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Endocrinology, Diabetes, and Metabolism Commons™
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Articles 1 - 30 of 58
Full-Text Articles in Endocrinology, Diabetes, and Metabolism
Drug Related Problems In Type 2 Diabetes Patients With Hypertension: A Cross-Sectional Retrospective Study, Hasniza Zaman Huri
Drug Related Problems In Type 2 Diabetes Patients With Hypertension: A Cross-Sectional Retrospective Study, Hasniza Zaman Huri
Hasniza Zaman Huri
Background: Type 2 diabetes (T2DM) patients with hypertension are at increased risk for experiencing drug-related problems (DRPs) since they often receive multiple medications and have multiple comorbidities. To date, there is a lack of studies conducted in T2DM patients with hypertension. This study aims to analyze the DRPs and identify factors affecting the DRPs in this patient population. Method: This retrospective study involved T2DM patients with hypertension and was conducted at a tertiary hospital in Malaysia from January 2009 to December 2011. The assessment of DRPs was based on the Pharmaceutical Network Care Europe (PCNE) tool version 5.01. Results: Two …
Brazilian Longitudinal Study Of Adult Health (Elsa-Brasil): Objectives And Design., Paulo A. Lotufo
Brazilian Longitudinal Study Of Adult Health (Elsa-Brasil): Objectives And Design., Paulo A. Lotufo
Paulo A Lotufo
The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an …
A Reappraisal In São Paulo, Brazil (2008) Of "The Ecology Of Medical Care:" The "One Per Thousand's Rule"., Adriana Roncoletta, Gustavo D. Gusso, Isabela M. Bensenor, Paulo A. Lotufo
A Reappraisal In São Paulo, Brazil (2008) Of "The Ecology Of Medical Care:" The "One Per Thousand's Rule"., Adriana Roncoletta, Gustavo D. Gusso, Isabela M. Bensenor, Paulo A. Lotufo
Paulo A Lotufo
This paper reassessed in Brazil, the concept of "Medical ecology" i introduced in 1961 to describe the relationship and utilization of health care services by a given population. This was a cross-sectional telephone survey among a random sample of people enrolled in a private HMO. We interviewed a random sample of non-pregnant adults over age 18 using 10 questions about symptoms and health care use during the month prior to interview. The final sample consisted of 1,065 participants (mean age 68 years, 68% female). From this sample, 424 (39.8%) reported the presence of symptoms, 311 (29.2%) had a medical office …
Hypothyroidism In The Elderly, Paulo A. Lotufo
Hypothyroidism In The Elderly, Paulo A. Lotufo
Paulo A Lotufo
An overview adressing observational and randomized clinical trials about hypothyroidism in the elderly.
Chronic Non-Communicable Diseases In Brazil: Priorities For Disease Management And Research, Bruce B. Duncan, Dora Chor, Estela M. Aquino, Isabela M. Bensenor, J.Geraldo Mill, M.Ines Schmidt, Paulo A. Lotufo, Alvaro Vigo, Sandhi M. Barreto
Chronic Non-Communicable Diseases In Brazil: Priorities For Disease Management And Research, Bruce B. Duncan, Dora Chor, Estela M. Aquino, Isabela M. Bensenor, J.Geraldo Mill, M.Ines Schmidt, Paulo A. Lotufo, Alvaro Vigo, Sandhi M. Barreto
Paulo A Lotufo
Chronic Non-Communicable Diseases are the main source of disease burden in Brazil. In 2011, the Brazilian Ministry of Health launched the Strategic Plan of Action for Management of Chronic Non-Communicable Diseases focusing on population-based interventions to manage cardiovascular diseases, diabetes, cancer, and chronic respiratory diseases mainly through fi ghting tobacco use, unhealthy diets, physical inactivity and the harmful use of alcohol. Although a signifi cant number of scientifi c studies on chronic diseases and their risk factors have been undertaken in Brazil, few are of cohort design. In this context, the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a cohort …
Elsa-Brasil: Historico [In Portuguese], Paulo A. Lotufo
