Internal Medicine Commons^™

Convalescent Plasma For Covid-19 Complicated By Ards Due To Trali, K. Y. Wang, P. Shah, M. Pierce

Journal Articles

© 2021 BMJ Publishing Group. All rights reserved. Convalescent plasma, which contains antibodies from recovered individuals, has been used as an effective treatment for infectious diseases in the past and is currently being used as a potential treatment option for COVID-19. Multiple studies have reported this treatment to be safe. We report a case of a patient who developed acute respiratory distress syndrome (ARDS) with features suggestive of transfusion-related acute lung injury after being treated with convalescent plasma for COVID-19. We emphasise the need to be aware of the potential risk of transfusion reactions and disease worsening with convalescent plasma …

Rationale And Design For The Study Of Rivaroxaban To Reduce Thrombotic Events, Hospitalization And Death In Outpatients With Covid-19: The Prevent-Hd Study, W. H. Capell, E. S. Barnathan, G. Piazza, A. C. Spyropoulos, J. Hsia, S. Bull, C. Lipardi, C. Sugarmann, E. Suh, M. P. Bonaca, +2 Additional Authors

Journal Articles

© 2021 Elsevier Inc. Background: COVID-19 is associated with both venous and arterial thrombotic complications. While prophylactic anticoagulation is now widely recommended for hospitalized patients with COVID-19, the effectiveness and safety of thromboprophylaxis in outpatients with COVID-19 has not been established. Study Design: PREVENT-HD is a double-blind, placebo-controlled, pragmatic, event-driven phase 3 trial to evaluate the efficacy and safety of rivaroxaban in symptomatic outpatients with laboratory-confirmed COVID-19 at risk for thrombotic events, hospitalization, and death. Several challenges posed by the pandemic have necessitated innovative approaches to clinical trial design, start-up, and conduct. Participants are randomized in a 1:1 ratio, stratified …

Ethnic Differences In Thromboprophylaxis For Covid-19 Patients: Should They Be Considered?, T. Iba, J. M. Connors, A. C. Spyropoulos, H. Wada, J. H. Levy

Journal Articles

© 2021, Japanese Society of Hematology. Thromboembolic events contribute to morbidity and mortality in coronavirus disease 2019 (COVID-19). As a result, thromboprophylaxis using low-molecular-weight heparin (LMWH) is universally recommended for hospitalized patients based on multiple guidelines. However, ethnic differences with respect to thrombogenicity have been reported and the incidence of thromboembolic events is considered to be lower in the Asian population. Despite the importance of thromboprophylaxis, bleeding is also a side effect that should be considered. We examine the data relating to potential ethnic differences in thrombosis and bleeding in COVID-19. Although sufficient data is not yet available, current evidence …

Cll Intraclonal Fractions Exhibit Established And Recently Acquired Patterns Of Dna Methylation, B. A. Bartholdy, X. Wang, X. Yan, M. Pascual, M. Fan, J. Barrientos, S. L. Allen, K. R. Rai, N. Chiorazzi, S. Roa, +2 Additional Authors

Journal Articles

No abstract provided.

Arterial Thromboembolic Complications In Covid-19 In Low-Risk Patients Despite Prophylaxis, D. O. Griffin, A. Jensen, M. Khan, J. Chin, K. Chin, R. Parnell, C. Awwad, D. Patel

Journal Articles

No abstract provided.

Famotidine Use Is Associated With Improved Clinical Outcomes In Hospitalized Covid-19 Patients: A Propensity Score Matched Retrospective Cohort Study., D. E. Freedberg, J. Conigliaro, T. C. Wang, K. J. Tracey, M. V. Callahan, J. A. Abrams, Famotidine Research Group Famotidine Research Grou, M. E. Sobieszczyk, D. D. Markowitz, A. Gupta, M. R. O'Donnell, J. Li, D. A. Tuveson, Z. Jin, W. C. Turner, D. W. Landry

Journal Articles

No abstract provided.

