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Full-Text Articles in Inorganic Chemistry
A Library Of Coumarin-Enaminone Chemodosimeters For The Detection Of Analytes, Aaron Berrell Davis
A Library Of Coumarin-Enaminone Chemodosimeters For The Detection Of Analytes, Aaron Berrell Davis
Dissertations
Many anions and metal ions are of biological and environmental importance. This work describes our attempts to synthesize molecular probes to specifically target cyanide, zinc, cadmium and mercury as these species can often result in negative effects to the environment and the human body.
The work in this dissertation, describes the synthesis of a family of coumarin-enamine chemodosimeters, in a straightforward synthetic procedure, the reaction between 7-(diethylamino)-4-hydroxycoumarin and a primary amine. The work presented in this dissertation demonstrates that these molecules can play dual roles and therefore the work is split into two distinct parts: Part 1 describes one role …
The Effects Of Hydrogen Bonding On The Reactivity Of Synthetic Ada Repair Protein Analogues, Josiah G. Elsberg
The Effects Of Hydrogen Bonding On The Reactivity Of Synthetic Ada Repair Protein Analogues, Josiah G. Elsberg
Boise State University Theses and Dissertations
The study of bioinorganic chemistry is an important field, as it can provide insight as to why Nature has chosen certain active sites and structures within different kinds of metalloproteins. Ada repair protein, a zinc-containing metalloprotein, is one such topic of interest. Although it is known that Ada RP is able to repair methyl-phosphotriester backbone damage by self-methylation of one of its cysteine groups, the mechanism is not fully understood. Two pathways have been proposed: a dissociative pathway where the Zn-S bond becomes a zinc/sulfur ion pair, and an associative pathway where a four ringed σ-metathesis occurs. Previous research has …