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Washington University in St. Louis

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Full-Text Articles in Substance Abuse and Addiction

Mu Opioid Receptor Desensitization In Inflammatory Pain, Matthew Bredder Jan 2016

Mu Opioid Receptor Desensitization In Inflammatory Pain, Matthew Bredder

Undergraduate Research Symposium Posters

Due to the epidemic level of opioid overdose deaths in the United States, improving the treatment of chronic pain has become a pressing concern. Opioid treatments such as fentanyl and morphine activate mu opioid receptors (MORs), causing an increase in dopamine release. Long term use of opioids, even as prescribed by a physician, can desensitize the MORs and lead to the appearance of withdrawal symptoms when the receptors are no longer stimulated. Since pain increases endogenous opioid release, we hypothesized that this increase may cause MOR desensitization and the appearance of withdrawal syndrome upon blockade of MORs, as seen in …

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Implementing Outside The Box: Community-Based Social Service Provider Experiences With Using An Alcohol Screening And Intervention, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Alex T. Ramsey, Carissa Van Den Berk-Clark Dec 2014

Implementing Outside The Box: Community-Based Social Service Provider Experiences With Using An Alcohol Screening And Intervention, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Alex T. Ramsey, Carissa Van Den Berk-Clark

Brown School Faculty Publications

Objective: The aim of this study is better understand perceptions of front-line social service workers who are not addiction specialists, but have to address addiction-related issues during their standard services. Method: Six social service organizations implemented a validated alcohol assessment and brief education intervention. After a 3-month trial implementation period, a convenience sample of 64 front-line providers participated in six focus groups to examine barriers and facilitators to the implementation of an alcohol screening and brief intervention. Results: Three themes emerged: (1) usefulness of the intervention, (2) intervention being an appropriate fit with the agency and client population, and (3) …

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Alcohol Screening And Brief Intervention As Standard Practice In Indian Country, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Bonnie Duran, Catherine N. Dulmus Phd, Amy R. Manning Mar 2014

Alcohol Screening And Brief Intervention As Standard Practice In Indian Country, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Bonnie Duran, Catherine N. Dulmus Phd, Amy R. Manning

Brown School Faculty Publications

Alcohol use and the resulting problems associated with high-risk drinking in the American Indian/Native Alaskan (AI/NA) population are well-documented, as alcohol misuse has taken an incredible toll on many AI/NA communities. Presently, both overall health issues and alcohol use occur disproportionately within this population. This article provides an updated overview of the impact of alcohol use in the United States and within AI/NA communities specifically. It also provides recommendations for an alcohol-related screening and brief intervention instrument that social workers can begin using in their practice and can be utilized within the AI/NA community.

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Prevalence, Nature, Context And Impact Of Alcohol Use In India: Recommendations For Practice And Research, S. Prabhu, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Catherine N. Dulmus Phd, K. S. Ratheeshkumar Jan 2010

Prevalence, Nature, Context And Impact Of Alcohol Use In India: Recommendations For Practice And Research, S. Prabhu, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Catherine N. Dulmus Phd, K. S. Ratheeshkumar

Brown School Faculty Publications

Presently alcohol policy in India takes a moral stand rather than a scientific approach towards understanding and dealing with the problem of alcoholism. To effectively address this social problem in India, public policy must take into account the nature, extent of the problem and the context in which it occurs. This literature review examines the nature, prevalence and impact of alcohol use and misuse in India, within its historical and cultural contexts, as a beginning step to inform policy. Recommendations for practice and future research directions are suggested.

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