Physics Commons^™

A Numerical Solution Of Water Flow In Unsaturated Soil With Evapotraspiration, Andrei Ludu, Harihar Khanal, Ramesh Chandra Timsina, Kedar Nath Uprety

Publications

Flow movement in unsaturated soil can be expressed by Richards equation. This equation can be obtained by applying the mass conversation law and the Darcy law. In this work, we solve one-dimensional Kirchhoff transformed Richards equation with loss of water due to the evaporation of unsaturated porous media (soils) and transpiration of plants numerically using Crank-Nicolson method. The result has compared with evapotranspiration function and without it in the governing equation. It has found that an additional work in time and flow movement is needs to reach the given boundary condition for the model without evapotranspiration.

A Nanoscale Shape-Discovery Framework Supporting Systematic Investigations Of Shape-Dependent Biological Effects And Immunomodulation, Wei Zhang, Hender Lopez, Luca Boselli, Paolo Bigini, André Perez-Potti, Zengchun Xie, Valentina Castagnola, Qi Cai, Camila P. Silveira, Joao M. De Araujo, Laura Talamini, Nicolò Panini, Giuseppe Ristagno, Martina B. Violatto, Stéphanie Devineau, Marco P. Monopoli, Mario Salmona, Valeria A. Giannone, Sandra Lara, Kenneth A. Dawson, Yan Yan

Articles

Since it is now possible to make, in a controlled fashion, an almost unlimited variety of nanostructure shapes, it is of increasing interest to understand the forms of biological control that nanoscale shape allows. However, a priori rational investigation of such a vast universe of shapes appears to present intractable fundamental and practical challenges. This has limited the useful systematic investigation of their biological interactions and the development of innovative nanoscale shape-dependent therapies. Here, we introduce a concept of biologically relevant inductive nanoscale shape discovery and evaluation that is ideally suited to, and will ultimately become, a vehicle for machine …

All-Sky Search For Short Gravitational-Wave Bursts In The Third Advanced Ligo And Advanced Virgo Run, R. Abbott, T. Abbott, F. Acernese, K. Ackley, Teviet Creighton, Mario C. Diaz, F. Llamas, Soma Mukherjee, Volker Quetschke, Wenhui Wang

Physics and Astronomy Faculty Publications and Presentations

This paper presents the results of a search for generic short-duration gravitational-wave transients in data from the third observing run of Advanced LIGO and Advanced Virgo. Transients with durations of milliseconds to a few seconds in the 24–4096 Hz frequency band are targeted by the search, with no assumptions made regarding the incoming signal direction, polarization, or morphology. Gravitational waves from compact binary coalescences that have been identified by other targeted analyses are detected, but no statistically significant evidence for other gravitational wave bursts is found. Sensitivities to a variety of signals are presented. These include updated upper limits on …

Splashing Of Large Helium Nanodroplets Upon Surface Collisions, Paul Martini, Simon Albertini, Felix Laimer, Miriam Meyer, Michael Gatchell, Olof E. Echt, Fabio Zappa, Paul Scheier

Faculty Publications

In the present work we observe that helium nanodroplets colliding with surfaces can exhibit splashing in a way that is analogous to classical liquids. We use transmission electron microscopy and mass spectrometry to demonstrate that neutral and ionic dopants embedded in the droplets are efficiently backscattered in such events. High abundances of weakly bound He-tagged ions of both polarities indicate a gentle extraction mechanism of these ions from the droplets upon collision with a solid surface. This backscattering process is observed for dopant particles with masses up to 400 kilodaltons, indicating an unexpected mechanism that effectively lowers deposition rates of …

Temperature-Immune Self-Referencing Fabry–Pérot Cavity Sensors, Hengky Chandrahalim, Jonathan W. Smith

AFIT Patents

A passive microscopic Fabry-Pérot Interferometer (FPI) sensor an optical fiber a three-dimensional microscopic optical structure formed on a cleaved tip of an optical fighter that reflects a light signal back through the optical fiber. The reflected light is altered by refractive index changes in the three-dimensional structure that is subject to at least one of: (i) thermal radiation; and (ii) volatile organic compounds.

