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A Comparison Of Standard-Dose And High-Dose Epinephrine In Cardiac Arrest Outside The Hospital, Charles G. Brown, Daniel R. Martin, Paul E. Pepe, Harlan Stueven, Richard O. Commins, Edgar Gonzalez, Michael Jastremski, The Multicenter High-Dose Epinephrine Study Group
A Comparison Of Standard-Dose And High-Dose Epinephrine In Cardiac Arrest Outside The Hospital, Charles G. Brown, Daniel R. Martin, Paul E. Pepe, Harlan Stueven, Richard O. Commins, Edgar Gonzalez, Michael Jastremski, The Multicenter High-Dose Epinephrine Study Group
Emergency Medicine Publications
BACKGROUND.
Experimental and uncontrolled clinical evidence suggests that intravenous epinephrine in doses higher than currently recommended may improve outcome after cardiac arrest. We conducted a prospective, multicenter study comparing standard-dose epinephrine with high-dose epinephrine in the management of cardiac arrest outside the hospital.
METHODS.
Adult patients were enrolled in the study if they remained in ventricular fibrillation, or if they had asystole or electromechanical dissociation, at the time the first drug was to be administered to treat the cardiac arrest. Patients were randomly assigned to receive either 0.02 mg of epinephrine per kilogram of body weight (standard-dose group, 632 patients) …