Nanotechnology Commons^™

Building For Safety: Design Considerations For Refuge Areas In Tall Buildings From Quality Management Perspective, Enass. A. Salama, Heba. M. Gaber, Ahmed. M. Selim

Journal of Engineering Research

New El Alamein City is one of the largest urban projects in Egypt, and the largest project on the north coast. Tall buildings (super high-rise buildings) are considered the prevailing trend by architectural designers to obtain the maximum view of the Mediterranean Sea. The provision of safety evacuation in emergencies for these buildings’ occupants is a crucial challenge from the Quality management point of view. In contrast, there are no sufficient architectural design guidelines for the tall buildings provided by the Egyptian code for protecting buildings from fire, especially the design of the refuge areas. This study aims to investigate …

Effect Of Organic Compounds Additives For Biodiesel Fuel Blends On Diesel Engine Vibrations And Noise Characteristics, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Mahmoud Soliman Eng.

Journal of Engineering Research

The extensive consumption of petroleum fuel directly correlates with both hazardous exhaust emissions affecting human health and contributing to global warming. Initially, biodiesel fuels were proposed as a viable alternative to address these issues. This perspective finds support in numerous published studies that highlight how the significant catalytic effect of nanoparticles allows for their integration into biodiesel blends, resulting in improved combustion characteristics, reduced exhaust emissions, and enhanced performance. This study investigates the impact of additives on biodiesel fuel properties and its effects on engine performance metrics such as brake power, brake thermal efficiency, exhaust gas concentration, engine vibration, and …

Investigation Into The Impact Of Ammonia Hydroxide On Performance And Emissions In Compression Ignition Engines Utilizing Diesel/Biodiesel Blends, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Mohammed Osama Elsamadony Dr. Eng., Abdallah Salem Abdalhadi

Journal of Engineering Research

In recent times, there has been a surge in scientific endeavors aimed at combating global warming. Various methods have been employed to address this issue, including the substitution of fossil fuels with more environmentally sustainable alternatives and the combination of different fuel types. This can be achieved through the integration of innovative injection systems and the simultaneous combustion of alternative fuels alongside fossil fuels, or by modifying fuel injection systems such as in the PCCI, RCCI, or HCCI systems. In a particular research investigation, a blend of ammonia hydroxide and diesel, with volume percentages of 7.5% and 92.5% respectively, was …

Enhancing Diesel Engine Performance By Directly Injecting Blends Of Ammonium Hydroxide And Including Liquid Petroleum Gas As A Partially Premixed Charge, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Mohammed Osama Elsamadony Dr. Eng., Abdallah Salem Abdalhadi

Journal of Engineering Research

Recently, scientists have made significant strides in addressing or mitigating environmental issues. Researchers have adopted various approaches to tackle these issues, such as replacing fossil fuels with more environmentally friendly alternatives or blending multiple fuel types. This can be achieved by either integrating these two trends through the use of new injection systems and simultaneous combustion of alternative fuels with fossil fuels or by modifying fuel injection systems, exemplified by the PCCI, RCCI, or HCCI systems. Consequently, these methods have proven effective in reducing environmental pollutants, enhancing thermal efficiency, and decreasing specific fuel consumption. In this study, ammonia hydroxide and …

Experimental Investigation On Combustion And Emission Characteristics Of Co-Combustion Of Pulverized Biomass With Diesel Fuel In An Industrial Burner, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Ahmed Abou El-Yazied Prof. Dr., Saad El-Malla Dr. Eng.

Journal of Engineering Research

This study presents the combustion and emission results obtained from a laboratory furnace equipped with a 35 kW industrial burner that utilizes co-combustion of pulverized biomass and diesel fuel. The experiment compared the co-combustion of pulverized biomass and diesel fuel with diesel fuel alone. Three different loading ratios of pulverized biomass from residual beet samples were used. Temperatures were measured at various positions inside the furnace to analyze combustion performance. It was observed that increasing the biomass loading ratios led to higher flame temperatures and improved combustion compared to diesel fuel alone. The concentrations of pollutants such as Co, HC, …

Analyse Permeability And Integration In Architectural Landscapes To Create A Seamless Environment, Ensuring Ease Of Movement And Blending With The Surrounding Environment., Amira Fawzy Helmy Almaz

Journal of Engineering Research

The study explores the understanding of connectedness, integration, and axial route selection in urban parks using space syntax. It uses the Theory of Space Syntax to analyze georeferenced photographs and urban morphology data. The findings suggest that creating rules for integration and linkage that directly influence users' decision-making processes could lead to significant improvements in urban parks.

