Neurosciences Commons^™

Quality Of Life Associated With Health In Spinal Tuberculosis, Juan C. Salcedo-Moreno, Pedro Aleixo-Nogueira, Armando Alpizar-Aguirre, Tania Arancibia-Baspineiro, Julio C. Burgos-Flores, Andrei Fernandes-Joaquim, Eduardo Laos-Plasier, Edson Lizarazu-Oroz, Carlos A. Llanos-Lucero, José L. López-Segales, Thiago Magalhães-De Souza, Juan F. Mier-García, Fernando Molina-Pizarro, Filadelfo Normabuena, María E. Núñez-Castillo, Erika Reyes-Quezada, Wilson Quispe-Alanoca, Paulo G. Sacramento-Da Silva, Byron Salazar-Maldonado, Jorge Salazar-Flores, Josselin M. Sánchez-Mamani, Felipe A. Santos-De Queiroz-Chaves, Reddy A. Simón-Nunes, Manuel E. Soto-García, Perla M. Del Valle-Oros, José A. Israel-Romero-Rangel, Luis M. Duchén-Rodríguez, José A. Soriano-Sánchez

LATIN Neurosurgery Journal

Introduction: Spinal tuberculosis, al though rare, is a variant of miliary TB, which when it occurs can lead to catastrophic in juries, since it is usually painful and disfig uring, and can lead to irreversible neurologi cal injuries. Which directly or indirectly has an impact on the quality of life of the patient. For this reason, our objective is to review the updated literature on the impact of spinal TB onthequality of life of patients and to identify variables that are directly or indirectly associ ated with better or worse results.
Methodology: Following the Prisma criteria for the development of …

Surgical Indicatios For Spinal Tuberculosis Systematic Review, Byron Salazar-Maldonado, Jorge Salazar-Flores, Pedro Aleixo-Nogueira, Armando Alpizar-Aguirre, Tania Arancibia-Baspineiro, Julio C. Burgos-Flores, Andrei Fernandes-Joaquim, Eduardo Laos-Plasier, Edson Lizarazu-Oroz, Carlos A. Llanos-Lucero, José L. López-Segales, Thiago Magalhães-De Souza, Juan F. Mier-García, Fernando Molina-Pizarro, Filadelfo Normabuena, María E. Núñez-Castillo, Erika Reyes-Quezada, Wilson Quispe-Alanoca, Paulo G. Sacramento-Da Silva, Juan C. Salcedo-Moreno, Josselin M. Sánchez-Mamani, Felipe A. Santos-De Queiroz-Chaves, Reddy A. Simón-Nunes, Manuel E. Soto-García, Perla M. Del Valle-Oros, José A. Israel-Romero-Rangel, Luis M. Duchén-Rodríguez, José A. Soriano-Sánchez

LATIN Neurosurgery Journal

Introduction: The objective of this systematic review is to establish the main indi cations for the treatment of spinal tuberculo sis. Although there are many factors to con sider this modality of treatment, with differ ent techniques and surgical approaches, we summarize the main indications for easy to re member reference check list.
Methodology: On this systematic review we analyze the quality of evidence generated on the subject “Indications for Surgical treat ment in spinal tuberculosis” from 2017-01-01 to 2022-01-08 to stablish an update and issue recommendtions on this regard.
Results: 20 articles met the criteria and were included in …

Interferon-Gamma Release Assays In The Diagnosis Of Spinal Tuberculosis: A Systemic Review, Eduardo Laos-Plasier, Pedro Aleixo-Nogueira, Armando Alpizar-Aguirre, Tania Arancibia-Baspineiro, Julio C. Burgos-Flores, Andrei Fernandes-Joaquim, Edson Lizarazu-Oroz, Carlos A. Llanos-Lucero, José L. López-Segales, Thiago Magalhães-De Souza, Juan F. Mier-García, Fernando Molina-Pizarro, Filadelfo Normabuena, María E. Núñez-Castillo, Erika Reyes-Quezada, Wilson Quispe-Alanoca, Paulo G. Sacramento-Da Silva, Byron Salazar-Maldonado, Jorge Salazar-Flores, Juan C. Salcedo-Moreno, Josselin M. Sánchez-Mamani, Felipe A. Santos-De Queiroz-Chaves, Reddy A. Simón-Nunes, Manuel E. Soto-García, Perla M. Del Valle-Oros, José A. Israel-Romero-Rangel, Luis M. Duchén-Rodríguez, José A. Soriano-Sánchez

