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Translational Medical Research Commons™
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Articles 31 - 60 of 208
Full-Text Articles in Translational Medical Research
Cystic Fibrosis Transmembrane Conductance Regulator Modulation May Improve Intestinal Inflammation In Adults With Cystic Fibrosis, Lauren G. Culver
Cystic Fibrosis Transmembrane Conductance Regulator Modulation May Improve Intestinal Inflammation In Adults With Cystic Fibrosis, Lauren G. Culver
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Ooi CY, Syed SA, Rossi L, Garg M, Needham B, Avolio J, Young K, Surette MG, Gonska T. Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation. Sci Rep. 2018 Dec 13;8(1):17834. https://doi.org/10.1038/s41598-018-36364-6
for a patient with cystic fibrosis experiencing small bowel obstruction.
Partial Outpatient Oral Antibiotic Treatment Of Infective Endocarditis Is Non-Inferior To Inpatient Intravenous Antibiotic Therapy, Nicholas J. Murphy
Partial Outpatient Oral Antibiotic Treatment Of Infective Endocarditis Is Non-Inferior To Inpatient Intravenous Antibiotic Therapy, Nicholas J. Murphy
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Iversen K, Ihlemann N, Gill SU, et al. Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis. N Engl J Med. 2019; 380:415-424. https://doi.org/10.1056/NEJMoa1808312
for a patient with infective endocarditis and intravenous drug use with desire to leave the hospital.
Baclofen As A Helpful Alternative In Treatment Of Painful Paroxysmal Attacks From Trigeminal Neuralgia, Samantha Ryan
Baclofen As A Helpful Alternative In Treatment Of Painful Paroxysmal Attacks From Trigeminal Neuralgia, Samantha Ryan
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Fromm GH, Terrance CF, Chattha AS. Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. Ann Neurol. 1984;15(3):240. https://doi.org/10.1002/ana.410150306
for a patient with paroxysmal attacks from trigeminal neuralgia who is unable to take carbamazepine.
Indwelling Pleural Catheterization Maximizes Functionality And Quality Of Life In Management Of Recurrent Malignant Pleural Effusions, Avinash Ramkissoon
Indwelling Pleural Catheterization Maximizes Functionality And Quality Of Life In Management Of Recurrent Malignant Pleural Effusions, Avinash Ramkissoon
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Davies HE, Mishra EK, Kahan BC, et al. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: The TIME2 randomized controlled trial. J Am Med Assoc. 2012;307(22):2383-2389. https://doi.org/10.1001/jama.2012.5535
for the management of recurrent malignant pleural effusions in a patient with metastatic renal cell carcinoma.
Exploring Alternative Treatment Options For A Patient With Heavy Menstrual Bleeding And Mistrust Of The Healthcare System, Rachel A. O'Dell
Exploring Alternative Treatment Options For A Patient With Heavy Menstrual Bleeding And Mistrust Of The Healthcare System, Rachel A. O'Dell
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Tinelli A, Gustapane S, D’Oria O, Licchelli M, Panese G. Nutraceuticals in fibroid management after ulipristal acetate administration: An observational study on patients’ compliance. International Journal of Gynecology and Obstetrics; 2022;156(1):133-138. https://doi.org/10.1002/ijgo.13692
for a patient with chronic, symptomatic anemia with menorrhagia and uterine fibroid.
The Importance Of Stigma Theory For Clinical Decisions Related To Diabetic Foot Amputations, Rachael Garcia, Callie Bartkowiak, Alison Nesbitt Do
The Importance Of Stigma Theory For Clinical Decisions Related To Diabetic Foot Amputations, Rachael Garcia, Callie Bartkowiak, Alison Nesbitt Do
Clinical Research in Practice: The Journal of Team Hippocrates
The authors examine the unconsidered impact of social stigma theory on the shared clinical decision-making process for a patient with foot osteomyelitis and MRSA bacteremia facing the prospect of an amputation.
Understanding How Social Determinants Of Health Are Integrated Within Clinical Decision Science, James Peter Meza Md, Phd, Nicholus H. Yee Md
Understanding How Social Determinants Of Health Are Integrated Within Clinical Decision Science, James Peter Meza Md, Phd, Nicholus H. Yee Md
Clinical Research in Practice: The Journal of Team Hippocrates
The editors reflect on the effect of Social Determinants of Health in Clinical Decision Science on questions of efficacy and effectiveness.