The study discusses space syntax as an architectural concept that views architecture as an interface between public and private spaces, analyzing landscapes through mirroring and focusing on internal configurations and exteriors. The study proposes a method to measure permeability and integration in urban …

Cfd Study On Two-Phase Flow Patterns In A Pipe With 90º Elbow In Different Operating Conditions, Hagar Alm-Eldin Bastawissi, Mohammed Ahmed Khafagy, E. A. El Shenawy Prof. Dr., Ahmed M. Salem Dr

Journal of Engineering Research

Recently, CFD has offered a technological solution for modelling multi-phase flow in which we can make endless simulations with reduced expenses and effort in high accuracy results; we shall also mention that experimental studies have limitations for safety considerations when experimenting with flow in high temperature or pressure values or medium nature as in nuclear or chemical flows.In this paper, we used the ANSYS FLUENT CFD program to simulate the two-phase flow in a pipe to study the effect of attaching a 90-degree elbow fitting to the piping system, seeking to find out the change in the pattern and resulting …

تقنيات الاضاءة الصناعية وتأثيرها فى الفراغ السكنى على السلوك الانسانى, Samah Kamal Elfeky, Walaa Ahmad Nour, Lobna Abdelfatah Agha

Journal of Engineering Research

* Lighting is considered of main items in daily life begining from natural Lighting to industrial lighting. with all of it's different shapes . it is considerdone of the most important data that point Blank spaces and works to show architectural spaces, aesthetic values through being sharp and weak, ensure borders show texture or hide Features, suggest wideness, narrowness of space as the most beautiful design don't see beautiful without good lighting which designed carefully.Due to diversity of human activities, architictums spaces and it is wideness. Increased dependence on industrial Lighting to strengthen Job of performance, beauty of internal, external …

An Injectable In Situ Forming Collagen/Alginate/Caso4 Composite Hydrogel For Tissue Engineering Applications: Optimization, Characterization And In Vitro Assessments, Samar A. Salim, Samar A. Salim

Nanotechnology Research Centre

In situ injectable hydrogels are effectively employed to fill irregular cavitary bone defects with initiating bone growth in targeted areas. Herein, an injectable composited hydrogel composed of collagen and alginate cross-linked in situ using different concentrations of calcium sulfate (0.15, 0.3 and 0.6%, wt./v) was synthesized. Recently, CaSO4 is frequently supported as a bone graft material for bone regeneration, owing to its biocompatibility and osteoconductive properties. Moreover, hydroxyapatite (Hap) after salinization-step by (3-Aminopropyl) triethoxysilane (APTES) was incorporated for further enhancing the osteoconductive property of injected hydrogels. All fabricated hydrogels were characterized by SEM, FTIR and XRD analyses. While physiochemical characteristics …

Development Of Liposomes Using Microfluids For Delivery Of Mir-205, Victoria Herrera, Rahul Tiwari, Meghana Kolli, Neeraj Chauhan, Eswara Naga Hanuma Kumar Ghali, Subhash C. Chauhan, Murali Yallapu

Research Symposium

Background: The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. miR-205 is a tumor suppressor in various cancers. However, the delivery of miR-205 is an unmet clinical need. Thus, the development of liposomal formulation platform to deliver miR-205 is highly sought. The most common applications of liposome formulations are vaccines and anticancer formulations (e.g., mRNA, small molecule drugs). However, large-scale production with precise control of size and size distribution of the lipid-based drug delivery systems (DDSs) is one of the major challenges in the pharmaceutical industry. The objective of this study is to …

Characterization Of Biological Particles Using An Integrated Hyperspectral Imaging And Machine Learning, Kaeul Lim, Arezoo Ardekani