The Uses Of Overnight Pulse Oximetry, S. Singh, S. Khan, D. Singh, S. Verma, A. Talwar

Journal Articles

© 2020 Indian Chest Society Published by Wolters Kluwer - Medknow. Overnight pulse oximetry (OPO) has proven to be an effective and beneficial technique to determine the cardiorespiratory status of patients in both the inpatient and outpatient settings. It is a cheap, safe, reliable, simple, and accurate method of patient monitoring as compared to the expensive and labor-intensive method of multichannel polysomnography for detecting sleep-disordered breathing. It provides accurate information about patient's oxygenation status and also helps in monitoring the response to continuous positive airway pressure and in the surgical treatment of obstructive sleep apnea (OSA). Nocturnal hypoxemia portends a …

Covid-19: Magnifying The Effect Of Health Disparities, E. J. Kim, L. Marrast, J. Conigliaro

Journal Articles

No abstract provided.

Knowledge, Attitudes, And Interactions With Chaplains And Nursing Northwell Health Outcomes: A Survey Study, T. Liberman, A. Kozikowski, M. Carney, M. Kline, A. Axelrud, A. Ofer, M. Rossetti, R. Pekmezaris

Journal Articles

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. We conducted a cross-sectional survey of nursing Northwell Health (n = 51) in an academic hospital finding a significant inverse relationship between the frequency of chaplaincy interaction and perceived stress (r = − 0.27, p = 0.05). We also found a significant positive relationship between rated importance of having a chaplain at the hospital and secondary trauma (r = 0.30, p = 0.03). There was a significant positive relationship between religiosity and rated importance for having a chaplain (r = 0.30, p = 0.03) and rated helpfulness of chaplains (r …

Obstructive Lung Disease Secondary To Compression Of The Bronchus By An Enlarged Pulmonary Artery, J. Panthappattu, V. Sharma, S. Verma, A. Talwar

Journal Articles

© 2020 Indian Chest Society Published by Wolters Kluwer - Medknow. In clinical practice, the presence of wheezing generally indicates an airway disease. In rare circumstances, adjacent mediastinal structures may compress the tracheobronchial tree leading to obstructive physiology. Compression of the tracheobronchial region by an enlarged pulmonary artery (PA) is exceedingly rare. We present here a case of pulmonary hypertension, where the enlarged PA resulted in obstructive lung physiology with a relevant review of the literature.

A Case Of Plasmodium Falciparum Malaria With A Prolonged Incubation Period Of Four Years., E. Sleiman, A. Upadhyaya, A. Glaser, M. Krzyzak

Journal Articles

With increased global travel, unique diseases from different parts of the world pose a new category of differential diagnosis, and an incubation period of different infectious diseases helps narrow differential diagnosis to point to one specific etiology. The normal incubation period of Plasmodium falciparum malariais 7-40 days. We report a case of symptomatic P. falciparum malaria that manifested four years after a visit to a malaria-endemic area in a 51-year-old female patient. Our case illustrates the importance of a broad differential with regard to infectious disease including remote travel history and raises questions of the survival of P. falciparum for …

Eikenella Corrodens And Streptococcus Anginosus Co-Infection Causing Skull Base Osteomyelitis And Internal Carotid Artery Lesion, K. Patel, C. Park, Z. Memon, N. Ilyas

Journal Articles

© 2020 The Author(s) A 35-year-old male presented with headaches and fevers. MRI of his head showed skull-based infection of the clivus extended to the right internal carotid artery. Blood and sinus cultures were positive for Eikenella corrodens and Streptococcus anginosus. He had intravenous antibiotics and sinus washout. The patient had full neurological recovery following this.

New Paradigms Of Extended Thromboprophylaxis In Medically Ill Patients, K. Macdougall, A. C. Spyropoulos

Journal Articles

No abstract provided.

External Validation Of A Venous Thromboembolic Risk Score For Cancer Outpatients With Solid Tumors: The Compass-Cat Venous Thromboembolism Risk Assessment Model, A. C. Spyropoulos, J. B. Eldredge, L. N. Anand, M. Zhang, M. Qiu, S. Nourabadi, D. J. Rosenberg

Journal Articles

No abstract provided.

Hospital-Based Use Of Thromboprophylaxis In Patients With Covid-19, A. C. Spyropoulos, W. Ageno, E. S. Barnathan

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No abstract provided.