Spin-Dependent Electronic Transport In Noncollinear Antiferromagnetic Antiperovskites, Gautam Gurung

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

Spin-dependent properties are the heart of spintronic devices. Spintronics exploits electron’s spin, in addition to charge, to process and store the information. Recently, antiferromagnetic (AFM) spintronics has emerged as a subfield of spintronics, where an AFM order parameter (the Néel vector) is exploited to control spin-dependent transport properties. Due to being robust against magnetic perturbations, producing no stray fields, and exhibiting ultrafast dynamics, antiferromagnets can serve as promising functional materials for spintronic applications.

Among antiferromagnets, high Néel temperature noncollinear antiperovskites ANMn₃ (A = Ga, Ni, Sn, and Pt) are interesting due to their magnetic group symmetry supporting non-trivial spin-dependent …

Piezoelectricity In Hafnia, Sangita Dutta, Pratyush Buragohain, Sebastjan Glinsek, Claudia Richter, Hugo Aramberri, Haidong Lu, Uwe Schroeder, Emmanuel Defay, Alexei Gruverman, Jorge Íñiguez

Department of Physics and Astronomy: Faculty Publications

Because of its compatibility with semiconductor-based technologies, hafnia (HfO₂) is today’s most promising ferroelectric material for applications in electronics. Yet, knowledge on the ferroic and electromechanical response properties of this all-important compound is still lacking. Interestingly, HfO₂ has recently been predicted to display a negative longitudinal piezoelectric effect, which sets it apart from classic ferroelectrics (e.g., perovskite oxides like PbTiO₃) and is reminiscent of the behavior of some organic compounds. The present work corroborates this behavior, by first-principles calculations and an experimental investigation of HfO₂ thin films using piezoresponse force microscopy. Further, the simulations …

Dark Energy At Early Times And Act Data: A Larger Hubble Constant Without Late-Time Priors, V. Poulin, Tristan L. Smith, A. Bartlett

Physics & Astronomy Faculty Works

Recent observations using the Atacama Cosmology Telescope (ACT) have provided ground-based cosmic microwave background (CMB) maps with higher angular resolution than the Planck satellite. These have the potential to put interesting constraints on models resolving the “Hubble tension.” In this paper we fit two models of early dark energy (EDE) (an increase in the expansion rate around matter/radiation equality) to the combination of ACT data with large-scale measurements of the CMB either from the WMAP or the Planck satellite (including lensing), along with measurements of the baryon acoustic oscillations and uncalibrated supernovae luminosity distance. We study a phenomenological axionlike potential …

Study Of The Reactions E+E-→Π+Π-ΠΠΠΠΠΠΠΠ And Π+Π-ΠΠΠΠΠΠΗ At Center-Of-Mass Energies From Threshold To 4.5 Gev Using Initial-State Radiation, J. P. Lees, V. Poireau, V Tisserand, E. Grauges, A. Palano, G. Eigen, D. N. Brown, Yu G. Kolomensky, M. Fritsch, H. Koch, T. Schroeder, R. Cheaib, C. Hearty, T. S. Mattison, J. A. Mckenna, R. Y. So, V. E. Blinov, A. R. Buzykaev, V. P. Druzhinin, Milind Purohit, Et. Al.

Faculty Publications

We study the processes e⁺e⁻→ π⁺π⁻π⁰π⁰π⁰π⁰γ and π⁺π⁻π⁰π⁰π⁰ηγ in which an energetic photon is radiated from the initial state. The data were collected with the BABAR detector at the SLAC National Accelerator Laboratory. About 7300 and 870 events, respectively, are selected from a data sample corresponding to an integrated luminosity of 469 fb⁻¹. The invariant mass of the hadronic final state defines the effective e⁺e⁻ center-of-mass energy. The center-of-mass …

Study Of The Process E+ E− → Π + Π − Π0 Using Initial State Radiation With Babar, J. P. Lees, V. Poireau, V. Tisserand, E. Grauges, A. Palano, G. Eigen, D. N. Brown, Yu. G. Kolomensky, M. Fritsch, H. Koch, T. Schroeder, R. Cheaib, C. Hearty, T. S. Mattison, J. A. Mckenna, R. Y. So, V. E. Blinov, A. R. Buzykaev, V. P. Druzhinin, Milind Purohit, Et. Al.

