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Community Health and Preventive Medicine Commons™
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Articles 1 - 5 of 5
Full-Text Articles in Community Health and Preventive Medicine
Is Adiposity Related To Repeat Measures Of Blood Leukocyte Dna Methylation Across Childhood And Adolescence?, Luke Montrose
Is Adiposity Related To Repeat Measures Of Blood Leukocyte Dna Methylation Across Childhood And Adolescence?, Luke Montrose
Public Health and Population Science Faculty Publications and Presentations
Epigenetic modifications such as DNA methylation may influence gene expression and phenotypes, including obesity in childhood. The directionality of this relationship is nevertheless unclear, and some evidence suggests that adiposity modifies the epigenome, rather than the other way around. In this pilot study, we utilize data from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) study to examine whether measures of adiposity in childhood and early adolescence are associated with repeated measures of blood leukocyte DNA methylation at LINE-1 repetitive elements and two genes implicated in growth and adiposity: H19 and HSD11B2. Longitudinal epigenetic data were generated …
The Impact Of Maternal Nutrition On The Development And Severity Of Generalized Anxiety Disorders In Rodent And Non-Human Primate Studies, Esmeralda H. Cardoso
The Impact Of Maternal Nutrition On The Development And Severity Of Generalized Anxiety Disorders In Rodent And Non-Human Primate Studies, Esmeralda H. Cardoso
University Honors Theses
Generalized anxiety has become more prevalent among children and adolescents in the United States which impacts their health and livelihood. Maternal nutrition during pregnancy is purported to play a role in cognitive development and mental health during childhood, adolescence, and into adulthood. The Developmental Origins of Health and Disease theory suggests maternal nutrition before and during pregnancy influences transgenerational susceptibility, onset, and severity of disease through epigenetic mechanisms that then impact the child’s overall health, including cognitive development and mental health later in life. A literature review of rodents and non-human primate studies was conducted to explore the association between …
Simulated Wildfire Smoke Significantly Alters Sperm Dna Methylation Patterns In A Murine Model, Adam Schuller, Chiara Bellini, Timothy G. Jenkins, Matthew Eden, Jacqueline Matz, Jessica Oakes, Luke Montrose
Simulated Wildfire Smoke Significantly Alters Sperm Dna Methylation Patterns In A Murine Model, Adam Schuller, Chiara Bellini, Timothy G. Jenkins, Matthew Eden, Jacqueline Matz, Jessica Oakes, Luke Montrose
Public Health and Population Science Faculty Publications and Presentations
Wildfires are now a common feature of the western US, increasing in both intensity and number of acres burned over the last three decades. The effects of this changing wildfire and smoke landscape are a critical public and occupational health issue. While respiratory morbidity due to smoke exposure is a priority, evaluating the molecular underpinnings that explain recent extrapulmonary observations is necessary. Here, we use an Apoe−/− mouse model to investigate the epigenetic impact of paternal exposure to simulated wildfire smoke. We demonstrate that 40 days of exposure to smoke from Douglas fir needles induces sperm DNA methylation changes …
Influence Of Woodsmoke Exposure On Molecular Mechanisms Underlying Alzheimer’S Disease: Existing Literature And Gaps In Our Understanding, Adam Schuller, Luke Montrose
Influence Of Woodsmoke Exposure On Molecular Mechanisms Underlying Alzheimer’S Disease: Existing Literature And Gaps In Our Understanding, Adam Schuller, Luke Montrose
Public Health and Population Science Faculty Publications and Presentations
Woodsmoke poses a significant health risk as a growing component of ambient air pollution in the United States. While there is a long history of association between woodsmoke exposure and diseases of the respiratory, circulatory, and cardiovascular systems, recent evidence has linked woodsmoke exposure to cognitive dysfunction, including Alzheimer’s disease dementia. Alzheimer’s disease is a progressive neurodegenerative disorder with largely idiopathic origins and no known cure. Here, we explore the growing body of literature which relates woodsmoke-generated and ambient air pollution particulate matter exposure to Alzheimer’s disease (AD) onset or exacerbation, in the context of an inflammation-centric view of AD. …
Epigenetic Modifications Of Human Placenta Associated With Preterm Birth, Drissa Toure
Epigenetic Modifications Of Human Placenta Associated With Preterm Birth, Drissa Toure
Theses & Dissertations
Preterm birth is a complex multifactorial process. Despite the well-known role of the placenta in supporting the fetal development and maternal-fetal tolerance, the placental epigenetic modifications and preterm birth (PTB) remains poorly understood and under investigated. Various maternal and environment factors can influence epigenetic programming during fetal development to affect the functioning and structures of organs, including the placenta, which can lead to adverse pregnancy outcomes, including PTB. The understanding of the placental epigenetic alterations and maternal determinants associated with PTB are apparently indispensable for the development of actual diagnosis and methods of prevention and treatment of premature labor. The …