LATIN Neurosurgery Journal

Introduction: Interferon-gamma release assays are indirect immunological tests used mainly for the diagnosis of latent tubercu losis, their use in active tuberculosis being controversial. This study aims to analyze the usefulness of gamma interferon release assays in the diagnosis of spinal tuberculosis and to obtain a consensus for their use.
Methods: A systematized search was carried out in PubMed and Scielo for ar ticles in English, Spanish, or Portuguese from 10/01/2012 to 10/01/2022, eligibility criteria were applied, the papers included were analyzed according to the GRADE methodology and then established the SORT type recommendation.
Results: We obtained 27 articles, of …

Imaging Signs Indicating Post Tubercular Kyphosis Progression In Children: Systematic Review, Juan F. Mier-García, Carlos A. Llanos-Lucero, Pedro Aleixo-Nogueira, Armando Alpizar-Aguirre, Tania Arancibia-Baspineiro, Julio C. Burgos-Flores, Andrei Fernandes-Joaquim, Eduardo Laos-Plasier, Byron Salazar-Maldonado, Jorge Salazar-Flores, Edson Lizarazu-Oroz, José L. López-Segales, Thiago Magalhães-De Souza, Fernando Molina-Pizarro, Filadelfo Normabuena, María E. Núñez-Castillo, Erika Reyes-Quezada, Wilson Quispe-Alanoca, Paulo G. Sacramento-Da Silva, Juan C. Salcedo-Moreno, Josselin M. Sánchez-Mamani, Felipe A. Santos-De Queiroz-Chaves, Reddy A. Simón-Nunes, Manuel E. Soto-García, Perla M. Del Valle-Oros, José A. Israel-Romero-Rangel, Luis M. Duchén-Rodríguez, Jose A. Soriano-Sánchez

LATIN Neurosurgery Journal

Introduction: One of the main complications of spine tuberculosis is the instability produced by the injury of the articular structures between the vertebrae as well as the adjacent tissues, which, depending on the degree of involvement, can lead to angular kyphosis with the consequent risk of neurological impairment that can end with paraplegia. While the criteria for vertebral instability secondary to tuberculosis were identified and the pathophysiological processes that determine the progression of kyphosis following tuberculosis were deter mined, there is no new criteria, following Rajasekaran’s 2001 work, which demon strated which imaging signs could predict a kyphosis progression in …

Genexpert Mtb/Rif As A Diagnostic Test For Spinal Tuberculosis: Systematic Review, Erika Reyes-Quezada, María E. Núñez-Castillo, Pedro Aleixo-Nogueira, Armando Alpizar-Aguirre, Tania Arancibia-Baspineiro, Julio C. Burgos-Flores, Andrei Fernandes-Joaquim, Eduardo Laos-Plasier, Byron Salazar-Maldonado, Jorge Salazar-Flores, Edson Lizarazu-Oroz, Carlos A. Llanos-Lucero, José L. López-Segales, Thiago Magalhães-De Souza, Juan F. Mier-García, Fernando Molina-Pizarro, Filadelfo Normabuena, Wilson Quispe-Alanoca, Paulo G. Sacramento-Da Silva, Juan C. Salcedo-Moreno, Josselin M. Sánchez-Mamani, Felipe A. Santos-De Queiroz-Chaves, Reddy A. Simón-Nunes, Manuel E. Soto-García, Perla M. Del Valle-Oros, José A. Israel-Romero-Rangel, Luis M. Duchén-Rodríguez, José A. Soriano-Sánchez