Faculty Publications

The process e⁺e⁻→ π⁺π⁻π⁰γ is studied at a center-of-mass energy near the ϒ(4S) resonance using a data sample of 469 fb⁻¹ collected with the BABAR detector at the PEP-II collider. We have performed a precise measurement of the e⁺e⁻→ π⁺π⁻π⁰ cross section in the center-of-mass energy range from 0.62 to 3.5 GeV. In the energy regions of theω and ϕ resonances, the cross section is measured with a systematic uncertainty of 1.3%. The leading-order hadronic contribution to the …

Influence Of Boreal Summer Intraseasonal Oscillation On Rainfall Extremes In The Philippines, Lyndon Mark P. Olaguera, John A. Manalo, Jun Matsumoto

Physics Faculty Publications

This study investigates the impact of the northward/northwestward propagating 30–60-day mode of the boreal summer intraseasonal oscillation (BSISO) on the extreme rainfall events in the Philippines during the June–September (JJAS) season from 1979 to 2018. The Philippines domain is divided into the three latitudinal regions: Luzon region (13°–22°N), Visayas region (10°–13°N), and Mindanao region (5°–10°N) to account for the regional differences in the timing of extreme rainfall events. The probability density functions of JJAS rainfall are skewed towards higher values relative to the non-BSISO days in BSISO Phases 6–8, Phases 5–7, and Phases 4–6 over the Luzon, Visayas, and Mindanao …

Reduced-Order Dynamic Modeling And Robust Nonlinear Control Of Fluid Flow Velocity Fields, Anu Kossery Jayaprakash, William Mackunis, Vladimir Golubev, Oksana Stalnov

Publications

A robust nonlinear control method is developed for fluid flow velocity tracking, which formally addresses the inherent challenges in practical implementation of closed-loop active flow control systems. A key challenge being addressed here is flow control design to compensate for model parameter variations that can arise from actuator perturbations. The control design is based on a detailed reduced-order model of the actuated flow dynamics, which is rigorously derived to incorporate the inherent time-varying uncertainty in the both the model parameters and the actuator dynamics. To the best of the authors’ knowledge, this is the first robust nonlinear closed-loop active flow …

Violation Of Magnetic Flux Conservation By Superconducting Nanorings, Iris Mowgood, Gurgen Melkonyan, Rajendra Dulal, Serafim Teknowijoyo, Sara Chahid, Armen Gulian

Mathematics, Physics, and Computer Science Faculty Articles and Research

The behavior of magnetic flux in the ring-shaped finite-gap superconductors is explored from the view-point of the flux-conservation theorem which states that under the variation of external magnetic field "the magnetic flux through the ring remains constant" (see, e.g., [L.D. Landau and E.M. Lifshitz, Electrodynamics of Continuos Media, vol. 8 (New York, Pergamon Press, 1960), Section 42]). Our results, based on the time-dependent Ginzburg-Landau equations and COMSOL modeling, made it clear that in the general case, this theorem is incorrect. While for rings of macroscopic sizes the corrections are small, for micro and nanorings they become rather substantial. The physical …

Computer Program Simulation Of A Quantum Turing Machine With Circuit Model, Shixin Wu

Mathematical Sciences Technical Reports (MSTR)

Molina and Watrous present a variation of the method to simulate a quantum Turing machine employed in Yao’s 1995 publication “Quantum Circuit Complexity”. We use a computer program to implement their method with linear algebra and an additional unitary operator defined to complete the details. Their method is verified to be correct on a quantum Turing machine.

Preparation And Characterization Of Multiwall Carbon Nanotubes Decorated With Copper Oxide, Mohamed Morsy

Nanotechnology Research Centre

Multi-walled carbon nanotubes (MWCNTs) are special form of carbon nano materials with amazing applications in many areas of research.MWCNTs were synthesized by anAtmospheric Chemical Vapor Deposition (ACVD) system then decorated on their surface with Copper Oxide (CuO) nanoparticles via the hydrothermal method. The prepared un-purifiedMWCNTs and purified MWCNTs were characterized by High Resolution Transmittance Electron Microscope (HRTEM), Xray Diffraction (XRD) and Raman spectroscopy. As well as the CuO/MWCNTs nanocomposite was characterized by HRTEM, XRD, Fourier Transform Infra-Red Spectroscopy (FTIR), Thermogravimetric Analysis (TGA) Differential Thermal Analysis (DTA) and Raman spectroscopy. The results demonstrated the distribution of CuO nano particles on the …