Graduate Industrial Research Symposium

Hyperspectral imaging (HSI) is a promising modality in medicine with many potential applications. This study focuses on developing a label-free lipid nanoparticle characterization method using a convolutional neural network (CNN) analysis of HSI images. The HSI data, hypercube, consists of a series of images acquired at different wavelengths for the same field of view, providing continuous spectra information for each pixel. Three distinct liposome samples were collected for analysis. Advanced image preprocessing and classification methods for HSI data were developed to differentiate liposomes based on their material compositions. Our machine learning-based classification method was able to distinguish different liposome types …

The Influence Of Green Building Design On Tourists' Intention To Stay In Eco-Friendly Hotels: A Study On Perceptions And Preferences, Enas Al Sayed Salama Dr., Gehad Nasr Abdelsalam Dr.

Journal of Engineering Research

Green building design involves integrating sustainable and environmentally friendly practices into the construction and operation of buildings, including hotels, with the goal of minimizing the adverse impact on the environment. This paper delves into the pivotal role of green building design and eco-service provision within the context of green hotels. The aim is to investigate the interconnections among tourists' environmental concerns, their perceived significance of green building design, and their intention to choose green hotels.

To enhance the understanding of tourist behavior and its implications for tourism in Egypt, a questionnaire was administered in Sharm El Sheikh, a prominent Egyptian …

Experimental Study Of Bent Glass Curtain Walls., Sarah Said Abd El Kariem, Moustafa El Shami, Mahmoud El Nagar

Journal of Engineering Research

A Bent Laminated Glass is commonly used in the residential and commercial structures, its methodology is not present in the curves and tables at the ASTM E1300. Therefore, it has become a need for architects to use basis for this type of glass. To the best of authors ‘knowledge, no one study the bent laminated glass in details. A variety of safety glass that has lately gained popularity in the construction sector is modern laminated glass. Given that it offers a safe failover capability, it is perfect for the automotive industry. Double-lite glass is produced using two or more …

Market Analysis And Bidding Strategy Of Hybrid Renewable Energy Systems Considering Emissions, Fatma Elzahraa, Mohamed Elnemr, Samir Dawoud

Journal of Engineering Research

The competition in the electricity markets makes it difficult to choose a suitable strategy for maximizing profit while reducing harmful emissions. To have an adequate energy price for consumers while minimizing the harmful emissions to the atmosphere and maximizing profits of all participants in the electricity market needs an aggressive bidding strategy. Developing these bidding strategies with the integration of renewable energy (RE) in the electricity market became important. This research studies various bidding strategies for maximizing profits in the deregulated energy market since participants are keen on developing bidding strategies considering emissions. These bidding strategies will consider the integration …

Effects Of Fuel Equivalence Ratio And Swirl Vane Angles On Premixed Burner Turbulent Flame Combustion Characteristics, Medhat Elkelawy Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., Ibrahim Ali Mousa Eng., Mohamed M. Abdel-Raouf Ibrahim Dr. Eng.

Journal of Engineering Research

A turbulent flow field has a major effect on the premixed flame structure and temperature distribution that specifically determines the effectiveness of the burned fuel and the amounts of produced emissions. However, the premixed flame tangential and axial velocity distribution through the flame length help to predict the combustion and emissions attributes of the burned fuel. In this regard, an experimental and analytical investigation on premixed turbulent burners at different equivalence fuel-air ratios with different swirl vane angles has been achieved in the present work to assess the combustion performance and emissions characteristics. A theoretical methodology was carried out to …

Enhancing The Performance Of Conventional Solar Still Using The Nano-Doped Paint (Ndp) Coating, Hagar Alm-Eldin Bastawissi Prof.Dr, Nermin Elgendy Engineer, Ayman R. El-Tohamy

Journal of Engineering Research

Nations are throughout the entire globe continuously confronting the problem of potable water shortage. Recently, it has been thought that using solar energy to desalinate brackish water offers a practical answer to the world's water crises. The output of these stills, is meager, and academics haven't done much to boost it in any way. Solar distillers have been proposed as an efficient method to produce potable water. In recent years, saltwater has produced drinking water by various ways. The efficiency of a solar distiller is significantly influenced by various factors, most important factor of them is the absorber surface. In …

Engine Performance And Emissions Improvement Study On Direct Injection Of Diesel/Ammonia Dual Fuel By Adding Cng As Partially Premixed Charge, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi Prof. Dr., Mohammed Osama Elsamadony Dr. Eng., Abdallah Salem Abdalhadi Eng.