LATIN Neurosurgery Journal

Introduction: Tuberculosis is an infectious disease that ranks as the thirteenth cause of death worldwide. As is known, tuberculo sis is not only limited to the lungs, but there is a wide range of extrapulmonary pathologies. Current diagnostic methods for spinal tuberculosis are limited by the time factor in order to provide results early and reliably. GeneX pert MTB/RIF is currently available as an al ternative, fast and reliable test for pathogen identification.
Methodology: This systematic review adheres to the PRISMA [1] criteria. The objective of the systematic review was to analyze the quality of the evidence gener ated on …

Effectiveness Of Vertebral Biopsy In Spinal Tuberculosis. Systematic Review, Armando Alpizar-Aguirre, Pedro Aleixo-Nogueira, Tania Arancibia-Baspineiro, Julio C. Burgos-Flores, Andrei Fernandes Joaquim, Eduardo Laos-Plasier, Edson Lizarazu-Oroz, Carlos A. Llanos-Lucero, Jose L. López-Segales, Thiago Magalhães-De Souza, Juan F. Mier-Gracía, Fernando Molina-Pizarro, Filadelfo Normabuena, María E. Núñez-Castillo, Erika Reyes-Quezada, Wilson Quispe-Alanoca, Paulo G. Sacramento-Da Silva, Juan C. Salcedo-Moreno, Josselin M. Sánchez-Mamani, Felipe A. Santos-De Queiroz-Chaves, Byron Salazar-Maldonado, Jorge Salazar-Flores, Reddy A. Simón-Nunes, Manuel E. Soto-García, Perla M. Del Valle-Oros, José A. Israel-Romero-Rangel, Luis M. Duchén-Rodríguez, José A. Soriano-Sánchez

LATIN Neurosurgery Journal

Introduction: Vertebral biopsy, espe cially percutaneous biopsy for histopathologi cal study and culture, continues to be the Gold Standard in the Diagnosis of Spinal Tubercu losis since the last century, however, there are no recent systematic reviews of the literature on its effectiveness in this pathology.
Method: A systematic review was car ried out on the PubMed platform, with the keywords ”Spinal tuberculosis” and ”Biopsy” in the title and abstract with a time limitation from January 1, 2017 to October 26, 2022. A summary of 11 selected articles was prepared, a list of the variables used in each article was …

Editorial Message: Vertebral Destruction Syndrome And Spinal Tuberculosis, Armando A. Aguirre

LATIN Neurosurgery Journal

No abstract provided.

Editorial Message: Top Class Neurosurgery Research Available From Latin America For The Benefit Of The World, José A. Soriano-Sánchez, Jose Israel-Romero

LATIN Neurosurgery Journal

No abstract provided.

Editorial Message, Luis Alencar Biurrum Borba

LATIN Neurosurgery Journal

No abstract provided.

Content Table

LATIN Neurosurgery Journal

No abstract provided.

Safety And Efficacy Of L5-S1 Inclusion In Multi-Level Oblique Lumbar Interbody Fusions, Danyal Quraishi, Shahed Elhamdani, Chen Xu, Alexander Yu

Tower Health Research Day

No abstract provided.

High-Grade Avm. Educational Vignette And Clinical Cases, Marcos Devanir Silva Da Costa, Marcelo Augusto Acosta Goiri, Daniela Coelho, Juan Alberto Paz Archila, Talita Helena Martins Sarti, Feres Chaddad-Neto

Archives of Neurosurgery

The arteriovenous malformation (AVM) is a vascular malformation characterized by fistulas between arteries and veins forming a nidus, without interposition of capillary vessels and of which early draining vein is identified at the digital angiography. Potential reports of its existence date from the second century AD. Spetzler and Martin (S-M) proposed a classification considering three features and Lawton then added new predictors. A maximum of 10 score can be achieved by applying the modified S-M grade system. This classification guides decision-making and the possible choice of the multimodal treatment (surgery, radiosurgery and embolization). We discuss historical, pathological, clinical and therapeutic …