The Decision I Never Thought I Would Have To Make, Mary Nixon
The Decision I Never Thought I Would Have To Make, Mary Nixon
Clinical Research in Practice: The Journal of Team Hippocrates
A brief essay on how the COVID pandemic has changed how we think about medicine and our patients.
Radiation Therapy For Older Women With Early Breast Cancer: An Unnecessary Hardship, Lauren E. Shawver
Radiation Therapy For Older Women With Early Breast Cancer: An Unnecessary Hardship, Lauren E. Shawver
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report appraising:
Kunkler IH, Williams LJ, Jack WJ, Cameron DA, Dixon JM; PRIME II investigators. Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial [published correction appears in Lancet Oncol. 2015 Mar;16(3):e105]. Lancet Oncol. 2015;16(3):266-273. https://doi.org/10.1016/S1470-2045(14)71221-5
for an older patient seeking treatment for Stage 1 Ductal Breast Carcinoma
Lisdexamfetamine Is An Effective Monotherapy For Moderate To Severe Binge Eating Disorder, Benjamin Young
Lisdexamfetamine Is An Effective Monotherapy For Moderate To Severe Binge Eating Disorder, Benjamin Young
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using
McElroy SL, Hudson J, Ferreira-Cornwell MC, Radewonuk J, Whitaker T, Gasior M. Lisdexamfetamine dimesylate for adults with moderate to severe binge eating disorder: Results of two pivotal phase 3 randomized controlled trials. Neuropsychopharmacology. 2016;41(5):1251-1260. https://doi.org/10.1038/npp.2015.275
for a young woman requesting a novel pharmacological intervention for a Binge Eating Disorder (BED).
Enhanced Recovery After Surgery (Eras) Protocols Decrease Length Of Hospital Stay And Maintain Functional Independence In Elderly Patients Undergoing Colorectal Surgery, Kristen Hawes
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using
Ostermann S, Morel P, Chalé JJ, et al. Randomized controlled trial of enhanced recovery program dedicated to elderly patients after colorectal surgery. Dis Colon Rectum. 2019;62(9):1105-1116. https://doi.org/10.1097/DCR.0000000000001442
for an elderly patient undergoing colorectal surgery.
Insulin Therapy Versus Oral Sitagliptin For Treatment Of Latent Autoimmune Diabetes In Adults, Sarah Nasser
Insulin Therapy Versus Oral Sitagliptin For Treatment Of Latent Autoimmune Diabetes In Adults, Sarah Nasser
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Hals IK, Fiskvik Fleiner H, Reimers N, et al. Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial. Diabetes Obes Metab. 2019;21(10):2219-2227. https://doi.org/10.1111/dom.13797
for a patient with an aversion to needles.
Indications For Esophagogastroduodenoscopy In Anemic Patients Without Overt Signs Of Upper Gastrointestinal Bleeding, Geoffrey M. Ginter
Indications For Esophagogastroduodenoscopy In Anemic Patients Without Overt Signs Of Upper Gastrointestinal Bleeding, Geoffrey M. Ginter
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Majid S, Salih M, Wasaya R, Jafri W. Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms. BMC Gastroenterol. 2008;8:52. https://doi.org/10.1186/1471-230X-8-52
for a patient with a complicated presentation of severe anemia
Exercise Therapy Improves Quality Of Life In Patients With Postural Orthostatic Tachycardia Syndrome (Pots), Heya Batah, Scott L. Baughan
Exercise Therapy Improves Quality Of Life In Patients With Postural Orthostatic Tachycardia Syndrome (Pots), Heya Batah, Scott L. Baughan
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using
George SA, Bivens TB, Howden EJ, et al. The international POTS registry: Evaluating the efficacy of an exercise training intervention in a community setting. Heart Rhythm. 2016;13(4):943-950. https://doi.org/10.1016/j.hrthm.2015.12.012
for exercise efficacy in patients with POTS.
Bridging The Gap From Clinical Research Done On Populations To The Care Of An Individual Patient, James Peter Meza
Bridging The Gap From Clinical Research Done On Populations To The Care Of An Individual Patient, James Peter Meza
Clinical Research in Practice: The Journal of Team Hippocrates
The Editor reflects on the application of clinical scales to Clinical Decision Making.