Elsa-Brasil: Historico [In Portuguese], Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Vigilância Em Doença Cerebrovascular [Portuguese], Paulo A. Lotufo
Vigilância Em Doença Cerebrovascular [Portuguese], Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Proliferation Of Acid-Secretory Cells In The Kidney During Adaptive Remodelling Of The Collecting Duct, Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A. Wagner
Proliferation Of Acid-Secretory Cells In The Kidney During Adaptive Remodelling Of The Collecting Duct, Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A. Wagner
Desa Welsh
The renal collecting duct adapts to changes in acid-base metabolism by remodelling and altering the relative number of acid or alkali secreting cells, a phenomenon termed plasticity. Acid secretory A intercalated cells (A-IC) express apical H+-ATPases and basolateral bicarbonate exchanger AE1 whereas bicarbonate secretory B intercalated cells (B-IC) express basolateral (and apical) H+-ATPases and the apical bicarbonate exchanger pendrin. Intercalated cells were thought to be terminally differentiated and unable to proliferate. However, a recent report in mouse kidney suggested that intercalated cells may proliferate and that this process is in part dependent on GDF-15. Here we extend these observations to …
Prevalence Of Thyroid Disorders Among Older People: Results From The São Paulo Ageing & Health Study, Paulo A. Lotufo
Prevalence Of Thyroid Disorders Among Older People: Results From The São Paulo Ageing & Health Study, Paulo A. Lotufo
Paulo A Lotufo
This study aimed to estimate prevalence of thyroid disorders in the São Paulo Ageing & Health Study, an epidemiological study addressing several health-adverse outcomes among elderly people living in a poor area of São Paulo, Brazil. All participants answered a questionnaire and had a blood sample collected to assess levels of tireotropic hormone and free-thyroxine. Among 1,373 people (60.8% women), prevalence rates (95% confidence interval) for thyroid dysfunction (%) were: overt hyperthyroidism, 0.7% (0.2-1.1) [women: 0.8% (0.2-1.5); men: 0.4% (0.01-0.9)]; overt hypothyroidism, 5.7% (4.5-6.9) [women: 5.9% (4.3-7.5); men: 5.4% (3.5-7.3)]; subclinical hyperthyroidism, 2.4% (1.6-3.2) [women: 2.8% (1.6-3.9); men: 1.9% (0.7-3.0)]; …
Pufa And Vitamin D And Type 2 Diabetes Inflammatory Markers, Paulo A. Lotufo
Pufa And Vitamin D And Type 2 Diabetes Inflammatory Markers, Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Socioeconomic Status And Coronary Heart Disease Mortality In The City Of Sao Paulo, Brazil (1996 To 2007), Paulo A. Lotufo
Socioeconomic Status And Coronary Heart Disease Mortality In The City Of Sao Paulo, Brazil (1996 To 2007), Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Non-Inferiority Trials [In Portuguese], Paulo A. Lotufo
Non-Inferiority Trials [In Portuguese], Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Cardiovascular And Cancer Mortality In Brazil, Paulo A. Lotufo
Cardiovascular And Cancer Mortality In Brazil, Paulo A. Lotufo
Paulo A Lotufo
Cancer are not surpassing Cardiovascular Diseases. Here you have an evaluation of mortality in Brazil. The debate was ignited by paper from IARC (International Agency for Research on Cancer) that forecasts cancer deaths surpassing heart diseases rates during de 2020’s. There is no dispute about the fact that - at least in the US and other countries - the decline of mortality deaths for heart diseases presenting a faster pace compared to cancer death rates. It is an epidemiological evidence that must be analyzed and some headline fueling hype as “heart diseases as an old agenda of public health and …
Gender Differences Of Case-Fatality Rate In A Brazilian Stroke Registry, Paulo A. Lotufo
Gender Differences Of Case-Fatality Rate In A Brazilian Stroke Registry, Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Characteristics Of Small Areas With A Higher Stroke Mortality, Paulo A. Lotufo