Utilizing Ai Integrated Neuroimaging Technology To Expand Upon Machine Learning In Positron Emission Tomography Technology With The Aim Of Detecting Amyloid Beta Biomarkers Early In The Onset Of Alzheimer's., Ethan S. Terman

Undergraduate Research Posters

Early intervention in Alzheimer's is vital for treatment. The earlier a professional can detect symptoms and make a diagnosis the earlier a prognosis can be implemented. With the prevalence of data in our day-to-day world combined with Artificial intelligence (AI), utilizing both for machine learning can pave the way for more accurate and efficient detection of Alzheimer's and other neurodegenerative diseases. AI combined with Machine learning (ML) increases diagnostic efficiency and reduces human errors, making it a valuable resource for physicians and clinicians alike. With the increasing amount of data processing and image interpretation required, the ability to use AI …

Phage Peptide Technology To Characterize Extracellular Vesicles In The Brain Tumors, Jadelynn Rudolf

Undergraduate Research Conference

Extracellular vesicles (EV) are lipid-bound containers derived from the endosomal membrane network or from the extracellular membrane of cells. They can carry proteins, lipids, miRNAs, and other molecules, and may be involved in intercellular communication via membrane-associated proteins. Glioblastomas (GBM) are aggressive cancers of the brain and spinal cord derived from astrocytes. Extracellular vesicles derived from glioblastomas can make their way through the blood brain barrier and find their way to different bodily fluids, and so could serve as biomarkers for this cancer. We have isolated phage-display peptides from a commercial library of random phage-displayed peptides that will bind glioblastoma …

Intravital Imaging Of Cellular Response Due To Traumatic Brain Injury Using Confocal Microscopy, Enoch G. Kim, Jeffrey Horbatiuk, Carolyn Harris

Medical Student Research Symposium

Introduction: Cellular reaction to traumatic brain injury is complex and involves considerable interactions between cells and reactivity to foreign bodies. Our objective was to assess neurons, microglia, astrocytes, and intracellular Ca²⁺ signaling by creating a novel confocal microscopy technique involving an air immersed lens that does not sacrifice resolution and limits signal attenuation. This study aimed to create a consistent dynamic methodology to observe the cortical cellular response using real-time intravital imaging as trauma is being induced.

Methods: Once surgical plane was achieved, rodent cortices were exposed via craniotomy and blunt insertion with a silicone shunt catheter into the …

Monitoring Intraventricular Hemorrhage In Preterm Infants, Lilian Mn Kebaya

Electronic Thesis and Dissertation Repository

Germinal Matrix-Intraventricular hemorrhage (GMH-IVH) remains a significant cause of adverse neurodevelopmental outcomes in preterm infants. Current management options for GMH-IVH rely on serial 2-dimensional cranial ultrasound (2D cUS) ventricular measurements and clinical signs. A need exists for reliable biomarkers to aid in the early detection of posthemorrhagic ventricular dilatation (PHVD) and cerebral palsy (CP). We incorporated 3-dimensional cranial US (3D cUS) and functional infrared spectroscopy (fNIRS) to monitor ventricle volumes (VV) and spontaneous functional connectivity (sFC) in preterm infants with GMH-IVH. Infants with severe GMH-IVH who underwent cerebrospinal fluid diversion showed larger VV, which correlated with decreased sFC. Our findings …

Seizure Prediction In Epilepsy Patients, Gary Dean Cravens

NSU REACH and IPE Day

Purpose/Objective: Characterize rigorously the preictal period in epilepsy patients to improve the development of seizure prediction techniques. Background/Rationale: 30% of epilepsy patients are not well-controlled on medications and would benefit immensely from reliable seizure prediction. Methods/Methodology: Computational model consisting of in-silico Hodgkin-Huxley neurons arranged in a small-world topology using the Watts-Strogatz algorithm is used to generate synthetic electrocorticographic (ECoG) signals. ECoG data from 18 epilepsy patients is used to validate the model. Unsupervised machine learning is used with both patient and synthetic data to identify potential electrophysiologic biomarkers of the preictal period. Results/Findings: The model has shown states corresponding to …

