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Articles 1 - 2 of 2
Full-Text Articles in Behavior and Behavior Mechanisms
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Electronic Thesis and Dissertation Repository
Nicotine dependence is causally linked to increased risk of mood/anxiety disorders in later life. Females are reported to experience a higher prevalence of anxiety/depressive disorders and challenges in smoking cessation therapies, suggesting a potential sex-specific response to nicotine exposure and mood/anxiety disorder risk. However, pre-clinical evidence of sex-specific responses to adolescent nicotine exposure is unclear. Thus, to determine any sex differences in anxiety/depressive-related outcomes, adolescent male and female Sprague Dawley rats received nicotine (0.4 mg/kg; 3x daily) or saline injections for 10 consecutive days, followed by behavioural testing, in-vivo electrophysiology and Western Blot analyses. Our results revealed that adolescent nicotine …
Cerebral Hyperemia Is Not A Sole Modulator Of Postexercise Executive Function Benefit: Evidence From Hypercapnia And Passive Exercise, Mustafa Shirzad
Cerebral Hyperemia Is Not A Sole Modulator Of Postexercise Executive Function Benefit: Evidence From Hypercapnia And Passive Exercise, Mustafa Shirzad
Electronic Thesis and Dissertation Repository
A single bout of exercise improves executive function (EF); however, the physiological mechanism(s) contributing to this benefit are unclear. One candidate mechanism for the benefit is an exercised-mediated increase in cerebral blood flow (CBF) that improves neural efficiency. In my thesis, I conducted two experiments to assess the relationship between an increase in CBF and EF. In Experiment 1, I examined passive exercise, and in Experiment 2, I examined a 2.5% hypercapnic environment given that both interventions increase CBF independent of the metabolic demands of volitional muscle activity. Experiment 1 indicated that passive exercise increased CBF and was associated with …