartz
Johns Hopkins University, Dept. of Biostatistics Working Papers
We previously showed that lifetime cumulative lead dose, measured as lead concentration in the tibia bone by X-ray fluorescence, was associated with persistent and progressive declines in cognitive function and with decreases in MRI-based brain volumes in former lead workers. Moreover, larger region-specific brain volumes were associated with better cognitive function. These findings motivated us to explore a novel application of path analysis to evaluate effect mediation. Voxel-wise path analysis, at face value, represents the natural evolution of voxel-based morphometry methods to answer questions of mediation. Application of these methods to the former lead worker data demonstrated potential limitations in …