Chemistry Commons^™

Preparation Of An Electrophilic 3-Methylindole Derivative: Difficulties In Forming A Stable, Suitable Material For The Preparation Of Tryptophan, Jason Boggs, Mariah Mcmasters, Robert W. Curley Jr., Michael J. Panigot

Journal of the Arkansas Academy of Science

In an attempt to prepare stereoselectively beta-deuterated tryptophan, N-protected indole-3-methanol compounds were prepared with model studies being done on undeuterated material. Conversion of these compounds to electrophilic species proved exceptionally difficult and resulted in very low yields or recovered starting material only. A summary of the current results utilizing N-tosyl indole-3-methanol will be presented as well as efforts using N-Boc indole-3-methanol.

Acidity Studies Of Deuterated Acids And Bases Commonly Used As Buffers In Nmr Studies, Rose M. Mcconnell, Walter E. Godwin, Brant Stanley, M. Shane Green

Journal of the Arkansas Academy of Science

Structure based drug development is currently considered to be an important strategy for drug discovery. This strategy requires that critical knowledge of the three dimensional binding site on receptor molecules be known. NMR studies are frequently employed to ascertain important structural data on individual proteins as well as complexes of proteins with ligands. Deuterium labeled acids and bases are frequently used as buffers in deuterium oxide solutions for NMR studies on the structural conformations of bioactive molecules. Since pH is an important factor in any study of the conformational and stereochemical aspects of biologically active molecules, deuterated buffers are an …

7li Nmr Of Normal Human Erythrocytes, Rao P. Gullapalli, Roger M. Hawk, Richard A. Komoroski

Journal of the Arkansas Academy of Science

Lithium has been known to be an effective medication for people with bipolar disorder. The mechanisms of action of lithium in the brain is not very well understood. NMR spectroscopy and imaging are effective both in determining lithium levels in tissue and brain. We have monitored lithium levels in red blood cells. We have been able to separate intra- and extracellular compartments of lithium using shift reagents, thereby obtaining T^1 's of both the compartments. Lithium uptake as a function of hematocrit was monitored weekly over a 3 week period. The time constant of 50 mM lithium uptake at 25°C …

Pulling The Wool Off, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

The Department of Agriculture has begun a three year project to study the potential for "chemical shearing" or, more correctly, biological defleecing.

The Use Of Pickled Wheat In Poultry Feeding, P Smetana

Journal of the Department of Agriculture, Western Australia, Series 4

FEEDING fungicides to poultry can result in harmful effects, to the birds themselves, and to their human consumers.

To prevent such effects it is advisable that wheat pickled with fungicides should not be included in poultry rations.