Point Absorber Limits To Future Gravitational-Wave Detectors, Wenxuan Jia, Hiroaki Yamamoto, Kevin Kuns, Anamaria Effler, Matthew Evans, Peter Fritschel, R. Abbott, C. Adams, R. Adhikari, Karla E. Ramirez

Physics and Astronomy Faculty Publications and Presentations

High-quality optical resonant cavities require low optical loss, typically on the scale of parts per million. However, unintended micron-scale contaminants on the resonator mirrors that absorb the light circulating in the cavity can deform the surface thermoelastically, and thus increase losses by scattering light out of the resonant mode. The point absorber effect is a limiting factor in some highpower cavity experiments, for example, the Advanced LIGO gravitational wave detector. In this Letter, we present a general approach to the point absorber effect from first principles and simulate its contribution to the increased scattering. The achievable circulating power in current …

Search For Lensing Signatures In The Gravitational-Wave Observations From The First Half Of Ligo–Virgo's Third Observing Run, Richard Abbott, Thomas D. Abbott, S. Abraham, Fausto Acernese, K. Ackley, Teviet Creighton, Mario C. Diaz, Soma Mukherjee, Volker Quetschke, Karla E. Ramirez, Wenhui Wang

Physics and Astronomy Faculty Publications and Presentations

We search for signatures of gravitational lensing in the gravitational-wave signals from compact binary coalescences detected by Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) and Advanced Virgo during O3a, the first half of their third observing run. We study: (1) the expected rate of lensing at current detector sensitivity and the implications of a non-observation of strong lensing or a stochastic gravitational-wave background on the merger-rate density at high redshift; (2) how the interpretation of individual high-mass events would change if they were found to be lensed; (3) the possibility of multiple images due to strong lensing by galaxies or galaxy …

Extracellular Vimentin As A Target Against Sars-Cov-2 Host Cell Invasion, Łukasz Suprewicz, Maxx Swoger, Sarthak Gupta, Ewelina Piktel, Fitzroy J. Byfield, Daniel V. Iwamoto, Danielle Germann, Joanna Reszeć, Natalia Marcińczyk, Robert J. Carroll, Paul A. Janmey, J. M. Schwarz, Robert Bucki, Alison E. Patteson

Physics - All Scholarship

Infection of human cells by pathogens, including SARS-CoV-2, typically proceeds by cell surface binding to a crucial receptor. The primary receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2), yet new studies reveal the importance of additional extracellular co-receptors that mediate binding and host cell invasion by SARS-CoV-2. Vimentin is an intermediate filament protein that is increasingly recognized as being present on the extracellular surface of a subset of cell types, where it can bind to and facilitate pathogens’ cellular uptake. Biophysical and cell infection studies are done to determine whether vimentin might bind SARS-CoV-2 and facilitate its uptake. Dynamic …

Evidence For Surface Effects On The Intermolecular Interactions In Fe (Ii) Spin Crossover Coordination Polymers, Thilini K. Ekanayaka, Hannah Kurz, Kayleigh A. Mcelveen, Guanhua Hao, Esha Mishra, Alpha T. N’Diaye, Rebecca Lai, Birgit Weber, Peter A. Dowben

Department of Physics and Astronomy: Faculty Publications

From X-ray absorption spectroscopy (XAS) and X-ray photoemission spectroscopy (XPS) it is evident that the spin state transition behavior of Fe(II) spin crossover coordination polymer crystallites at the surface differs from the bulk. A comparison of four different coordination polymers reveals that the observed surface properties may differ from bulk for a variety of reasons. There are Fe(II) spin crossover coordination polymers with either almost complete switching of the spin state at the surface or no switching at all. Oxidation, differences in surface packing, and changes in coordination could all contribute to making the surface very different from the bulk. …

Measurement Of Speed Of Sound Using Smartphones, Omotolani Adelekan

Publications and Research

The goal of this experiment is to determine the speed of sound in air. To measure the speed of sound, I used two smartphones and an app called Phyphox This app uses the microphone of the smartphone to detect the time between two acoustic events The “acoustic stopwatch” tool on the app is used to measure the time between two sound signals These two signals are produced by hand clapping In this experiment, the speed of sound is determined using the time of flight method This method is based on measuring the time delay between the generation and the detection …