Journal of Engineering Research

Researchers have recently moved on in their studies to find a solution to prevent or reduce this problem. There have been directions taken by researchers to solve the problem, including, replacing fossil fuels with environmentally friendly types or by combining two or more types of fuel. This is by modifying fuel injection systems as appears in the PCCI, RCCI, or HCCI systems, or working to integrate the two trends by using new injection systems and burning alternative fuels with fossil fuels. Therefore, the trend has good results on the specific consumption of fuel, raising thermal efficiency, and working to reduce …

Experimental Study On The Impact Of Secondary Air Injection And Different Swirl Van Angles On Premixed Turbulent Flame Propagation And Emission Behaviors, Medhat Elkelawy Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., Ibrahim Ali Mousa Eng., Mohamed M. Abdel-Raouf Ibrahim Dr. Eng.

Journal of Engineering Research

The objective of the present paper is to investigate experimentally the flame characteristics utilizing different secondary air inlet direction for different primary air swirl numbers and equivalence fuel-air ratios. In this study, an experimental test rig was carried out to investigate the flame temperature and emission behavior with flame length at the equivalence fuel-air ratios taken0.96, 0.80, 0.70, and 0.60, and swirl vane angles were varied as 20, 30, 45, and 60° to generate different swirl numbers of 0.26, 0.416, 0.71 and 1.23, respectively. In addition to the introduction of secondary air in test combustor, whereas the primary air and …

The Effect Of An Existing Tunnel And A Newly Excavated Tunnel On Ground Loss Beneath Sand Slope-3d Numerical Study, Ashraf Nazir, Ahmed Nasr, Asmaa Saeed

Journal of Engineering Research

Abstract- Most researchers perform their numerical models for tunnels by modeling perfectly horizontal ground surfaces above the tunnels. The prediction of surface settlement of a sandy slope due to the interaction mechanism between the slope and the tunnels is one of the critical problems in urban areas. As a result, in this work, a numerical analysis using PLAXIS 3D TUNNEL has been performed to investigate the effect of tunnel excavation on the deformation of a shallow sandy slope, and empirically by the Herzog method. The study also assesses the influence of parameters on slope deformation that have not been …

Quantum Dots' Toxicity: A Multi-Level Investigation On The Impact Of Quantum Dots On The Actin Cytoskeleton, Nhi Le

MSU Graduate Theses

Quantum dots (QDs) are fluorescence nanomaterials with unique optical and physical properties. As such, they are highly sought after for their potential use in several biomedical and industrial applications. Despite their vast potential, recent studies have suggested that quantum dots are toxic to cells. Yet, the mechanism of quantum dots’ toxicity remains unclear. As such, my thesis aims to comprehensively examine the mechanism of quantum dots’ toxicity, emphasizing how quantum dots disrupt the actin cytoskeleton. In this study, I used RNA sequencing and mass spectrometry to investigate the influence of CdSe/ZnS QDs on the transcriptomic proteomic level of Saccharomyces cerevisiae …

Functionalized Surface Of Plga Nanoparticles In Thermosensitive Gel To Enhance The Efficacy Of Antibiotics Against Antibiotic Resistant Infections In Endodontics: A Randomized Clinical Trial, Mona Arafa, Hadeel Moussa, Mohamed Medhat Kataia

Pharmacy

Enterococcus faecalis plays the key role in endodontic infections and is responsible for the formation of biofilm on dentin, which causes a resistance against periradicular lesions treatment, consequently the aim of this study is to use nanoparticles entrapping anibacterial agents coated with chitosan that in authors previous study showed a successful in vitro biofilm inhibition, additionally incorporated in thermoresponsive gel.to benefit nanoparticles` small size, and the positive charge of their surfaces that binds with the negatively charged surface of bacterial cell causing its destruction, in addition to the sustained release pattern of the drug based nanoparticles in gel. Therefore, Ciprofloxacin …