Short Chain Fatty Acids Taken At Time Of Thrombectomy In Acute Ischemic Stroke Patients Are Independent Of Stroke Severity But Associated With Inflammatory Markers And Worse Symptoms At Discharge, Nicholas Henry, Jacqueline A. Frank, Christopher J. Mclouth, Amanda L. Trout, Andrew J. Morris, Jianzhong Chen, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker

Behavioral Science Faculty Publications

Introduction: Short chain fatty acids (SCFA) are gut microbiota-derived metabolites that contribute to the gut-brain axis and may impact stroke outcomes following gut dysbiosis. We evaluated plasma SCFA concentrations against stroke severity parameters and identified SCFA-associated protein networks.

Methods: The Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC), a continuously enrolling tissue bank, was used to obtain stroke samples. Arterial blood distal and proximal to the thrombus was obtained from Acute Ischemic Stroke (AIS) Patients (n=53) during thrombectomy. Patient demographics, stroke presentation and outcome parameters were reported. The SCFAs were isolated from proximal plasma via chemical derivatization UHPLC coupled tandem …

Aneurysmal Subarachnoid Hemorrhage And Acute Subdural Hematoma, Neurosurgical And Endovascular Rescue. Case Report., José Omar Santellan Resident, José Ramón Aguilar Dr., Abraham Ibarra Dr., Ulises García Dr.

Archives of Neurosurgery

Introduction: Acute subdural hemorrhage (aSDH) in association with aneurismal subarachnoid hemorrhage (SAH) is a severe disease with an incidence of 0.5% to 7.9% of all SAH. Due to the rarity of aneurysmal aSDH, it remains difficult to define a comprehensive management protocol. In this case review, following the CARE guidelines, we show the hybrid management of this pathology to know the importance of using different types of neurosurgical treatments in case of two severe diseases in critical patients.

We present two patients who developed sudden onset cephalea and neurological impairment secondary to aneurysmal subarachnoid hemorrhage associated with acute subdural hematoma. …

Effects Of Subthalamic Deep Brain Stimulation On Treating Motor Symptoms In Early Parkinson's Disease, Emily Reale, Gina Legaluppi

Physician Assistant Capstones, 2020-current

Objective: Assess the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) versus solely optimal pharmacological use in early Parkinson's Disease to improve motor dysfunction. Design: Systematic Literature Review. Methods: Searches were completed on PubMed utilizing the MeSH terms: “subthalamic, deep brain stimulation, and early parkinson.” Using PubMed the following limits and terms were used: published in the last 10 years, randomized controlled trial, English, human, and removing duplicates. A total of three studies resulted after the search. Results: All three studies showed statistically significant results in reduction in disease progressive motor symptoms. Additionally, at the end of each study …

Cessation And Resumption Of Elective Neurointerventional Procedures During The Coronavirus Disease 2019 Pandemic And Future Pandemics, Tim W. Malisch, Sameer A. Ansari, Gary R. Duckwiler, Kyle M. Fargen, Steven W. Hetts, Franklin A. Marden, Athos Patsalides, Clemens M. Schirmer, Allan Brook, Justin F. Fraser

Neurosurgery Faculty Publications

At the time of this writing, the coronavirus disease 2019 pandemic continues to be a global threat, disrupting usual processes, and protocols for delivering health care around the globe. There have been significant regional and national differences in the scope and timing of these disruptions. Many hospitals were forced to temporarily halt elective neurointerventional procedures with the first wave of the pandemic in the spring of 2020, in order to prioritize allocation of resources for acutely ill patients and also to minimize coronavirus disease 2019 transmission risks to non-acute patients, their families, and health care workers. This temporary moratorium on …

Intra-Arterial Combination Therapy For Experimental Acute Ischemic Stroke, Michael E. Maniskas, Jill M. Roberts, Amanda A. Gorman, Gregory J. Bix, Justin F. Fraser