Metformin Monotherapy Is An Effective Alternative For Management Of Gestational Diabetes Mellitus In Patients Refusing Insulin Monotherapy, Tyler Russeth
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Ghomian N, Vahed SHM, Firouz S, Yaghoubi MA, Mohebbi M, Sahebkar A. The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial. J Cell Physiol. 2019;234(4):4695-4701. https://doi.org/10.1002/jcp.27238
for a patient with gestational diabetes mellitus (GDM) who does not wish to undergo insulin monotherapy.
Weight Loss As Sole Treatment For Obstructive Sleep Apnea In A Patient With Significant Risks Posed By Daytime Sleepiness, Steven Daws
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Kuna ST, Reboussin DM, Borradaile KE, Sanders MH, Millman RP, Zammit G, Newman AB, Wadden TA, Jakicic JM, Wing RR, Pi-Sunyer FX, Foster GD; Sleep AHEAD Research Group of the Look AHEAD Research Group. Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes. Sleep. 2013 May 1;36(5):641-649A. https://doi.org/10.5665/sleep.2618
to inform whether weight loss alone can adequately and promptly treat OSA in a patient with high-risk employment and an aversion to more invasive intervention.
A Light In The Dark: End-Of-Life Conversations In Advanced Cancer Patients Improve Caregiver Grief, Nicole Meeks
A Light In The Dark: End-Of-Life Conversations In Advanced Cancer Patients Improve Caregiver Grief, Nicole Meeks
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Wright AA, Zhang B, Ray A, Mack JW, Trice E, Balboni T, Mitchell SL, Jackson VA, Block SD, Maciejewski PK, & Prigerson HG. Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA. 2008;300(14):1665-1673. https://doi.org/10.1001/jama.300.14.1665
for a patient with end stage cancer and an anxious caregiver.
Does Hiv Status Confer A Higher Risk Of Acquiring Covid-19? Using Clinical Decision Science To Combat Patients’ Anxiety, Camilo Guzman
Does Hiv Status Confer A Higher Risk Of Acquiring Covid-19? Using Clinical Decision Science To Combat Patients’ Anxiety, Camilo Guzman
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using
del Amo J, Polo R, Moreno S, et al. “Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy.” Annals of Internal Medicine. 2020;173(7):536-541. doi.org/10.7326/m20-3689
for a patient with HIV and concerns about COVID-19 for immunocompromised individuals.
A Moral Dilemma: The Use Of Zinc In Patients Hospitalized With Covid Pneumonia, Ebony M. Manigault, Laura Donohue, Elizabeth Moore, Yara Abuaita
A Moral Dilemma: The Use Of Zinc In Patients Hospitalized With Covid Pneumonia, Ebony M. Manigault, Laura Donohue, Elizabeth Moore, Yara Abuaita
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Yao JS, Paguio JA, Dee EC, Tan HC, Moulick A, Milazzo C, Jurado J, Della Penna N, Celi LA. The minimal effect of zinc on the survival of hospitalized patients with COVID-19: an observational study. Chest. 2021 Jan;159(1):108-111. https://doi.org/10.1016/j.chest.2020.06.082
for a patient hospitalized with COVID pneumonia requiring high flow oxygen.
The Effect Of Nurse Case Coordination On Management Of Chronic Conditions, Aayush Mittal Ms-Hsm
The Effect Of Nurse Case Coordination On Management Of Chronic Conditions, Aayush Mittal Ms-Hsm
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Ishani A, Greer N, Taylor BC, et al. Effect of nurse case management compared with usual care on controlling cardiovascular risk factors in patients with diabetes: a randomized controlled trial. Diabetes Care. 2011;34(8):1689-1694. https://doi.org/10.2337/dc10-2121
for a patient requiring care coordination for management of hypertension, diabetes, and hyperlipidemia.
Conjugated Estrogen Is An Effective Option To Manage Chronic Gi Bleeding In A Patient With Atrial Fibrillation And End-Stage Renal Disease, Matthew T. Compton, Krupa Patel
Conjugated Estrogen Is An Effective Option To Manage Chronic Gi Bleeding In A Patient With Atrial Fibrillation And End-Stage Renal Disease, Matthew T. Compton, Krupa Patel
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Livio M, Mannucci PM, Viganò G, Mingardi G, Lombardi R, Mecca G, Remuzzi G. Conjugated estrogens for the management of bleeding associated with renal failure. N Engl J Med. 1986;315:731-735 https://doi.org/10.1056/NEJM198609183151204
for a patient with chronic GI bleeding and complicated pro- and anti-coagulation needs.