The Hashtag Project: The First Submillimeter Images Of The Andromeda Galaxy From The Ground, Matthew W.L. Smith, Stephen A. Eales, Thomas G. Williams, Bumhyun Lee, Zongnan Li, Pauline Barmby, Martin Bureau, Scott Chapman, Brian S. Cho, Aeree Chung, Eun Jung Chung, Hui Hsuan Chung, Christopher J.R. Clark, David L. Clements, Timothy A. Davis, Ilse De Looze, David J. Eden, Gayathri Athikkat-Eknath, George P. Ford, Yu Gao, Walter Gear, Haley L. Gomez, Richard De Grijs, Jinhua He, Luis C. Ho, Thomas M. Hughes, Sihan Jiao, Zhiyuan Li, Francisca Kemper

Physics and Astronomy Publications

Observing nearby galaxies with submillimeter telescopes on the ground has two major challenges. First, the brightness is significantly reduced at long submillimeter wavelengths compared to the brightness at the peak of the dust emission. Second, it is necessary to use a high-pass spatial filter to remove atmospheric noise on large angular scales, which has the unwelcome side effect of also removing the galaxy's large-scale structure. We have developed a technique for producing high-resolution submillimeter images of galaxies of large angular size by using the telescope on the ground to determine the small-scale structure (the large Fourier components) and a space …

Clmm: A Lsst-Desc Cluster Weak Lensing Mass Modeling Library For Cosmology, H. Wu

Physics Faculty Publications and Presentations

We present the v1.0 release of CLMM, an open source PYTHON library for the estimation of the weak lensing masses of clusters of galaxies. CLMM is designed as a stand-alone toolkit of building blocks to enable end-to-end analysis pipeline validation for upcoming cluster cosmology analyses such as the ones that will be performed by the Vera C. Rubin Legacy Survey of Space and Time-Dark Energy Science Collaboration (LSST-DESC). Its purpose is to serve as a flexible, easy-to-install, and easy-to-use interface for both weak lensing simulators and observers and can be applied to real and mock data to study the systematics …

Voltage Controlled Néel Vector Rotation In Zero Magnetic Field, Ather Mahmood, Will Echtenkamp, Mike Street, Jun Lei Wang, Shi Cao, Takashi Komesu, Peter Dowben, Pratyush Buragohain, Haidong Lu, Alexei Gruverman, Arun Parthasarathy, Shaloo Rakheja, Christian Binek

Peter Dowben Publications

Multi-functional thin films of boron (B) doped Cr₂O₃ exhibit voltage-controlled and nonvolatile Néel vector reorientation in the absence of an applied magnetic field, H. Toggling of antiferromagnetic states is demonstrated in prototype device structures at CMOS compatible temperatures between 300 and 400 K. The boundary magnetization associated with the Néel vector orientation serves as state variable which is read via magnetoresistive detection in a Pt Hall bar adjacent to the B:Cr₂O₃ film. Switching of the Hall voltage between zero and non-zero values implies Néel vector rotation by 90 degrees. Combined magnetometry, spin resolved inverse …

Triply Differential Positron And Electron Impact Ionization Of Argon: Systematic Features And Scaling, Robert D. Dubois, O. G. De Lucio

Physics Faculty Research & Creative Works

Triply differential data are presented for the 200 eV positron and electron impact ionization of argon. Six electron emission energies between 2.6 and 19 eV, and for scattering angles of 2, 3, and 4 degrees cover a momentum transfer range of 0.16 to 0.31 a.u. The binary and recoil intensities are fitted using a double peak structure in both regions, which, for the present kinematic conditions, are unresolved. The fitted peak intensities and angular positions are shown to have systematic dependences as a function of the momentum transfer and kinematic emission angle, respectively, and illustrate projectile charge effects. A comparison …

Quantum State Tomography Of Molecules By Ultrafast Diffraction, Ming Zhang, Shuqiao Zhang, Yanwei Xiong, Hankai Zhang, Anatoly A. Ischenko, Oriol Vendrell, Xiaolong Dong, Xiangxu Mu, Martin Centurion, Haitan Xu, R. J.Dwayne Miller, Zheng Li

Martin Centurion Publications

Ultrafast electron diffraction and time-resolved serial crystallography are the basis of the ongoing revolution in capturing at the atomic level of detail the structural dynamics of molecules. However, most experiments capture only the probability density of the nuclear wavepackets to determine the time-dependent molecular structures, while the full quantum state has not been accessed. Here, we introduce a framework for the preparation and ultrafast coherent diffraction from rotational wave packets of molecules, and we establish a new variant of quantum state tomography for ultrafast electron diffraction to characterize the molecular quantum states. The ability to reconstruct the density matrix, which …