Neurosurgery Faculty Publications

Acute ischemic stroke continues to devastate millions of individuals worldwide. Current treatments work to restore blood flow but not rescue affected tissue. Our goal was to develop a combination of neuroprotective agents administered intra-arterially following recanalization to target ischemic tissue. Using C57Bl/6J male mice, we performed tandem transient ipsilateral middle cerebral/common carotid artery occlusion, followed by immediate intra-arterial pharmacotherapy administration through a standardized protocol. Two pharmacotherapy agents, verapamil and lubeluzole, were selected based on their potential to modulate different aspects of the ischemic cascade; verapamil, a calcium channel blocker, works in an acute fashion blocking L-type calcium channels, whereas lubeluzole, …

Smoking-Induced Sex Differences In Clinical Outcomes In Patients Undergoing Mechanical Thrombectomy For Stroke, Jacqueline A. Frank, Kara Jo Swafford, Jill M. Roberts, Amanda L. Trout, Ann M. Stowe, Douglas E. Lukins, Stephen Grupke, Keith R. Pennypacker, Justin F. Fraser

Neurology Faculty Publications

OBJECTIVE: Ischemic stroke is the fifth leading cause of death in the United States. Smoking accelerates the onset of stroke by 10 years. The effects of smoking status on percent change in National Institutes of Health Stroke Scale (NIHSS) score, infarct volume, and edema volume were examined following mechanical thrombectomy for large vessel occlusion in patients with acute ischemic stroke.

METHODS: Subjects (N = 90; >18 years old) were divided into 3 groups based on smoking status: current smokers, previous smokers (defined as having quit >6 months before the ischemic event), and nonsmokers. Percent change in NIHSS score was …

Intracranial Vcam1 At Time Of Mechanical Thrombectomy Predicts Ischemic Stroke Severity, Benton Maglinger, Madison Sands, Jacqueline A. Frank, Christopher J. Mclouth, Amanda L. Trout, Jill M. Roberts, Stephen Grupke, Jadwiga Turchan-Cholewo, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker

Behavioral Science Faculty Publications

BACKGROUND: Emergent large vessel occlusion (ELVO) strokes are devastating ischemic vascular events for which novel treatment options are needed. Using vascular cell adhesion molecule 1 (VCAM1) as a prototype, the objective of this study was to identify proteomic biomarkers and network signaling functions that are potential therapeutic targets for adjuvant treatment for mechanical thrombectomy.

METHODS: The blood and clot thrombectomy and collaboration (BACTRAC) study is a continually enrolling tissue bank and registry from stroke patients undergoing mechanical thrombectomy. Plasma proteins from intracranial (distal to clot) and systemic arterial blood (carotid) were analyzed by Olink Proteomics for N=42 subjects. Statistical …

The Impact Of Synchrony On Neuronal Coding And Behavior, Natasha Kharas

Dissertations & Theses (Open Access)

Cortical columns represent the elementary functional and computational module of the neocortex. Although much is known about its laminar structure and synaptic connectivity, how patterns of spiking activity propagate within columnar circuits when the state of the brain changes remains poorly understood. We used multi-electrode laminar arrays to reveal that brain state modulates the propagation of neural activity across the layers of early and mid-level visual cortex (areas V1 and V4). We found a high prevalence of neuronal synchrony (vigorous (On) and weak (Off) spiking) in rest but low prevalence of synchrony during wakefulness. We next tested whether propagation of …

Minimally Invasive Non-Expansile Tubular Extradural Posterior Fossa Decompression (Minted Technique) For The Management Of Chiari I.5 Malformation: Historical Overview Of Surgical Techniques, Technical Note, Proof Of Concept, Illustrative Case And Case Series. Lesser Is Better, José Alberto Israel Romero Rangel, Manuel Eduardo Soto García, Sergio Soriano Solís, Carlos Raúl Rangel Morales, Gerson Reyes Rodríguez, José Antonio Soriano Sánchez