Chronic Disease And The Inflammatory Body Burden: Social And Environmental Factors And Implications For Longevity, Catherine L. Zeman, Junu Shrestha, Raihan Khan, Ashley N. Oginz Wilson, Lisa A. Beltz

Department of Health Sciences - Faculty Scholarship

Everyday our body’s immune and detoxification systems are working to protect us from pathogens, cancerous cells, foreign substances, and chemical exposures. Declining trends in per capita longevity in the US suggest that these systems are being stressed beyond their natural resiliency. Several of these trends are discussed in light of funding for preventive vs. illness care. The authors then use a systems and interdisciplinary approach to introduce the immunobiological and biotransformation systems, and the concept of the exposome for those unfamiliar. The science of the immune and detoxification systems is explored considering the idea of chronic low-level inflammation. Additionally, new …

Binding Interactions Of Biologically Relevant Molecules Studied Using Surface-Modified And Nanostructured Surfaces, Palak Sondhi

Dissertations

This research focuses on the field of surface nanobioscience, wherein different nanosurfaces that will be used as working electrodes in the electrochemical cell are manufactured and surface modified to understand the critical binding interactions between biologically significant molecules like proteins, carbohydrates, small drug molecules, and glycoproteins. This research is essential if we are to determine whether a synthetic molecule can serve as a therapeutic candidate or diagnose a disease in its early stages. In order to fully understand the binding interactions, the study begins with defining some of the fundamental concepts, principles, and analytical tools for biosensing.

Afterwards, we addressed …

Liposome Synthesis And Evaluation In The Hek-293 Cell Line, Christine Skibinski

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

Liposomes were synthesized using the thin film method. A lyophilized power of egg-derived phosphatidylcholine, stearylamine, and cholesterol were added to ethanol and dried under argon to form a lipid cake. The lipid cake was rehydrated with dPBS and sonicated at 60°C forming a heterogenous batch of liposomes. Our results revealed the average size of the liposomes, determined by Dynamic Light Scattering, was approximately 223.1nm, while demonstrating a weakly positive zeta-potential of 1.9± 8.07mv. Next, we tested the antitumor action of the liposomes in the HEK-293 cell line via an MTT assay. We observed that the liposomes were able to inhibit …

Development Of Targeted Drug Delivery System To Improve Immunotherapy In Pancreatic Cancer, Poornima Devi Shaji, Ana Martinez Bulnes, Nirnoy Dan, Subhash C. Chauhan, Sheema Khan, Murali M. Yallapu

Research Colloquium

Introduction: About 95% of tumor arises from epithelial cell lining ducts known to be pancreatic ductal adenocarcinomas, with less than 5-7% survival rate. Unfortunately, little progress has been seen in the outcomes of patients with PDAC as tumor develops high desmoplasia and chemo-resistance to chemotherapeutic drugs, such as gemcitabine (Gem). Immunotherapy has shown promising results in other cancers but limited response in pancreatic cancer due to desmoplasia and fibrotic tumor microenvironment. A recently identified mucin, MUC13 is aberrantly expressed in pancreatic tumors but not in normal pancreas. Due to its high membrane expression, MUC13 may serve as an excellent target …

Novel Therapy Targeting Mutant-Krasg12d And Galectin-1 In Pancreatic Cancer, Ana I. Martinez Bulnes, Nirnoy Dan, Poornima Devi Shaji, Swathi Holla, Murali M. Yallapu, Sheema Khan

Research Colloquium

Introduction: Although, surgical resection and chemotherapy are the gold standard for treating Pancreatic Ductal Adenocarcinoma (PDAC), low patient survival rate remains the problem. The activating point mutation of the KRAS on codon-12 is present in 70–95% of PDAC cases and so far, no success has been achieved to inhibit KRAS. KRASG12D regulates cell proliferation, differentiation, apoptosis. Recent preliminary and published studies show high Galectin-1 (Gal-1) levels in both pancreatic cancer and stromal cells, which modulate tumor microenvironment and metastasis. Additionally, genetic deletion of gal1 inhibits metastasis and improves survival in KRAS mouse model of PDAC (1). Therefore, our objective is …