Characteristics Of Small Areas With A Higher Stroke Mortality, Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Higher Frequency Of Stroke Deaths On Monday And Saturday, Paulo A. Lotufo
Higher Frequency Of Stroke Deaths On Monday And Saturday, Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Social Inequalities And The Decline Of Stroke Mortality In The City Of Sao Paulo, Brazil, Paulo A. Lotufo
Social Inequalities And The Decline Of Stroke Mortality In The City Of Sao Paulo, Brazil, Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Subclinical Hyperthyroidism And Dementia: The Sao Paulo Ageing & Health Study (Spah), Paulo A. Lotufo
Subclinical Hyperthyroidism And Dementia: The Sao Paulo Ageing & Health Study (Spah), Paulo A. Lotufo
Paulo A Lotufo
Background: Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older people. Methods: A cross-sectional study - São Paulo Ageing & Health Study (SPAH) - in a population sample of low-income elderly people ≥ 65 years-old to evaluate presence of subclinical thyroid disease as a risk factor for dementia. Thyroid function was assessed using thyrotropic hormone and free-thyroxine as well as routine use of thyroid hormones or antithyroid medications. Cases of dementia were assessed using a harmonized one-phase …
F-2-Isoprostanes As Novel Biomarkers For Type 2 Diabetes: A Review, Ikram Shah Ismail
F-2-Isoprostanes As Novel Biomarkers For Type 2 Diabetes: A Review, Ikram Shah Ismail
Ikram Shah Ismail
Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F-2-Isoprostanes (F-2-IsoPs) have been observed. The measurement of bioactive F-2-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in …
Nutritional Evaluation Of The Patients With Head And Neck Squamous Cell Carcinoma [Portuguese], Paulo A. Lotufo
Nutritional Evaluation Of The Patients With Head And Neck Squamous Cell Carcinoma [Portuguese], Paulo A. Lotufo
Paulo A Lotufo
Patients with head and neck squamous cell carcinoma (HNSCC) usually present nutritional disorders, secondary to the upper aerodigestive tract involvement or due to the treatment sequels. Objective: To assess the nutritional status of patients with HNSCC in different phases of the disease treatment. Methods: Cross-sectional study with 155 patients divided in 4 groups: 103 patients with HNSCC (29 before treatment, 47 post-treatment with no recurrence and 27 post treatment with recurrent disease) and 52 controls without HNSCC. Clinical and epidemiological data were collected and a nutrition assessment was performed from anthropometric parameters (weight, height and Body Mass Index – BMI), …
Patterns Of Viral Load In Chronic Hepatitis B Patients In Brazil And Their Association Withalt Levels And Hbeag Status, Paulo A. Lotufo
Patterns Of Viral Load In Chronic Hepatitis B Patients In Brazil And Their Association Withalt Levels And Hbeag Status, Paulo A. Lotufo
Paulo A Lotufo
Serum hepatitis B virus (HBV) DNA level is a predictor of the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis B patients. Nevertheless, the distribution of viral load levels in chronic HBV patients in Brazil has yet to be described. This cross-sectional study included 564 participants selected in nine Brazilian cities located in four of the five regions of the country using the database of a medical diagnostics company. Admission criteria included hepatitis B surface antigen seropositivity, availability of HBV viral load samples and age >or=18 years. Males comprised 64.5% of the study population. Mean age was 43.7 years. …
Estudo Longitudinal De Saúde Do Adulto -Elsa-Brasil [English], Paulo A. Lotufo
Estudo Longitudinal De Saúde Do Adulto -Elsa-Brasil [English], Paulo A. Lotufo
Paulo A Lotufo
Presentation update on September, 2011.
Framingham Score For Cardiovascular Diseases [Portuguese], Paulo A. Lotufo
Framingham Score For Cardiovascular Diseases [Portuguese], Paulo A. Lotufo
Paulo A Lotufo
Review about cardiovascular risk factors.
