Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Theory and Algorithms
A Novel Method For Sensitivity Analysis Of Time-Averaged Chaotic System Solutions, Christian A. Spencer-Coker
A Novel Method For Sensitivity Analysis Of Time-Averaged Chaotic System Solutions, Christian A. Spencer-Coker
Theses and Dissertations
The direct and adjoint methods are to linearize the time-averaged solution of bounded dynamical systems about one or more design parameters. Hence, such methods are one way to obtain the gradient necessary in locally optimizing a dynamical system’s time-averaged behavior over those design parameters. However, when analyzing nonlinear systems whose solutions exhibit chaos, standard direct and adjoint sensitivity methods yield meaningless results due to time-local instability of the system. The present work proposes a new method of solving the direct and adjoint linear systems in time, then tests that method’s ability to solve instances of the Lorenz system that exhibit …
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Theses and Dissertations
miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …
Optimizing The Replication Of Multi-Quality Web Applications Using Aco And Wolf, Judson C. Dressler
Optimizing The Replication Of Multi-Quality Web Applications Using Aco And Wolf, Judson C. Dressler
Theses and Dissertations
This thesis presents the adaptation of Ant Colony Optimization to a new NP-hard problem involving the replication of multi-quality database-driven web applications (DAs) by a large application service provider (ASP). The ASP must assign DA replicas to its network of heterogeneous servers so that user demand is satisfied and replica update loads are minimized. The algorithm proposed, AntDA, for solving this problem is novel in several respects: ants traverse a bipartite graph in both directions as they construct solutions, pheromone is used for traversing from one side of the bipartite graph to the other and back again, heuristic edge values …