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Internal Medicine Commons™

Open Access. Powered by Scholars. Published by Universities.®

1991

Articles 1 - 2 of 2

Full-Text Articles in Internal Medicine

The Alpha-Adrenergic Stimulation Of Atrial Natriuretic Factor Expression In Cardiac Myocytes Requires Calcium Influx, Protein Kinase C, And Calmodulin-Regulated Pathways, C A. Sei, C E. Irons, A B. Sprenkle, P M. Mcdonough, J H. Brown, C C. Glembotski Aug 1991

The Alpha-Adrenergic Stimulation Of Atrial Natriuretic Factor Expression In Cardiac Myocytes Requires Calcium Influx, Protein Kinase C, And Calmodulin-Regulated Pathways, C A. Sei, C E. Irons, A B. Sprenkle, P M. Mcdonough, J H. Brown, C C. Glembotski

Amy Sprenkle

It has been shown recently that a-adrenergic agonists can stimulate atrial natriuretic factor (ANF) expression in ventricular cardiac myocytes; however, little is known about the intracellular signals mediating this activation. The present study focused on the potential roles of calcium-regulated kinases and calcium influx in the a-adrenergic stimulation of ANF gene expression in ventricular myocardial cell cultures. Myocardial cells maintained for 48 h in serumfree medium supplemented with phenylephrine (PE) possessed up to 15-fold higher levels of ANF peptide and ANF mRNA than control cells. The removal of PE, or the addition of nifedipine, resulted in a rapid decline in …

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Bacterial Isolates In Neutropenic Febrile Patients, M Karim, W Khan, B Farooqi, I Malik Feb 1991

Bacterial Isolates In Neutropenic Febrile Patients, M Karim, W Khan, B Farooqi, I Malik

Section of Internal Medicine

One hundred consecutive patients with documented bacteremia and neutrophil count of 0.5 x 10(9)/L or below were retrospectively studied to determine the pattern of infection at the Aga Khan University Hospital in Karachi. These included patients with primary haematologic malignancies presenting with low counts, and those patients with cancer who developed neutropenia as a result of chemotherapy. The gram negative organism pseudomonas aeruginosa was the most common bacterial organism isolated constituting 31% of all positive blood cultures. Gram positive organisms were frequently isolated comprising 24% of all isolates of which 15% were Staph.aureus. Staph. epidermidis was not isolated in this …

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