Scientific And Standardization Committee Communication: Clinical Guidance On The Diagnosis, Prevention And Treatment Of Venous Thromboembolism In Hospitalized Patients With Covid-19., A. C. Spyropoulos, J. H. Levy, W. Ageno, J. M. Connors, B. J. Hunt, T. Iba, M. Levi, C. M. Samama, D. Giannis, +2 Additional Authors

Journal Articles

The novel coronavirus disease of 2019 (COVID-19) pandemic, as declared by the World Health Organization, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Cardiovascular disease and, in particular, venous thromboembolism (VTE) has emerged as an important consideration in the management of hospitalized patients with COVID-19. The diagnosis of VTE using standardized objective testing is problematic in these patients, given the risk of infecting non-COVID-19 hospitalized patients and hospital personnel, coupled with the usual challenges of performing diagnostic testing in critically-ill patients. Early reports suggest a high incidence of VTE in hospitalized COVID-19 patients, particularly those with severe …

Post-Discharge Prophylaxis With Rivaroxaban Reduces Fatal And Major Thromboembolic Events In Medically Ill Patients, A. C. Spyropoulos, W. Ageno, G. W. Albers, C. G. Elliott, J. L. Halperin, W. R. Hiatt, G. A. Maynard, P. G. Steg, J. I. Weitz, G. E. Raskob, +3 Additional Authors

Journal Articles

© 2020 The Authors Background: Hospitalized acutely ill medical patients are at risk for fatal and major thromboembolic events. Whether use of extended-duration primary thromboprophylaxis can prevent such events is unknown. Objectives: The purpose of this study was to evaluate whether extended-duration rivaroxaban reduces the risk of venous and arterial fatal and major thromboembolic events without significantly increasing major bleeding in acutely ill medical patients after discharge. Methods: MARINER (A Study of Rivaroxaban [JNJ-39039039] on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients) studied acutely ill medical patients with additional risk factors for venous thromboembolism (VTE). Medically ill patients with …

Decreasing The Peril Of Antimicrobial Resistance Through Enhanced Health Literacy In Outpatient Settings: An Underrecognized Approach To Advance Antimicrobial Stewardship, E. D. Hermsen, E. L. Macgeorge, M. L. Andresen, L. M. Myers, C. J. Lillis, B. M. Rosof

Journal Articles

© 2020, The Author(s). Globally, antimicrobial resistance (AMR) is a serious problem causing 700,000 deaths annually. By 2050, AMR is expected to cause approximately 10 million deaths globally each year if allowed to increase at the present rate. Many individuals have limited knowledge regarding appropriate antibiotic use and AMR. Most antibiotic use occurs in the outpatient setting, with approximately 30% of antibiotics prescribed deemed unnecessary. Antimicrobial stewardship (AMS) is a means to reduce inappropriate antibiotic use and AMR. While existing AMS efforts generally focus on the inpatient setting, a significant gap is present in the outpatient setting. A common theme …

Management Of Iron-Deficiency Anemia On Inpatients And Appropriate Discharge And Follow-Up., K. Patel, Z. Memon, R. Mazurkiewicz

Journal Articles

Background:The aims of the study were to identify appropriate supplementation of iron for inpatients and to identify factors involved in appropriate discharge documentation and follow-up. Methods:This was a retrospective analysis of 103 patients at a community hospital in New York City. Results:A total of 57 (57/103, 55.3%) patients were admitted due to symptomatic anemia. Twenty (20/103, 19.4%) of those with iron-deficiency anemia had either esophagogastroduodenoscopy or colonoscopy. Gastroenterologist or hematologist was consulted for 45/103 (43.7%). Inpatient iron supplementation was given for 62/103 (60.2%) of patients; and 43/103 (41.7%) had blood transfusion. Upon discharge, 50/103 (48.5%) had appropriate documentation of iron-deficiency …

The Covid-19 Pandemic: Experiences Of A Geriatrician-Hospitalist Caring For Older Adults, L Sinvani

Journal Articles

No abstract provided.

Scientific And Standardization Committee Communication: Clinical Guidance On The Diagnosis, Prevention And Treatment Of Venous Thromboembolism In Hospitalized Patients With Covid-19., Ac Spyropoulos, Jh Levy, W Ageno, Jm Connors, Bj Hunt, T Iba, M Levi, Cm Samama, D Giannis, Jd Douketis, +1 Additional Author

Journal Articles

No abstract provided.

