Small or Companion Animal Medicine Commons^™

Efficacy Of Oral Famotidine And 2 Omeprazole Formulations For The Control Of Intragastric Ph In Dogs, K Tolbert, S Bissett, A King, G Davidson, M Papich, E Peters, L Degernes

M Katherine Tolbert DVM, PhD, DACVIM

BACKGROUND: Little is known about the efficacy of commonly used acid suppressants on intragastric pH in dogs. OBJECTIVE: To compare the effect of oral famotidine, 2 formulations of omeprazole, and placebo on intragastric pH in dogs with a catheter-free, continuous pH monitoring system. ANIMALS: Six healthy adult mixed-breed colony dogs. METHODS: Utilizing a randomized, 4-way cross over, open-label study, dogs were administered famotidine PO (1.0-1.3 mg/kg q12h), omeprazole tablet (1.5-2.6 mg/kg q24h), omeprazole reformulated paste (RP) (Gastrogard, 1.5-2.6 mg/kg q24h), and placebo for 7 days followed by a 10-day washout period. Radiotelemetric pH capsules were placed with gastroscopy assistance to …