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Full-Text Articles in Influenza Humans
Glycan Shielding Of The Influenza Virus Hemagglutinin Elicits Evasion Of The Adaptive Immune Response And T-Cell-Driven Pathology, Keith C. Wanzeck
Glycan Shielding Of The Influenza Virus Hemagglutinin Elicits Evasion Of The Adaptive Immune Response And T-Cell-Driven Pathology, Keith C. Wanzeck
Theses and Dissertations (ETD)
Three separate influenza pandemics have emerged in the human population since 1918, each characterized by viruses that lack N-linked glycosylation sites on the globular head of the hemagglutinin protein. In contrast, recent non-pandemic isolates have acquired such sites. Here we constructed isogenic viruses containing differing numbers of additional N-linked glycosylation sites to assess the impact on the host immune response. These studies show that mice infected with a glycosylated virus remain susceptible to challenge with a non-glycosylated virus, glycosylated viruses elicit an inferior immune response, and in this context T-cell pathology and death may occur. We conclude from these data …
Send Only Your Serious Cases: Delivering Flu To Toronto: An Anthropological Analysis Of The 1918 -1919 Influenza Epidemic In Toronto, Ontario, Canada., Karen Slonim
Publications and Scholarship
This project looks at the 1918-19 pandemic influenza experience in Toronto, Ontario, Canada. Based on historical records (most notably death registries and archival material) this work strives to understand the social, biological, and environmental conditions that facilitated the spread of this virulent microorganism throughout the city. Grounded in the anthropological frameworks of evolutionary medicine, political economy and syndemics, this dissertation is designed to present a qualitative historical account of the pandemic in one of Canada's largest cities. This piece adds to the growing body of literature aimed at documenting one of the most catastrophic events of the 20th century. It …