Famotidine Use And Quantitative Symptom Tracking For Covid-19 In Non-Hospitalised Patients: A Case Series., T Janowitz, E Gablenz, D Pattinson, Tc Wang, J Conigliaro, K Tracey, D Tuveson

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No abstract provided.

Emergence Of Institutional Antithrombotic Protocols For Coronavirus 2019., Kp Cohoon, G Mahé, Aj Tafur, Ac Spyropoulos

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No abstract provided.

The Renin–Angiotensin System: An Integrated View Of Lung Disease And Coagulopathy In Covid-19 And Therapeutic Implications, B Diamond

Journal Articles

No abstract provided.

Personal Preferences For Personalised Trials Among Patients With Chronic Diseases: An Empirical Bayesian Analysis Of A Conjoint Survey., Y.K. Cheung, D. Wood, K. Zhang, T. A. Ridenour, L. Derby, T. St Onge, N. Duan, J. Duer-Hefele, K. W. Davidson, N. Moise, +1 Additional Author

Journal Articles

OBJECTIVE: To describe individual patient preferences for Personalised Trials and to identify factors and conditions associated with patient preferences.

DESIGN: Each participant was presented with 18 conjoint questions via an online survey. Each question provided two choices of Personalised Trials that were defined by up to eight attributes, including treatment types, clinician involvement, study logistics and trial burden on a patient.

SETTING: Online survey of adults with at least two common chronic conditions in the USA.

PARTICIPANTS: A nationally representative sample of 501 individuals were recruited from the Chronic Illness Panel by Harris Poll Online. Participants were recruited from several …

Acute Limb Ischemia In Covid-19 Disease: A Mysterious Coagulopathy., S. Anwar, S. Acharya, S. Shabih, A. Khabut

Journal Articles

Severe coronavirus disease 2019 (COVID-19) as a respiratory tract infection has been noted to be a causative agent for acute respiratory distress syndrome, shock, and multiple organ failure. It is also being suggested that COVID-19 results in serious systemic coagulopathies similar to disseminated intravascular coagulation. We describe a case of severe arterial thrombosis induced by COVID-19 infection along with its pathological implications.

Introduction To The Special Series: Translating Behavioral Medicine Research To Prevent And Control The Spread Of Covid-19., A. M. Delamater, S. M. Miller, D. J. Bowen, M. A. Diefenbach, K. P. Tercyak

Journal Articles

No abstract provided.

Physiologic Response To Angiotensin Ii Treatment For Coronavirus Disease 2019-Induced Vasodilatory Shock: A Retrospective Matched Cohort Study., D. E. Leisman, F. Mastroianni, G. Fisler, S. Shah, Z. Hasan, M. Narasimhan, M. D. Taylor, C. S. Deutschman

Journal Articles

Objectives:To assess the early physiologic response to angiotensin-II treatment in patients with coronavirus disease 2019-induced respiratory failure and distributive shock. Design:Retrospective consecutive-sample cohort study. Setting:Three medical ICUs in New York during the coronavirus disease 2019 outbreak. Patients:All patients were admitted to the ICU with respiratory failure and were receiving norepinephrine for distributive shock. Interventions:The treatment groups were patients who received greater than or equal to 1 hour of angiotensin-II treatment. Time-zero was the time of angiotensin-II initiation. Controls were identified using a 2:1 hierarchical process that matched for 1) date and unit of admission; 2) specific organ support modalities; 3) …

The Management Of Venous Thromboembolism In Hospitalized Patients With Covid-19, A. C. Spyropoulos

Journal Articles

No abstract provided.

Unique Case Of Central Retinal Artery Occlusion Secondary To Covid-19 Disease, S. Acharya, M. Diamond, S. Anwar, A. Glaser, P. Tyagi

Journal Articles

© 2020 The Authors SARS-COVID-2 has been noted to be associated with neurological symptoms and complications including stroke. Hypercoagulability associated with COVID-19 has been described as a “sepsis-induced coagulopathy” and may predispose to spectrum of thromboembolic events. We present a unique article of isolated central retinal artery occlusion secondary to SARS-COV 2.