Role Of N-Epsilon-(Carboxymethyl)Lysine In The Development Of Ischemic Heart Disease In Type 2 Diabetes Mellitus, Ikram Shah Ismail
Role Of N-Epsilon-(Carboxymethyl)Lysine In The Development Of Ischemic Heart Disease In Type 2 Diabetes Mellitus, Ikram Shah Ismail
Ikram Shah Ismail
This study aims to determine the levels of N-epsilon-(carboxymethyl)lysine (CML) in patients with Type 2 diabetic patients with and without ischemic heart disease (IHD) and to find for a possible association between circulating CML and a number of clinical parameters including lipids, hemoglobin Ale (HbA1c) and malondialdehyde (NIDA) in Type 2 diabetic 1111) patients. Serum CML levels were measured by enzyme-linked immunosorbent assay using polyclonal anti-CML antibodies. Serum levels of CML and NIDA were assessed in 60 IHD patients with Type 2 diabetes, 43 HID patients without Type 2 diabetes, 64 Type 2 diabetics without IHD, and 80 sex- and …
Race, Gender And Stroke Subtypes Mortality In Sao Paulo, Brazil., Paulo A. Lotufo
Race, Gender And Stroke Subtypes Mortality In Sao Paulo, Brazil., Paulo A. Lotufo
Paulo A Lotufo
Stroke mortality rates have a discrepant distribution according to socioeconomic variables as social exclusion in Brazil. Recently, data from race has been available from the official health statistics considering five categories: White, Mixed, Black, Asian and Native. We addressed in the city of São Paulo, Brazil, an analysis of cerebrovascular mortality according to race (excluding Asian and Native due to small number of events) and gender during 1999-2001 for people aged 30 to 79 years-old. For all cerebrovascular diseases, age-adjusted mortality rates (x 100,000) for men were higher for Black (150.2), intermediate for Mixed (124.2) and lower for White (104.5) …
Air Pollutants And Respiratory Symptoms Among Adults, Paulo A. Lotufo
Air Pollutants And Respiratory Symptoms Among Adults, Paulo A. Lotufo
Paulo A Lotufo
Air pollutants are associated with adverse respiratory effects mainly in susceptible groups such as children, elderly people and people with pre-existent respiratory disease. This study was designed to assess the impact of the inorganic composition of particulate matter on 33 adult asthmatics respiratory functions in São Paulo city, Brazil. From May to July 2002, fine and coarse particulate matter fractions were collected and trace metals (Fe2+, Mn2+, Zn2+, Pb2+, Cu2+) and major ions (Na+, Mg2+, K+, Ca2+, NH4 +, Cl-, NO3-, SO42-) composition was determined in each aqueous-extract fraction by Atomic Absorption Spectrometry with Graphite Furnace (AAS-GF) and Ion Chromatography, …
The Acute-Phase Proteins Serum Amyloid A And C Reactive Protein In Transudates And Exudates, Paulo A. Lotufo
The Acute-Phase Proteins Serum Amyloid A And C Reactive Protein In Transudates And Exudates, Paulo A. Lotufo
Paulo A Lotufo
The distinction between exudates and transudates is very important in the patient management. Here we evaluate whether the acute-phase protein serum amyloid A (SAA), in comparison with C reactive protein (CRP) and total protein (TP), can be useful in this discrimination. CRP, SAA, and TP were determined in 36 exudate samples (27 pleural and 9 ascitic) and in 12 transudates (9 pleural and 3 ascitic). CRP, SAA, and TP were measured. SAA present in the exudate corresponded to 10% of the amount found in serum, that is, the exudate/serum ratio (E/S) was 0.10±0.13. For comparison, the exudate/serum ratio for CRP …
Epidemiological Studies In The Information And Genomics Era: Experience Of The Clinical Genome Of Cancer Project In São Paulo, Brazil, V Wunsch, Jose Eluf-Neto, Paulo A. Lotufo, Marco A. Zago
Epidemiological Studies In The Information And Genomics Era: Experience Of The Clinical Genome Of Cancer Project In São Paulo, Brazil, V Wunsch, Jose Eluf-Neto, Paulo A. Lotufo, Marco A. Zago
Paulo A Lotufo
No abstract provided.
Stroke In Brazil: A Neglected Disease, Paulo A. Lotufo
Stroke In Brazil: A Neglected Disease, Paulo A. Lotufo
Paulo A Lotufo
The turning point in the transition from infectious diseases to non-transmittable diseases in Brazil occurred in the 1960s, taking the country as a whole. However, considering the main cities, such as São Paulo and Rio de Janeiro, cerebrovascular disease mortality rates have surpassed the “old cardiovascular diseases” like rheumatic heart disease and syphilitic aortic disease since the end of World War II. Until the end of the 1980s, the burden of stroke mortality observed in the main Brazilian cities was higher than in the United States, Canada and western European countries, and similar to what is observed in Eastern Europe …
Why Brazil Does Not Have An Epidemic Of Chronic Diseases: Some Answers From Cardiovascular Diseases, Paulo A. Lotufo
Why Brazil Does Not Have An Epidemic Of Chronic Diseases: Some Answers From Cardiovascular Diseases, Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.