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Oxidation Of Native And Modified Hemoglobin And Myoglobin By Sodium Nitrate. Effect Of Inositol Hexaphosphate, Ali Mansouri
Oxidation Of Native And Modified Hemoglobin And Myoglobin By Sodium Nitrate. Effect Of Inositol Hexaphosphate, Ali Mansouri
Journal of the Arkansas Academy of Science
Native and modified hemoglobin, myoglobin and a and phemoglobin subunits were oxidized by sodium nitrite at pH 6. The experiments were carried out under oxy and deoxy conditions with and without inositol hexaphosphate (IHP). It is shown (a) that under oxy condition low concentration of IHP inhibits the oxidation of native hemoglobin only. However, high concentration of IHP inhibits the oxidation of both myoglobin and modified hemoglobin (digested or 0-93-SH groups blocked). This inhibition is partially counteracted by high oxygen pressure, (b) Under deoxy condition the oxidation rates of all hemeproteins studied are significantly faster than that of native hemoglobin. …