Chemistry Commons^™

Acidity Studies Of Deuterated Acids And Bases Commonly Used As Buffers In Nmr Studies, Rose M. Mcconnell, Walter E. Godwin, Brant Stanley, M. Shane Green

Journal of the Arkansas Academy of Science

Structure based drug development is currently considered to be an important strategy for drug discovery. This strategy requires that critical knowledge of the three dimensional binding site on receptor molecules be known. NMR studies are frequently employed to ascertain important structural data on individual proteins as well as complexes of proteins with ligands. Deuterium labeled acids and bases are frequently used as buffers in deuterium oxide solutions for NMR studies on the structural conformations of bioactive molecules. Since pH is an important factor in any study of the conformational and stereochemical aspects of biologically active molecules, deuterated buffers are an …