Archives of Neurosurgery

BACKGROUND: Chiari's Malformation surgical treatment has significantly changed since the "classical" technique description by Gardner (1950). It is probably the most commonly performed approach, even when multiple techniques are available because no substantial changes nor any clear surgical objectives have been made. OBJECTIVE: To demonstrate a new cutting-edge surgical technique mastering the advantage of each surgical procedure ever described in the history of Chiari's Malformation establishing three critical points in surgical technique: clear patient-specific surgical goals, dynamic posterior fossa reconstruction, and extradural occipitoatlantal dense-adhesions release. METHODS: A comprehensive review of historically described approaches, proof of concept of surgical technique in …

Gait And Balance Changes With Investigational Peripheral Nerve Cell Therapy During Deep Brain Stimulation In People With Parkinson’S Disease, Geetanjali Gera, Zain Guduru, Tritia R. Yamasaki, Julie A. Gurwell, Monica Chau, Anna Krotinger, Frederick A. Schmitt, John T. Slevin, Greg A. Gerhardt, Craig G. Van Horne, Jorge E. Quintero

Physical Therapy Faculty Publications

Background: The efficacy of deep brain stimulation (DBS) and dopaminergic therapy is known to decrease over time. Hence, a new investigational approach combines implanting autologous injury-activated peripheral nerve grafts (APNG) at the time of bilateral DBS surgery to the globus pallidus interna. Objectives: In a study where APNG was unilaterally implanted into the substantia nigra, we explored the effects on clinical gait and balance assessments over two years in 14 individuals with Parkinson’s disease. Methods: Computerized gait and balance evaluations were performed without medication, and stimulation was in the off state for at least 12 h to best assess the …

Method Of Intra-Arterial Drug Administration In A Rat: Sex Based Optimization Of Infusion Rate, Sarah J. Messmer, Justin F. Fraser, Keith R. Pennypacker, Jill M. Roberts

Center for Advanced Translational Stroke Science Faculty Publications

BACKGROUND: Endovascular thrombectomy is the process of removing a blood clot and re-establishing blood flow in patients with emergent large vessel occlusion. The technique provides an opportunity to deliver therapeutics directly to the site of injury. The intra-arterial (IA) route of drug administration in the mouse was developed to bridge the gap between animal stroke treatments and clinical stroke therapy. Here, we adapted the IA method for use in rats, by investigating various flow rates to optimize the IA injection through the internal carotid artery (ICA).

METHODS: Male and female Sprague-Dawley rats (∼4 months of age) were subjected to placement …

Machine Intelligence Identifies Soluble Tnfa As A Therapeutic Target For Spinal Cord Injury, J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K.-A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, John C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, M. S. Beattie

Spinal Cord and Brain Injury Research Center Faculty Publications

Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore likely to manifest multi-factorial effects across a broad range of biological and functional outcome measures. Thus, multivariate analytic approaches are needed to capture the linkage between biological and neurobehavioral outcomes. Injury-induced neuroinflammation (NI) presents a particularly challenging therapeutic target, since NI is involved in both degeneration and repair. Here, we used big-data integration and large-scale analytics to examine a large dataset of preclinical efficacy tests combining five …

Self-Administered Behavioral Skills-Based At-Home Virtual Reality Therapy For Chronic Low Back Pain: Protocol For A Randomized Controlled Trial., Laura Garcia, Beth Darnall, Parthasarathy Krishnamurthy, Ian Mackey, Josh Sackman, Robert Louis, Todd Maddox, Brandon Birckhead

Articles, Abstracts, and Reports

BACKGROUND: Chronic pain is one of the most common and debilitating health conditions. Treatments for chronic low back pain typically focus on biomedical treatment approaches. While psychosocial treatments exist, multiple barriers prevent broad access. There is a significant unmet need for integrative, easily accessible, non-opioid solutions for chronic pain. Virtual reality (VR) is an immersive technology allowing innovation in the delivery of behavioral pain treatments. Behavioral skills-based VR is effective at facilitating pain management and reducing pain-related concerns. Continued research on these emerging approaches is needed.

OBJECTIVE: In this randomized controlled trial, we seek to test the efficacy of a …