Interventional Treatment With The Transjugular Intrahepatic Portosystemic Shunt (Tips) Procedure May Offer A Preferable Alternative To Systemic Anticoagulation In Patients With Cirrhosis And Portal Vein Thrombosis, Molly N. Pantelic
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report appraising:
Wang Z, Jiang MS, Zhang HL, et al. Is post-tips anticoagulation therapy necessary in patients with cirrhosis and portal vein thrombosis? A randomized controlled trial. Radiology. 2016;279(3):943-951. https://doi.org/10.1148/radiol.2015150369
for a patient with cryptogenic cirrhosis, gastroesophageal varices, pancreatic cancer, and portal vein thrombosis.
Luspatercept Diminishes The Need For Red Blood Cell Replacement In Transfusion-Dependent Β-Thalassemia Patients, Joudeh B. Freij
Luspatercept Diminishes The Need For Red Blood Cell Replacement In Transfusion-Dependent Β-Thalassemia Patients, Joudeh B. Freij
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report appraising:
Cappellini MD, Viprakasit V, Taher AT, et al. A phase 3 trial of luspatercept in patients with transfusion-dependent β-thalassemia. N Engl J Med. 2020;382(13):1219-1231. https://doi.org/10.1056/NEJMoa1910182
for a patient with transfusion-dependent beta-thalassemia.
Sleeve Gastrectomy Improves Metabolic Syndrome In Psychologically Stable Patients With Schizophrenia, Irene Chen
Sleeve Gastrectomy Improves Metabolic Syndrome In Psychologically Stable Patients With Schizophrenia, Irene Chen
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report appraising:
Archid R, Archid N, Meile T, Hoffman J, Wulff D, Teufel M, Muthig M, Quante M, Konigsrainer A, Lange J. Patients with schizophrenia do not demonstrate worse outcome after sleeve gastrectomy: a short-term cohort study. Obesity Surgery. 2019;29:506-510. https://doi.org/10.1007/s11695-018-3578-0
for a patient with schizophrenia and obesity.
External Beam Radiation Therapy Carries Lower Risk Of Sexual Dysfunction As Compared To Radical Prostatectomy In Treatment Of Patients With Localized Prostate Cancer, Aamod S. Dekhne
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report appraising:
Donovan JL, Hamdy FC, Lane JA, et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. N Engl J Med. 2016;375(15):1425-1437. https://doi.org/10.1056/NEJMoa1606221
for a patient with localized prostate cancer and concerns regarding future sexual dysfunction.
Clinical Decision Science: Experience Can Be Shared; Can It Be Taught?, James Peter Meza
Clinical Decision Science: Experience Can Be Shared; Can It Be Taught?, James Peter Meza
Clinical Research in Practice: The Journal of Team Hippocrates
The editor reflects on the biopsychosocial model of clinical decision making and whether it can be taught in clinical medicine.
Low-Dose Psoralen–Uv-A Maintenance Therapy Prolongs Disease-Free Remission Rates In Mycosis Fungoides Patients, Joshua M. Brady
Low-Dose Psoralen–Uv-A Maintenance Therapy Prolongs Disease-Free Remission Rates In Mycosis Fungoides Patients, Joshua M. Brady
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using Vieyra-Garcia P, Fink-Puches R, Porkert S, et al. Evaluation of Low-Dose, Low-Frequency Oral Psoralen–UV-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides. JAMA Dermatology. 2019;155(5):538. https://doi.org/10.1001/jamadermatol.2018.5905 for a patient weighing whether to continue treatment in light of socioeconomic circumstances.
Medical Social Science And Clinical Decision Science, James Peter Meza
Medical Social Science And Clinical Decision Science, James Peter Meza
Clinical Research in Practice: The Journal of Team Hippocrates
Exploring the curricular link between Medical Social Science and Clinical Decision Science in the development of a physician.
Il-1 Inhibitor Anakinra Is An Effective Alternative To Standard Treatments For Reducing Pain Due To Acute Gout Flare, Cheryl Craig
Il-1 Inhibitor Anakinra Is An Effective Alternative To Standard Treatments For Reducing Pain Due To Acute Gout Flare, Cheryl Craig
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report appraising Janssen CA, Voshaar MAHO, Vonkeman HE, et al. Anakinra for the treatment of acute gout flares: a randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial. Rheumatology. 2019;58(8):1344-1352. https://doi.org/10.1093/rheumatology/key402 for a patient with an acute gouty attack refractory to standard treatment.