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A Role For Cox Inhibition In The Prevention Of Progression Of Barrett’S Esophagus To Esophageal Adenocarcinoma, John Speakman
A Role For Cox Inhibition In The Prevention Of Progression Of Barrett’S Esophagus To Esophageal Adenocarcinoma, John Speakman
Theses and Graduate Projects
Background: Barrett’s esophagus is the most significant predictor of the development of esophageal adenocarcinoma. The current treatment recommendation is a proton pump inhibitor to control acid reflux, yet there remains a significant number of individuals who progress to cancer. More can be done to prevent this progression.
Purpose: To this end, this paper seeks to answer the following PICO question: P: Patients with Barrett’s esophagus not yet esophageal adenocarcinoma; I: Standard PPI treatment with the addition of Aspirin; C: Standard PPI treatment only; O: Prevention of progression of Barrett’s esophagus to esophageal adenocarcinoma.
Methods: A comprehensive literature …