Developing A Chlorophyll-Based Near-Infrared Fluorescent Probe For Cancer Cell Imaging, Benilde E. Adriano, Nycol M. Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

Research Colloquium

Introduction: Near-Infrared (NIR) fluorescence-based imaging is a noteworthy and safer strategy for cancer cells/tissues imaging compared to radiological imaging. NIR fluorescence offers deep tissue penetration and have minimal obstruction by autofluorescence and photon scattering [1]. There are several NIR dyes including indocyanine green (ICG) [2] and IR-1061 [3] that allow high-resolution tissue imaging. However, these dyes possess some low-quality characteristics which limit their use, namely photo instability, toxicity, poor water solubility, and short half-lives [4]. Therefore, more efficient and effective alternatives are urgently required to provide the desired clinical outcomes. Chlorophyll (Chl) is a natural dietary NIR fluorescence emitting …

Novel Therapy Targeting Mutant-Krasg12d And Galectin-1 In Pancreatic Cancer, Ana I. Martinez Bulnes, Poornima Devi Shaji, Swathi Holla, Nirnoy Dan, Shabnam Malik, Murali M. Yallapu, Meena Jaggi, Stephen W. Behrman, Subhash C. Chauhan, Sheema Khan

Research Colloquium

Introduction: In pancreatic ductal adenocarcinoma (PDAC), low patient survival rate remains a problem. The activating point mutation of KRAS on codon-12 is present in 70–95% of PDAC cases and so far, no success has been achieved to inhibit KRAS. KRAS^G12D regulates cell proliferation, differentiation, apoptosis; recent preliminary and published studies show high Galectin-1 (Gal-1) levels in both PDAC and stromal cells, which modulate tumor microenvironment and metastasis. Therefore, we have developed a novel combination therapy for PDAC by targeting mutated KRAS^G12D and Gal-1 to target both proliferation and metastasis in PDAC. This includes the delivery of KRAS^{G12D …}

Thermal Dose Inactivation Of Escherichia Coli By Magnetic Induced Hyperthermia, Silverio A. Lopez, Carlos Trevino De Leo, Ivan Davila, Karen S. Martirosyan

Research Symposium

Background: Apoptosis of mutated cells via magnetic hyperthermia has gained advocacy as technology capable of being used in lieu of chemotherapy for targeting cancer tumors. Progress of nanotechnology offers effective remote heating of magnetic fluid via hyperthermia. The heating and specific power absorption of these nanoparticles use in the magnetic fluid are dependent on particle properties and treatment locations.

Methods: Nanoparticles were fabricated using microfluidic system by interaction of two solutions containing 2Fe(NO3)3+FeSO4 and NaOH+2%Dextran to create nanostructured media with a biocompatible dextran coating and a Fe3O4 core. The nanoparticles, of a concentration of 5mg/ml, were placed in a vile …

Smoking And Drinking Activates Nf-Κb /Il-6 Axis To Promote Inflammation During Cervical Carcinogenesis, Vivek Kumar Kashyap, Prashanth Kb Nagesh, Ajay K. Singh, Andrew Massey, Godwin P. Darkwah, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Background: High-risk strains of HPV are known to cause cervical cancer. Multiple clinical studies have emphasized that smoking and drinking are critical risk factors for cervical cancer and its high-grade precursors. In this study, we investigated the molecular mechanisms involved in the interplay of smoking and/or drinking with HPV infectivity and defined a systematic therapeutic approach for their attenuation in cervical cancer.

Methods: The impact of benzo[a]pyrene (B[a]P) and/or ethanol (EtOH) exposure on cervical cancer cells was assessed by measuring changes in cell proliferation, clonogenicity, biophysical properties, cell migration, and invasion. Expression of HPV16 E6/E7, NF-κB, cytokines, cell cycle, and …