Formation And Quench Of Homonuclear And Heteronuclear Quantum Droplets In One Dimension, Simeon I. Mistakidis, T. Mithun, P. G. Kevrekidis, H. R. Sadeghpour, P. Schmelcher

Physics Faculty Research & Creative Works

We Study The Impact Of Beyond Lee-Huang-Yang (LHY) Physics, Especially Due To Intercomponent Correlations, In The Ground State And The Quench Dynamics Of One-Dimensional Quantum Droplets With An Ab Initio Nonperturbative Approach. It Is Found That The Droplet Gaussian-Shaped Configuration Arising For Intercomponent Attractive Couplings Becomes Narrower For Stronger Intracomponent Repulsion And Transits Towards A Flat-Top Structure Either For Larger Particle Numbers Or Weaker Intercomponent Attraction. Additionally, A Harmonic Trap Prevents The Flat-Top Formation. At The Balance Point Where Mean-Field Interactions Cancel Out, We Show That A Correlation Hole Is Present In The Few-Particle Limit Of LHY Fluids As Well …

Molecular Structure Retrieval Directly From Laboratory-Frame Photoelectron Spectra In Laser-Induced Electron Diffraction, A. Sanchez, K. Amini, S. J. Wang, T. Steinle, B. Belsa, J. Danek, Anh-Thu Le, For Full List Of Authors, See Publisher's Website.

Physics Faculty Research & Creative Works

Ubiquitous to most molecular scattering methods is the challenge to retrieve bond distance and angle from the scattering signals since this requires convergence of pattern matching algorithms or fitting methods. This problem is typically exacerbated when imaging larger molecules or for dynamic systems with little a priori knowledge. Here, we employ laser-induced electron diffraction (LIED) which is a powerful means to determine the precise atomic configuration of an isolated gas-phase molecule with picometre spatial and attosecond temporal precision. We introduce a simple molecular retrieval method, which is based only on the identification of critical points in the oscillating molecular interference …

Enhancing Gravitational-Wave Science With Machine Learning, Elena Cuoco, Jade Powell, Marco Cavaglia, Kendall Ackley, For Full List Of Authors, See Publisher's Website.

Physics Faculty Research & Creative Works

Machine learning has emerged as a popular and powerful approach for solving problems in astrophysics. We review applications of machine learning techniques for the analysis of ground-based gravitational-wave (GW) detector data. Examples include techniques for improving the sensitivity of Advanced Laser Interferometer GW Observatory and Advanced Virgo GW searches, methods for fast measurements of the astrophysical parameters of GW sources, and algorithms for reduction and characterization of non-astrophysical detector noise. These applications demonstrate how machine learning techniques may be harnessed to enhance the science that is possible with current and future GW detectors.

2d Vs 3d Tracking In Bacterial Motility Analysis, Jacqueline Acres, Jay Nadeau

Physics Faculty Publications and Presentations

Digital holographic microscopy provides the ability to observe throughout a large volume without refocusing. This capability enables simultaneous observations of large numbers of microorganisms swimming in an essentially unconstrained fashion. However, computational tools for tracking large 4D datasets remain lacking. In this paper, we examine the errors introduced by tracking bacterial motion as 2D projections vs. 3D volumes under different circumstances: bacteria free in liquid media and bacteria near a glass surface. We find that while XYZ speeds are generally equal to or larger than XY speeds, they are still within empirical uncertainties. Additionally, when studying dynamic surface behavior, the …

Identification And Characterization Of Bisbenzimide Compounds That Inhibit Human Cytomegalovirus Replication, Nicole Falci Finardi, Hyeongjun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang

Physics and Astronomy Faculty Publications and Presentations

The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit HCMV replication. Of these compounds, we selected bisbenzimide compound RO-90-7501 for further study. We generated analogues of RO-90-7501 and found that one compound, MRT00210423, had increased anti-HCMV activity compared to RO-90-7501. Using a combination of compound analogues, microscopy and biochemical assays we found RO-90-7501 and MRT00210423 interacted with DNA. In single molecule microscopy experiments we found RO-90-7501, but not MRT00210423, was able to compact DNA, …